#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62991	uniprotkb:Q99835	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	intact:EBI-766024|uniprotkb:A4D1K5|ensembl:ENSP00000249373	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:smo_human(display_long)|uniprotkb:Protein Gx(gene name synonym)|uniprotkb:SMO(gene name)|psi-mi:SMO(display_short)|uniprotkb:SMOH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2012)	pubmed:22253573|doi:10.1371/journal.pbio.1001238|imex:IM-17605	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964244|imex:IM-17605-1|dip:DIP-188908E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	refseq:NP_005622.1|dip:DIP-34574N|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0040018"(positive regulation of multicellular organism growth)|ensembl:ENSG00000128602(gene)|ensembl:ENST00000249373(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007494"(midgut development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0007417"(central nervous system development)|rcsb pdb:6OT0|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5620922|reactome:R-HSA-5632684|reactome:R-HSA-5635838|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|mint:Q99835|rcsb pdb:4JKV|rcsb pdb:4N4W|rcsb pdb:4O9R|rcsb pdb:4QIM|rcsb pdb:4QIN|rcsb pdb:5L7D|rcsb pdb:5L7I|rcsb pdb:5V56|rcsb pdb:5V57	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rogid:U/2EljQsTdy+9hVvzURz0CkburQ9606	rigid:+mQUpX+RjgZxL4S29YRzOUB2oM4	false	-	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VDD8	uniprotkb:P91682	intact:EBI-153542|ensemblmetazoa:FBpp0083419	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:q9vdd8_drome(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubpy-RA(gene name synonym)|uniprotkb:CT18196(gene name synonym)|uniprotkb:Dmel\CG5798(gene name synonym)|uniprotkb:Q9VDD8(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:USP8(gene name synonym)|uniprotkb:UbpY(gene name synonym)|uniprotkb:dUBPY(gene name synonym)|uniprotkb:ubpy(gene name synonym)|uniprotkb:usp8(gene name synonym)|uniprotkb:Dmel_CG5798(orf name)|uniprotkb:CG5798(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xia et al. (2012)	pubmed:22253573|doi:10.1371/journal.pbio.1001238|imex:IM-17605	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964293|imex:IM-17605-3|dip:DIP-188909E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_650948.2|flybase:FBgn0038862|ensemblmetazoa:FBgn0038862(gene)|ensemblmetazoa:FBtr0084016(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|reactome:R-DME-5689880|reactome:R-DME-1358803	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:wp/1Jk6wykNg3nVH14w3EmaPjg07227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:etcYW0NfCFxZKFN1SWYqCZYW4F8	false	flag tag:n-n	glutathione s tranferase tag:n-n|mutation increasing interaction:746-746,743-743,740-740,693-693,690-690,687-687,673-673,670-670,667-667|binding-associated region:625-753	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9VDD8	uniprotkb:P91682	intact:EBI-153542|ensemblmetazoa:FBpp0083419	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:q9vdd8_drome(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubpy-RA(gene name synonym)|uniprotkb:CT18196(gene name synonym)|uniprotkb:Dmel\CG5798(gene name synonym)|uniprotkb:Q9VDD8(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:USP8(gene name synonym)|uniprotkb:UbpY(gene name synonym)|uniprotkb:dUBPY(gene name synonym)|uniprotkb:ubpy(gene name synonym)|uniprotkb:usp8(gene name synonym)|uniprotkb:Dmel_CG5798(orf name)|uniprotkb:CG5798(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2012)	pubmed:22253573|doi:10.1371/journal.pbio.1001238|imex:IM-17605	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964327|imex:IM-17605-4|dip:DIP-188909E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_650948.2|flybase:FBgn0038862|ensemblmetazoa:FBgn0038862(gene)|ensemblmetazoa:FBtr0084016(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|reactome:R-DME-5689880|reactome:R-DME-1358803	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:wp/1Jk6wykNg3nVH14w3EmaPjg07227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:etcYW0NfCFxZKFN1SWYqCZYW4F8	false	sufficient binding region:536-896|ha tag:n-n	myc tag:n-n|sufficient binding region:556-1036|mutation increasing interaction:746-746,743-743,740-740,693-693,690-690,687-687,673-673,670-670,667-667|mutation decreasing interaction:740-740,687-687,667-667	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P68198	uniprotkb:P91682	intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2012)	pubmed:22253573|doi:10.1371/journal.pbio.1001238|imex:IM-17605	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964368|imex:IM-17605-5|dip:DIP-188907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:GWxeoWMvnIicSmTpm8LJYI8JUTU	false	ha tag:0-0	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P68198	uniprotkb:Q99835	intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N	intact:EBI-766024|uniprotkb:A4D1K5|ensembl:ENSP00000249373	psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name)	psi-mi:smo_human(display_long)|uniprotkb:Protein Gx(gene name synonym)|uniprotkb:SMO(gene name)|psi-mi:SMO(display_short)|uniprotkb:SMOH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2012)	pubmed:22253573|doi:10.1371/journal.pbio.1001238|imex:IM-17605	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964389|imex:IM-17605-6|dip:DIP-188910E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558	refseq:NP_005622.1|dip:DIP-34574N|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0040018"(positive regulation of multicellular organism growth)|ensembl:ENSG00000128602(gene)|ensembl:ENST00000249373(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007494"(midgut development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0007417"(central nervous system development)|rcsb pdb:6OT0|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5620922|reactome:R-HSA-5632684|reactome:R-HSA-5635838|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|mint:Q99835|rcsb pdb:4JKV|rcsb pdb:4N4W|rcsb pdb:4O9R|rcsb pdb:4QIM|rcsb pdb:4QIN|rcsb pdb:5L7D|rcsb pdb:5L7I|rcsb pdb:5V56|rcsb pdb:5V57	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227	rogid:U/2EljQsTdy+9hVvzURz0CkburQ9606	rigid:d6ObpDGmxHA3qBOBqKqVSkGbFpk	false	ha tag:0-0	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P68198	uniprotkb:P91682	intact:EBI-86340|uniprotkb:Q0E8I1|uniprotkb:Q9VKW6|uniprotkb:Q9VQX7|uniprotkb:Q9VZL4|dip:DIP-32843N	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:ubiq_drome(display_long)|uniprotkb:RpL40(gene name)|psi-mi:RpL40(display_short)|uniprotkb:CG2960(orf name)|uniprotkb:RpS27A(gene name)|psi-mi:RpS27A(display_short)|uniprotkb:UBI-F80(gene name synonym)|uniprotkb:Ubi-f(gene name synonym)|uniprotkb:CG5271(orf name)|uniprotkb:Ubi-p63E(gene name)|psi-mi:Ubi-p63E(display_short)|uniprotkb:Ubi-m(gene name synonym)|uniprotkb:CG11624(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2012)	pubmed:22253573|doi:10.1371/journal.pbio.1001238|imex:IM-17605	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964263|imex:IM-17605-2|dip:DIP-188907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|flybase:FBgn0003941(RpL40)|flybase:FBgn0003943(Ubi-p63E)|go:"GO:0006911"(phagocytosis, engulfment)|refseq:NP_476776.1|refseq:NP_476778.1|refseq:NP_728908.1|go:"GO:0005515"(protein binding)|flybase:FBgn0003942(RpS27A)|go:"GO:0030528"(obsolete transcription regulator activity)|go:"GO:0045941"|go:"GO:0016567"(protein ubiquitination)|go:"GO:0009408"(response to heat)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:FBgn0003943|ensembl:FBgn0003941|ensembl:FBgn0003942|refseq:NP_523909.2|refseq:NP_995994.1|ensembl:FBgn0086558	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:GWxeoWMvnIicSmTpm8LJYI8JUTU	false	-	myc tag:n-n|mutation decreasing interaction:746-746,743-743,740-740,693-693,690-690,687-687,673-673,670-670,667-667	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VDD8	uniprotkb:P91682	intact:EBI-153542|ensemblmetazoa:FBpp0083419	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:q9vdd8_drome(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubpy-RA(gene name synonym)|uniprotkb:CT18196(gene name synonym)|uniprotkb:Dmel\CG5798(gene name synonym)|uniprotkb:Q9VDD8(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:USP8(gene name synonym)|uniprotkb:UbpY(gene name synonym)|uniprotkb:dUBPY(gene name synonym)|uniprotkb:ubpy(gene name synonym)|uniprotkb:usp8(gene name synonym)|uniprotkb:Dmel_CG5798(orf name)|uniprotkb:CG5798(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2012)	pubmed:22253573|doi:10.1371/journal.pbio.1001238|imex:IM-17605	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964410|imex:IM-17605-7|dip:DIP-188909E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_650948.2|flybase:FBgn0038862|ensemblmetazoa:FBgn0038862(gene)|ensemblmetazoa:FBtr0084016(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|reactome:R-DME-5689880|reactome:R-DME-1358803	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:wp/1Jk6wykNg3nVH14w3EmaPjg07227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:etcYW0NfCFxZKFN1SWYqCZYW4F8	false	flag tag:n-n	myc tag:n-n|sufficient binding region:556-730|sufficient binding region:679-1036	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)