#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16876814|imex:IM-27380-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:wnOaKbCBGoMA1uWmMO9fZhvKneE	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46108-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-287556|ensembl:ENSP00000300574	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16876814|imex:IM-27380-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:wnOaKbCBGoMA1uWmMO9fZhvKneE	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9UKW4	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297568|uniprotkb:O95230|uniprotkb:Q9Y5X8|uniprotkb:B1APV5|uniprotkb:B1AMM0|uniprotkb:B4E232|uniprotkb:B7ZLR1|uniprotkb:E9PQ97|uniprotkb:O60498|ensembl:ENSP00000359073	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:vav3_human(display_long)|uniprotkb:VAV3(gene name)|psi-mi:VAV3(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16876814|imex:IM-27380-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001073343.1|refseq:NP_006104.4|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035734|interpro:IPR035881|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q9UKW4|rcsb pdb:2D86|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|ensembl:ENSG00000134215(gene)|ensembl:ENST00000370056(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001772"(immunological synapse)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_005270417.1	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:sCvtyb/upL3UweAEXaHjZEkKH6M9606	rigid:wnOaKbCBGoMA1uWmMO9fZhvKneE	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O15357	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16876814|imex:IM-27380-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rigid:wnOaKbCBGoMA1uWmMO9fZhvKneE	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P19174	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16876814|imex:IM-27380-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:wnOaKbCBGoMA1uWmMO9fZhvKneE	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P52735	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16876814|imex:IM-27380-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rigid:wnOaKbCBGoMA1uWmMO9fZhvKneE	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9Y490	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877243|imex:IM-27380-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	rigid:8TkRIyiWL6sop0l6j57ygfSjZYA	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q92835	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877243|imex:IM-27380-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	rigid:8TkRIyiWL6sop0l6j57ygfSjZYA	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877243|imex:IM-27380-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:8TkRIyiWL6sop0l6j57ygfSjZYA	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P29353	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877243|imex:IM-27380-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rigid:8TkRIyiWL6sop0l6j57ygfSjZYA	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O15357	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877243|imex:IM-27380-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rigid:8TkRIyiWL6sop0l6j57ygfSjZYA	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877280|imex:IM-27380-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:YzTlSM/XwQR3eGrZGvo/b7oGQac	false	phosphorylated residue:520-520|binding-associated region:512-525|mutation:514-515	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P41240	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877280|imex:IM-27380-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rigid:YzTlSM/XwQR3eGrZGvo/b7oGQac	false	phosphorylated residue:520-520|binding-associated region:512-525|mutation:514-515	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46108-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-287556|ensembl:ENSP00000300574	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16877280|imex:IM-27380-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:YzTlSM/XwQR3eGrZGvo/b7oGQac	false	phosphorylated residue:520-520|binding-associated region:512-525|mutation:514-515	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P15311	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034217|imex:IM-27380-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	rigid:uM8BstpWC1XUamuL2/Z25//Sl/M	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034217|imex:IM-27380-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:uM8BstpWC1XUamuL2/Z25//Sl/M	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O15357	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034217|imex:IM-27380-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rigid:uM8BstpWC1XUamuL2/Z25//Sl/M	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q92835	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034217|imex:IM-27380-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	rigid:uM8BstpWC1XUamuL2/Z25//Sl/M	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034217|imex:IM-27380-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:uM8BstpWC1XUamuL2/Z25//Sl/M	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034217|imex:IM-27380-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:uM8BstpWC1XUamuL2/Z25//Sl/M	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034403|imex:IM-27380-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:3Z7NE4+q24l+K4z/dyBMlv1upQ4	false	phosphorylated residue:543-543|binding-associated region:535-548|mutation:537-538	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034403|imex:IM-27380-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:3Z7NE4+q24l+K4z/dyBMlv1upQ4	false	phosphorylated residue:543-543|binding-associated region:535-548|mutation:537-538	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q8WX93	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2803991|uniprotkb:Q9Y2J6|uniprotkb:Q9UQF5|uniprotkb:Q8N1M2|uniprotkb:Q7Z3W0|uniprotkb:Q86WE8|uniprotkb:B5MD56|uniprotkb:Q7L3E0|uniprotkb:Q9UGA0|uniprotkb:Q9Y3E9|uniprotkb:B7ZMM5|uniprotkb:B3KTG2	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:palld_human(display_long)|uniprotkb:KIAA0992(gene name synonym)|uniprotkb:SIH002(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-77(gene name synonym)|uniprotkb:CGI-151(orf name)|uniprotkb:PALLD(gene name)|psi-mi:PALLD(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034589|imex:IM-27380-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	interpro:IPR033017|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|rcsb pdb:2DM2|rcsb pdb:2DM3|go:"GO:0016477"(cell migration)|refseq:NP_001159580.1|refseq:NP_001159581.1|refseq:NP_001159582.1|refseq:NP_057165.3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|mint:Q8WX93	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:0GUVyoDYzf03b+bZXUa1n/fnP/Y9606	rigid:BiwWtINeJblaRXlwChgv3E4zqZw	false	binding-associated region:535-548|mutation:537-538|phosphorylated residue:547-547	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034589|imex:IM-27380-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:BiwWtINeJblaRXlwChgv3E4zqZw	false	binding-associated region:535-548|mutation:537-538|phosphorylated residue:547-547	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034589|imex:IM-27380-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:BiwWtINeJblaRXlwChgv3E4zqZw	false	binding-associated region:535-548|mutation:537-538|phosphorylated residue:547-547	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07947	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034655|imex:IM-27380-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:SF4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rigid:denc6VsT98SZIkXNrPDKkf4re74	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034655|imex:IM-27380-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:denc6VsT98SZIkXNrPDKkf4re74	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	binding-associated region:561-574|phosphorylated residue:569-569	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P07948	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034655|imex:IM-27380-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:SF4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:denc6VsT98SZIkXNrPDKkf4re74	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O43639	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22034655|imex:IM-27380-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1	-	-	-	figure legend:SF4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	rigid:denc6VsT98SZIkXNrPDKkf4re74	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q8WX93	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2803991|uniprotkb:Q9Y2J6|uniprotkb:Q9UQF5|uniprotkb:Q8N1M2|uniprotkb:Q7Z3W0|uniprotkb:Q86WE8|uniprotkb:B5MD56|uniprotkb:Q7L3E0|uniprotkb:Q9UGA0|uniprotkb:Q9Y3E9|uniprotkb:B7ZMM5|uniprotkb:B3KTG2	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:palld_human(display_long)|uniprotkb:KIAA0992(gene name synonym)|uniprotkb:SIH002(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-77(gene name synonym)|uniprotkb:CGI-151(orf name)|uniprotkb:PALLD(gene name)|psi-mi:PALLD(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	interpro:IPR033017|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|rcsb pdb:2DM2|rcsb pdb:2DM3|go:"GO:0016477"(cell migration)|refseq:NP_001159580.1|refseq:NP_001159581.1|refseq:NP_001159582.1|refseq:NP_057165.3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|mint:Q8WX93	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:0GUVyoDYzf03b+bZXUa1n/fnP/Y9606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9Y490	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07947	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P41240	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46108-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-287556|ensembl:ENSP00000300574	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q06124	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O15357	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00459	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035093|imex:IM-27380-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:LGx6uDeWLGyrHxzW6GV82BoBNCw	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q8WX93	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2803991|uniprotkb:Q9Y2J6|uniprotkb:Q9UQF5|uniprotkb:Q8N1M2|uniprotkb:Q7Z3W0|uniprotkb:Q86WE8|uniprotkb:B5MD56|uniprotkb:Q7L3E0|uniprotkb:Q9UGA0|uniprotkb:Q9Y3E9|uniprotkb:B7ZMM5|uniprotkb:B3KTG2	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:palld_human(display_long)|uniprotkb:KIAA0992(gene name synonym)|uniprotkb:SIH002(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-77(gene name synonym)|uniprotkb:CGI-151(orf name)|uniprotkb:PALLD(gene name)|psi-mi:PALLD(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035156|imex:IM-27380-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	interpro:IPR033017|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|rcsb pdb:2DM2|rcsb pdb:2DM3|go:"GO:0016477"(cell migration)|refseq:NP_001159580.1|refseq:NP_001159581.1|refseq:NP_001159582.1|refseq:NP_057165.3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|mint:Q8WX93	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:0GUVyoDYzf03b+bZXUa1n/fnP/Y9606	rigid:TkyJ5U8SaaIxlPZ5VG6AWL4ofnQ	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9Y490	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035156|imex:IM-27380-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	rigid:TkyJ5U8SaaIxlPZ5VG6AWL4ofnQ	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42338	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035156|imex:IM-27380-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	rigid:TkyJ5U8SaaIxlPZ5VG6AWL4ofnQ	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035156|imex:IM-27380-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:TkyJ5U8SaaIxlPZ5VG6AWL4ofnQ	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035156|imex:IM-27380-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:TkyJ5U8SaaIxlPZ5VG6AWL4ofnQ	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035156|imex:IM-27380-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:TkyJ5U8SaaIxlPZ5VG6AWL4ofnQ	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q92835	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035223|imex:IM-27380-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	rigid:JPEhtK9fkbTdGCOnibfckXiuh5s	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035223|imex:IM-27380-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:JPEhtK9fkbTdGCOnibfckXiuh5s	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P29353	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035223|imex:IM-27380-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rigid:JPEhtK9fkbTdGCOnibfckXiuh5s	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O15357	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035223|imex:IM-27380-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rigid:JPEhtK9fkbTdGCOnibfckXiuh5s	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P40763	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035455|imex:IM-27380-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rigid:xTPHY0j+EFdZ2R44F7Ry9YzxOms	false	phosphorylated residue:797-797|binding-associated region:788-801|mutation:791-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46108-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-287556|ensembl:ENSP00000300574	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035455|imex:IM-27380-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:xTPHY0j+EFdZ2R44F7Ry9YzxOms	false	phosphorylated residue:797-797|binding-associated region:788-801|mutation:791-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P40763	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035549|imex:IM-27380-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rigid:GD729DoRqqrQaqiE2+bA5KIhVkU	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42338	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035549|imex:IM-27380-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	rigid:GD729DoRqqrQaqiE2+bA5KIhVkU	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00459	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035549|imex:IM-27380-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rigid:GD729DoRqqrQaqiE2+bA5KIhVkU	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035549|imex:IM-27380-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:GD729DoRqqrQaqiE2+bA5KIhVkU	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P19174	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035549|imex:IM-27380-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:GD729DoRqqrQaqiE2+bA5KIhVkU	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035549|imex:IM-27380-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:GD729DoRqqrQaqiE2+bA5KIhVkU	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035657|imex:IM-27380-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:3Z7NE4+q24l+K4z/dyBMlv1upQ4	false	phosphorylated residue:543-543|binding-associated region:535-548|mutation:537-538|phosphorylated residue:547-547	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035657|imex:IM-27380-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:3Z7NE4+q24l+K4z/dyBMlv1upQ4	false	phosphorylated residue:543-543|binding-associated region:535-548|mutation:537-538|phosphorylated residue:547-547	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07947	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035768|imex:IM-27380-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42338	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035768|imex:IM-27380-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035768|imex:IM-27380-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035768|imex:IM-27380-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9Y490	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P40763	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00459	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9UKW4	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297568|uniprotkb:O95230|uniprotkb:Q9Y5X8|uniprotkb:B1APV5|uniprotkb:B1AMM0|uniprotkb:B4E232|uniprotkb:B7ZLR1|uniprotkb:E9PQ97|uniprotkb:O60498|ensembl:ENSP00000359073	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:vav3_human(display_long)|uniprotkb:VAV3(gene name)|psi-mi:VAV3(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001073343.1|refseq:NP_006104.4|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035734|interpro:IPR035881|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q9UKW4|rcsb pdb:2D86|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|ensembl:ENSG00000134215(gene)|ensembl:ENST00000370056(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001772"(immunological synapse)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_005270417.1	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:sCvtyb/upL3UweAEXaHjZEkKH6M9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P52735	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P19174	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035794|imex:IM-27380-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:hl3ww5mMyao7MXwfYVp3yFPrZ3A	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q92835	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035940|imex:IM-27380-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	rigid:QO2jcpJRDA5wRsNoUfGpu94AJWg	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00329	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-718309|uniprotkb:A6NCG0|uniprotkb:O15445|uniprotkb:Q5SR49|uniprotkb:G1FFP1|ensembl:ENSP00000366563	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cd_human(display_long)|uniprotkb:PIK3CD(gene name)|psi-mi:PIK3CD(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035940|imex:IM-27380-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_005017.3|ensembl:ENSG00000171608(gene)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:5DXU|rcsb pdb:5M6U|rcsb pdb:5T8F|rcsb pdb:5UBT|rcsb pdb:5VLR|rcsb pdb:6G6W|rcsb pdb:6OCO|rcsb pdb:6OCU|rcsb pdb:6PYR|rcsb pdb:6PYU|rcsb pdb:7JIS|rcsb pdb:7LM2|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-512988|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-983695|refseq:XP_006710750.1|refseq:XP_006710752.1|ensembl:ENST00000377346(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001819"(positive regulation of cytokine production)	-	-	crc64:A38B5D1A1081A3D0	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:CT7WEvRXYa2x7ZAkEYSrVwrGXRQ9606	rigid:QO2jcpJRDA5wRsNoUfGpu94AJWg	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42338	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035940|imex:IM-27380-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	rigid:QO2jcpJRDA5wRsNoUfGpu94AJWg	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42336	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035940|imex:IM-27380-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	rigid:QO2jcpJRDA5wRsNoUfGpu94AJWg	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00459	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035940|imex:IM-27380-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rigid:QO2jcpJRDA5wRsNoUfGpu94AJWg	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035940|imex:IM-27380-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:QO2jcpJRDA5wRsNoUfGpu94AJWg	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P40763	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035959|imex:IM-27380-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rigid:3qFVQbe8RTrPWOnKkq/PHHS/OVE	false	binding-associated region:861-874|phosphorylated residue:869-869|mutation:863-864	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42224	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22035959|imex:IM-27380-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	rigid:3qFVQbe8RTrPWOnKkq/PHHS/OVE	false	binding-associated region:861-874|phosphorylated residue:869-869|mutation:863-864	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22037610|imex:IM-27380-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:eGD65z0/ZhPtN4PX6sFzfCus29Q	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22037610|imex:IM-27380-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:eGD65z0/ZhPtN4PX6sFzfCus29Q	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P19174	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22037610|imex:IM-27380-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:eGD65z0/ZhPtN4PX6sFzfCus29Q	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22037610|imex:IM-27380-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:eGD65z0/ZhPtN4PX6sFzfCus29Q	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22049961|imex:IM-27380-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:F3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:htNGS9TGpdN0bAVjT0pKBMMg8Ww	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	phosphorylated residue:484-484|binding-associated region:479-489	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22049961|imex:IM-27380-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:F3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:htNGS9TGpdN0bAVjT0pKBMMg8Ww	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46108-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-287556|ensembl:ENSP00000300574	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22049961|imex:IM-27380-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)	-	-	-	figure legend:F3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:htNGS9TGpdN0bAVjT0pKBMMg8Ww	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9UKW4	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297568|uniprotkb:O95230|uniprotkb:Q9Y5X8|uniprotkb:B1APV5|uniprotkb:B1AMM0|uniprotkb:B4E232|uniprotkb:B7ZLR1|uniprotkb:E9PQ97|uniprotkb:O60498|ensembl:ENSP00000359073	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:vav3_human(display_long)|uniprotkb:VAV3(gene name)|psi-mi:VAV3(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22049961|imex:IM-27380-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001073343.1|refseq:NP_006104.4|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035734|interpro:IPR035881|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q9UKW4|rcsb pdb:2D86|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|ensembl:ENSG00000134215(gene)|ensembl:ENST00000370056(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001772"(immunological synapse)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_005270417.1	-	-	-	figure legend:F3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:sCvtyb/upL3UweAEXaHjZEkKH6M9606	rigid:htNGS9TGpdN0bAVjT0pKBMMg8Ww	false	phosphorylated residue:484-484|binding-associated region:476-489|mutation:478-479	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053505|imex:IM-27380-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:F3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:mpv4qEEID5+pDcTfi9YES2a2jDE	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	binding-associated region:876-886|phosphorylated residue:881-881	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:Q92569	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053505|imex:IM-27380-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	-	-	-	figure legend:F3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rigid:mpv4qEEID5+pDcTfi9YES2a2jDE	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00329	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-718309|uniprotkb:A6NCG0|uniprotkb:O15445|uniprotkb:Q5SR49|uniprotkb:G1FFP1|ensembl:ENSP00000366563	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cd_human(display_long)|uniprotkb:PIK3CD(gene name)|psi-mi:PIK3CD(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053505|imex:IM-27380-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_005017.3|ensembl:ENSG00000171608(gene)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:5DXU|rcsb pdb:5M6U|rcsb pdb:5T8F|rcsb pdb:5UBT|rcsb pdb:5VLR|rcsb pdb:6G6W|rcsb pdb:6OCO|rcsb pdb:6OCU|rcsb pdb:6PYR|rcsb pdb:6PYU|rcsb pdb:7JIS|rcsb pdb:7LM2|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-512988|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-983695|refseq:XP_006710750.1|refseq:XP_006710752.1|ensembl:ENST00000377346(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001819"(positive regulation of cytokine production)	-	-	crc64:A38B5D1A1081A3D0	figure legend:F3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:CT7WEvRXYa2x7ZAkEYSrVwrGXRQ9606	rigid:mpv4qEEID5+pDcTfi9YES2a2jDE	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42338	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053505|imex:IM-27380-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N	-	-	-	figure legend:F3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	rigid:mpv4qEEID5+pDcTfi9YES2a2jDE	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42336	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053505|imex:IM-27380-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	-	-	-	figure legend:F3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	rigid:mpv4qEEID5+pDcTfi9YES2a2jDE	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00459	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053505|imex:IM-27380-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:F3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rigid:mpv4qEEID5+pDcTfi9YES2a2jDE	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053505|imex:IM-27380-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:F3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:mpv4qEEID5+pDcTfi9YES2a2jDE	false	binding-associated region:873-886|phosphorylated residue:881-881|mutation:875-876	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053547|imex:IM-27380-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:F3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:gTJnx/rN3gNzO35Io2Q+vaFGNNw	false	phosphorylated residue:797-797|binding-associated region:788-801|mutation:791-792	phosphorylated residue:797-797|binding-associated region:791-801	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P40763	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053547|imex:IM-27380-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:F3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rigid:gTJnx/rN3gNzO35Io2Q+vaFGNNw	false	phosphorylated residue:797-797|binding-associated region:788-801|mutation:791-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053574|imex:IM-27380-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:F3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:J0oA55NQ/4Hv3FBpNBh1/Yc1AAw	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	phosphorylated residue:740-740|binding-associated region:735-745	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:Q92835	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053574|imex:IM-27380-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	-	-	-	figure legend:F3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	rigid:J0oA55NQ/4Hv3FBpNBh1/Yc1AAw	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q06124	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053574|imex:IM-27380-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N	-	-	-	figure legend:F3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	rigid:J0oA55NQ/4Hv3FBpNBh1/Yc1AAw	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O15357	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053574|imex:IM-27380-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:F3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rigid:J0oA55NQ/4Hv3FBpNBh1/Yc1AAw	false	phosphorylated residue:740-740|binding-associated region:732-745|mutation:734-735	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053593|imex:IM-27380-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:XraGEih0oXipJw85WD+EZKwVuzU	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	phosphorylated residue:513-513|binding-associated region:508-518	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:Q92835	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053593|imex:IM-27380-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	-	-	-	figure legend:SF4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	rigid:XraGEih0oXipJw85WD+EZKwVuzU	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P29353	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053593|imex:IM-27380-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:SF4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rigid:XraGEih0oXipJw85WD+EZKwVuzU	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O15357	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053593|imex:IM-27380-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526	-	-	-	figure legend:SF4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	rigid:XraGEih0oXipJw85WD+EZKwVuzU	false	phosphorylated residue:513-513|binding-associated region:505-518|mutation:507-508	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053629|imex:IM-27380-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:Qnj3X84LAMXgv3+gTwC2sFXs+D8	false	phosphorylated residue:520-520|binding-associated region:512-525|mutation:514-515	phosphorylated residue:520-520|binding-associated region:515-525	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P41240	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053629|imex:IM-27380-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369	-	-	-	figure legend:SF4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rigid:Qnj3X84LAMXgv3+gTwC2sFXs+D8	false	phosphorylated residue:520-520|binding-associated region:512-525|mutation:514-515	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46108-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-287556|ensembl:ENSP00000300574	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053629|imex:IM-27380-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)	-	-	-	figure legend:SF4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:Qnj3X84LAMXgv3+gTwC2sFXs+D8	false	phosphorylated residue:520-520|binding-associated region:512-525|mutation:514-515	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053664|imex:IM-27380-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:qGFzkbJA/X4HBICyybMKV5M25nM	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	phosphorylated residue:586-586|binding-associated region:581-591	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P07947	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053664|imex:IM-27380-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:SF4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rigid:qGFzkbJA/X4HBICyybMKV5M25nM	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P41240	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053664|imex:IM-27380-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369	-	-	-	figure legend:SF4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rigid:qGFzkbJA/X4HBICyybMKV5M25nM	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46108-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-287556|ensembl:ENSP00000300574	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p46108-1(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053664|imex:IM-27380-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-886(crk_human)|uniprotkb:P46108(isoform-parent)|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)	-	-	-	figure legend:SF4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:qGFzkbJA/X4HBICyybMKV5M25nM	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07948	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053664|imex:IM-27380-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:SF4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:qGFzkbJA/X4HBICyybMKV5M25nM	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053664|imex:IM-27380-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:SF4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:qGFzkbJA/X4HBICyybMKV5M25nM	false	phosphorylated residue:586-586|binding-associated region:578-591|mutation:580-581	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053686|imex:IM-27380-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:SnAHd+9SthVpzFYQ3lJG49jEZuU	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	phosphorylated residue:703-703|binding-associated region:698-708	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P42338	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053686|imex:IM-27380-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N	-	-	-	figure legend:SF4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	rigid:SnAHd+9SthVpzFYQ3lJG49jEZuU	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053686|imex:IM-27380-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:SF4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:SnAHd+9SthVpzFYQ3lJG49jEZuU	false	phosphorylated residue:703-703|binding-associated region:695-708|mutation:697-698	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053702|imex:IM-27380-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:vqU37BqQZegoGHr6ExZmaw6YwcQ	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	phosphorylated residue:796-796|binding-associated region:791-801	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:Q92835	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053702|imex:IM-27380-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	-	-	-	figure legend:SF4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	rigid:vqU37BqQZegoGHr6ExZmaw6YwcQ	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053702|imex:IM-27380-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:SF4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:vqU37BqQZegoGHr6ExZmaw6YwcQ	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053821|imex:IM-27380-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:SF4I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:4GJZoHjT/gqozMLcDNu1LgMc0vo	false	binding-associated region:861-874|phosphorylated residue:869-869|mutation:863-864	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42224	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053821|imex:IM-27380-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:SF4I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	rigid:4GJZoHjT/gqozMLcDNu1LgMc0vo	false	binding-associated region:861-874|phosphorylated residue:869-869|mutation:863-864	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053821|imex:IM-27380-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:4GJZoHjT/gqozMLcDNu1LgMc0vo	false	binding-associated region:861-874|phosphorylated residue:869-869|mutation:863-864	binding-associated region:864-874|phosphorylated residue:869-869	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053849|imex:IM-27380-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	phosphorylated residue:796-796|binding-associated region:791-801|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P07947	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053849|imex:IM-27380-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:SF4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P42338	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2609540|uniprotkb:D3DNF0|uniprotkb:Q24JU2|ensembl:ENSP00000289153|ensembl:ENSP00000418143|ensembl:ENSP00000501150	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pk3cb_human(display_long)|uniprotkb:PIK3CB(gene name)|psi-mi:PIK3CB(display_short)|uniprotkb:PIK3C1(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053849|imex:IM-27380-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006210.1|refseq:XP_011511197.1|refseq:XP_005247587.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0070527"(platelet aggregation)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9673767|reactome:R-HSA-9673770|ensembl:ENSG00000051382(gene)|ensembl:ENST00000289153(transcript)|ensembl:ENST00000477593(transcript)|ensembl:ENST00000674063(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_006713722.1|refseq:XP_016862108.1|dip:DIP-44775N	-	-	-	figure legend:SF4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Nga6TlSCXWs2NVRR5XfxvnLfWUk9606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053849|imex:IM-27380-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:SF4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053849|imex:IM-27380-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:SF4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:gcVxSxM9vnFAJHwx164uWvGvgPA	false	phosphorylated residue:796-796|binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053875|imex:IM-27380-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	-	-	-	figure legend:SF4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rigid:WISZf6xgLCXj04s/k6zjX+o7/5Q	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	binding-associated region:791-801|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q08345-1	uniprotkb:P40763	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053875|imex:IM-27380-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:SF4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rigid:WISZf6xgLCXj04s/k6zjX+o7/5Q	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053875|imex:IM-27380-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:SF4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:WISZf6xgLCXj04s/k6zjX+o7/5Q	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053875|imex:IM-27380-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:SF4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:WISZf6xgLCXj04s/k6zjX+o7/5Q	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792|phosphorylated residue:797-797	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P12931	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P06241	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P16333	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P27986	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P52735	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07947	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07948	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O43639	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22053903|imex:IM-27380-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	rigid:WDWwMuoLYQ9pWDuqtYNA2bdlEIA	false	binding-associated region:561-574|mutation:563-564|phosphorylated residue:569-569	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q8WX93	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2803991|uniprotkb:Q9Y2J6|uniprotkb:Q9UQF5|uniprotkb:Q8N1M2|uniprotkb:Q7Z3W0|uniprotkb:Q86WE8|uniprotkb:B5MD56|uniprotkb:Q7L3E0|uniprotkb:Q9UGA0|uniprotkb:Q9Y3E9|uniprotkb:B7ZMM5|uniprotkb:B3KTG2	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:palld_human(display_long)|uniprotkb:KIAA0992(gene name synonym)|uniprotkb:SIH002(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-77(gene name synonym)|uniprotkb:CGI-151(orf name)|uniprotkb:PALLD(gene name)|psi-mi:PALLD(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226197|imex:IM-27380-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	interpro:IPR033017|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|rcsb pdb:2DM2|rcsb pdb:2DM3|go:"GO:0016477"(cell migration)|refseq:NP_001159580.1|refseq:NP_001159581.1|refseq:NP_001159582.1|refseq:NP_057165.3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|mint:Q8WX93	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:0GUVyoDYzf03b+bZXUa1n/fnP/Y9606	rigid:Vvp+E7V0xWXKDATPyrUxq05MBY4	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P15311	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226197|imex:IM-27380-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606	rigid:Vvp+E7V0xWXKDATPyrUxq05MBY4	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q06124	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226197|imex:IM-27380-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	rigid:Vvp+E7V0xWXKDATPyrUxq05MBY4	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O00459	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226197|imex:IM-27380-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	rigid:Vvp+E7V0xWXKDATPyrUxq05MBY4	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P19174	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226197|imex:IM-27380-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:Vvp+E7V0xWXKDATPyrUxq05MBY4	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P20936	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226197|imex:IM-27380-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2020/01/07	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rigid:Vvp+E7V0xWXKDATPyrUxq05MBY4	false	binding-associated region:788-801|mutation:790-791|phosphorylated residue:792-792	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P51692	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226232|imex:IM-27380-66	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	rigid:7Yz8uhsTeQulpyojt1H9L/o7YWA	false	binding-associated region:751-764|phosphorylated residue:756-756|mutation:751-751	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P19174	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226232|imex:IM-27380-66	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:T2 F4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/11/20	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:7Yz8uhsTeQulpyojt1H9L/o7YWA	false	binding-associated region:751-764|phosphorylated residue:756-756|mutation:751-751	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q9Y277-2	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-21506455|ensembl:ENSP00000428845	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q9y277-2(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	uniprotkb:Q9Y277-2(isoform-parent)|intact:EBI-354196(isoform-parent)|ensembl:ENSG00000078668(gene)|ensembl:ENST00000521158(transcript)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Ynzk/7MIjixCf6G0ILVPEIlsRi89606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q96J02-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033294|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q96j02-1(display_long)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-1564678(isoform-parent)|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)	-	-	isoform-comment:No experimental confirmation available.	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q8TF42	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1380492|uniprotkb:Q53GT5|uniprotkb:Q53GT8|uniprotkb:Q8NBV7|uniprotkb:Q96IG9|uniprotkb:Q96NZ2|ensembl:ENSP00000284273	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ubs3b_human(display_long)|uniprotkb:UBASH3B(gene name)|psi-mi:UBASH3B(display_short)|uniprotkb:KIAA1959(gene name synonym)|uniprotkb:STS1(gene name synonym)|uniprotkb:Suppressor of T-cell receptor signaling 1(gene name synonym)|uniprotkb:Cbl-interacting protein p70(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 2(gene name synonym)|uniprotkb:Tyrosine-protein phosphatase STS1/TULA2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_116262.2|ensembl:ENSG00000154127(gene)|ensembl:ENST00000284273(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090331"(negative regulation of platelet aggregation)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035632|interpro:IPR036028|mint:Q8TF42|rcsb pdb:2CPW|rcsb pdb:2E5K|rcsb pdb:5VR6|rcsb pdb:5W5G|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:rInBY4dNsLDJJPjZQqMSkuKJwns9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q16891-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-11614103|ensembl:ENSP00000387262	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q16891-1(display_long)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-473801(isoform-parent)|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q16543	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:iajhitd2iEmd17KfpU/nMaKc4049606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q15645-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-20724403	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q15645-1(display_long)|uniprotkb:TRIP13(gene name)|psi-mi:TRIP13(display_short)|uniprotkb:PCH2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	uniprotkb:Q15645-1(isoform-parent)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:heF2f3R2lGIpZ80mZHnhMktXTE49606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q15059-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033351|ensembl:ENSP00000305918	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q15059-1(display_long)|uniprotkb:RING3-like protein(gene name synonym)|uniprotkb:BRD3(gene name)|psi-mi:BRD3(display_short)|uniprotkb:KIAA0043(gene name synonym)|uniprotkb:RING3L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-1383460(isoform-parent)|ensembl:ENSG00000169925(gene)|ensembl:ENST00000303407(transcript)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:RIwhmbGQ4NziOcjy4M80p+TY1OQ9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q14978-2	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-396172|ensembl:ENSP00000385410	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q14978-2(display_long)|uniprotkb:NOLC1(gene name)|psi-mi:NOLC1(display_short)|uniprotkb:KIAA0035(gene name synonym)|uniprotkb:NS5ATP13(gene name synonym)|uniprotkb:140 kDa nucleolar phosphoprotein(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 13(gene name synonym)|uniprotkb:Nucleolar 130 kDa protein(gene name synonym)|uniprotkb:Nucleolar phosphoprotein p130(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-396155(nolc1_human)|ensembl:ENSG00000166197(gene)|ensembl:ENST00000405356(transcript)|uniprotkb:Q14978-2(isoform-parent)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:jDgoxSNX2C7LsKZ8VDMgn4s0BRo9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q14315-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-15532913|ensembl:ENSP00000327145	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q14315-1(display_long)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-489954(isoform-parent)|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q08345-5	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033282|ensembl:ENSP00000427552	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q08345-5(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000204580(gene)|ensembl:ENST00000513240(transcript)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:lX92bu6o0fFmWUiFhB0Q1CmDLHU9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q05682-2	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033249	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:q05682-2(display_long)|uniprotkb:CALD1(gene name)|psi-mi:CALD1(display_short)|uniprotkb:CAD(gene name synonym)|uniprotkb:CDM(gene name synonym)|uniprotkb:WI-38 L-CAD I(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-1642116(isoform-parent)	-	-	isoform-comment:Contains a phosphoserine at position 202.	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pkBmjt0adcjylGCHwrR/lWbAh/g9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P80723-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033299	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p80723-1(display_long)|uniprotkb:BASP1(gene name)|psi-mi:BASP1(display_short)|uniprotkb:NAP22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	uniprotkb:P80723-1(isoform-parent)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:X+L20HKimV3J+vLnQljg+x78+e09606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P62993-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-15787932|ensembl:ENSP00000339007|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913|uniprotkb:P29354-1	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p62993-1(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Ash-L(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000177885(gene)|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|intact:EBI-401755(isoform-parent)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P55209	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P46060	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P45880-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-16813972|ensembl:ENSP00000361635	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p45880-1(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000165637(gene)|ensembl:ENST00000313132(transcript)|intact:EBI-354022(isoform-parent)|uniprotkb:P45880-1(isoform-parent)	-	-	isoform-comment:"Ref.1 (AAA60144) sequence differs from that shown due to frameshift."	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:7+C9ApIV4ujBMpzQcBRMY70bMSQ9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P35240-2	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-1014505	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p35240-2(display_long)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	intact:EBI-1014472(merl_human)|uniprotkb:P35240-2(isoform-parent)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Kbr6nUKfYdR92+LtMrYQs6mDp+A9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P29317	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-702104|uniprotkb:Q8N3Z2|uniprotkb:B5A968|intact:EBI-28989000|ensembl:ENSP00000351209	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:epha2_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:EPHA2(gene name)|psi-mi:EPHA2(display_short)|uniprotkb:ECK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_004422.2|ensembl:ENSP00000351209|dip:DIP-96N|ensembl:ENSG00000142627(gene)|ensembl:ENST00000358432(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:P29317|rcsb pdb:1MQB|rcsb pdb:2E8N|rcsb pdb:2K9Y|rcsb pdb:2KSO|rcsb pdb:2X10|rcsb pdb:2X11|rcsb pdb:3C8X|rcsb pdb:3CZU|rcsb pdb:3FL7|rcsb pdb:3HEI|rcsb pdb:3HPN|rcsb pdb:3KKA|rcsb pdb:3MBW|rcsb pdb:3MX0|rcsb pdb:3SKJ|rcsb pdb:4P2K|rcsb pdb:4PDO|rcsb pdb:4TRL|rcsb pdb:5EK7|rcsb pdb:5I9U|rcsb pdb:5I9V|rcsb pdb:5I9W|rcsb pdb:5I9X|rcsb pdb:5I9Y|rcsb pdb:5I9Z|rcsb pdb:5IA0|rcsb pdb:5IA1|rcsb pdb:5IA2|rcsb pdb:5IA3|rcsb pdb:5IA4|rcsb pdb:5IA5|rcsb pdb:5NJZ|rcsb pdb:5NK0|rcsb pdb:5NK1|rcsb pdb:5NK2|rcsb pdb:5NK3|rcsb pdb:5NK4|rcsb pdb:5NK5|rcsb pdb:5NK6|rcsb pdb:5NK7|rcsb pdb:5NK8|rcsb pdb:5NK9|rcsb pdb:5NKA|rcsb pdb:5NKB|rcsb pdb:5NKC|rcsb pdb:5NKD|rcsb pdb:5NKE|rcsb pdb:5NKF|rcsb pdb:5NKG|rcsb pdb:5NKH|rcsb pdb:5NKI|rcsb pdb:5NZ9|rcsb pdb:6B9L|rcsb pdb:6F7M|rcsb pdb:6F7N|rcsb pdb:6FNF|rcsb pdb:6FNG|rcsb pdb:6FNH|rcsb pdb:6HES|rcsb pdb:6HET|rcsb pdb:6HEU|rcsb pdb:6HEV|rcsb pdb:6HEW|rcsb pdb:6HEX|rcsb pdb:6HEY|rcsb pdb:6NJZ|rcsb pdb:6NK0|rcsb pdb:6NK1|rcsb pdb:6NK2|rcsb pdb:6NKP|rcsb pdb:6Q7B|rcsb pdb:6Q7C|rcsb pdb:6Q7D|rcsb pdb:6Q7E|rcsb pdb:6Q7F|rcsb pdb:6Q7G|rcsb pdb:6RW2|rcsb pdb:7B7N|rcsb pdb:7CZE|rcsb pdb:7CZF|rcsb pdb:7KJA|rcsb pdb:7KJB|rcsb pdb:7KJC|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:9VFikLd4ftRmEyBpY0JHdpHINT09606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P25440-2	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-21567525	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:p254402(display_long)|uniprotkb:BRD2(gene name)|psi-mi:BRD2(display_short)|uniprotkb:KIAA9001(gene name synonym)|uniprotkb:RING3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	uniprotkb:P25440-2(isoform-parent)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Y++9BWHrsAuZHqZQ7/sMXDjHZR49606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P21589	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-6393623|ensembl:ENSP00000257770|uniprotkb:B3KQI8|uniprotkb:O75520|uniprotkb:Q5W116	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:5ntd_human(display_long)|uniprotkb:NT5E(gene name)|psi-mi:NT5E(display_short)|uniprotkb:NT5(gene name synonym)|uniprotkb:NTE(gene name synonym)|uniprotkb:Ecto-5'-nucleotidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000135318(gene)|ensembl:ENST00000257770(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006196"(AMP catabolic process)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0046032"(ADP catabolic process)|go:"GO:0046086"(adenosine biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006146(5'-Nucleotidase, conserved site)|interpro:IPR006179(5'-Nucleotidase and apyrase)|interpro:IPR008334(5'-Nucleotidase, C-terminal)|interpro:IPR029052|interpro:IPR036907|rcsb pdb:4H1S|rcsb pdb:4H1Y|rcsb pdb:4H2B|rcsb pdb:4H2F|rcsb pdb:4H2G|rcsb pdb:4H2I|rcsb pdb:6HXW|rcsb pdb:6S7F|rcsb pdb:6S7H|rcsb pdb:6TVE|rcsb pdb:6TVG|rcsb pdb:6TVX|rcsb pdb:6TW0|rcsb pdb:6TWA|rcsb pdb:6TWF|rcsb pdb:6XUE|rcsb pdb:6XUG|rcsb pdb:6XUQ|rcsb pdb:6YE1|rcsb pdb:6YE2|rcsb pdb:6Z9B|rcsb pdb:6Z9D|rcsb pdb:7JV8|rcsb pdb:7JV9|reactome:R-HSA-196807|reactome:R-HSA-73621|reactome:R-HSA-74259|reactome:R-HSA-9660826|refseq:NP_001191742.1|refseq:NP_002517.1|dip:DIP-59992N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Tn2KldD6XKIKJl1lnpG5WyvYS4w9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P21399	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-2847111|uniprotkb:Q5VZA7|uniprotkb:Q14652|uniprotkb:D3DRK7|ensembl:ENSP00000309477|ensembl:ENSP00000369255|ensembl:ENSP00000438733	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:acohc_human(display_long)|uniprotkb:ACO1(gene name)|psi-mi:ACO1(display_short)|uniprotkb:IREB1(gene name synonym)|uniprotkb:Citrate hydro-lyase(gene name synonym)|uniprotkb:Ferritin repressor protein(gene name synonym)|uniprotkb:Iron regulatory protein 1(gene name synonym)|uniprotkb:Iron-responsive element-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_011516190.1|refseq:NP_001265281.1|refseq:NP_002188.1|refseq:XP_005251533.1|ensembl:ENSG00000122729(gene)|ensembl:ENST00000309951(transcript)|ensembl:ENST00000379923(transcript)|ensembl:ENST00000541043(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003994"(aconitate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0047780"(citrate dehydratase activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000573(Aconitase A/isopropylmalate dehydratase small subunit, swivel)|interpro:IPR001030(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)|interpro:IPR006249(Aconitase/iron regulatory protein 2)|interpro:IPR015928(Aconitase/3-isopropylmalate dehydratase, swivel)|interpro:IPR015931(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomains 1 and 3)|interpro:IPR018136|interpro:IPR029784|interpro:IPR036008|interpro:IPR044137|mint:P21399|rcsb pdb:2B3X|rcsb pdb:2B3Y|reactome:R-HSA-917937|go:"GO:0009791"(post-embryonic development)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:hcZPPf3fTfqol8El1L5kwVEljyY9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P14324	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-948245|ensembl:ENSP00000349078|ensembl:ENSP00000357340|uniprotkb:Q96G29|uniprotkb:D3DV91|uniprotkb:E9PCI9	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:fpps_human(display_long)|uniprotkb:Farnesyl diphosphate synthase(gene name synonym)|uniprotkb:FDPS(gene name)|psi-mi:FDPS(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:KIAA1293(gene name synonym)|uniprotkb:"(2E,6E)-farnesyl diphosphate synthase"(gene name synonym)|uniprotkb:Dimethylallyltranstransferase(gene name synonym)|uniprotkb:Geranyltranstransferase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000160752(gene)|ensembl:ENST00000356657(transcript)|ensembl:ENST00000368356(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004161"(dimethylallyltranstransferase activity)|go:"GO:0004337"(geranyltranstransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0033384"(geranyl diphosphate biosynthetic process)|go:"GO:0045337"(farnesyl diphosphate biosynthetic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000092(Polyprenyl synthetase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR033749|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1YQ7|rcsb pdb:1ZW5|rcsb pdb:2F7M|rcsb pdb:2F89|rcsb pdb:2F8C|rcsb pdb:2F8Z|rcsb pdb:2F92|rcsb pdb:2F94|rcsb pdb:2F9K|rcsb pdb:2OPM|rcsb pdb:2OPN|rcsb pdb:2QIS|rcsb pdb:2RAH|rcsb pdb:2VF6|rcsb pdb:3B7L|rcsb pdb:3CP6|rcsb pdb:3N1V|rcsb pdb:3N1W|rcsb pdb:3N3L|rcsb pdb:3N45|rcsb pdb:3N46|rcsb pdb:1YV5|rcsb pdb:3N49|rcsb pdb:3N5H|rcsb pdb:3N5J|rcsb pdb:3N6K|rcsb pdb:3RYE|rcsb pdb:3S4J|rcsb pdb:4DEM|rcsb pdb:4GA3|rcsb pdb:4H5D|rcsb pdb:4H5E|rcsb pdb:4JVJ|rcsb pdb:4KFA|rcsb pdb:4KPD|rcsb pdb:4KPJ|rcsb pdb:4KQ5|rcsb pdb:4KQS|rcsb pdb:4KQU|rcsb pdb:4L2X|rcsb pdb:4LFV|rcsb pdb:4LPG|rcsb pdb:4LPH|rcsb pdb:4N1Z|rcsb pdb:4N9U|rcsb pdb:4NFI|rcsb pdb:4NFJ|rcsb pdb:4NFK|rcsb pdb:4NG6|rcsb pdb:4NKE|rcsb pdb:4NKF|rcsb pdb:4NUA|rcsb pdb:4OGU|rcsb pdb:4P0V|rcsb pdb:4P0W|rcsb pdb:4P0X|rcsb pdb:4PVX|rcsb pdb:4PVY|rcsb pdb:4H5C|rcsb pdb:4Q23|rcsb pdb:4QPF|rcsb pdb:4QXS|rcsb pdb:4RXA|rcsb pdb:4XQR|rcsb pdb:4XQS|rcsb pdb:4XQT|reactome:R-HSA-2426168|rcsb pdb:5CG6|rcsb pdb:5DGM|rcsb pdb:5CG5|rcsb pdb:5DGN|rcsb pdb:5DGS|rcsb pdb:5DIQ|rcsb pdb:5DJP|rcsb pdb:5DJR|rcsb pdb:5DJV|rcsb pdb:5JA0|rcsb pdb:5JUZ|rcsb pdb:5JV0|rcsb pdb:5JV1|rcsb pdb:5JV2|rcsb pdb:5KSX|rcsb pdb:5YGI|rcsb pdb:6N7Y|rcsb pdb:6N7Z|rcsb pdb:6N82|rcsb pdb:6N83|rcsb pdb:6OAG|rcsb pdb:6OAH|reactome:R-HSA-191273|refseq:NP_001129293.1|refseq:NP_001129294.1|refseq:NP_001229753.1|refseq:NP_001229754.1|refseq:NP_001995.1|refseq:XP_005245019.1|refseq:XP_005245020.1|dip:DIP-50059N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:cLrS58XE4dKJiiK96hQt7JPO5T89606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07947	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P07737	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-713780|ensembl:ENSP00000225655|uniprotkb:Q53Y44	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:prof1_human(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:PFN1(gene name)|psi-mi:PFN1(display_short)|uniprotkb:Epididymis tissue protein Li 184a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000108518(gene)|ensembl:ENST00000225655(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P07737|rcsb pdb:1AWI|rcsb pdb:1CF0|rcsb pdb:1CJF|rcsb pdb:1FIK|rcsb pdb:1FIL|rcsb pdb:1PFL|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|rcsb pdb:4X1L|rcsb pdb:4X1M|rcsb pdb:4X25|rcsb pdb:6NAS|rcsb pdb:6NBE|rcsb pdb:6NBW|reactome:R-HSA-114608|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-4086400|reactome:R-HSA-5663220|reactome:R-HSA-376176|refseq:NP_005013.1|dip:DIP-30N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:CncaC5RMylvzFLhqzpS+VbhQn6I9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P04216	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-9071715|ensembl:ENSP00000284240|ensembl:ENSP00000431301|uniprotkb:Q9NSP1|uniprotkb:Q16008	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:thy1_human(display_long)|uniprotkb:CDw90(gene name synonym)|uniprotkb:Thy-1 antigen(gene name synonym)|uniprotkb:THY1(gene name)|psi-mi:THY1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_006279.2|refseq:NP_001298089.1|refseq:NP_001298091.1|ensembl:ENSG00000154096(gene)|ensembl:ENST00000284240(transcript)|ensembl:ENST00000528522(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033292|interpro:IPR036179|mint:P04216|reactome:R-HSA-163125	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:oJQb/vrYoN49IHy3OI4SmCXYtJY9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P02786	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P00491	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-712238|ensembl:ENSP00000354532|uniprotkb:Q15160|uniprotkb:Q5PZ03|uniprotkb:B2R8S5|uniprotkb:D3DS00	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:pnph_human(display_long)|uniprotkb:Inosine phosphorylase(gene name synonym)|uniprotkb:PNP(gene name)|psi-mi:PNP(display_short)|uniprotkb:NP(gene name synonym)|uniprotkb:Inosine-guanosine phosphorylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	go:"GO:0001882"(nucleoside binding)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0004731"(purine-nucleoside phosphorylase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006148"(inosine catabolic process)|go:"GO:0006149"(deoxyinosine catabolic process)|go:"GO:0006157"(deoxyadenosine catabolic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006204"(IMP catabolic process)|go:"GO:0006738"(nicotinamide riboside catabolic process)|go:"GO:0006955"(immune response)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0019428"(allantoin biosynthetic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043101"(purine-containing compound salvage)|go:"GO:0046059"(dAMP catabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0047975"(guanosine phosphorylase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000845(Nucleoside phosphorylase)|interpro:IPR011268(Inosine guanosine and xanthosine phosphorylase)|interpro:IPR011270(Purine nucleoside phosphorylase I, inosine and guanosine-specific)|interpro:IPR018099|interpro:IPR035994|mint:P00491|rcsb pdb:1M73|rcsb pdb:1PF7|rcsb pdb:1PWY|rcsb pdb:1RCT|rcsb pdb:1RFG|rcsb pdb:1RR6|rcsb pdb:1RSZ|rcsb pdb:1RT9|rcsb pdb:1ULA|rcsb pdb:1ULB|rcsb pdb:1V2H|rcsb pdb:1V3Q|rcsb pdb:1V41|rcsb pdb:1V45|rcsb pdb:1YRY|rcsb pdb:2A0W|rcsb pdb:2A0X|rcsb pdb:2A0Y|rcsb pdb:2OC4|rcsb pdb:2OC9|rcsb pdb:2ON6|rcsb pdb:2Q7O|rcsb pdb:3BGS|rcsb pdb:3D1V|rcsb pdb:3GB9|rcsb pdb:3GGS|ensembl:ENSG00000198805(gene)|ensembl:ENST00000361505(transcript)|go:"GO:0000255"(allantoin metabolic process)|rcsb pdb:3K8O|rcsb pdb:3K8Q|rcsb pdb:3PHB|rcsb pdb:4EAR|rcsb pdb:3INY|rcsb pdb:4EB8|rcsb pdb:4ECE|rcsb pdb:4GKA|rcsb pdb:5ETJ|rcsb pdb:5UGF|reactome:R-HSA-6798695|reactome:R-HSA-74217|reactome:R-HSA-74259|refseq:NP_000261.2|dip:DIP-50406N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:FOpaxV/M6HIA+THugPZDfN1ej1o9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O95218-1	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033343|ensembl:ENSP00000359958	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:o95218-1(display_long)|uniprotkb:Zinc finger, splicing(gene name synonym)|uniprotkb:ZIS-1(isoform synonym)|uniprotkb:Zinc finger protein 265(gene name synonym)|uniprotkb:ZRANB2(gene name)|psi-mi:ZRANB2(display_short)|uniprotkb:ZIS(gene name synonym)|uniprotkb:ZNF265(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	ensembl:ENSG00000132485(gene)|ensembl:ENST00000370920(transcript)|intact:EBI-1051583(isoform-parent)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:NSsZyRDwY5bF3I5OGvd1jGYTijY9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O75942	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033257	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:o75942_human(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	interpro:IPR000817(Prion protein)|interpro:IPR036924|interpro:IPR022416|interpro:IPR020949|interpro:IPR025860|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0051260"(protein homooligomerization)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:SDcrjYo+hx53hg21RD0JWbH/g2g9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O75390	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-487493|ensembl:ENSP00000342056|uniprotkb:Q71UT9|uniprotkb:Q7KZH0|uniprotkb:Q96FZ8|uniprotkb:Q9BWN8	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:cisy_human(display_long)|uniprotkb:CS(gene name)|psi-mi:CS(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	go:"GO:0006101"(citrate metabolic process)|refseq:NP_004068.2|ensembl:ENSG00000062485(gene)|go:"GO:0004108"("citrate (Si)-synthase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000351328(transcript)|rcsb pdb:5UZQ|rcsb pdb:5UZR|reactome:R-HSA-1268020|reactome:R-HSA-71403|go:"GO:0070062"(extracellular exosome)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|rcsb pdb:5UZP	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:XKpnEsGOlGRNIAXMk4tTBH2okzo9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:O43913	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:P29353	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:B4DRL5	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-22033330	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:b4drl5_human(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030713|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0098609"(cell-cell adhesion)	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:9gbB606amN7gGM7yfSS0ADbSDSs9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q08345-1	uniprotkb:Q14203	intact:EBI-22033193|ensembl:ENSP00000318217|ensembl:ENSP00000365752|ensembl:ENSP00000372868|ensembl:ENSP00000383265|ensembl:ENSP00000383338|ensembl:ENSP00000383339|ensembl:ENSP00000391805|ensembl:ENSP00000397769|ensembl:ENSP00000401397|ensembl:ENSP00000405039|ensembl:ENSP00000414285|ensembl:ENSP00000448377|ensembl:ENSP00000449190|ensembl:ENSP00000449255|ensembl:ENSP00000449611	intact:EBI-724352|uniprotkb:O95296|uniprotkb:Q9BRM9|uniprotkb:Q9UIU1|intact:EBI-28971695|ensembl:ENSP00000487279|uniprotkb:Q9UIU2|uniprotkb:E9PGE1|uniprotkb:G5E9H4|uniprotkb:Q6IQ37|intact:EBI-2560059|uniprotkb:B4DM45|uniprotkb:E9PFS5|uniprotkb:A8MY36|intact:EBI-10962300	psi-mi:q08345-1(display_long)|uniprotkb:CD167 antigen-like family member A(gene name synonym)|uniprotkb:Cell adhesion kinase(gene name synonym)|uniprotkb:Discoidin receptor tyrosine kinase(gene name synonym)|uniprotkb:HGK2(gene name synonym)|uniprotkb:Mammary carcinoma kinase 10(gene name synonym)|uniprotkb:Protein-tyrosine kinase 3A(gene name synonym)|uniprotkb:Protein-tyrosine kinase RTK-6(gene name synonym)|uniprotkb:TRK E(gene name synonym)|uniprotkb:Tyrosine kinase DDR(gene name synonym)|uniprotkb:Tyrosine-protein kinase CAK(gene name synonym)|uniprotkb:CAK I(isoform synonym)|uniprotkb:DDR1b(isoform synonym)|uniprotkb:DDR1(gene name)|psi-mi:DDR1(display_short)|uniprotkb:CAK(gene name synonym)|uniprotkb:EDDR1(gene name synonym)|uniprotkb:NEP(gene name synonym)|uniprotkb:NTRK4(gene name synonym)|uniprotkb:PTK3A(gene name synonym)|uniprotkb:RTK6(gene name synonym)|uniprotkb:TRKE(gene name synonym)	psi-mi:dctn1_human(display_long)|uniprotkb:DCTN1(gene name)|psi-mi:DCTN1(display_short)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:p135(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22227061|imex:IM-27380-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-711879(isoform-parent)|ensembl:ENSG00000137332(gene)|ensembl:ENSG00000204580(gene)|ensembl:ENSG00000215522(gene)|ensembl:ENSG00000230456(gene)|ensembl:ENSG00000234078(gene)|ensembl:ENST00000324771(transcript)|ensembl:ENST00000376568(transcript)|ensembl:ENST00000383377(transcript)|ensembl:ENST00000400414(transcript)|ensembl:ENST00000400491(transcript)|ensembl:ENST00000400492(transcript)|ensembl:ENST00000412329(transcript)|ensembl:ENST00000429699(transcript)|ensembl:ENST00000430933(transcript)|ensembl:ENST00000449518(transcript)|ensembl:ENST00000452441(transcript)|ensembl:ENST00000548133(transcript)|ensembl:ENST00000550395(transcript)|ensembl:ENST00000552068(transcript)|ensembl:ENST00000553015(transcript)	refseq:NP_001128512.1|refseq:NP_001128513.1|refseq:NP_001177766.1|refseq:NP_004073.2|refseq:NP_075408.1|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-381038|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|reactome:R-HSA-380259|ensembl:ENSG00000204843(gene)|ensembl:ENST00000628224(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007399"(nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048156"(tau protein binding)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0099558"(maintenance of synapse structure)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:Q14203|rcsb pdb:1TXQ|rcsb pdb:2COY|rcsb pdb:2HKN|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2HQH|rcsb pdb:3E2U|rcsb pdb:3TQ7|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|ensembl:ENST00000394003|ensembl:ENSP00000377571|ensembl:ENST00000409240|ensembl:ENSP00000386406|ensembl:ENST00000409438|ensembl:ENSP00000387270|ensembl:ENST00000409567|ensembl:ENSP00000386843|ensembl:ENSP00000487279|ensembl:ENST00000633691|ensembl:ENSP00000487724|refseq:NP_001177765.1|dip:DIP-31365N	-	-	-	figure legend:ST1 ST2 F2 T1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human_sf268)|taxid:9606(Human malignant CNS glioma cell line)	-	2017/11/30	2019/11/21	rogid:gveV0C3v43aJ6QWuK1zI8Ioo+Ns9606	rogid:PKchWdLWycCErGzSVMXq/xCQJRM9606	rigid:DHEEio1QWpMMufhg39diRlqFTP4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P62993	uniprotkb:P29353	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22226336|imex:IM-27380-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:SF3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/12/02	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rigid:EnKc1SonrBsRuGJTSr4GjfE5GkU	false	binding-associated region:60..60-152..152	binding-associated region:419-432|phosphorylated residue:427-427|mutation:421-422	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P29353	uniprotkb:P29353	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22235164|imex:IM-27380-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:SF3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/12/02	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rigid:EnKc1SonrBsRuGJTSr4GjfE5GkU	false	binding-associated region:419-432|phosphorylated residue:427-427|mutation:421-422	binding-associated region:419-432|phosphorylated residue:427-427|mutation:421-422	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P29353	uniprotkb:P62993	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lemeer et al. (2012)	pubmed:22057045|imex:IM-27380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22235164|imex:IM-27380-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:SF3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/30	2019/12/02	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rigid:EnKc1SonrBsRuGJTSr4GjfE5GkU	false	binding-associated region:419-432|phosphorylated residue:427-427|mutation:421-422	binding-associated region:60..60-152..152	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)