#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hohl et al. (2011)	pubmed:21892167|doi:10.1038/nsmb.2116|imex:IM-17083	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15942921|imex:IM-17083-1|dip:DIP-2918E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/07	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	rigid:vJK543uqRq1hmrItqlQd9FtIePA	false	flag tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hohl et al. (2011)	pubmed:21892167|doi:10.1038/nsmb.2116|imex:IM-17083	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15942960|imex:IM-17083-3|dip:DIP-2918E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/07	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	rigid:vJK543uqRq1hmrItqlQd9FtIePA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Hohl et al. (2011)	pubmed:21892167|doi:10.1038/nsmb.2116|imex:IM-17083	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15942942|imex:IM-17083-2|dip:DIP-143338E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32829	uniprotkb:P33301	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Hohl et al. (2011)	pubmed:21892167|doi:10.1038/nsmb.2116|imex:IM-17083	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15942942|imex:IM-17083-2|dip:DIP-143338E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:833DAD6D20F6693E	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hohl et al. (2011)	pubmed:21892167|doi:10.1038/nsmb.2116|imex:IM-17083	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15942977|imex:IM-17083-4|dip:DIP-2918E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	psi-mi:"MI:0465"(dip)	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	rigid:vJK543uqRq1hmrItqlQd9FtIePA	false	his tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)