#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-4399559 uniprotkb:P51810 dip:DIP-24261N intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7 psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Giordano et al. (2011) pubmed:21730137|doi:10.1073/pnas.1103381108|imex:IM-17687 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15934312|imex:IM-17687-1|dip:DIP-189030E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N psi-mi:"MI:0465"(dip) no-uniprot-update: - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rogid:5MujRgqKPE16sLr4bggbtISx2Io9606 rigid:ABqpEhXNNAW3ZqshaY6/asQGw7Q false ha tag:0-0 mutation disrupting interaction strength:355-355,325-325,248-248,243-243,225-225,215-215,391-391|flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99LI8 uniprotkb:P51810 intact:EBI-2119135|uniprotkb:Q61691|uniprotkb:Q8BQW3|ensembl:ENSMUSP00000101811 intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7 psi-mi:hgs_mouse(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym) psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Giordano et al. (2011) pubmed:21730137|doi:10.1073/pnas.1103381108|imex:IM-17687 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15934342|imex:IM-17687-2|dip:DIP-189031E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001152800.1|refseq:NP_032270.3|dip:DIP-29102N|ensembl:ENSMUSG00000025793(gene)|ensembl:ENSMUST00000106205(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|reactome:R-MMU-182971|reactome:R-MMU-432720|reactome:R-MMU-5689880|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013420|reactome:R-MMU-917729|reactome:R-MMU-9706019 go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:FS8KSHYryqJPQyo6wRWGNz86/kw10090 rogid:5MujRgqKPE16sLr4bggbtISx2Io9606 rigid:knocOVU4wTfDqto9rEALmXLyW0A false myc tag:c-c flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)