#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6IUF8 uniprotkb:Q6UY77 intact:EBI-15954762 intact:EBI-15954744 psi-mi:l_machu(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym) psi-mi:q6uy77_machu(display_long)|uniprotkb:Z(gene name)|psi-mi:Z(display_short)|uniprotkb:Zinc-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Kranzusch et al. (2011) pubmed:22106304|doi:10.1073/pnas.1112742108|imex:IM-17790 taxid:11628(machu)|taxid:11628(machupo virus) taxid:11628(machu)|taxid:11628(machupo virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15954783|imex:IM-17790-1|dip:DIP-189179E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|go:"GO:0075526"(cap snatching)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR010453(RNA polymerase, arenaviral)|interpro:IPR026382|dip:DIP-59721N go:"GO:0003723"(RNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046761"(viral budding from plasma membrane)|interpro:IPR003224(Zinc finger, P11-type)|interpro:IPR024183|interpro:IPR038485|rcsb pdb:7CKM|rcsb pdb:7EL9|rcsb pdb:7ELB|rcsb pdb:7ELC|refseq:NP_899214.1|dip:DIP-59719N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ayXZIsSTy0mEzpo1D6KYlJ9Mj3811628 rogid:jT6vKYamrA6w53tOfyTqBW43Zfg11628 rigid:rZos5OjdyOW+t9dVm9Ui30CL71A false - glutathione s tranferase tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q6IUF8 uniprotkb:Q6UY77 intact:EBI-15954762 intact:EBI-15954744 psi-mi:l_machu(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym) psi-mi:q6uy77_machu(display_long)|uniprotkb:Z(gene name)|psi-mi:Z(display_short)|uniprotkb:Zinc-binding protein(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Kranzusch et al. (2011) pubmed:22106304|doi:10.1073/pnas.1112742108|imex:IM-17790 taxid:11628(machu)|taxid:11628(machupo virus) taxid:11628(machu)|taxid:11628(machupo virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15954840|imex:IM-17790-3|dip:DIP-189179E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|go:"GO:0075526"(cap snatching)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR010453(RNA polymerase, arenaviral)|interpro:IPR026382|dip:DIP-59721N go:"GO:0003723"(RNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046761"(viral budding from plasma membrane)|interpro:IPR003224(Zinc finger, P11-type)|interpro:IPR024183|interpro:IPR038485|rcsb pdb:7CKM|rcsb pdb:7EL9|rcsb pdb:7ELB|rcsb pdb:7ELC|refseq:NP_899214.1|dip:DIP-59719N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ayXZIsSTy0mEzpo1D6KYlJ9Mj3811628 rogid:jT6vKYamrA6w53tOfyTqBW43Zfg11628 rigid:rZos5OjdyOW+t9dVm9Ui30CL71A false - maltose binding protein tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q6IUF8 uniprotkb:Q6UY77 intact:EBI-15954762 intact:EBI-15954744 psi-mi:l_machu(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym) psi-mi:q6uy77_machu(display_long)|uniprotkb:Z(gene name)|psi-mi:Z(display_short)|uniprotkb:Zinc-binding protein(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Kranzusch et al. (2011) pubmed:22106304|doi:10.1073/pnas.1112742108|imex:IM-17790 taxid:11628(machu)|taxid:11628(machupo virus) taxid:11628(machu)|taxid:11628(machupo virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15954859|imex:IM-17790-4|dip:DIP-189179E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|go:"GO:0075526"(cap snatching)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR010453(RNA polymerase, arenaviral)|interpro:IPR026382|dip:DIP-59721N go:"GO:0003723"(RNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046761"(viral budding from plasma membrane)|interpro:IPR003224(Zinc finger, P11-type)|interpro:IPR024183|interpro:IPR038485|rcsb pdb:7CKM|rcsb pdb:7EL9|rcsb pdb:7ELB|rcsb pdb:7ELC|refseq:NP_899214.1|dip:DIP-59719N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ayXZIsSTy0mEzpo1D6KYlJ9Mj3811628 rogid:jT6vKYamrA6w53tOfyTqBW43Zfg11628 rigid:rZos5OjdyOW+t9dVm9Ui30CL71A false - glutathione s tranferase tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18541 uniprotkb:P63073 intact:EBI-15954802|uniprotkb:Q49K85 intact:EBI-2000006|uniprotkb:P20415|ensembl:ENSMUSP00000029803 psi-mi:z_lycva(display_long)|uniprotkb:Z(gene name)|psi-mi:Z(display_short)|uniprotkb:Zinc-binding protein(gene name synonym)|uniprotkb:Segment L(locus name) psi-mi:if4e_mouse(display_long)|uniprotkb:Eif4e(gene name)|psi-mi:Eif4e(display_short)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Kranzusch et al. (2011) pubmed:22106304|doi:10.1073/pnas.1112742108|imex:IM-17790 taxid:11624(lcmv)|taxid:11624("Lymphocytic choriomeningitis virus (strain Armstrong)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15954821|imex:IM-17790-2|dip:DIP-189181E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046761"(viral budding from plasma membrane)|interpro:IPR003224(Zinc finger, P11-type)|interpro:IPR024183|interpro:IPR038485|dip:DIP-59720N refseq:NP_031943.3|dip:DIP-42768N|ensembl:ENSMUSG00000028156(gene)|ensembl:ENSMUST00000029803(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:1EJ1|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1L8B|rcsb pdb:5BXV|rcsb pdb:5J5O|rcsb pdb:5J5Y|rcsb pdb:5M7V|rcsb pdb:5M7W|rcsb pdb:5M7X|rcsb pdb:5M7Z|rcsb pdb:5M80|rcsb pdb:5M81|rcsb pdb:5M83|rcsb pdb:5M84|rcsb pdb:5OSX|rcsb pdb:6GKJ|rcsb pdb:6GKK|rcsb pdb:6GKL|rcsb pdb:6U06|rcsb pdb:6U09|rcsb pdb:6YLR|rcsb pdb:6YLT|rcsb pdb:6YLV|reactome:R-MMU-1169408|reactome:R-MMU-156827|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-166208|reactome:R-MMU-429947|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:iX9ezdNUfWNMW/fsE23cbSl6BSM11624 rogid:DnMmfgiMq6RHbSuRPwy/TaoeySU10090 rigid:Uf3uOGKmZ/qVjYsxzqrLLcoE81g false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63073 uniprotkb:Q6UY77 intact:EBI-2000006|uniprotkb:P20415|ensembl:ENSMUSP00000029803 intact:EBI-15954744 psi-mi:if4e_mouse(display_long)|uniprotkb:Eif4e(gene name)|psi-mi:Eif4e(display_short)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym) psi-mi:q6uy77_machu(display_long)|uniprotkb:Z(gene name)|psi-mi:Z(display_short)|uniprotkb:Zinc-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Kranzusch et al. (2011) pubmed:22106304|doi:10.1073/pnas.1112742108|imex:IM-17790 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:11628(machu)|taxid:11628(machupo virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15954878|imex:IM-17790-5|dip:DIP-189180E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031943.3|dip:DIP-42768N|ensembl:ENSMUSG00000028156(gene)|ensembl:ENSMUST00000029803(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:1EJ1|rcsb pdb:1EJ4|rcsb pdb:1EJH|rcsb pdb:1L8B|rcsb pdb:5BXV|rcsb pdb:5J5O|rcsb pdb:5J5Y|rcsb pdb:5M7V|rcsb pdb:5M7W|rcsb pdb:5M7X|rcsb pdb:5M7Z|rcsb pdb:5M80|rcsb pdb:5M81|rcsb pdb:5M83|rcsb pdb:5M84|rcsb pdb:5OSX|rcsb pdb:6GKJ|rcsb pdb:6GKK|rcsb pdb:6GKL|rcsb pdb:6U06|rcsb pdb:6U09|rcsb pdb:6YLR|rcsb pdb:6YLT|rcsb pdb:6YLV|reactome:R-MMU-1169408|reactome:R-MMU-156827|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-166208|reactome:R-MMU-429947|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706 go:"GO:0003723"(RNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046761"(viral budding from plasma membrane)|interpro:IPR003224(Zinc finger, P11-type)|interpro:IPR024183|interpro:IPR038485|rcsb pdb:7CKM|rcsb pdb:7EL9|rcsb pdb:7ELB|rcsb pdb:7ELC|refseq:NP_899214.1|dip:DIP-59719N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:DnMmfgiMq6RHbSuRPwy/TaoeySU10090 rogid:jT6vKYamrA6w53tOfyTqBW43Zfg11628 rigid:+UXLutUdWEb8jM37PofzxhEr68Y false - glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)