#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41159	uniprotkb:P48357	intact:EBI-12994693|ensembl:ENSP00000312652|uniprotkb:O15158|uniprotkb:Q56A88	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	psi-mi:lep_human(display_long)|uniprotkb:LEP(gene name)|psi-mi:LEP(display_short)|uniprotkb:OB(gene name synonym)|uniprotkb:OBS(gene name synonym)|uniprotkb:Obese protein(gene name synonym)|uniprotkb:Obesity factor(gene name synonym)	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Carpenter et al. (2012)	pubmed:22405007|doi:"https://doi.org/10.1016/j.str.2012.01.019"|imex:IM-17591	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973915|imex:IM-17591-1|dip:DIP-10989E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174697(gene)|ensembl:ENST00000308868(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003677"(DNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006114"(glycerol biosynthetic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006909"(phagocytosis)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007565"(female pregnancy)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032814"(regulation of natural killer cell activation)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035904"(aorta development)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0045471"(response to ethanol)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060587"(regulation of lipoprotein lipid oxidation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0071298"(cellular response to L-ascorbic acid)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0019953"(sexual reproduction)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030073"(insulin secretion)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0030217"(T cell differentiation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:1904651"(positive regulation of fat cell apoptotic process)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990460"(leptin receptor binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000486"(negative regulation of glutamine transport)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR000065(Obesity factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1AX8|reactome:R-HSA-2586552|reactome:R-HSA-381340|reactome:R-HSA-381771|reactome:R-HSA-422085|refseq:NP_000221.1|refseq:XP_005250397.1|dip:DIP-6116N	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:9EbJ+u6ZLggQUr7jBDCWDUSDlHI9606	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rigid:vlc9QIXGTmLFskTbBRCU+DPGzC8	false	-	sufficient binding region:428-635	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)