#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05106	uniprotkb:P26039	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Moore et al. (2012)	pubmed:22210111|doi:10.1073/pnas.1117220108|imex:IM-21263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15961494|imex:IM-21263-1|dip:DIP-67799E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090	rigid:8UvjGET60CMXjcAb6Ir1zWwZekM	false	sufficient binding region:746-788|bodipy label:745-745	sufficient binding region:1-425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05106	uniprotkb:P26039	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Moore et al. (2012)	pubmed:22210111|doi:10.1073/pnas.1117220108|imex:IM-21263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15961517|imex:IM-21263-2|dip:DIP-67799E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090	rigid:8UvjGET60CMXjcAb6Ir1zWwZekM	false	sufficient binding region:746-788	sufficient binding region:1-425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05106	uniprotkb:P26039	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Moore et al. (2012)	pubmed:22210111|doi:10.1073/pnas.1117220108|imex:IM-21263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15961538|imex:IM-21263-3|dip:DIP-67799E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090	rigid:8UvjGET60CMXjcAb6Ir1zWwZekM	false	sufficient binding region:746-788	sufficient binding region:1-425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60331	uniprotkb:P26039	intact:EBI-8869029|uniprotkb:B7Z9E7|uniprotkb:C6GIJ7|uniprotkb:C6GIJ8|uniprotkb:Q7LE07|ensembl:ENSP00000335333	intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187	psi-mi:pi51c_human(display_long)|uniprotkb:PIP5K1C(gene name)|psi-mi:PIP5K1C(display_short)|uniprotkb:KIAA0589(gene name synonym)|uniprotkb:Type I phosphatidylinositol 4-phosphate 5-kinase gamma(gene name synonym)	psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Moore et al. (2012)	pubmed:22210111|doi:10.1073/pnas.1117220108|imex:IM-21263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15961559|imex:IM-21263-4|dip:DIP-67798E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000335333|ensembl:ENST00000537021|ensembl:ENSP00000444779|ensembl:ENST00000539785|ensembl:ENSP00000445992|ensembl:ENST00000589578|ensembl:ENSP00000466363|refseq:NP_001287778.1|refseq:NP_001182662.1|refseq:NP_036530.1|dip:DIP-39809N|ensembl:ENSG00000186111(gene)|ensembl:ENST00000335312(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|rcsb pdb:2G35|rcsb pdb:3H1Z|rcsb pdb:3H85|reactome:R-HSA-1660499|reactome:R-HSA-399955|reactome:R-HSA-6811558|reactome:R-HSA-8856828	refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/10/31	rogid:Xle7kUnkAh2gtQLx2/gl7d2Gz049606	rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090	rigid:t7Vpz/G/tUR925jzOLloEL1t6C8	false	sufficient binding region:646-654|fluorescein isothiocyanate label:?-?	sufficient binding region:1-425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)