#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P69924 uniprotkb:P00452 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:"MI:0114"(x-ray crystallography) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958757|imex:IM-17946-1|dip:DIP-170755E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rigid:xhs3cusljmEtIUyQmpoYlCn/MbM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00452 uniprotkb:P00452 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:"MI:0826"(x ray scattering) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958790|imex:IM-17946-3|dip:DIP-50186E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rigid:GgY1R3PibGXVunCsIVYKNIW9E90 false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69924 uniprotkb:P69924 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:"MI:0028"(cosedimentation in solution) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958806|imex:IM-17946-4|dip:DIP-108979E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rigid:ITxa3fzBA0amajYR2K2/jfWTKvw false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69924 uniprotkb:P00452 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:"MI:0826"(x ray scattering) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958822|imex:IM-17946-5|dip:DIP-170755E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rigid:xhs3cusljmEtIUyQmpoYlCn/MbM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69924 uniprotkb:P69924 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:"MI:0826"(x ray scattering) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958839|imex:IM-17946-6|dip:DIP-108979E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rigid:ITxa3fzBA0amajYR2K2/jfWTKvw false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69924 uniprotkb:P00452 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:"MI:0020"(transmission electron microscopy) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958855|imex:IM-17946-7|dip:DIP-170755E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rigid:xhs3cusljmEtIUyQmpoYlCn/MbM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00452 uniprotkb:P00452 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:"MI:0028"(cosedimentation in solution) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958774|imex:IM-17946-2|dip:DIP-50186E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rigid:GgY1R3PibGXVunCsIVYKNIW9E90 false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69924 uniprotkb:P00452 intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054 intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053 psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name) psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name) psi-mi:"MI:0028"(cosedimentation in solution) Ando et al. (2011) pubmed:22160671|doi:10.1073/pnas.1112715108|imex:IM-17946 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15958872|imex:IM-17946-8|dip:DIP-170755E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333 rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333 rigid:xhs3cusljmEtIUyQmpoYlCn/MbM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)