#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O00180 uniprotkb:O00180 intact:EBI-3914675|uniprotkb:Q5T5E8|uniprotkb:Q13307|ensembl:ENSP00000355580 intact:EBI-3914675|uniprotkb:Q5T5E8|uniprotkb:Q13307|ensembl:ENSP00000355580 psi-mi:kcnk1_human(display_long)|uniprotkb:KCNK1(gene name)|psi-mi:KCNK1(display_short)|uniprotkb:HOHO1(gene name synonym)|uniprotkb:KCNO1(gene name synonym)|uniprotkb:TWIK1(gene name synonym)|uniprotkb:Inward rectifying potassium channel protein TWIK-1(gene name synonym)|uniprotkb:Potassium channel KCNO1(gene name synonym)|uniprotkb:Potassium channel K2P1(gene name synonym) psi-mi:kcnk1_human(display_long)|uniprotkb:KCNK1(gene name)|psi-mi:KCNK1(display_short)|uniprotkb:HOHO1(gene name synonym)|uniprotkb:KCNO1(gene name synonym)|uniprotkb:TWIK1(gene name synonym)|uniprotkb:Inward rectifying potassium channel protein TWIK-1(gene name synonym)|uniprotkb:Potassium channel KCNO1(gene name synonym)|uniprotkb:Potassium channel K2P1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Miller et al. (2012) pubmed:22282804|doi:10.1126/science.1213274|imex:IM-25221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15965917|imex:IM-25221-1|dip:DIP-188396E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002236.1|ensembl:ENSG00000135750(gene)|ensembl:ENST00000366621(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:0031526"(brush border membrane)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035094"(response to nicotine)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097060"(synaptic membrane)|go:"GO:1902937"(inward rectifier potassium channel complex)|interpro:IPR001779(Potassium channel, two pore-domain, TWIK-1)|interpro:IPR003092(Potassium channel, two pore-domain, TASK)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR005408(Potassium channel, two pore-domain, TWIK)|interpro:IPR013099(Ion transport 2)|rcsb pdb:3UKM|reactome:R-HSA-1299308|reactome:R-HSA-5576886|dip:DIP-59532N refseq:NP_002236.1|ensembl:ENSG00000135750(gene)|ensembl:ENST00000366621(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:0031526"(brush border membrane)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035094"(response to nicotine)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097060"(synaptic membrane)|go:"GO:1902937"(inward rectifier potassium channel complex)|interpro:IPR001779(Potassium channel, two pore-domain, TWIK-1)|interpro:IPR003092(Potassium channel, two pore-domain, TASK)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR005408(Potassium channel, two pore-domain, TWIK)|interpro:IPR013099(Ion transport 2)|rcsb pdb:3UKM|reactome:R-HSA-1299308|reactome:R-HSA-5576886|dip:DIP-59532N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4922(picpa)|taxid:4922("Pichia pastoris (Yeast)") - 2017/08/07 2017/08/10 rogid:SnGdXEw8Kfxf9+pwOAFFc3pfJRk9606 rogid:SnGdXEw8Kfxf9+pwOAFFc3pfJRk9606 rigid:mLRJcsIgcvPZY+ylJhn7KYPe2Ik false sufficient binding region:19-288 sufficient binding region:19-288 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)