#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07333	uniprotkb:P07333	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956900|imex:IM-17064-3|dip:DIP-187849E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rigid:DQNPJ5WZHeQ6+jp3OHiiFd2IpL4	false	binding-associated region:20-517	binding-associated region:20-517	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09603	uniprotkb:P09603	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956861|imex:IM-17064-1|dip:DIP-187845E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:Bw1zUXjkOK2vInm8i7xreby3peM	false	binding-associated region:33-181	binding-associated region:33-181	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09581	uniprotkb:P07141	intact:EBI-6305373|ensembl:ENSMUSP00000025523|ensembl:ENSMUSP00000110923|uniprotkb:Q3U3P1|uniprotkb:Q9DBH9	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	psi-mi:csf1r_mouse(display_long)|uniprotkb:Csf1r(gene name)|psi-mi:Csf1r(display_short)|uniprotkb:Csfmr(gene name synonym)|uniprotkb:Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956879|imex:IM-17064-2|dip:DIP-88423E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-449836|rcsb pdb:4EXP|ensembl:ENSMUSG00000024621(gene)|ensembl:ENSMUST00000025523(transcript)|ensembl:ENSMUST00000115268(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032944"(regulation of mononuclear cell proliferation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|rcsb pdb:3EJJ|dip:DIP-46415N|refseq:XP_006525647.1|refseq:XP_006525648.1|refseq:XP_006525649.1|refseq:NP_001032948.2|refseq:XP_017173299.1	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jWzzruMZt6wnD2QFpQ4/aov3vlU10090	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rigid:b4khIml1CluaacslcnXfWI5+7s8	false	sufficient binding region:20-298	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07333	uniprotkb:P09603	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956918|imex:IM-17064-4|dip:DIP-187846E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:VQnvskaT6Aur2dieh+eymgERYNw	false	binding-associated region:20-517	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07333	uniprotkb:P09603	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15957017|imex:IM-17064-9|dip:DIP-187846E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:VQnvskaT6Aur2dieh+eymgERYNw	false	sufficient binding region:20-290	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07141	uniprotkb:P07333	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15957038|imex:IM-17064-10|dip:DIP-187847E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rigid:1tiJbpVg9tZk3CEl3P4Z+VH8m1o	false	binding-associated region:33-181	binding-associated region:20-517	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07333	uniprotkb:P09603	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:1022"(field flow fractionation)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15957059|imex:IM-17064-11|dip:DIP-187846E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:VQnvskaT6Aur2dieh+eymgERYNw	false	sufficient binding region:20-290	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07333	uniprotkb:P09603	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956996|imex:IM-17064-8|dip:DIP-187846E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:VQnvskaT6Aur2dieh+eymgERYNw	false	sufficient binding region:20-290	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07333	uniprotkb:P09603	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956975|imex:IM-17064-7|dip:DIP-187846E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:VQnvskaT6Aur2dieh+eymgERYNw	false	sufficient binding region:20-290	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09581	uniprotkb:P07141	intact:EBI-6305373|ensembl:ENSMUSP00000025523|ensembl:ENSMUSP00000110923|uniprotkb:Q3U3P1|uniprotkb:Q9DBH9	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	psi-mi:csf1r_mouse(display_long)|uniprotkb:Csf1r(gene name)|psi-mi:Csf1r(display_short)|uniprotkb:Csfmr(gene name synonym)|uniprotkb:Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15957080|imex:IM-17064-12|dip:DIP-88423E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-449836|rcsb pdb:4EXP|ensembl:ENSMUSG00000024621(gene)|ensembl:ENSMUST00000025523(transcript)|ensembl:ENSMUST00000115268(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032944"(regulation of mononuclear cell proliferation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|rcsb pdb:3EJJ|dip:DIP-46415N|refseq:XP_006525647.1|refseq:XP_006525648.1|refseq:XP_006525649.1|refseq:NP_001032948.2|refseq:XP_017173299.1	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jWzzruMZt6wnD2QFpQ4/aov3vlU10090	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rigid:b4khIml1CluaacslcnXfWI5+7s8	false	binding-associated region:20-298	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09603	uniprotkb:P09603	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956939|imex:IM-17064-5|dip:DIP-187845E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:Bw1zUXjkOK2vInm8i7xreby3peM	false	binding-associated region:33-181	binding-associated region:33-181	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09603	uniprotkb:P09603	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15956957|imex:IM-17064-6|dip:DIP-187845E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:Bw1zUXjkOK2vInm8i7xreby3peM	false	binding-associated region:33-181	binding-associated region:33-181	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09603	uniprotkb:P09581	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	intact:EBI-6305373|ensembl:ENSMUSP00000025523|ensembl:ENSMUSP00000110923|uniprotkb:Q3U3P1|uniprotkb:Q9DBH9	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:csf1r_mouse(display_long)|uniprotkb:Csf1r(gene name)|psi-mi:Csf1r(display_short)|uniprotkb:Csfmr(gene name synonym)|uniprotkb:Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15957122|imex:IM-17064-14|dip:DIP-187848E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	reactome:R-MMU-449836|rcsb pdb:4EXP|ensembl:ENSMUSG00000024621(gene)|ensembl:ENSMUST00000025523(transcript)|ensembl:ENSMUST00000115268(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032944"(regulation of mononuclear cell proliferation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|rcsb pdb:3EJJ|dip:DIP-46415N|refseq:XP_006525647.1|refseq:XP_006525648.1|refseq:XP_006525649.1|refseq:NP_001032948.2|refseq:XP_017173299.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rogid:jWzzruMZt6wnD2QFpQ4/aov3vlU10090	rigid:mF8umfUqbG/Z2ECjPkmvMtwQrPk	false	binding-associated region:33-181	binding-associated region:20-515	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07333	uniprotkb:P09603	intact:EBI-2835440|uniprotkb:Q6LDY4|uniprotkb:Q6LDW5|uniprotkb:D3DQG2|uniprotkb:Q86VW7|ensembl:ENSP00000501699|ensembl:ENSP00000286301|uniprotkb:B5A955	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1r_human(display_long)|uniprotkb:CSF1R(gene name)|psi-mi:CSF1R(display_short)|uniprotkb:FMS(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15957101|imex:IM-17064-13|dip:DIP-187846E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005202.2|refseq:NP_001275634.1|ensembl:ENSG00000182578(gene)|ensembl:ENST00000286301(transcript)|ensembl:ENST00000675795(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|mint:P07333|rcsb pdb:2I0V|rcsb pdb:2I0Y|rcsb pdb:2I1M|rcsb pdb:2OGV|rcsb pdb:3BEA|rcsb pdb:3DPK|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3LCD|rcsb pdb:3LCO|rcsb pdb:4DKD|rcsb pdb:4HW7|rcsb pdb:4LIQ|rcsb pdb:4R7H|rcsb pdb:4R7I|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:6IG8|rcsb pdb:6N33|rcsb pdb:6T2W|rcsb pdb:6WXJ|reactome:R-HSA-449836|reactome:R-HSA-8853884|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|dip:DIP-59421N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:jQm6P/lLSEcWghoU0ISq63srNn09606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:VQnvskaT6Aur2dieh+eymgERYNw	false	sufficient binding region:20-290	binding-associated region:33-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09603	uniprotkb:P09603	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym)	psi-mi:"MI:1022"(field flow fractionation)	Elegheert et al. (2011)	pubmed:22153499|doi:10.1016/j.str.2011.10.012|imex:IM-17064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15957143|imex:IM-17064-15|dip:DIP-187845E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606	rigid:Bw1zUXjkOK2vInm8i7xreby3peM	false	binding-associated region:33-181	binding-associated region:33-181	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)