#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:E2JF22 uniprotkb:E2JF22 intact:EBI-9837938 intact:EBI-9837938 psi-mi:piez1_mouse(display_long)|uniprotkb:Piezo1(gene name)|psi-mi:Piezo1(display_short)|uniprotkb:Fam38a(gene name synonym)|uniprotkb:Protein FAM38A(gene name synonym) psi-mi:piez1_mouse(display_long)|uniprotkb:Piezo1(gene name)|psi-mi:Piezo1(display_short)|uniprotkb:Fam38a(gene name synonym)|uniprotkb:Protein FAM38A(gene name synonym) psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis) Coste et al. (2012) pubmed:22343900|doi:10.1038/nature10812|imex:IM-17638 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15971354|imex:IM-17638-1|dip:DIP-188944E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-59655N|go:"GO:0005261"(cation channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR027272|interpro:IPR031334|interpro:IPR031805|rcsb pdb:3JAC|rcsb pdb:4RAX|rcsb pdb:5Z10|rcsb pdb:6B3R|rcsb pdb:6BPZ|rcsb pdb:6LQI dip:DIP-59655N|go:"GO:0005261"(cation channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR027272|interpro:IPR031334|interpro:IPR031805|rcsb pdb:3JAC|rcsb pdb:4RAX|rcsb pdb:5Z10|rcsb pdb:6B3R|rcsb pdb:6BPZ|rcsb pdb:6LQI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:hdah8UO1NXUhBKy6tqyZOD22z+E10090 rogid:hdah8UO1NXUhBKy6tqyZOD22z+E10090 rigid:Fgbs1GhJsqm9h1Kxed9FkE2ZwwQ false glutathione s tranferase tag:c-c glutathione s tranferase tag:c-c - 0 psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:E2JF22 uniprotkb:E2JF22 intact:EBI-9837938 intact:EBI-9837938 psi-mi:piez1_mouse(display_long)|uniprotkb:Piezo1(gene name)|psi-mi:Piezo1(display_short)|uniprotkb:Fam38a(gene name synonym)|uniprotkb:Protein FAM38A(gene name synonym) psi-mi:piez1_mouse(display_long)|uniprotkb:Piezo1(gene name)|psi-mi:Piezo1(display_short)|uniprotkb:Fam38a(gene name synonym)|uniprotkb:Protein FAM38A(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Coste et al. (2012) pubmed:22343900|doi:10.1038/nature10812|imex:IM-17638 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15971372|imex:IM-17638-2|dip:DIP-188944E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-59655N|go:"GO:0005261"(cation channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR027272|interpro:IPR031334|interpro:IPR031805|rcsb pdb:3JAC|rcsb pdb:4RAX|rcsb pdb:5Z10|rcsb pdb:6B3R|rcsb pdb:6BPZ|rcsb pdb:6LQI dip:DIP-59655N|go:"GO:0005261"(cation channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR027272|interpro:IPR031334|interpro:IPR031805|rcsb pdb:3JAC|rcsb pdb:4RAX|rcsb pdb:5Z10|rcsb pdb:6B3R|rcsb pdb:6BPZ|rcsb pdb:6LQI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:hdah8UO1NXUhBKy6tqyZOD22z+E10090 rogid:hdah8UO1NXUhBKy6tqyZOD22z+E10090 rigid:Fgbs1GhJsqm9h1Kxed9FkE2ZwwQ false glutathione s tranferase tag:c-c glutathione s tranferase tag:c-c - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:E2JF22 uniprotkb:E2JF22 intact:EBI-9837938 intact:EBI-9837938 psi-mi:piez1_mouse(display_long)|uniprotkb:Piezo1(gene name)|psi-mi:Piezo1(display_short)|uniprotkb:Fam38a(gene name synonym)|uniprotkb:Protein FAM38A(gene name synonym) psi-mi:piez1_mouse(display_long)|uniprotkb:Piezo1(gene name)|psi-mi:Piezo1(display_short)|uniprotkb:Fam38a(gene name synonym)|uniprotkb:Protein FAM38A(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Coste et al. (2012) pubmed:22343900|doi:10.1038/nature10812|imex:IM-17638 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15971390|imex:IM-17638-3|dip:DIP-188944E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-59655N|go:"GO:0005261"(cation channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR027272|interpro:IPR031334|interpro:IPR031805|rcsb pdb:3JAC|rcsb pdb:4RAX|rcsb pdb:5Z10|rcsb pdb:6B3R|rcsb pdb:6BPZ|rcsb pdb:6LQI dip:DIP-59655N|go:"GO:0005261"(cation channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR027272|interpro:IPR031334|interpro:IPR031805|rcsb pdb:3JAC|rcsb pdb:4RAX|rcsb pdb:5Z10|rcsb pdb:6B3R|rcsb pdb:6BPZ|rcsb pdb:6LQI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:hdah8UO1NXUhBKy6tqyZOD22z+E10090 rogid:hdah8UO1NXUhBKy6tqyZOD22z+E10090 rigid:Fgbs1GhJsqm9h1Kxed9FkE2ZwwQ false glutathione s tranferase tag:c-c glutathione s tranferase tag:c-c - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)