#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O01501	uniprotkb:O61847	intact:EBI-6499833|ensemblmetazoa:C37A2.4a.1|uniprotkb:O77098|uniprotkb:Q86FL2	intact:EBI-14063070|ensemblmetazoa:K03E5.3a.1	psi-mi:ccne_caeel(display_long)|uniprotkb:cye-1(gene name)|psi-mi:cye-1(display_short)|uniprotkb:C37A2.4(orf name)	psi-mi:cdk2_caeel(display_long)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:K03E5.3(orf name)|uniprotkb:cdk-2(gene name)|psi-mi:cdk-2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Korzelius et al. (2011)	imex:IM-25780|pubmed:22102824	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14063691|imex:IM-25780-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C37A2.4a.1(transcript)|ensemblmetazoa:WBGene00000871(gene)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0048815"(hermaphrodite genitalia morphogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904776"(regulation of protein localization to cell cortex)|reactome:R-CEL-1538133|reactome:R-CEL-187577|reactome:R-CEL-2559586|reactome:R-CEL-6804116|reactome:R-CEL-69017|reactome:R-CEL-69202|reactome:R-CEL-69563|reactome:R-CEL-9706019|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|refseq:NP_001021027.1|refseq:NP_001021028.1|wormbase:C37A2.4a|wormbase:C37A2.4b|interpro:IPR036915|interpro:IPR039361	reactome:R-CEL-176187|reactome:R-CEL-1538133|reactome:R-CEL-187577|reactome:R-CEL-2559586|reactome:R-CEL-6804116|reactome:R-CEL-68911|reactome:R-CEL-68949|reactome:R-CEL-68962|reactome:R-CEL-69017|reactome:R-CEL-69202|reactome:R-CEL-69563|reactome:R-CEL-69656|ensemblmetazoa:K03E5.3a.1(transcript)|ensemblmetazoa:WBGene00019362(gene)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002119"(nematode larval development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0030332"(cyclin binding)|go:"GO:0030588"(pseudocleavage)|go:"GO:0046872"(metal ion binding)|go:"GO:0048815"(hermaphrodite genitalia morphogenesis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|refseq:NP_001021537.1|wormbase:K03E5.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)	-	-	-	figure legend:Supp. 2D|comment:"Both proteins expressed from the myo-3 promoter (Pmyo-3) to drive expression of Cyclins and CDKs in muscle"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	2017/05/19	2017/05/19	rogid:THl5Hcv1lfLuT3xEXRZhEQm1+886239	rogid:KxJvKVLIyG8O9jxp4lCunE9w3XE6239	rigid:dHPVPHw0LsV6PwPk+PFLUo++QgU	false	-	venus fluorescent protein tag:?-?|mutation:55-56	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O01501	uniprotkb:O61847	intact:EBI-6499833|ensemblmetazoa:C37A2.4a.1|uniprotkb:O77098|uniprotkb:Q86FL2	intact:EBI-14063070|ensemblmetazoa:K03E5.3a.1	psi-mi:ccne_caeel(display_long)|uniprotkb:cye-1(gene name)|psi-mi:cye-1(display_short)|uniprotkb:C37A2.4(orf name)	psi-mi:cdk2_caeel(display_long)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:K03E5.3(orf name)|uniprotkb:cdk-2(gene name)|psi-mi:cdk-2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Korzelius et al. (2011)	imex:IM-25780|pubmed:22102824	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14063707|imex:IM-25780-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C37A2.4a.1(transcript)|ensemblmetazoa:WBGene00000871(gene)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0048815"(hermaphrodite genitalia morphogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904776"(regulation of protein localization to cell cortex)|reactome:R-CEL-1538133|reactome:R-CEL-187577|reactome:R-CEL-2559586|reactome:R-CEL-6804116|reactome:R-CEL-69017|reactome:R-CEL-69202|reactome:R-CEL-69563|reactome:R-CEL-9706019|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|refseq:NP_001021027.1|refseq:NP_001021028.1|wormbase:C37A2.4a|wormbase:C37A2.4b|interpro:IPR036915|interpro:IPR039361	reactome:R-CEL-176187|reactome:R-CEL-1538133|reactome:R-CEL-187577|reactome:R-CEL-2559586|reactome:R-CEL-6804116|reactome:R-CEL-68911|reactome:R-CEL-68949|reactome:R-CEL-68962|reactome:R-CEL-69017|reactome:R-CEL-69202|reactome:R-CEL-69563|reactome:R-CEL-69656|ensemblmetazoa:K03E5.3a.1(transcript)|ensemblmetazoa:WBGene00019362(gene)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002119"(nematode larval development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0030332"(cyclin binding)|go:"GO:0030588"(pseudocleavage)|go:"GO:0046872"(metal ion binding)|go:"GO:0048815"(hermaphrodite genitalia morphogenesis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|refseq:NP_001021537.1|wormbase:K03E5.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)	-	-	-	figure legend:Supp. 2D|comment:"Both proteins expressed from the myo-3 promoter (Pmyo-3) to drive expression of Cyclins and CDKs in muscle"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	2017/05/19	2017/05/19	rogid:THl5Hcv1lfLuT3xEXRZhEQm1+886239	rogid:KxJvKVLIyG8O9jxp4lCunE9w3XE6239	rigid:dHPVPHw0LsV6PwPk+PFLUo++QgU	false	-	venus fluorescent protein tag:?-?|mutation:55-56	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O01501	uniprotkb:O61847	intact:EBI-6499833|ensemblmetazoa:C37A2.4a.1|uniprotkb:O77098|uniprotkb:Q86FL2	intact:EBI-14063070|ensemblmetazoa:K03E5.3a.1	psi-mi:ccne_caeel(display_long)|uniprotkb:cye-1(gene name)|psi-mi:cye-1(display_short)|uniprotkb:C37A2.4(orf name)	psi-mi:cdk2_caeel(display_long)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:K03E5.3(orf name)|uniprotkb:cdk-2(gene name)|psi-mi:cdk-2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Korzelius et al. (2011)	imex:IM-25780|pubmed:22102824	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14063722|imex:IM-25780-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C37A2.4a.1(transcript)|ensemblmetazoa:WBGene00000871(gene)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0048815"(hermaphrodite genitalia morphogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904776"(regulation of protein localization to cell cortex)|reactome:R-CEL-1538133|reactome:R-CEL-187577|reactome:R-CEL-2559586|reactome:R-CEL-6804116|reactome:R-CEL-69017|reactome:R-CEL-69202|reactome:R-CEL-69563|reactome:R-CEL-9706019|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|refseq:NP_001021027.1|refseq:NP_001021028.1|wormbase:C37A2.4a|wormbase:C37A2.4b|interpro:IPR036915|interpro:IPR039361	reactome:R-CEL-176187|reactome:R-CEL-1538133|reactome:R-CEL-187577|reactome:R-CEL-2559586|reactome:R-CEL-6804116|reactome:R-CEL-68911|reactome:R-CEL-68949|reactome:R-CEL-68962|reactome:R-CEL-69017|reactome:R-CEL-69202|reactome:R-CEL-69563|reactome:R-CEL-69656|ensemblmetazoa:K03E5.3a.1(transcript)|ensemblmetazoa:WBGene00019362(gene)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002119"(nematode larval development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0030332"(cyclin binding)|go:"GO:0030588"(pseudocleavage)|go:"GO:0046872"(metal ion binding)|go:"GO:0048815"(hermaphrodite genitalia morphogenesis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|refseq:NP_001021537.1|wormbase:K03E5.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)	-	-	-	figure legend:Supp. 2C|comment:"Both proteins expressed from the myo-3 promoter (Pmyo-3) to drive expression of Cyclins and CDKs in muscle"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel-larva)|taxid:6239(Immature form of the adult worm)	-	2017/05/19	2017/05/19	rogid:THl5Hcv1lfLuT3xEXRZhEQm1+886239	rogid:KxJvKVLIyG8O9jxp4lCunE9w3XE6239	rigid:dHPVPHw0LsV6PwPk+PFLUo++QgU	false	-	venus fluorescent protein tag:?-?|mutation:55-56	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)