#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9DCC8 uniprotkb:Q8VCN5 intact:EBI-8071628|intact:MINT-4616302|ensembl:ENSMUSP00000136493 intact:EBI-8363035|intact:MINT-1855831|uniprotkb:Q6H324|ensembl:ENSMUSP00000113672 psi-mi:tom20_mouse(display_long)|uniprotkb:Tomm20(gene name)|psi-mi:Tomm20(display_short)|uniprotkb:Mitochondrial 20 kDa outer membrane protein(gene name synonym)|uniprotkb:Outer mitochondrial membrane receptor Tom20(gene name synonym) psi-mi:cgl_mouse(display_long)|uniprotkb:Cth(gene name)|psi-mi:Cth(display_short)|uniprotkb:Cysteine-protein sulfhydrase(gene name synonym)|uniprotkb:Gamma-cystathionase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fu et al. (2012) pubmed:22323590|doi:10.1073/pnas.1115634109|imex:IM-20637 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15967872|imex:IM-20637-1|dip:DIP-190234E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077176.1|dip:DIP-60017N|ensembl:ENSMUSG00000093904(gene)|ensembl:ENSMUST00000179857(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016031"(tRNA import into mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|interpro:IPR002056(Protein import receptor MAS20)|interpro:IPR022422|interpro:IPR023392|reactome:R-MMU-5205685|reactome:R-MMU-5689880 refseq:NP_666065.1|dip:DIP-60018N|ensembl:ENSMUSG00000028179(gene)|ensembl:ENSMUST00000118539(transcript)|go:"GO:0004121"(cystathionine beta-lyase activity)|go:"GO:0004123"(cystathionine gamma-lyase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016846"(carbon-sulfur lyase activity)|go:"GO:0018272"(protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0019346"(transsulfuration)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044524"(protein sulfhydration)|go:"GO:0044540"("L-cystine L-cysteine-lyase (deaminating)")|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|go:"GO:1904831"(positive regulation of aortic smooth muscle cell differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000277(Cys/Met metabolism, pyridoxal phosphate-dependent enzyme)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:Q8VCN5|reactome:R-MMU-1614558|reactome:R-MMU-1614603|go:"GO:0005516"(calmodulin binding) psi-mi:"MI:0465"(dip) function:Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore|comment:mint comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:wxN3IjghW7Z6ip/A0KxDZ/tDfIQ10090 rogid:hengdMPuKYDjl6Ivt8ulOkMgDA410090 rigid:uJp6bZ5E6jvUw3B+4e1VJ5xeFx4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)