#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z0F8	uniprotkb:Q80WQ6	intact:EBI-7848498|ensembl:ENSMUSP00000067953|uniprotkb:Q9R1U4|uniprotkb:Q9Z0K3|uniprotkb:O88726|uniprotkb:Q505A7|intact:MINT-246289	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	psi-mi:ada17_mouse(display_long)|uniprotkb:Adam17(gene name)|psi-mi:Adam17(display_short)|uniprotkb:Tace(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Adrain et al. (2012)	pubmed:22246777|doi:10.1126/science.1214400|imex:IM-25218	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964074|imex:IM-25218-1|dip:DIP-200834E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052593(gene)|ensembl:ENSMUST00000064536(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|reactome:R-MMU-193692|reactome:R-MMU-75893|refseq:NP_033745.4|refseq:NP_001264195.1|refseq:NP_001278800.1|dip:DIP-41747N	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	psi-mi:"MI:0465"(dip)	function:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway|comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:W3i2jBO2/JqainCbVRsCBU9wAmc10090	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	rigid:nXY867S1r97JNcH0XlKr7JfJhCE	false	v5 tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P78536	uniprotkb:Q80WQ6	intact:EBI-78188|intact:EBI-28987181|ensembl:ENSP00000309968|uniprotkb:O60226	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	psi-mi:ada17_human(display_long)|uniprotkb:ADAM17(gene name)|psi-mi:ADAM17(display_short)|uniprotkb:CSVP(gene name synonym)|uniprotkb:TACE(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)|uniprotkb:Snake venom-like protease(gene name synonym)	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Adrain et al. (2012)	pubmed:22246777|doi:10.1126/science.1214400|imex:IM-25218	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964095|imex:IM-25218-2|dip:DIP-200835E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0045121"(membrane raft)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0035624"(receptor transactivation)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|mint:P78536|rcsb pdb:1BKC|rcsb pdb:1ZXC|rcsb pdb:2A8H|rcsb pdb:2DDF|rcsb pdb:2FV5|rcsb pdb:2FV9|rcsb pdb:2I47|rcsb pdb:2M2F|rcsb pdb:2OI0|rcsb pdb:3B92|rcsb pdb:3CKI|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|rcsb pdb:3E8R|rcsb pdb:3EDZ|rcsb pdb:3EWJ|rcsb pdb:3G42|rcsb pdb:3KMC|rcsb pdb:3KME|rcsb pdb:3L0T|rcsb pdb:3L0V|rcsb pdb:3LE9|rcsb pdb:3LEA|rcsb pdb:3LGP|rcsb pdb:3O64|reactome:R-HSA-1251985|reactome:R-HSA-1442490|reactome:R-HSA-177929|reactome:R-HSA-193692|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-5362798|ensembl:ENSG00000151694(gene)|ensembl:ENST00000310823(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002467"(germinal center formation)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008233"(peptidase activity)|reactome:R-HSA-9662834|reactome:R-HSA-982772|reactome:R-HSA-75893|refseq:NP_003174.3|ensembl:ENSP00000309968|dip:DIP-31044N	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:9ZXiwccqzkHXJUHY1KNhH/ZGG+89606	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	rigid:I3DNMkn9u4T2xeFJEaV4EXY1b3g	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z0F8	uniprotkb:Q80WQ6	intact:EBI-7848498|ensembl:ENSMUSP00000067953|uniprotkb:Q9R1U4|uniprotkb:Q9Z0K3|uniprotkb:O88726|uniprotkb:Q505A7|intact:MINT-246289	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	psi-mi:ada17_mouse(display_long)|uniprotkb:Adam17(gene name)|psi-mi:Adam17(display_short)|uniprotkb:Tace(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Adrain et al. (2012)	pubmed:22246777|doi:10.1126/science.1214400|imex:IM-25218	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964150|imex:IM-25218-5|dip:DIP-200834E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052593(gene)|ensembl:ENSMUST00000064536(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|reactome:R-MMU-193692|reactome:R-MMU-75893|refseq:NP_033745.4|refseq:NP_001264195.1|refseq:NP_001278800.1|dip:DIP-41747N	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	psi-mi:"MI:0465"(dip)	function:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway|comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:W3i2jBO2/JqainCbVRsCBU9wAmc10090	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	rigid:nXY867S1r97JNcH0XlKr7JfJhCE	false	strep tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z0F8	uniprotkb:Q80WQ6	intact:EBI-7848498|ensembl:ENSMUSP00000067953|uniprotkb:Q9R1U4|uniprotkb:Q9Z0K3|uniprotkb:O88726|uniprotkb:Q505A7|intact:MINT-246289	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	psi-mi:ada17_mouse(display_long)|uniprotkb:Adam17(gene name)|psi-mi:Adam17(display_short)|uniprotkb:Tace(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Adrain et al. (2012)	pubmed:22246777|doi:10.1126/science.1214400|imex:IM-25218	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964133|imex:IM-25218-4|dip:DIP-200834E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052593(gene)|ensembl:ENSMUST00000064536(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|reactome:R-MMU-193692|reactome:R-MMU-75893|refseq:NP_033745.4|refseq:NP_001264195.1|refseq:NP_001278800.1|dip:DIP-41747N	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	psi-mi:"MI:0465"(dip)	function:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway|comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:W3i2jBO2/JqainCbVRsCBU9wAmc10090	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	rigid:nXY867S1r97JNcH0XlKr7JfJhCE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78536	uniprotkb:Q80WQ6	intact:EBI-78188|intact:EBI-28987181|ensembl:ENSP00000309968|uniprotkb:O60226	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	psi-mi:ada17_human(display_long)|uniprotkb:ADAM17(gene name)|psi-mi:ADAM17(display_short)|uniprotkb:CSVP(gene name synonym)|uniprotkb:TACE(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)|uniprotkb:Snake venom-like protease(gene name synonym)	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Adrain et al. (2012)	pubmed:22246777|doi:10.1126/science.1214400|imex:IM-25218	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964114|imex:IM-25218-3|dip:DIP-200835E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0045121"(membrane raft)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0035624"(receptor transactivation)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|mint:P78536|rcsb pdb:1BKC|rcsb pdb:1ZXC|rcsb pdb:2A8H|rcsb pdb:2DDF|rcsb pdb:2FV5|rcsb pdb:2FV9|rcsb pdb:2I47|rcsb pdb:2M2F|rcsb pdb:2OI0|rcsb pdb:3B92|rcsb pdb:3CKI|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|rcsb pdb:3E8R|rcsb pdb:3EDZ|rcsb pdb:3EWJ|rcsb pdb:3G42|rcsb pdb:3KMC|rcsb pdb:3KME|rcsb pdb:3L0T|rcsb pdb:3L0V|rcsb pdb:3LE9|rcsb pdb:3LEA|rcsb pdb:3LGP|rcsb pdb:3O64|reactome:R-HSA-1251985|reactome:R-HSA-1442490|reactome:R-HSA-177929|reactome:R-HSA-193692|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-5362798|ensembl:ENSG00000151694(gene)|ensembl:ENST00000310823(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002467"(germinal center formation)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008233"(peptidase activity)|reactome:R-HSA-9662834|reactome:R-HSA-982772|reactome:R-HSA-75893|refseq:NP_003174.3|ensembl:ENSP00000309968|dip:DIP-31044N	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:9ZXiwccqzkHXJUHY1KNhH/ZGG+89606	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	rigid:I3DNMkn9u4T2xeFJEaV4EXY1b3g	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z0F8	uniprotkb:Q80WQ6	intact:EBI-7848498|ensembl:ENSMUSP00000067953|uniprotkb:Q9R1U4|uniprotkb:Q9Z0K3|uniprotkb:O88726|uniprotkb:Q505A7|intact:MINT-246289	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	psi-mi:ada17_mouse(display_long)|uniprotkb:Adam17(gene name)|psi-mi:Adam17(display_short)|uniprotkb:Tace(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Adrain et al. (2012)	pubmed:22246777|doi:10.1126/science.1214400|imex:IM-25218	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964171|imex:IM-25218-6|dip:DIP-200834E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052593(gene)|ensembl:ENSMUST00000064536(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|reactome:R-MMU-193692|reactome:R-MMU-75893|refseq:NP_033745.4|refseq:NP_001264195.1|refseq:NP_001278800.1|dip:DIP-41747N	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	psi-mi:"MI:0465"(dip)	function:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway|comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:W3i2jBO2/JqainCbVRsCBU9wAmc10090	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	rigid:nXY867S1r97JNcH0XlKr7JfJhCE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)