#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P25694 uniprotkb:P54860 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938061|imex:IM-21361-1|dip:DIP-95555E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:877ACB59AC29634A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rigid:/4pL8X2HbTaQ24qbQGjOsCndNbg false - mutation disrupting interaction strength:274-274|mutation disrupting interaction strength:385-385 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-19797 intact:EBI-19797 dip:DIP-1549N|uniprotkb:P04838|uniprotkb:Q6LA96 dip:DIP-1549N|uniprotkb:P04838|uniprotkb:Q6LA96 psi-mi:ubiq_yeast(display_short)|psi-mi:EBI-19797(display_long)|uniprotkb:UBI1(gene name)|psi-mi:UBI1(display_short)|uniprotkb:RPL40A(gene name synonym)|uniprotkb:YIL148W(locus name)|uniprotkb:UBI2(gene name)|psi-mi:UBI2(display_short)|uniprotkb:RPL40B(gene name synonym)|uniprotkb:YKR094C(locus name)|uniprotkb:UBI3(gene name)|psi-mi:UBI3(display_short)|uniprotkb:RPS31(gene name synonym)|uniprotkb:YLR167W(locus name)|uniprotkb:L9470.14(orf name)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name) psi-mi:ubiq_yeast(display_short)|psi-mi:EBI-19797(display_long)|uniprotkb:UBI1(gene name)|psi-mi:UBI1(display_short)|uniprotkb:RPL40A(gene name synonym)|uniprotkb:YIL148W(locus name)|uniprotkb:UBI2(gene name)|psi-mi:UBI2(display_short)|uniprotkb:RPL40B(gene name synonym)|uniprotkb:YKR094C(locus name)|uniprotkb:UBI3(gene name)|psi-mi:UBI3(display_short)|uniprotkb:RPS31(gene name synonym)|uniprotkb:YLR167W(locus name)|uniprotkb:L9470.14(orf name)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938084|imex:IM-21361-2|dip:DIP-191545E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001410(RPL40A)|sgd:S000001802(RPL40B)|sgd:S000004157(RPS31)|sgd:S000003962(UBI4)|uniprotkb:P61864(see-also)|refseq:NP_012118.1|refseq:NP_013020.1|refseq:NP_013061.1|refseq:NP_013268.1|ensembl:YIL148W|ensembl:YKR094C|ensembl:YLR167W|go:"GO:0005515"(protein binding)|interpro:IPR000626(Ubiquitin)|cygd:YLR167w|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0005739"(mitochondrion)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0006412"(translation)|ensembl:YLL039C|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|cygd:YIL148w|cygd:YKR094c|cygd:YLL039c|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:3CMM|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3MHS|rcsb pdb:2KDI sgd:S000001410(RPL40A)|sgd:S000001802(RPL40B)|sgd:S000004157(RPS31)|sgd:S000003962(UBI4)|uniprotkb:P61864(see-also)|refseq:NP_012118.1|refseq:NP_013020.1|refseq:NP_013061.1|refseq:NP_013268.1|ensembl:YIL148W|ensembl:YKR094C|ensembl:YLR167W|go:"GO:0005515"(protein binding)|interpro:IPR000626(Ubiquitin)|cygd:YLR167w|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0005739"(mitochondrion)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0006412"(translation)|ensembl:YLL039C|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|cygd:YIL148w|cygd:YKR094c|cygd:YLL039c|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:3CMM|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3MHS|rcsb pdb:2KDI psi-mi:"MI:0465"(dip) no-uniprot-update:obsolete protein no-uniprot-update:obsolete protein full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/15 rogid:sUFDb7kGedoC/k80bI4sjOaMLHs4932 rogid:sUFDb7kGedoC/k80bI4sjOaMLHs4932 rigid:XFcAZ2ETg9dDXEl+t1RxGQ4nR2s false ha tag:0-0 fusion protein:0-0 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P32628 uniprotkb:P54860 intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938145|imex:IM-21361-5|dip:DIP-13997E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 psi-mi:"MI:0465"(dip) crc64:B3F0436DAB60B833 crc64:877ACB59AC29634A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rigid:Q6LvJOSm9hsZcypwKZuQm7tF5aM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P53044 uniprotkb:P25694 intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name) psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:"MI:0676"(tandem affinity purification) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938126|imex:IM-21361-4|dip:DIP-11327E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044 refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 psi-mi:"MI:0465"(dip) crc64:198E0CD48B863B98 crc64:02ADDB9A227614D8 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rigid:j+dNoizH2ofz0UoM6OTHBCHte/g false - tandem tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P54860 uniprotkb:P32628 intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938105|imex:IM-21361-3|dip:DIP-13997E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 psi-mi:"MI:0465"(dip) crc64:877ACB59AC29634A crc64:B3F0436DAB60B833 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:Q6LvJOSm9hsZcypwKZuQm7tF5aM false myc tag:c-c flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P32628 uniprotkb:P54860 intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15938269|imex:IM-21361-11|dip:DIP-13997E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 psi-mi:"MI:0465"(dip) crc64:B3F0436DAB60B833 crc64:877ACB59AC29634A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rigid:Q6LvJOSm9hsZcypwKZuQm7tF5aM false flag tag:c-c myc tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25694 uniprotkb:P54860 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938290|imex:IM-21361-12|dip:DIP-95555E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:877ACB59AC29634A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rigid:/4pL8X2HbTaQ24qbQGjOsCndNbg false his tag:n-n mutation disrupting interaction strength:274-274|mutation disrupting interaction strength:385-385|myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P25694 uniprotkb:P32628 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938248|imex:IM-21361-10|dip:DIP-191546E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:B3F0436DAB60B833 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:R55bYtsGi1r/b/5NOTVEl65Qqck false his tag:n-n flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P32628 uniprotkb:P54860 intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938227|imex:IM-21361-9|dip:DIP-13997E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 psi-mi:"MI:0465"(dip) crc64:B3F0436DAB60B833 crc64:877ACB59AC29634A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rigid:Q6LvJOSm9hsZcypwKZuQm7tF5aM false flag tag:c-c myc tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25694 uniprotkb:P54860 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15938200|imex:IM-21361-8|dip:DIP-95555E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:877ACB59AC29634A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rigid:/4pL8X2HbTaQ24qbQGjOsCndNbg false his tag:n-n mutation disrupting interaction strength:274-274|mutation disrupting interaction strength:385-385|myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P53044 uniprotkb:P25694 intact:EBI-19997|uniprotkb:D6VUI5|uniprotkb:Q45U36|ensemblfungi:YGR048W intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 psi-mi:ufd1_yeast(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:Polymerase-interacting protein 3(gene name synonym)|uniprotkb:YGR048W(locus name) psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:"MI:0096"(pull down) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938181|imex:IM-21361-7|dip:DIP-11327E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011562.1|sgd:S000003280|go:"GO:0006274"(DNA replication termination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|rcsb pdb:1ZC1|rcsb pdb:6JWJ|reactome:R-SCE-110320|ensemblfungi:YGR048W(gene)|ensemblfungi:YGR048W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|dip:DIP-1476N|mint:P53044 refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 psi-mi:"MI:0465"(dip) crc64:198E0CD48B863B98 crc64:02ADDB9A227614D8 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:u/YG6aRuJ38NLsxGkUsfM9nXAnU559292 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rigid:j+dNoizH2ofz0UoM6OTHBCHte/g false - his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P33297 uniprotkb:P32628 intact:EBI-13920|uniprotkb:D6W2H6|ensemblfungi:YOR117W intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:prs6a_yeast(display_long)|uniprotkb:RPT5(gene name)|psi-mi:RPT5(display_short)|uniprotkb:YTA1(gene name synonym)|uniprotkb:YOR117W(locus name)|uniprotkb:O3258(orf name)|uniprotkb:YOR3258W(orf name)|uniprotkb:Tat-binding protein homolog 1(gene name synonym) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15938162|imex:IM-21361-6|dip:DIP-18257E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005643|rcsb pdb:3WHL|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MP9|rcsb pdb:5MPA|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6EF0|rcsb pdb:6EF1|rcsb pdb:6EF2|rcsb pdb:6EF3|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|rcsb pdb:3WHK|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|ensemblfungi:YOR117W(gene)|ensemblfungi:YOR117W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070682"(proteasome regulatory particle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|rcsb pdb:3JCO|rcsb pdb:3JCP|refseq:NP_014760.3|mint:P33297|dip:DIP-1590N sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 psi-mi:"MI:0465"(dip) crc64:C215422033FCE830 crc64:B3F0436DAB60B833 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:jsQE3SjBA0ZZcysuLgFe/5M6pOc559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:jPgUqwJh+hBYYBg3GhjFrI1V4uE false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25694 uniprotkb:P54860 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:"MI:0096"(pull down) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15938317|imex:IM-21361-13|dip:DIP-191547E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:877ACB59AC29634A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rigid:wWv0k7DOCMMqMayAtoYwsA+J0V8 false his tag:n-n myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P25694 uniprotkb:P32628 intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4 intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0096"(pull down) Baek et al. (2011) pubmed:21807993|doi:10.1073/pnas.1104051108|imex:IM-21361 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15938317|imex:IM-21361-13|dip:DIP-191547E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 psi-mi:"MI:0465"(dip) crc64:02ADDB9A227614D8 crc64:B3F0436DAB60B833 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:wWv0k7DOCMMqMayAtoYwsA+J0V8 false his tag:n-n flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)