#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92843 uniprotkb:Q92843 intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2011) pubmed:22000515|doi:10.1016/j.str.2011.07.015|imex:IM-17055 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15947834|imex:IM-17055-2|dip:DIP-187816E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rigid:looGuSKeA+a6Krx0wR6QyahH5Aw false mutation disrupting interaction:96-96,91-91,89-89,88-88|mutation:29-29 mutation disrupting interaction:96-96,91-91,89-89,88-88|mutation:29-29 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92934 uniprotkb:Q92843 intact:EBI-700771|uniprotkb:O14803|uniprotkb:Q6FH21|ensembl:ENSP00000309103|ensembl:ENSP00000378040 intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 psi-mi:bad_human(display_long)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-2-like protein 8(gene name synonym)|uniprotkb:BAD(gene name)|psi-mi:BAD(display_short)|uniprotkb:BBC6(gene name synonym)|uniprotkb:BCL2L8(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym) psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Lee et al. (2011) pubmed:22000515|doi:10.1016/j.str.2011.07.015|imex:IM-17055 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15947815|imex:IM-17055-1|dip:DIP-78749E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004313.1|refseq:NP_116784.1|dip:DIP-29184N|ensembl:ENSG00000002330(gene)|ensembl:ENST00000309032(transcript)|ensembl:ENST00000394532(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|mint:Q92934|rcsb pdb:1G5J|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-198323|reactome:R-HSA-5674400 refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:2c2kSu+3ZHnx458SDbvIcdGV4PA9606 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rigid:QF/U6RNUpns2UH2o9gBBoSK8//U false binding-associated region:103-127 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15947859 uniprotkb:Q92843 dip:DIP-59411N intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 psi-mi:puma(display_short)|psi-mi:EBI-15947859(display_long) psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2011) pubmed:22000515|doi:10.1016/j.str.2011.07.015|imex:IM-17055 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15947862|imex:IM-17055-3|dip:DIP-187818E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:vSCQHsBqfS0kjsXDDYBOmB0So4w-2 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rigid:KIIsR7CVmnaUouj9sVPiRUgFVE0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92843 uniprotkb:Q92843 intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Lee et al. (2011) pubmed:22000515|doi:10.1016/j.str.2011.07.015|imex:IM-17055 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15947879|imex:IM-17055-4|dip:DIP-187816E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rigid:looGuSKeA+a6Krx0wR6QyahH5Aw false mutation:29-29 mutation:29-29 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92843 uniprotkb:Q92843 intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Lee et al. (2011) pubmed:22000515|doi:10.1016/j.str.2011.07.015|imex:IM-17055 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15947919|imex:IM-17055-6|dip:DIP-187816E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rigid:looGuSKeA+a6Krx0wR6QyahH5Aw false mutation:29-29 mutation:29-29 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15947898 uniprotkb:Q92843 dip:DIP-59410N intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 psi-mi:bim(display_short)|psi-mi:EBI-15947898(display_long) psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2011) pubmed:22000515|doi:10.1016/j.str.2011.07.015|imex:IM-17055 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15947901|imex:IM-17055-5|dip:DIP-187817E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:O4gIvJmd1r+Ns1PkTOx2IVW+p+A-2 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rigid:rQAvOdOgdO4s68a6GpbMnGpFCnY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15947898 uniprotkb:Q92843 dip:DIP-59410N intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570 psi-mi:bim(display_short)|psi-mi:EBI-15947898(display_long) psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Lee et al. (2011) pubmed:22000515|doi:10.1016/j.str.2011.07.015|imex:IM-17055 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15947938|imex:IM-17055-7|dip:DIP-187817E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:O4gIvJmd1r+Ns1PkTOx2IVW+p+A-2 rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606 rigid:rQAvOdOgdO4s68a6GpbMnGpFCnY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)