#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q7Z2W4 uniprotkb:Q8IU60 intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351 intact:EBI-521577|uniprotkb:Q6P2D4|uniprotkb:Q7Z5W5|uniprotkb:Q8NBG5|uniprotkb:C9J778|ensembl:ENSP00000373715 psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym) psi-mi:dcp2_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 20(gene name synonym)|uniprotkb:DCP2(gene name)|psi-mi:DCP2(display_short)|uniprotkb:NUDT20(gene name synonym)|uniprotkb:mRNA-decapping enzyme 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942519|imex:IM-21353-2|dip:DIP-191531E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N refseq:NP_001229306.1|refseq:NP_689837.2|dip:DIP-31126N|ensembl:ENSG00000172795(gene)|ensembl:ENST00000389063(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0016896"(exoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030054"(cell junction)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR007722(Dcp2, box A)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR036189|interpro:IPR044099|rcsb pdb:5MP0|rcsb pdb:5QOH|rcsb pdb:5QOI|rcsb pdb:5QOJ|rcsb pdb:5QOK|rcsb pdb:5QOL|rcsb pdb:5QOM|rcsb pdb:5QON|rcsb pdb:5QOO|rcsb pdb:5QOP|rcsb pdb:5QOQ|rcsb pdb:5QOR|rcsb pdb:5QOS|rcsb pdb:5QOT|rcsb pdb:5QOU|rcsb pdb:5QOV|rcsb pdb:5QOW|rcsb pdb:5QOX|rcsb pdb:5QOY|rcsb pdb:5QOZ|rcsb pdb:5QP0|rcsb pdb:5QP1|rcsb pdb:5QP2|rcsb pdb:5QP3|rcsb pdb:5QP4|rcsb pdb:5QP5|rcsb pdb:5QP6|rcsb pdb:5QP7|rcsb pdb:5QP8|rcsb pdb:5QP9|rcsb pdb:5QPA|rcsb pdb:5QPB|rcsb pdb:5QPC|reactome:R-HSA-380994|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2018/09/18 rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606 rogid:3Bo/mLVHBcFZ4VmRqgvE2PWTw+Y9606 rigid:AX6fwgBydXXzTRLydRQ678cmtlc false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NQT5 uniprotkb:Q7Z2W4 intact:EBI-371866|uniprotkb:Q5QP85|uniprotkb:Q9Y3A8|ensembl:ENSP00000323046|uniprotkb:A8K0K6 intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351 psi-mi:exos3_human(display_long)|uniprotkb:EXOSC3(gene name)|psi-mi:EXOSC3(display_short)|uniprotkb:RRP40(gene name synonym)|uniprotkb:CGI-102(orf name)|uniprotkb:Ribosomal RNA-processing protein 40(gene name synonym)|uniprotkb:Exosome component 3(gene name synonym)|uniprotkb:p10(gene name synonym) psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942500|imex:IM-21353-1|dip:DIP-191522E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001002269.1|refseq:NP_057126.2|ensembl:ENSG00000107371(gene)|ensembl:ENST00000327304(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0035327"|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045006"(DNA deamination)|go:"GO:0045190"(isotype switching)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0071034"(CUT catabolic process)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071049"|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR026699|interpro:IPR036612|interpro:IPR037319|mint:Q9NQT5|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|dip:DIP-29847N refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:ZyFFgoy7HM3oZ35I16XAH3jCook9606 rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606 rigid:ByZs2fwqKG7k4fIuyDoSfzemCHU false - myc tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZH2 uniprotkb:Q7Z2W4 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351 psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942540|imex:IM-21353-3|dip:DIP-191529E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606 rigid:0zM9iPdiJrTahNJA7DSvVpG22sw false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q92841 uniprotkb:Q9NPI6 intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942561|imex:IM-21353-4|dip:DIP-191527E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2018/09/18 rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rigid:6cJY+aF2dOsM8EVRw6Mi1qpHpSc false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:F1LSX7 uniprotkb:Q8K3Y6 intact:EBI-15942582|ensembl:ENSRNOP00000028026 intact:EBI-8860250 psi-mi:f1lsx7_rat(display_long)|uniprotkb:Exosc5(gene name)|psi-mi:Exosc5(display_short) psi-mi:zcchv_rat(display_long)|uniprotkb:Zc3hav1(gene name)|psi-mi:Zc3hav1(display_short)|uniprotkb:Zap(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:"MI:0096"(pull down) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942614|imex:IM-21353-5|dip:DIP-191525E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0035327"|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045006"(DNA deamination)|go:"GO:0051607"(defense response to virus)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR036345|reactome:R-RNO-429958|reactome:R-RNO-450385|reactome:R-RNO-450513|reactome:R-RNO-450604|reactome:R-RNO-6791226|ensembl:ENSRNOG00000020635(gene)|ensembl:ENSRNOT00000028026(transcript)|go:"GO:0000176"("nuclear exosome (RNase complex)")|refseq:NP_001100963.2|refseq:XP_006228499.1|rgd:1307861 rgd:628694|dip:DIP-29842N|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0042802"(identical protein binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|rcsb pdb:3U9G psi-mi:"MI:0465"(dip) crc64:0A296D88E9AE8A9D - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:xG1L7gmztVORIr9JIQrrTn/i7sk10116 rogid:1v/UHcQ3JSTi4YGD1l3f7258qGs10116 rigid:vCPhQ3soU6xEuCl8b5Ctn8cplj0 false glutathione s tranferase tag:n-n myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQT4 uniprotkb:Q8K3Y6 intact:EBI-371876|uniprotkb:Q32Q81|uniprotkb:Q8NG16|uniprotkb:Q96I89|ensembl:ENSP00000221233 intact:EBI-8860250 psi-mi:exos5_human(display_long)|uniprotkb:EXOSC5(gene name)|psi-mi:EXOSC5(display_short)|uniprotkb:CML28(gene name synonym)|uniprotkb:RRP46(gene name synonym)|uniprotkb:Ribosomal RNA-processing protein 46(gene name synonym)|uniprotkb:Exosome component 5(gene name synonym)|uniprotkb:p12B(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 28(gene name synonym) psi-mi:zcchv_rat(display_long)|uniprotkb:Zc3hav1(gene name)|psi-mi:Zc3hav1(display_short)|uniprotkb:Zap(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:"MI:0096"(pull down) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942635|imex:IM-21353-6|dip:DIP-59333E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064543.3|ensembl:ENSG00000077348(gene)|ensembl:ENST00000221233(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0035327"|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045006"(DNA deamination)|go:"GO:0051607"(defense response to virus)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR036345|mint:Q9NQT4|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|dip:DIP-29846N rgd:628694|dip:DIP-29842N|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0042802"(identical protein binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|rcsb pdb:3U9G psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:xrrhCz6a15mgW/t9HRyvTtrjKMQ9606 rogid:1v/UHcQ3JSTi4YGD1l3f7258qGs10116 rigid:60TcjagzkuADG31/MJdCxRC+ukQ false glutathione s tranferase tag:n-n myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z2W4-2 uniprotkb:Q9NQT5 intact:EBI-922559|ensembl:ENSP00000419855 intact:EBI-371866|uniprotkb:Q5QP85|uniprotkb:Q9Y3A8|ensembl:ENSP00000323046|uniprotkb:A8K0K6 psi-mi:q7z2w4-2(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPS(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:exos3_human(display_long)|uniprotkb:EXOSC3(gene name)|psi-mi:EXOSC3(display_short)|uniprotkb:RRP40(gene name synonym)|uniprotkb:CGI-102(orf name)|uniprotkb:Ribosomal RNA-processing protein 40(gene name synonym)|uniprotkb:Exosome component 3(gene name synonym)|uniprotkb:p10(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942656|imex:IM-21353-7|dip:DIP-191522E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000471652(transcript)|uniprotkb:Q7Z2W4-2(isoform-parent) refseq:NP_001002269.1|refseq:NP_057126.2|ensembl:ENSG00000107371(gene)|ensembl:ENST00000327304(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0035327"|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045006"(DNA deamination)|go:"GO:0045190"(isotype switching)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0071034"(CUT catabolic process)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071049"|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR026699|interpro:IPR036612|interpro:IPR037319|mint:Q9NQT5|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|dip:DIP-29847N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:iYC6SVjVUbaBJ7RnzFluOsH9UAQ9606 rogid:ZyFFgoy7HM3oZ35I16XAH3jCook9606 rigid:RMM0k9fuuB/mksygfuCRfANNigM false myc tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z2W4 uniprotkb:Q9NPI6 intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942675|imex:IM-21353-8|dip:DIP-191530E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2018/09/18 rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rigid:BGPTu6zz7oj/sf6Ou1aKz9DXkk8 false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:G3V6K3 uniprotkb:Q7Z2W4 intact:EBI-15942738|ensembl:ENSRNOP00000069523 intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351 psi-mi:g3v6k3_rat(display_long)|uniprotkb:Exosc7(gene name)|psi-mi:Exosc7(display_short)|uniprotkb:rCG_26079(orf name) psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym) psi-mi:"MI:0096"(pull down) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942758|imex:IM-21353-11|dip:DIP-191524E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000060337(gene)|ensembl:ENSRNOT00000084725(transcript)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034473"(U1 snRNA 3'-end processing)|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0034476"(U5 snRNA 3'-end processing)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR036345|reactome:R-RNO-429958|reactome:R-RNO-450385|reactome:R-RNO-450513|reactome:R-RNO-450604|reactome:R-RNO-6791226|refseq:NP_001094195.1|rgd:1309758 refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N psi-mi:"MI:0465"(dip) crc64:2CE35F59311725FD - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:+7fwwLk7M4xSPDEQY/8Eoo7XCKQ10116 rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606 rigid:9JK4AH9CZFGJ/k9sWWULrXYBx6Y false glutathione s tranferase tag:n-n myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95453 uniprotkb:Q7Z2W4 intact:EBI-372832|uniprotkb:B2RCB3|ensembl:ENSP00000387911|ensembl:ENSP00000478668|intact:EBI-28988750|uniprotkb:B4DSB0|uniprotkb:B4DDG8|uniprotkb:B4DWR4|uniprotkb:B4E1H6 intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351 psi-mi:parn_human(display_long)|uniprotkb:PARN(gene name)|psi-mi:PARN(display_short)|uniprotkb:Polyadenylate-specific ribonuclease(gene name synonym)|uniprotkb:Deadenylating nuclease(gene name synonym)|uniprotkb:Deadenylation nuclease(gene name synonym)|uniprotkb:DAN(gene name synonym) psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942717|imex:IM-21353-10|dip:DIP-191526E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002573.1|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:0110008"(ncRNA deadenylation)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014789("Poly(A)-specific ribonuclease, RNA binding")|interpro:IPR034042|interpro:IPR035979|interpro:IPR036397|interpro:IPR036867|mint:O95453|rcsb pdb:2A1R|rcsb pdb:2A1S|rcsb pdb:3CTR|reactome:R-HSA-380994|reactome:R-HSA-429947|reactome:R-HSA-450604|ensembl:ENSG00000140694(gene)|ensembl:ENSG00000274829(gene)|ensembl:ENST00000437198(transcript)|ensembl:ENST00000615183(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007292"(female gamete generation)|go:"GO:0009451"(RNA modification)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043169"(cation binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|refseq:NP_001127949.1|refseq:NP_001229921.1|ensembl:ENST00000341484|ensembl:ENSP00000345456|ensembl:ENST00000420015|ensembl:ENSP00000410525|ensembl:ENSP00000387911|ensembl:ENST00000539279|ensembl:ENSP00000444381|ensembl:ENSP00000478668|ensembl:ENST00000618929|ensembl:ENSP00000484279|ensembl:ENST00000631868|ensembl:ENSP00000488554|ensembl:ENST00000634004|ensembl:ENSP00000487634|dip:DIP-31124N refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:V/6onCtb7dz2cK4pEHQwvHqEFuQ9606 rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606 rigid:WCW8IKlu5V7GdtWOSJJKukZ7o9E false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IU60 uniprotkb:Q92841 intact:EBI-521577|uniprotkb:Q6P2D4|uniprotkb:Q7Z5W5|uniprotkb:Q8NBG5|uniprotkb:C9J778|ensembl:ENSP00000373715 intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536 psi-mi:dcp2_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 20(gene name synonym)|uniprotkb:DCP2(gene name)|psi-mi:DCP2(display_short)|uniprotkb:NUDT20(gene name synonym)|uniprotkb:mRNA-decapping enzyme 2(gene name synonym) psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942696|imex:IM-21353-9|dip:DIP-191528E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001229306.1|refseq:NP_689837.2|dip:DIP-31126N|ensembl:ENSG00000172795(gene)|ensembl:ENST00000389063(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0016896"(exoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030054"(cell junction)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR007722(Dcp2, box A)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR036189|interpro:IPR044099|rcsb pdb:5MP0|rcsb pdb:5QOH|rcsb pdb:5QOI|rcsb pdb:5QOJ|rcsb pdb:5QOK|rcsb pdb:5QOL|rcsb pdb:5QOM|rcsb pdb:5QON|rcsb pdb:5QOO|rcsb pdb:5QOP|rcsb pdb:5QOQ|rcsb pdb:5QOR|rcsb pdb:5QOS|rcsb pdb:5QOT|rcsb pdb:5QOU|rcsb pdb:5QOV|rcsb pdb:5QOW|rcsb pdb:5QOX|rcsb pdb:5QOY|rcsb pdb:5QOZ|rcsb pdb:5QP0|rcsb pdb:5QP1|rcsb pdb:5QP2|rcsb pdb:5QP3|rcsb pdb:5QP4|rcsb pdb:5QP5|rcsb pdb:5QP6|rcsb pdb:5QP7|rcsb pdb:5QP8|rcsb pdb:5QP9|rcsb pdb:5QPA|rcsb pdb:5QPB|rcsb pdb:5QPC|reactome:R-HSA-380994|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604 refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2018/09/18 rogid:3Bo/mLVHBcFZ4VmRqgvE2PWTw+Y9606 rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606 rigid:2fjb8NDjDiGv7luYmJtJyExhXiU false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z2W4 uniprotkb:Q15024 intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351 intact:EBI-371841|uniprotkb:Q96E72|ensembl:ENSP00000265564 psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym) psi-mi:exos7_human(display_long)|uniprotkb:KIAA0116(gene name synonym)|uniprotkb:RRP42(gene name synonym)|uniprotkb:EXOSC7(gene name)|psi-mi:EXOSC7(display_short)|uniprotkb:Ribosomal RNA-processing protein 42(gene name synonym)|uniprotkb:Exosome component 7(gene name synonym)|uniprotkb:p8(gene name synonym) psi-mi:"MI:0096"(pull down) Zhu et al. (2011) pubmed:21876179|doi:10.1073/pnas.1101676108|imex:IM-21353 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15942779|imex:IM-21353-12|dip:DIP-191523E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N refseq:NP_055819.2|ensembl:ENSG00000075914(gene)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034473"(U1 snRNA 3'-end processing)|ensembl:ENST00000265564(transcript)|go:"GO:0034476"(U5 snRNA 3'-end processing)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR036345|mint:Q15024|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|go:"GO:0034475"(U4 snRNA 3'-end processing)|dip:DIP-31266N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606 rogid:gFGj7nvYM3a56Pu7vryrP+XfUxE9606 rigid:YrqM8knJfIQyWJeVkYebpSsaEUM false myc tag:n-n glutathione s tranferase tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)