#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-15948079 uniprotkb:P29074 dip:DIP-59412N intact:EBI-710431|ensembl:ENSP00000263708|uniprotkb:B2RBV8|uniprotkb:Q9UDA7 psi-mi:cyto(display_short)|psi-mi:EBI-15948079(display_long) psi-mi:ptn4_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG1(gene name synonym)|uniprotkb:PTPN4(gene name)|psi-mi:PTPN4(display_short) psi-mi:"MI:0114"(x-ray crystallography) Babault et al. (2011) pubmed:22000519|doi:"https://doi.org/10.1016/j.str.2011.07.007"|imex:IM-17057 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15948082|imex:IM-17057-1|dip:DIP-187820E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_002821.1|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|rcsb pdb:2CS5|rcsb pdb:2I75|rcsb pdb:2VPH|rcsb pdb:3NFK|rcsb pdb:3NFL|rcsb pdb:5EYZ|rcsb pdb:5EZ0|reactome:R-HSA-166016|reactome:R-HSA-9008059|reactome:R-HSA-9022699|ensembl:ENSG00000088179(gene)|ensembl:ENST00000263708(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:XP_016860089.1|dip:DIP-34634N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:qAe6QZ5wY2LeATBajb8mhCgglPQ-2 rogid:o2XCVGiLiaTRa6iC4bbwOdzepQ89606 rigid:mPcb+kXQz6yHlaCjHB6goipkwV4 false - binding-associated region:499-604 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15948101 uniprotkb:P29074 dip:DIP-59414N intact:EBI-710431|ensembl:ENSP00000263708|uniprotkb:B2RBV8|uniprotkb:Q9UDA7 psi-mi:glud213(display_short)|psi-mi:EBI-15948101(display_long) psi-mi:ptn4_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG1(gene name synonym)|uniprotkb:PTPN4(gene name)|psi-mi:PTPN4(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Babault et al. (2011) pubmed:22000519|doi:"https://doi.org/10.1016/j.str.2011.07.007"|imex:IM-17057 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15948104|imex:IM-17057-2|dip:DIP-187822E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_002821.1|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|rcsb pdb:2CS5|rcsb pdb:2I75|rcsb pdb:2VPH|rcsb pdb:3NFK|rcsb pdb:3NFL|rcsb pdb:5EYZ|rcsb pdb:5EZ0|reactome:R-HSA-166016|reactome:R-HSA-9008059|reactome:R-HSA-9022699|ensembl:ENSG00000088179(gene)|ensembl:ENST00000263708(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:XP_016860089.1|dip:DIP-34634N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ljpKQDABIGOm3w+bkm/gzWdGHEo-2 rogid:o2XCVGiLiaTRa6iC4bbwOdzepQ89606 rigid:UXRcBowbxWhINGBYYRT5sI4Xhao false - binding-associated region:499-604 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15948124 uniprotkb:P29074 dip:DIP-59413N intact:EBI-710431|ensembl:ENSP00000263708|uniprotkb:B2RBV8|uniprotkb:Q9UDA7 psi-mi:glun2a16(display_short)|psi-mi:EBI-15948124(display_long) psi-mi:ptn4_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG1(gene name synonym)|uniprotkb:PTPN4(gene name)|psi-mi:PTPN4(display_short) psi-mi:"MI:0114"(x-ray crystallography) Babault et al. (2011) pubmed:22000519|doi:"https://doi.org/10.1016/j.str.2011.07.007"|imex:IM-17057 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15948127|imex:IM-17057-3|dip:DIP-187821E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_002821.1|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|rcsb pdb:2CS5|rcsb pdb:2I75|rcsb pdb:2VPH|rcsb pdb:3NFK|rcsb pdb:3NFL|rcsb pdb:5EYZ|rcsb pdb:5EZ0|reactome:R-HSA-166016|reactome:R-HSA-9008059|reactome:R-HSA-9022699|ensembl:ENSG00000088179(gene)|ensembl:ENST00000263708(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:XP_016860089.1|dip:DIP-34634N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:CySzvQp8eSBvucRMjrQShWgemhE-2 rogid:o2XCVGiLiaTRa6iC4bbwOdzepQ89606 rigid:UuNHarblbMZckTodCSjdHu+AtwY false - binding-associated region:499-604 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15948079 uniprotkb:P29074 dip:DIP-59412N intact:EBI-710431|ensembl:ENSP00000263708|uniprotkb:B2RBV8|uniprotkb:Q9UDA7 psi-mi:cyto(display_short)|psi-mi:EBI-15948079(display_long) psi-mi:ptn4_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG1(gene name synonym)|uniprotkb:PTPN4(gene name)|psi-mi:PTPN4(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Babault et al. (2011) pubmed:22000519|doi:"https://doi.org/10.1016/j.str.2011.07.007"|imex:IM-17057 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15948146|imex:IM-17057-4|dip:DIP-187820E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_002821.1|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|rcsb pdb:2CS5|rcsb pdb:2I75|rcsb pdb:2VPH|rcsb pdb:3NFK|rcsb pdb:3NFL|rcsb pdb:5EYZ|rcsb pdb:5EZ0|reactome:R-HSA-166016|reactome:R-HSA-9008059|reactome:R-HSA-9022699|ensembl:ENSG00000088179(gene)|ensembl:ENST00000263708(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:XP_016860089.1|dip:DIP-34634N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:qAe6QZ5wY2LeATBajb8mhCgglPQ-2 rogid:o2XCVGiLiaTRa6iC4bbwOdzepQ89606 rigid:mPcb+kXQz6yHlaCjHB6goipkwV4 false mutation increasing interaction:9-9,12-12|mutation increasing interaction:13-13,12-12,11-11|mutation decreasing interaction:10-10|mutation decreasing interaction:6-6,5-5,11-11|mutation decreasing interaction:8-8,5-5,4-4,11-11,10-10 binding-associated region:499-604 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15948124 uniprotkb:P29074 dip:DIP-59413N intact:EBI-710431|ensembl:ENSP00000263708|uniprotkb:B2RBV8|uniprotkb:Q9UDA7 psi-mi:glun2a16(display_short)|psi-mi:EBI-15948124(display_long) psi-mi:ptn4_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG1(gene name synonym)|uniprotkb:PTPN4(gene name)|psi-mi:PTPN4(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Babault et al. (2011) pubmed:22000519|doi:"https://doi.org/10.1016/j.str.2011.07.007"|imex:IM-17057 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15948189|imex:IM-17057-5|dip:DIP-187821E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_002821.1|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|rcsb pdb:2CS5|rcsb pdb:2I75|rcsb pdb:2VPH|rcsb pdb:3NFK|rcsb pdb:3NFL|rcsb pdb:5EYZ|rcsb pdb:5EZ0|reactome:R-HSA-166016|reactome:R-HSA-9008059|reactome:R-HSA-9022699|ensembl:ENSG00000088179(gene)|ensembl:ENST00000263708(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:XP_016860089.1|dip:DIP-34634N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:CySzvQp8eSBvucRMjrQShWgemhE-2 rogid:o2XCVGiLiaTRa6iC4bbwOdzepQ89606 rigid:UuNHarblbMZckTodCSjdHu+AtwY false - binding-associated region:499-604 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)