#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q8WXG1 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12737242|imex:IM-25639-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet)|go:"GO:0019034"(viral replication complex) chain-seq-start:1977|chain-seq-end:2442 - figure legend:1D, 2 A/B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:UJ5ljA4zOPyPvxEnZgWTshYOsdo false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9WPH5 uniprotkb:Q8WXG1 intact:EBI-12737269 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q9wph5_9hepc(display_long)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Gp32(gene name synonym)|uniprotkb:Hepacivirin(gene name synonym)|uniprotkb:NS1(gene name synonym)|uniprotkb:NS3P(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:gp35(gene name synonym)|uniprotkb:gp68(gene name synonym)|uniprotkb:gp70(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:p27(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:p8(gene name synonym)|uniprotkb:Mature core protein(gene name synonym)|uniprotkb:NS3 helicase(gene name synonym)|uniprotkb:NS3 protease(gene name synonym)|uniprotkb:Protease NS2(gene name synonym)|uniprotkb:Serine protease/helicase NS3(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)|uniprotkb:Viroporin p70(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:p56/58(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:31647(hepatitis c virus subtype 1b)|taxid:31647(Hepatitis C virus subtype 1b) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12737261|imex:IM-25639-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR042205|interpro:IPR042209|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|rcsb pdb:3M5M|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504|interpro:IPR043128 ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet)|go:"GO:0019034"(viral replication complex) - - figure legend:2C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:bl0/L7amzrr/kt51Jf27JyCyWeo31647 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:VoUpAxgbqkUwxBk5FxQSUq4NuE4 false sufficient binding region:1977..1977-2442..2442 - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q99IB8-PRO_0000045593 uniprotkb:Q8WXG1 intact:EBI-12737359 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q99ib8-pro_0000045593(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12737327|imex:IM-25639-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet) chain-seq-start:2|chain-seq-end:177 - figure legend:2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:nJpI2+OvJqSHRLwHaWulJeHaXO0356411 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:lsGT6l0Zo6xktZl0zIa4wa9H/EE false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12737699|imex:IM-25639-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet)|go:"GO:0019034"(viral replication complex) - - figure legend:7A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:VR7VWHkH6fSC/aBPpJpDKRJEnZM false mcherry fluorescent protein tag:?-? flag tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q99IB8-PRO_0000045593 uniprotkb:Q8WXG1 intact:EBI-12737359 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q99ib8-pro_0000045593(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-12737408|imex:IM-25639-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet) chain-seq-start:2|chain-seq-end:177 - figure legend:3B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:nJpI2+OvJqSHRLwHaWulJeHaXO0356411 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:lsGT6l0Zo6xktZl0zIa4wa9H/EE false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q8WXG1 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-12737424|imex:IM-25639-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet)|go:"GO:0019034"(viral replication complex) chain-seq-start:1977|chain-seq-end:2442 - figure legend:3C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:UJ5ljA4zOPyPvxEnZgWTshYOsdo false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q99IB8-PRO_0000045593 uniprotkb:Q8WXG1 intact:EBI-12737359 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q99ib8-pro_0000045593(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-12737763|imex:IM-25639-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet) chain-seq-start:2|chain-seq-end:177 - figure legend:5B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:nJpI2+OvJqSHRLwHaWulJeHaXO0356411 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:lsGT6l0Zo6xktZl0zIa4wa9H/EE false - necessary binding region:345-361|flag tag:n-n - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q8WXG1 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-12737778|imex:IM-25639-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0005811"(lipid droplet)|go:"GO:0019034"(viral replication complex) chain-seq-start:1977|chain-seq-end:2442 - figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:UJ5ljA4zOPyPvxEnZgWTshYOsdo false - necessary binding region:345-361|flag tag:n-n - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Helbig et al. (2011) pubmed:22045669|imex:IM-25639 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-12737667|imex:IM-25639-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 go:"GO:0019034"(viral replication complex) - - figure legend:7B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2017/01/10 2017/01/11 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:VR7VWHkH6fSC/aBPpJpDKRJEnZM false mcherry fluorescent protein tag:?-? enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)