#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q95XS0 uniprotkb:O44406-1 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-863698|ensemblmetazoa:T07A9.5b.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:o44406-1(display_long)|uniprotkb:eri-1b(isoform synonym)|uniprotkb:eri-1(gene name)|psi-mi:eri-1(display_short)|uniprotkb:Enhanced RNAi protein(gene name synonym)|uniprotkb:T07A9.5(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959827|imex:IM-21857-2|dip:DIP-192294E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 intact:EBI-863689(eri1_caeel)|ensemblmetazoa:T07A9.5b.1(transcript)|ensemblmetazoa:WBGene00001332(gene) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:jTIG36IFR533chYBlgvs+bf/qQ06239 rigid:iUXO9rf2rJ5tLZc5JQJibZn6Cw8 false - - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q95XS0 uniprotkb:Q22707 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-895783|ensemblmetazoa:T23G7.5a.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:dus11_caeel(display_long)|uniprotkb:pir-1(gene name)|psi-mi:pir-1(display_short)|uniprotkb:Dual specificity protein phosphatase 11 homolog(gene name synonym)|uniprotkb:Phosphatase interacting with RNA/RNP complex-1(gene name synonym)|uniprotkb:T23G7.5(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959827|imex:IM-21857-2|dip:DIP-192294E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 refseq:NP_495959.2|wormbase:T23G7.5a|dip:DIP-35121N|ensemblmetazoa:T23G7.5a.1(transcript)|ensemblmetazoa:WBGene00011967(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0004651"(polynucleotide 5'-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0050355"(triphosphatase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:vydbIbHQIJ3WwSf3S9ZWseAbp9s6239 rigid:iUXO9rf2rJ5tLZc5JQJibZn6Cw8 false - - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q95XS0 uniprotkb:Q9GZI7 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-866569|ensemblmetazoa:W09B6.3a.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:q9gzi7_caeel(display_long)|uniprotkb:eri-3(gene name)|psi-mi:eri-3(display_short)|uniprotkb:CELE_W09B6.3(orf name)|uniprotkb:W09B6.3(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959827|imex:IM-21857-2|dip:DIP-192294E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 refseq:NP_493918.2|wormbase:W09B6.3a|dip:DIP-35117N|ensemblmetazoa:W09B6.3a.1(transcript)|ensemblmetazoa:WBGene00021103(gene)|go:"GO:0007283"(spermatogenesis) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:X4381iUL6MORWbAK3dbQaMhCAxc6239 rigid:iUXO9rf2rJ5tLZc5JQJibZn6Cw8 false - - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q95XS0 uniprotkb:G5EBF5 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959827|imex:IM-21857-2|dip:DIP-192294E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:iUXO9rf2rJ5tLZc5JQJibZn6Cw8 false - - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q95XS0 uniprotkb:P34529 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959827|imex:IM-21857-2|dip:DIP-192294E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:iUXO9rf2rJ5tLZc5JQJibZn6Cw8 false - - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q95XS0 uniprotkb:Q93413 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-866549|ensemblmetazoa:D2005.5.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:q93413_caeel(display_long)|uniprotkb:drh-3(gene name)|psi-mi:drh-3(display_short)|uniprotkb:CELE_D2005.5(orf name)|uniprotkb:D2005.5(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959827|imex:IM-21857-2|dip:DIP-192294E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 refseq:NP_492161.3|wormbase:D2005.5|dip:DIP-35120N|mint:Q93413|ensemblmetazoa:D2005.5.1(transcript)|ensemblmetazoa:WBGene00008400(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0016246"(RNA interference)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0043186"(P granule)|go:"GO:0045087"(innate immune response)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070090"(metaphase plate)|go:"GO:1903863"(P granule assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|rcsb pdb:6M6Q|rcsb pdb:6M6R|rcsb pdb:6M6S|reactome:R-CEL-1169408|reactome:R-CEL-5689880|reactome:R-CEL-936440 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:0bG0c5rbqjEXqKVpRnlBGVd878M6239 rigid:iUXO9rf2rJ5tLZc5JQJibZn6Cw8 false - - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q95XS0 uniprotkb:G5EE53 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959827|imex:IM-21857-2|dip:DIP-192294E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rigid:iUXO9rf2rJ5tLZc5JQJibZn6Cw8 false - - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q9GZI7 uniprotkb:P34529 intact:EBI-866569|ensemblmetazoa:W09B6.3a.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:q9gzi7_caeel(display_long)|uniprotkb:eri-3(gene name)|psi-mi:eri-3(display_short)|uniprotkb:CELE_W09B6.3(orf name)|uniprotkb:W09B6.3(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0096"(pull down) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15959850|imex:IM-21857-3|dip:DIP-192303E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_493918.2|wormbase:W09B6.3a|dip:DIP-35117N|ensemblmetazoa:W09B6.3a.1(transcript)|ensemblmetazoa:WBGene00021103(gene)|go:"GO:0007283"(spermatogenesis) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:X4381iUL6MORWbAK3dbQaMhCAxc6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:G1f8wPIZDqYjGQ3lTM74qhTKJGU false flag tag:c-c sufficient binding region:220-427|sufficient binding region:272-1045|glutathione s tranferase tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P34529 uniprotkb:G5EBF5 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959809|imex:IM-21857-1|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EDI8 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959809|imex:IM-21857-1|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EEH0 uniprotkb:G5EBF5 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959950|imex:IM-21857-7|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false ha tag:c-c flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EEH0 uniprotkb:P34529 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959950|imex:IM-21857-7|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EEH0 uniprotkb:G5EDI8 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959950|imex:IM-21857-7|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EDI8 uniprotkb:G5EEH0 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959973|imex:IM-21857-8|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EDI8 uniprotkb:G5EBF5 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959973|imex:IM-21857-8|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EDI8 uniprotkb:P34529 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959973|imex:IM-21857-8|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95XS0 uniprotkb:G5EE53 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15959992|imex:IM-21857-9|dip:DIP-192302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rigid:AOmZD75a0tmZcTSrthKL01R+09I false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:Q93413 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866549|ensemblmetazoa:D2005.5.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:q93413_caeel(display_long)|uniprotkb:drh-3(gene name)|psi-mi:drh-3(display_short)|uniprotkb:CELE_D2005.5(orf name)|uniprotkb:D2005.5(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960009|imex:IM-21857-10|dip:DIP-192300E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 refseq:NP_492161.3|wormbase:D2005.5|dip:DIP-35120N|mint:Q93413|ensemblmetazoa:D2005.5.1(transcript)|ensemblmetazoa:WBGene00008400(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0016246"(RNA interference)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0043186"(P granule)|go:"GO:0045087"(innate immune response)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070090"(metaphase plate)|go:"GO:1903863"(P granule assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|rcsb pdb:6M6Q|rcsb pdb:6M6R|rcsb pdb:6M6S|reactome:R-CEL-1169408|reactome:R-CEL-5689880|reactome:R-CEL-936440 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:0bG0c5rbqjEXqKVpRnlBGVd878M6239 rigid:J0IBXgUPiNxfdZDxBhKzAnwOz8w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:Q95XS0 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960009|imex:IM-21857-10|dip:DIP-192300E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rigid:J0IBXgUPiNxfdZDxBhKzAnwOz8w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EE53 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960009|imex:IM-21857-10|dip:DIP-192300E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rigid:J0IBXgUPiNxfdZDxBhKzAnwOz8w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:G5EEH0 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959927|imex:IM-21857-6|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false flag tag:c-c ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:P34529 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959927|imex:IM-21857-6|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:G5EDI8 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15959927|imex:IM-21857-6|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EBF5 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0071"(molecular sieving) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15959909|imex:IM-21857-5|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EDI8 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0071"(molecular sieving) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15959909|imex:IM-21857-5|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q19731 uniprotkb:G5EE53 intact:EBI-15959875|ensemblmetazoa:F22D6.6.1 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 psi-mi:q19731_caeel(display_long)|uniprotkb:ekl-1(gene name)|psi-mi:ekl-1(display_short)|uniprotkb:CELE_F22D6.6(orf name)|uniprotkb:F22D6.6(orf name) psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15959892|imex:IM-21857-4|dip:DIP-192299E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:F22D6.6.1(transcript)|ensemblmetazoa:WBGene00009052(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0070090"(metaphase plate)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:1903863"(P granule assembly)|interpro:IPR002999(Tudor)|refseq:NP_492009.1|wormbase:F22D6.6|dip:DIP-60529N uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/Y6aAt4rz/wRUHfFsOOgXbKdUYA6239 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rigid:lDrNNJrAIPLaUs9GVjUPGgdQ+5w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EEH0 uniprotkb:G5EBF5 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960028|imex:IM-21857-11|dip:DIP-192307E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:nZZ2G1+gJ4Euc4e6tqoByWimQ7Q false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:G5EEH0 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960045|imex:IM-21857-12|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:P34529 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960045|imex:IM-21857-12|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:G5EDI8 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960045|imex:IM-21857-12|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:P34529 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960064|imex:IM-21857-13|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBF5 uniprotkb:G5EDI8 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960064|imex:IM-21857-13|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EDI8 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960082|imex:IM-21857-14|dip:DIP-192295E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:elmt+/so+RcGL6yab78VPb9v+js false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95XS0 uniprotkb:Q93413 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-866549|ensemblmetazoa:D2005.5.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:q93413_caeel(display_long)|uniprotkb:drh-3(gene name)|psi-mi:drh-3(display_short)|uniprotkb:CELE_D2005.5(orf name)|uniprotkb:D2005.5(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960099|imex:IM-21857-15|dip:DIP-192300E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 refseq:NP_492161.3|wormbase:D2005.5|dip:DIP-35120N|mint:Q93413|ensemblmetazoa:D2005.5.1(transcript)|ensemblmetazoa:WBGene00008400(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0016246"(RNA interference)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0043186"(P granule)|go:"GO:0045087"(innate immune response)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070090"(metaphase plate)|go:"GO:1903863"(P granule assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|rcsb pdb:6M6Q|rcsb pdb:6M6R|rcsb pdb:6M6S|reactome:R-CEL-1169408|reactome:R-CEL-5689880|reactome:R-CEL-936440 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:0bG0c5rbqjEXqKVpRnlBGVd878M6239 rigid:J0IBXgUPiNxfdZDxBhKzAnwOz8w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95XS0 uniprotkb:P34529 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960099|imex:IM-21857-15|dip:DIP-192300E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:J0IBXgUPiNxfdZDxBhKzAnwOz8w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95XS0 uniprotkb:G5EE53 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960099|imex:IM-21857-15|dip:DIP-192300E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rigid:J0IBXgUPiNxfdZDxBhKzAnwOz8w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:Q95XS0 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:"MI:0096"(pull down) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960118|imex:IM-21857-16|dip:DIP-192305E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rigid:zWAfQ6xcpewHFdKwntAC5qSA4lE false glutathione s tranferase tag:c-c|binding-associated region:272-1045 calmodulin binding protein tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P34529 uniprotkb:Q9GZI7 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866569|ensemblmetazoa:W09B6.3a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:q9gzi7_caeel(display_long)|uniprotkb:eri-3(gene name)|psi-mi:eri-3(display_short)|uniprotkb:CELE_W09B6.3(orf name)|uniprotkb:W09B6.3(orf name) psi-mi:"MI:0096"(pull down) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960118|imex:IM-21857-16|dip:DIP-192305E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 refseq:NP_493918.2|wormbase:W09B6.3a|dip:DIP-35117N|ensemblmetazoa:W09B6.3a.1(transcript)|ensemblmetazoa:WBGene00021103(gene)|go:"GO:0007283"(spermatogenesis) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:X4381iUL6MORWbAK3dbQaMhCAxc6239 rigid:zWAfQ6xcpewHFdKwntAC5qSA4lE false glutathione s tranferase tag:c-c|binding-associated region:272-1045 flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q93413 uniprotkb:Q95XS0 intact:EBI-866549|ensemblmetazoa:D2005.5.1 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 psi-mi:q93413_caeel(display_long)|uniprotkb:drh-3(gene name)|psi-mi:drh-3(display_short)|uniprotkb:CELE_D2005.5(orf name)|uniprotkb:D2005.5(orf name) psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960144|imex:IM-21857-17|dip:DIP-192296E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_492161.3|wormbase:D2005.5|dip:DIP-35120N|mint:Q93413|ensemblmetazoa:D2005.5.1(transcript)|ensemblmetazoa:WBGene00008400(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0016246"(RNA interference)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0043186"(P granule)|go:"GO:0045087"(innate immune response)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070090"(metaphase plate)|go:"GO:1903863"(P granule assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|rcsb pdb:6M6Q|rcsb pdb:6M6R|rcsb pdb:6M6S|reactome:R-CEL-1169408|reactome:R-CEL-5689880|reactome:R-CEL-936440 wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:0bG0c5rbqjEXqKVpRnlBGVd878M6239 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rigid:OIAI6HD+1GLOxHn+UlRipmotcPE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EBQ3 uniprotkb:Q19731 intact:EBI-2464759|ensemblmetazoa:F26A3.3.1 intact:EBI-15959875|ensemblmetazoa:F22D6.6.1 psi-mi:g5ebq3_caeel(display_long)|uniprotkb:ego-1(gene name)|psi-mi:ego-1(display_short)|uniprotkb:CELE_F26A3.3(orf name)|uniprotkb:F26A3.3(orf name) psi-mi:q19731_caeel(display_long)|uniprotkb:ekl-1(gene name)|psi-mi:ekl-1(display_short)|uniprotkb:CELE_F22D6.6(orf name)|uniprotkb:F22D6.6(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960161|imex:IM-21857-18|dip:DIP-192301E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_492132.1|uniprotkb:Q93593(uniprot-removed-ac)|wormbase:F26A3.3|dip:DIP-60530N|ensemblmetazoa:F26A3.3.1(transcript)|ensemblmetazoa:WBGene00001214(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0043186"(P granule)|go:"GO:0048477"(oogenesis)|go:"GO:0051664"(nuclear pore localization)|go:"GO:0070090"(metaphase plate)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|go:"GO:1903863"(P granule assembly)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) ensemblmetazoa:F22D6.6.1(transcript)|ensemblmetazoa:WBGene00009052(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0070090"(metaphase plate)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:1903863"(P granule assembly)|interpro:IPR002999(Tudor)|refseq:NP_492009.1|wormbase:F22D6.6|dip:DIP-60529N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:8EtrLk7nSwXSMbfeiQNBao96JVg6239 rogid:/Y6aAt4rz/wRUHfFsOOgXbKdUYA6239 rigid:PEsDP16tlnDSeDP+HTgGPLV/cxI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EDI8 uniprotkb:G5EBF5 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960178|imex:IM-21857-19|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EDI8 uniprotkb:P34529 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960178|imex:IM-21857-19|dip:DIP-192306E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:70tpz7lpb+wyO0pb0j0oPeEtxI0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95XS0 uniprotkb:P34529 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0096"(pull down) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15960196|imex:IM-21857-20|dip:DIP-192304E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:+uxY3CsNtpZqk/FJE4znY54GHhY false calmodulin binding protein tag:c-c sufficient binding region:220-427|sufficient binding region:272-1045|glutathione s tranferase tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P34529 uniprotkb:O44406 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-863689|uniprotkb:O44407|uniprotkb:U4PC85|uniprotkb:U4PCK7|ensemblmetazoa:T07A9.5b.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:eri1_caeel(display_long)|uniprotkb:Enhanced RNAi protein(gene name synonym)|uniprotkb:eri-1(gene name)|psi-mi:eri-1(display_short)|uniprotkb:T07A9.5(orf name) psi-mi:"MI:0071"(molecular sieving) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960221|imex:IM-21857-21|dip:DIP-192308E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 refseq:NP_741292.1|refseq:NP_741293.1|wormbase:T07A9.5a|wormbase:T07A9.5b|wormbase:T07A9.5c|wormbase:T07A9.5d|dip:DIP-35116N|ensemblmetazoa:T07A9.5b.1(transcript)|ensemblmetazoa:WBGene00001332(gene)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0007281"(germ cell development)|go:"GO:0016246"(RNA interference)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:1900369"(negative regulation of RNA interference)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|refseq:NP_001294645.1|refseq:NP_001294646.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:jTIG36IFR533chYBlgvs+bf/qQ06239 rigid:RARbOg24Q1IdoAuWJKbunJfzrLE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EBF5 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0071"(molecular sieving) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960221|imex:IM-21857-21|dip:DIP-192308E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:RARbOg24Q1IdoAuWJKbunJfzrLE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EE53 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:"MI:0071"(molecular sieving) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960221|imex:IM-21857-21|dip:DIP-192308E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rigid:RARbOg24Q1IdoAuWJKbunJfzrLE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:Q93413 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866549|ensemblmetazoa:D2005.5.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:q93413_caeel(display_long)|uniprotkb:drh-3(gene name)|psi-mi:drh-3(display_short)|uniprotkb:CELE_D2005.5(orf name)|uniprotkb:D2005.5(orf name) psi-mi:"MI:0071"(molecular sieving) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960221|imex:IM-21857-21|dip:DIP-192308E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 refseq:NP_492161.3|wormbase:D2005.5|dip:DIP-35120N|mint:Q93413|ensemblmetazoa:D2005.5.1(transcript)|ensemblmetazoa:WBGene00008400(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0016246"(RNA interference)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0043186"(P granule)|go:"GO:0045087"(innate immune response)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070090"(metaphase plate)|go:"GO:1903863"(P granule assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|rcsb pdb:6M6Q|rcsb pdb:6M6R|rcsb pdb:6M6S|reactome:R-CEL-1169408|reactome:R-CEL-5689880|reactome:R-CEL-936440 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:0bG0c5rbqjEXqKVpRnlBGVd878M6239 rigid:RARbOg24Q1IdoAuWJKbunJfzrLE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:Q95XS0 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:"MI:0071"(molecular sieving) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960221|imex:IM-21857-21|dip:DIP-192308E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rigid:RARbOg24Q1IdoAuWJKbunJfzrLE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EDI8 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15960261|imex:IM-21857-23|dip:DIP-192295E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:elmt+/so+RcGL6yab78VPb9v+js false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EEH0 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-895898|ensemblmetazoa:K08H10.7.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5eeh0_caeel(display_long)|uniprotkb:rde-1(gene name)|psi-mi:rde-1(display_short)|uniprotkb:CELE_K08H10.7(orf name)|uniprotkb:K08H10.7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960242|imex:IM-21857-22|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q9XU82(uniprot-removed-ac)|refseq:NP_741611.1|wormbase:K08H10.7|dip:DIP-60528N|reactome:R-CEL-203927|reactome:R-CEL-426486|reactome:R-CEL-5578749|ensemblmetazoa:K08H10.7.1(transcript)|ensemblmetazoa:WBGene00004323(gene)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035197"(siRNA binding)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:l5yED3BdHj3D9Mx0yMi0jzb3P706239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EBF5 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-328046|ensemblmetazoa:T20G5.11.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5ebf5_caeel(display_long)|uniprotkb:rde-4(gene name)|psi-mi:rde-4(display_short)|uniprotkb:T20G5.11(orf name)|uniprotkb:CELE_T20G5.11(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960242|imex:IM-21857-22|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:Q22617(uniprot-removed-ac)|rcsb pdb:2LTR|rcsb pdb:2LTS|interpro:IPR014720(Double-stranded RNA-binding-like)|refseq:NP_499265.1|wormbase:T20G5.11|ensemblmetazoa:T20G5.11.1(transcript)|ensemblmetazoa:WBGene00004326(gene)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0016246"(RNA interference)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:KP9wT0JggVuuriaDYCy0gSMvD9Y6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34529 uniprotkb:G5EDI8 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 intact:EBI-327837|ensemblmetazoa:F15B10.2a.1 psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:g5edi8_caeel(display_long)|uniprotkb:drh-1(gene name)|psi-mi:drh-1(display_short)|uniprotkb:CELE_F15B10.2(orf name)|uniprotkb:F15B10.2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960242|imex:IM-21857-22|dip:DIP-192297E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 uniprotkb:O44165(uniprot-removed-ac)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|wormbase:F15B10.2a|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|refseq:NP_501018.1|interpro:IPR027417|ensemblmetazoa:F15B10.2a.1(transcript)|ensemblmetazoa:WBGene00001090(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016246"(RNA interference)|go:"GO:0016787"(hydrolase activity)|go:"GO:0045087"(innate immune response)|interpro:IPR038557 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rogid:UluTW3RVd7aJr0Q13S+bvVkfVjg6239 rigid:gtJASvAG76FxmT8DmVMsBMdpTQc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EE53 uniprotkb:Q19731 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 intact:EBI-15959875|ensemblmetazoa:F22D6.6.1 psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:q19731_caeel(display_long)|uniprotkb:ekl-1(gene name)|psi-mi:ekl-1(display_short)|uniprotkb:CELE_F22D6.6(orf name)|uniprotkb:F22D6.6(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960278|imex:IM-21857-24|dip:DIP-192298E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) ensemblmetazoa:F22D6.6.1(transcript)|ensemblmetazoa:WBGene00009052(gene)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0070090"(metaphase plate)|go:"GO:0070918"(primary sncRNA processing)|go:"GO:1903863"(P granule assembly)|interpro:IPR002999(Tudor)|refseq:NP_492009.1|wormbase:F22D6.6|dip:DIP-60529N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rogid:/Y6aAt4rz/wRUHfFsOOgXbKdUYA6239 rigid:8dxFP48q9mUAy0CDUXGs08ExM3Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EE53 uniprotkb:Q95XS0 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 intact:EBI-866573|ensemblmetazoa:Y38F2AR.1a.1 psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:q95xs0_caeel(display_long)|uniprotkb:eri-5(gene name)|psi-mi:eri-5(display_short)|uniprotkb:CELE_Y38F2AR.1(orf name)|uniprotkb:Y38F2AR.1(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960278|imex:IM-21857-24|dip:DIP-192298E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) wormbase:Y38F2AR.1a|refseq:NP_500199.2|dip:DIP-35118N|ensemblmetazoa:WBGene00021419(gene)|ensemblmetazoa:Y38F2AR.1a.1(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070918"(primary sncRNA processing)|interpro:IPR002999(Tudor)|interpro:IPR035437 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rogid:bfekkew2b+Heav1EWIHJ8mP+Gns6239 rigid:8dxFP48q9mUAy0CDUXGs08ExM3Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G5EE53 uniprotkb:P34529 intact:EBI-866561|ensemblmetazoa:F10B5.7.1 intact:EBI-326716|ensemblmetazoa:K12H4.8.1|ensemblmetazoa:K12H4.8.2 psi-mi:g5ee53_caeel(display_long)|uniprotkb:rrf-3(gene name)|psi-mi:rrf-3(display_short)|uniprotkb:CELE_F10B5.7(orf name)|uniprotkb:F10B5.7(orf name) psi-mi:dcr1_caeel(display_long)|uniprotkb:dcr-1(gene name)|psi-mi:dcr-1(display_short)|uniprotkb:eri-4(gene name synonym)|uniprotkb:let-740(gene name synonym)|uniprotkb:K12H4.8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thivierge et al. (2011) pubmed:22179787|doi:10.1038/nsmb.2186|imex:IM-21857 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15960278|imex:IM-21857-24|dip:DIP-192298E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q19285(uniprot-removed-ac)|refseq:NP_495713.2|wormbase:F10B5.7|dip:DIP-60527N|ensemblmetazoa:F10B5.7.1(transcript)|ensemblmetazoa:WBGene00004510(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type) refseq:NP_498761.2|wormbase:K12H4.8|ensemblmetazoa:K12H4.8.1(transcript)|ensemblmetazoa:K12H4.8.2(transcript)|ensemblmetazoa:WBGene00000939(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0002119"(nematode larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0008355"(olfactory learning)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031050"|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:2000636"(positive regulation of primary miRNA processing)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0005737"(cytoplasm)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|dip:DIP-25340N|reactome:R-CEL-203927|reactome:R-CEL-426486 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/07 2017/08/10 rogid:p7LHOELESS6CHFwM3+W5KFx9VoY6239 rogid:/RbRoUynfE9DKTUPTS2cMWrX7SM6239 rigid:8dxFP48q9mUAy0CDUXGs08ExM3Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)