#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:E0CZ16 uniprotkb:P55017 intact:EBI-13585540|ensembl:ENSMUSP00000123701|uniprotkb:F7A5U9|uniprotkb:I6L891 intact:EBI-13572998|intact:EBI-28983031|ensembl:ENSP00000456149|uniprotkb:A8MSJ2|uniprotkb:C9JNN9 psi-mi:klhl3_mouse(display_long)|uniprotkb:Klhl3(gene name)|psi-mi:Klhl3(display_short) psi-mi:s12a3_human(display_long)|uniprotkb:SLC12A3(gene name)|psi-mi:SLC12A3(display_short)|uniprotkb:NCC(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:Na-Cl cotransporter(gene name synonym)|uniprotkb:Na-Cl symporter(gene name synonym)|uniprotkb:Thiazide-sensitive sodium-chloride cotransporter(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Louis-Dit-Picard et al. (2012) pubmed:22406640|imex:IM-25624 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13573035|imex:IM-25624-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000014164(gene)|ensembl:ENSMUST00000160860(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0003824"(catalytic activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030578|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:NP_001182004.1 ensembl:ENST00000438926|ensembl:ENSP00000402152|ensembl:ENSP00000456149|ensembl:ENST00000566786|ensembl:ENSP00000457552|ensembl:ENSG00000070915(gene)|ensembl:ENST00000563236(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015378"("sodium:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002948(Thiazide-sensitive Na-K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|reactome:R-HSA-426117|reactome:R-HSA-5619087|refseq:NP_000330.2|refseq:NP_001119579.1|refseq:NP_001119580.1 - - - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/01/20 2017/01/20 rogid:cJjhcgkPR4eY9JCYDQf2HTR9MmY10090 rogid:G1eZ+Ps2/5MKgushTwGyMMsPyi09606 rigid:W+tCrJj/HN7LFsCc4pnltEtJyK0 false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)