#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-15952770	uniprotkb:O97111	dip:DIP-59419N	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:ligand(display_short)|psi-mi:EBI-15952770(display_long)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Whitney et al. (2011)	pubmed:22078569|doi:10.1016/j.str.2011.07.018|imex:IM-17062	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15952773|imex:IM-17062-1|dip:DIP-187842E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:g7mCSKrOubHFZYvtqRE7dHT7PpA-2	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rigid:PN4SNmu1v/D7qIOQQhTuJuP+n9c	false	fluorescent dye label:?-?	sufficient binding region:156-255|mutation increasing interaction:164-164,144-144|mutation decreasing interaction:165-165|mutation decreasing interaction:164-164|mutation increasing interaction:164-164	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40793	uniprotkb:O97111	intact:EBI-114324|uniprotkb:Q540W4|ensemblmetazoa:FBpp0074520|ensemblmetazoa:FBpp0301153|ensemblmetazoa:FBpp0301154|uniprotkb:Q9U9S3|uniprotkb:Q9U9S4|uniprotkb:Q9U9S5|uniprotkb:Q9U9S6|uniprotkb:Q9V465	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:cdc42_drome(display_long)|uniprotkb:CG12530(orf name)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Whitney et al. (2011)	pubmed:22078569|doi:10.1016/j.str.2011.07.018|imex:IM-17062	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15952807|imex:IM-17062-2|dip:DIP-187833E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245762.1|refseq:NP_001245763.1|refseq:NP_523414.1|flybase:FBgn0010341|go:"GO:0007286"(spermatid development)|go:"GO:0007349"(cellularization)|go:"GO:0007391"(dorsal closure)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009611"(response to wounding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035318"(imaginal disc-derived wing hair outgrowth)|go:"GO:0042060"(wound healing)|go:"GO:0045177"(apical part of cell)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0030027"(lamellipodium)|ensemblmetazoa:FBgn0010341(gene)|ensemblmetazoa:FBtr0074751(transcript)|ensemblmetazoa:FBtr0309214(transcript)|ensemblmetazoa:FBtr0309215(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007266"(Rho protein signal transduction)|interpro:IPR027417|interpro:IPR037874|reactome:R-DME-114604|reactome:R-DME-182971|reactome:R-DME-2029482|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-4420097|reactome:R-DME-525793|reactome:R-DME-5627123|reactome:R-DME-5663220|reactome:R-DME-5687128|reactome:R-DME-8964616|reactome:R-DME-9013148|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013406|reactome:R-DME-9013409|reactome:R-DME-9013420|reactome:R-DME-9013424|reactome:R-DME-983231|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-31003N	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:p1Wn2f2lqp9i9DPM0uMTy/eVs+47227	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rigid:SGV0KsOo3CQ3Rfjte2+qSN4ZDrw	false	-	binding-associated region:130-255	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)