#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02787	uniprotkb:Q09057	intact:EBI-714319|uniprotkb:O43890|uniprotkb:Q9NQB8|uniprotkb:Q9UHV0|uniprotkb:Q1HBA5|ensembl:ENSP00000385834	intact:EBI-15970048	psi-mi:trfe_human(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:TF(gene name)|psi-mi:TF(display_short)|uniprotkb:PRO1400(orf name)	psi-mi:tbpb1_neimi(display_long)|uniprotkb:tbpB(gene name)|psi-mi:tbpB(display_short)|uniprotkb:tbp2(gene name synonym)|uniprotkb:TbpB receptor(gene name synonym)|uniprotkb:Transferrin-binding protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Calmettes et al. (2012)	pubmed:22343719|doi:10.1038/nsmb.2251|imex:IM-18089	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:491(Neisseria meningitidis serogroup B)|taxid:491(Neisseria meningitidis serogroup B)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15970061|imex:IM-18089-1|dip:DIP-189801E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001054.1|rcsb pdb:1JQF|rcsb pdb:1N7W|rcsb pdb:1N7X|rcsb pdb:1N84|rcsb pdb:1OQG|rcsb pdb:1OQH|rcsb pdb:1RYO|rcsb pdb:1SUV|rcsb pdb:2HAU|rcsb pdb:2HAV|rcsb pdb:2O7U|rcsb pdb:2O84|rcsb pdb:3FGS|rcsb pdb:3QYT|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:1FQF|rcsb pdb:3S9N|rcsb pdb:3SKP|rcsb pdb:3V83|rcsb pdb:3V89|rcsb pdb:3V8X|rcsb pdb:4H0W|rcsb pdb:4X1B|rcsb pdb:4X1D|rcsb pdb:5DYH|rcsb pdb:5H52|rcsb pdb:5WTD|rcsb pdb:5X5P|rcsb pdb:5Y6K|rcsb pdb:6CTC|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:3VE1|rcsb pdb:6JAS|rcsb pdb:6SOY|rcsb pdb:6SOZ|rcsb pdb:6UJ6|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8957275|reactome:R-HSA-917937|reactome:R-HSA-917977|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0072562"(blood microparticle)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:P02787|rcsb pdb:1A8E|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:1A8F|rcsb pdb:1B3E|rcsb pdb:1BP5|rcsb pdb:1BTJ|rcsb pdb:1D3K|rcsb pdb:1D4N|rcsb pdb:1DTG|rcsb pdb:1FQE|ensembl:ENSG00000091513(gene)|ensembl:ENST00000402696(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|refseq:XP_016862578.1|refseq:XP_016862579.1|dip:DIP-2738N	go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|interpro:IPR001677(Transferrin binding protein)|interpro:IPR011250(Outer membrane protein, beta-barrel)|interpro:IPR035313|interpro:IPR035316|interpro:IPR038197|interpro:IPR038669|rcsb pdb:3VE1|rcsb pdb:3VE2|rcsb pdb:5KKX|dip:DIP-59922N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CN9nME9TVV6/FGrhH6XHtJF9/HI9606	rogid:q2W35+FJ3G/babUc1r6vqEM9JSo491	rigid:HjDxnqkT3x1JIkWEBJV/7AWOX0o	false	-	sufficient binding region:56-711	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02787	uniprotkb:Q09057	intact:EBI-714319|uniprotkb:O43890|uniprotkb:Q9NQB8|uniprotkb:Q9UHV0|uniprotkb:Q1HBA5|ensembl:ENSP00000385834	intact:EBI-15970048	psi-mi:trfe_human(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:TF(gene name)|psi-mi:TF(display_short)|uniprotkb:PRO1400(orf name)	psi-mi:tbpb1_neimi(display_long)|uniprotkb:tbpB(gene name)|psi-mi:tbpB(display_short)|uniprotkb:tbp2(gene name synonym)|uniprotkb:TbpB receptor(gene name synonym)|uniprotkb:Transferrin-binding protein 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Calmettes et al. (2012)	pubmed:22343719|doi:10.1038/nsmb.2251|imex:IM-18089	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:491(Neisseria meningitidis serogroup B)|taxid:491(Neisseria meningitidis serogroup B)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15970081|imex:IM-18089-2|dip:DIP-189801E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001054.1|rcsb pdb:1JQF|rcsb pdb:1N7W|rcsb pdb:1N7X|rcsb pdb:1N84|rcsb pdb:1OQG|rcsb pdb:1OQH|rcsb pdb:1RYO|rcsb pdb:1SUV|rcsb pdb:2HAU|rcsb pdb:2HAV|rcsb pdb:2O7U|rcsb pdb:2O84|rcsb pdb:3FGS|rcsb pdb:3QYT|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:1FQF|rcsb pdb:3S9N|rcsb pdb:3SKP|rcsb pdb:3V83|rcsb pdb:3V89|rcsb pdb:3V8X|rcsb pdb:4H0W|rcsb pdb:4X1B|rcsb pdb:4X1D|rcsb pdb:5DYH|rcsb pdb:5H52|rcsb pdb:5WTD|rcsb pdb:5X5P|rcsb pdb:5Y6K|rcsb pdb:6CTC|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:3VE1|rcsb pdb:6JAS|rcsb pdb:6SOY|rcsb pdb:6SOZ|rcsb pdb:6UJ6|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8957275|reactome:R-HSA-917937|reactome:R-HSA-917977|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0072562"(blood microparticle)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:P02787|rcsb pdb:1A8E|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:1A8F|rcsb pdb:1B3E|rcsb pdb:1BP5|rcsb pdb:1BTJ|rcsb pdb:1D3K|rcsb pdb:1D4N|rcsb pdb:1DTG|rcsb pdb:1FQE|ensembl:ENSG00000091513(gene)|ensembl:ENST00000402696(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|refseq:XP_016862578.1|refseq:XP_016862579.1|dip:DIP-2738N	go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|interpro:IPR001677(Transferrin binding protein)|interpro:IPR011250(Outer membrane protein, beta-barrel)|interpro:IPR035313|interpro:IPR035316|interpro:IPR038197|interpro:IPR038669|rcsb pdb:3VE1|rcsb pdb:3VE2|rcsb pdb:5KKX|dip:DIP-59922N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CN9nME9TVV6/FGrhH6XHtJF9/HI9606	rogid:q2W35+FJ3G/babUc1r6vqEM9JSo491	rigid:HjDxnqkT3x1JIkWEBJV/7AWOX0o	false	-	sufficient binding region:56-711	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02787	uniprotkb:Q09057	intact:EBI-714319|uniprotkb:O43890|uniprotkb:Q9NQB8|uniprotkb:Q9UHV0|uniprotkb:Q1HBA5|ensembl:ENSP00000385834	intact:EBI-15970048	psi-mi:trfe_human(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:TF(gene name)|psi-mi:TF(display_short)|uniprotkb:PRO1400(orf name)	psi-mi:tbpb1_neimi(display_long)|uniprotkb:tbpB(gene name)|psi-mi:tbpB(display_short)|uniprotkb:tbp2(gene name synonym)|uniprotkb:TbpB receptor(gene name synonym)|uniprotkb:Transferrin-binding protein 2(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Calmettes et al. (2012)	pubmed:22343719|doi:10.1038/nsmb.2251|imex:IM-18089	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:491(Neisseria meningitidis serogroup B)|taxid:491(Neisseria meningitidis serogroup B)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15970100|imex:IM-18089-3|dip:DIP-189801E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001054.1|rcsb pdb:1JQF|rcsb pdb:1N7W|rcsb pdb:1N7X|rcsb pdb:1N84|rcsb pdb:1OQG|rcsb pdb:1OQH|rcsb pdb:1RYO|rcsb pdb:1SUV|rcsb pdb:2HAU|rcsb pdb:2HAV|rcsb pdb:2O7U|rcsb pdb:2O84|rcsb pdb:3FGS|rcsb pdb:3QYT|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:1FQF|rcsb pdb:3S9N|rcsb pdb:3SKP|rcsb pdb:3V83|rcsb pdb:3V89|rcsb pdb:3V8X|rcsb pdb:4H0W|rcsb pdb:4X1B|rcsb pdb:4X1D|rcsb pdb:5DYH|rcsb pdb:5H52|rcsb pdb:5WTD|rcsb pdb:5X5P|rcsb pdb:5Y6K|rcsb pdb:6CTC|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:3VE1|rcsb pdb:6JAS|rcsb pdb:6SOY|rcsb pdb:6SOZ|rcsb pdb:6UJ6|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8957275|reactome:R-HSA-917937|reactome:R-HSA-917977|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0072562"(blood microparticle)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:P02787|rcsb pdb:1A8E|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:1A8F|rcsb pdb:1B3E|rcsb pdb:1BP5|rcsb pdb:1BTJ|rcsb pdb:1D3K|rcsb pdb:1D4N|rcsb pdb:1DTG|rcsb pdb:1FQE|ensembl:ENSG00000091513(gene)|ensembl:ENST00000402696(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|refseq:XP_016862578.1|refseq:XP_016862579.1|dip:DIP-2738N	go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|interpro:IPR001677(Transferrin binding protein)|interpro:IPR011250(Outer membrane protein, beta-barrel)|interpro:IPR035313|interpro:IPR035316|interpro:IPR038197|interpro:IPR038669|rcsb pdb:3VE1|rcsb pdb:3VE2|rcsb pdb:5KKX|dip:DIP-59922N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CN9nME9TVV6/FGrhH6XHtJF9/HI9606	rogid:q2W35+FJ3G/babUc1r6vqEM9JSo491	rigid:HjDxnqkT3x1JIkWEBJV/7AWOX0o	false	-	sufficient binding region:56-711	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)