#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P68198	uniprotkb:P91682	intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2012)	pubmed:22253574|doi:10.1371/journal.pbio.1001239|imex:IM-17606	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964445|imex:IM-17606-1|dip:DIP-188907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	comment:Deletion of region 661-818 decreased the interaction rate/strength.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:GWxeoWMvnIicSmTpm8LJYI8JUTU	false	-	myc tag:n-n|mutation decreasing interaction:746-746,743-743,740-740,693-693,690-690,687-687,673-673,670-670,667-667|mutation decreasing interaction:801-801,782-782,773-773,772-772,762-762,753-753,752-752,733-733,710-710,702-702,700-700,695-695,665-665|mutation decreasing interaction:733-733,710-710,702-702,700-700,695-695,665-665|mutation decreasing interaction strength:801-801,782-782,772-773,762-762,752-753	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VDD8	uniprotkb:P91682	intact:EBI-153542|ensemblmetazoa:FBpp0083419	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:q9vdd8_drome(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubpy-RA(gene name synonym)|uniprotkb:CT18196(gene name synonym)|uniprotkb:Dmel\CG5798(gene name synonym)|uniprotkb:Q9VDD8(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:USP8(gene name synonym)|uniprotkb:UbpY(gene name synonym)|uniprotkb:dUBPY(gene name synonym)|uniprotkb:ubpy(gene name synonym)|uniprotkb:usp8(gene name synonym)|uniprotkb:Dmel_CG5798(orf name)|uniprotkb:CG5798(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2012)	pubmed:22253574|doi:10.1371/journal.pbio.1001239|imex:IM-17606	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964539|imex:IM-17606-3|dip:DIP-188909E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_650948.2|flybase:FBgn0038862|ensemblmetazoa:FBgn0038862(gene)|ensemblmetazoa:FBtr0084016(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|reactome:R-DME-5689880|reactome:R-DME-1358803	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:wp/1Jk6wykNg3nVH14w3EmaPjg07227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:etcYW0NfCFxZKFN1SWYqCZYW4F8	false	flag tag:n-n	myc tag:n-n|sufficient binding region:556-1036	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9VVX3	uniprotkb:P68198	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2012)	pubmed:22253574|doi:10.1371/journal.pbio.1001239|imex:IM-17606	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964562|imex:IM-17606-4|dip:DIP-188912E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/15	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227	rigid:9pu+EZh4gVqM796EcL2uK/s9sG0	false	myc tag:n-n	ha tag:0-0	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9V393	uniprotkb:P91682	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2012)	pubmed:22253574|doi:10.1371/journal.pbio.1001239|imex:IM-17606	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964505|imex:IM-17606-2|dip:DIP-188911E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:1+xdnH4pP382KydQz3seZrmwkrw	false	yellow fluorescent protein tag:c-c	myc tag:n-n|sufficient binding region:556-1036|mutation decreasing interaction:746-746,743-743,740-740,693-693,690-690,687-687,673-673,670-670,667-667	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P68198	uniprotkb:P91682	intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2012)	pubmed:22253574|doi:10.1371/journal.pbio.1001239|imex:IM-17606	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964583|imex:IM-17606-5|dip:DIP-188907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:GWxeoWMvnIicSmTpm8LJYI8JUTU	false	ha tag:0-0	myc tag:n-n|mutation decreasing interaction:801-801,782-782,773-773,772-772,762-762,753-753,752-752,733-733,710-710,702-702,700-700,695-695,665-665|mutation decreasing interaction strength:801-801,782-782,772-773,762-762,752-753|mutation decreasing interaction:733-733,710-710,702-702,700-700,695-695,665-665	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)