#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P59215	uniprotkb:Q08116	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-716918|uniprotkb:Q07918|uniprotkb:Q9H1W2|uniprotkb:B2RDM9|uniprotkb:B4DZY0|ensembl:ENSP00000356429	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs1_human(display_long)|uniprotkb:Early response protein 1R20(gene name synonym)|uniprotkb:B-cell activation protein BL34(gene name synonym)|uniprotkb:RGS1(gene name)|psi-mi:RGS1(display_short)|uniprotkb:1R20(gene name synonym)|uniprotkb:BL34(gene name synonym)|uniprotkb:IER1(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15932995|imex:IM-16113-1|dip:DIP-187019E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	refseq:NP_002913.3|ensembl:ENSG00000090104(gene)|ensembl:ENST00000367459(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0061737"(leukotriene signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR030409|interpro:IPR036305|rcsb pdb:2BV1|rcsb pdb:2GTP|reactome:R-HSA-416476|reactome:R-HSA-418594|dip:DIP-59091N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:2NRxpj0QO1Empw4FjC8qQAepe9M9606	rigid:2PxL5laClqcMjR8D8N8Gqp0PGqU	false	-	binding-associated region:85-200	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:P49802	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-1754797|uniprotkb:Q8TD66|uniprotkb:Q8TD67|uniprotkb:Q9UNU7|uniprotkb:Q9Y6B9|uniprotkb:Q5T3H4|uniprotkb:Q8WW09|ensembl:ENSP00000404399	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs7_human(display_long)|uniprotkb:RGS7(gene name)|psi-mi:RGS7(display_short)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933014|imex:IM-16113-2|dip:DIP-187021E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	refseq:NP_001269702.1|refseq:NP_001269704.1|refseq:NP_001269707.1|refseq:NP_002915.3|refseq:XP_005273275.1|dip:DIP-40869N|interpro:IPR036390|interpro:IPR040759|mint:P49802|rcsb pdb:2A72|rcsb pdb:2D9J|reactome:R-HSA-418594|reactome:R-HSA-6814122|interpro:IPR036388|go:"GO:0043547"(positive regulation of GTPase activity)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036284|ensembl:ENSG00000182901(gene)|ensembl:ENST00000440928(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR036305	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:epeNPVu00d27S9hlaKto1/bKwhI9606	rigid:ZGlfOc6zk5uqwQMKi/qxAwziWiw	false	-	binding-associated region:333-448	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:O43665	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-1057034|uniprotkb:Q6IAZ6|uniprotkb:Q96GN0|uniprotkb:A8K408|uniprotkb:B1AMR8|ensembl:ENSP00000358099	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs10_human(display_long)|uniprotkb:RGS10(gene name)|psi-mi:RGS10(display_short)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933033|imex:IM-16113-3|dip:DIP-187023E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	refseq:NP_001005339.1|refseq:NP_002916.1|ensembl:ENSG00000148908(gene)|ensembl:ENST00000369103(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036305|interpro:IPR037879|rcsb pdb:2DLR|rcsb pdb:2I59|rcsb pdb:2IHB|reactome:R-HSA-418594|interpro:IPR024066|dip:DIP-50368N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2019/04/15	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:uQdjEd/bgehHbP/LPYeW+Mfpt5A9606	rigid:ku9La8LkV+lfZp1/QcAV9+/FRkE	false	-	binding-associated region:41-156	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:Q9NS28	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-15933052|ensembl:ENSP00000356430|uniprotkb:B2RD23	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs18_human(display_long)|uniprotkb:RGS18(gene name)|psi-mi:RGS18(display_short)|uniprotkb:RGS13(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933078|imex:IM-16113-4|dip:DIP-187027E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	ensembl:ENSG00000150681(gene)|ensembl:ENST00000367460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034950|interpro:IPR036305|rcsb pdb:2DLV|rcsb pdb:2JM5|rcsb pdb:2OWI|reactome:R-HSA-416476|reactome:R-HSA-418594|refseq:NP_570138.1|dip:DIP-59096N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:3sIzXdM7J6zA4EXJqOieZMEYYGA9606	rigid:8UVbP0Gi1AT3Nvk57rj9/xw1rFQ	false	-	binding-associated region:86-202|mutation increasing interaction:186-186,158-158,156-156,141-141|mutation increasing interaction:186-186|mutation increasing interaction:158-158,156-156,141-141|mutation increasing interaction:158-158,156-156	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:P49798	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-9688865|uniprotkb:A7XA56|uniprotkb:A7XA58|uniprotkb:A7XA59|uniprotkb:A7YVV7|uniprotkb:B1APZ3|ensembl:ENSP00000356885	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs4_human(display_long)|uniprotkb:RGS4(gene name)|psi-mi:RGS4(display_short)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933115|imex:IM-16113-5|dip:DIP-187020E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	dip:DIP-59092N|refseq:NP_001095915.1|refseq:NP_001106851.1|refseq:NP_001106852.1|refseq:NP_005604.1|ensembl:ENSG00000117152(gene)|ensembl:ENST00000367909(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1900924"(negative regulation of glycine import across plasma membrane)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034952|interpro:IPR034953|interpro:IPR036305|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-418597	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:txTUJ5lIHkBDZ4palUD4jGSZAA89606	rigid:0IRFvYg6FQ1D2a/RADd9kGaoNgk	false	-	binding-associated region:62-178|mutation disrupting interaction:128-128|mutation disrupting interaction:166-166,134-134,126-126|mutation decreasing interaction:134-134|mutation decreasing interaction:166-166,134-134	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:Q9UGC6	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-3918154|uniprotkb:Q9UJS8|uniprotkb:Q5TF49|uniprotkb:Q8TD61|ensembl:ENSP00000206262|ensembl:ENSP00000356194	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs17_human(display_long)|uniprotkb:RGS17(gene name)|psi-mi:RGS17(display_short)|uniprotkb:RGSZ2(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933149|imex:IM-16113-6|dip:DIP-187026E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	refseq:NP_036551.3|ensembl:ENSG00000091844(gene)|ensembl:ENST00000206262(transcript)|ensembl:ENST00000367225(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036305|rcsb pdb:1ZV4|rcsb pdb:6AM3|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-418597|dip:DIP-59095N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:RPGO5Be/i36A1eH1BQSw/4Kqk6Q9606	rigid:RRdoeY4DTJs0X2nLFXp738N9wH8	false	-	binding-associated region:84-200|mutation increasing interaction:192-192,184-184,183-183,150-150,145-145,144-144,143-143|mutation increasing interaction:192-192,150-150,145-145,144-144,143-143	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:O43566	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-750603|uniprotkb:O43565|uniprotkb:Q506M1|uniprotkb:Q6ZWA4|uniprotkb:Q8TD62|ensembl:ENSP00000386229	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs14_human(display_long)|uniprotkb:RGS14(gene name)|psi-mi:RGS14(display_short)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933184|imex:IM-16113-7|dip:DIP-187024E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	refseq:NP_006471.2|dip:DIP-41167N|ensembl:ENSG00000169220(gene)|ensembl:ENST00000408923(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0010070"(zygote asymmetric cell division)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR030776|interpro:IPR036305|interpro:IPR037881|rcsb pdb:2JNU|rcsb pdb:2OM2|rcsb pdb:2XNS|rcsb pdb:3ONW|rcsb pdb:3QI2|reactome:R-HSA-418594|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:KEcGh5F6Ml7JlltMf4YWgSBStTI9606	rigid:XWEDOm1F9bB7/XYT8y0IgbKlsuI	false	-	binding-associated region:67-184	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:P57771	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-10216117|uniprotkb:Q3SYD2|uniprotkb:B4DGL9|ensembl:ENSP00000356527|ensembl:ENSP00000356528|ensembl:ENSP00000426289	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs8_human(display_long)|uniprotkb:RGS8(gene name)|psi-mi:RGS8(display_short)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933238|imex:IM-16113-9|dip:DIP-187022E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	refseq:NP_001095920.1|refseq:NP_203131.1|refseq:XP_005245612.1|refseq:XP_011508391.1|refseq:XP_011508392.1|rcsb pdb:5DO9|reactome:R-HSA-418594|ensembl:ENSG00000135824(gene)|ensembl:ENST00000367556(transcript)|ensembl:ENST00000367557(transcript)|ensembl:ENST00000483095(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034948|interpro:IPR034949|interpro:IPR036305|rcsb pdb:2IHD|rcsb pdb:2ODE|refseq:XP_016858120.1|refseq:XP_016858121.1|refseq:XP_016858122.1|refseq:XP_016858123.1|refseq:XP_016858124.1|refseq:XP_016858125.1|refseq:XP_016858126.1|dip:DIP-59093N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:fFIkq2ua98Eey5N09q0Dnq58EYM9606	rigid:Kc9HJtdVZkbURt4b7sGS6JdAMVw	false	-	binding-associated region:56-171	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:Q9NS28	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-15933052|ensembl:ENSP00000356430|uniprotkb:B2RD23	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs18_human(display_long)|uniprotkb:RGS18(gene name)|psi-mi:RGS18(display_short)|uniprotkb:RGS13(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933203|imex:IM-16113-8|dip:DIP-187027E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	ensembl:ENSG00000150681(gene)|ensembl:ENST00000367460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034950|interpro:IPR036305|rcsb pdb:2DLV|rcsb pdb:2JM5|rcsb pdb:2OWI|reactome:R-HSA-416476|reactome:R-HSA-418594|refseq:NP_570138.1|dip:DIP-59096N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:3sIzXdM7J6zA4EXJqOieZMEYYGA9606	rigid:8UVbP0Gi1AT3Nvk57rj9/xw1rFQ	false	-	mutation increasing interaction:186-186,158-158,156-156,141-141|mutation increasing interaction:186-186|mutation increasing interaction:158-158,156-156,141-141|mutation increasing interaction:158-158,156-156	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59215	uniprotkb:O15492	intact:EBI-8071125|intact:MINT-5028451|uniprotkb:P04900|intact:MINT-6380317|uniprotkb:P30033|ensembl:ENSRNOP00000026373	intact:EBI-3913042|uniprotkb:Q99701|uniprotkb:Q5VYN9|uniprotkb:B2R4M4|ensembl:ENSP00000356529	psi-mi:gnao_rat(display_long)|uniprotkb:Gnao1(gene name)|psi-mi:Gnao1(display_short)|uniprotkb:Gna0(gene name synonym)|uniprotkb:Gnao(gene name synonym)	psi-mi:rgs16_human(display_long)|uniprotkb:RGS16(gene name)|psi-mi:RGS16(display_short)|uniprotkb:RGSR(gene name synonym)|uniprotkb:A28-RGS14P(gene name synonym)|uniprotkb:Retinal-specific RGS(gene name synonym)|uniprotkb:Retinally abundant regulator of G-protein signaling(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Kosloff et al. (2011)	pubmed:21685921|doi:10.1038/nsmb.2068|imex:IM-16113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15933257|imex:IM-16113-10|dip:DIP-187025E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628732|refseq:NP_059023.1|dip:DIP-59090N|ensembl:ENSRNOG00000019482(gene)|ensembl:ENSRNOT00000026373(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009987"(cellular process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P59215|reactome:R-RNO-4086398|go:"GO:0010243"(response to organonitrogen compound)	refseq:NP_002919.3|ensembl:ENSG00000143333(gene)|ensembl:ENST00000367558(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR036305|rcsb pdb:2BT2|rcsb pdb:2IK8|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-418597|dip:DIP-59094N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LuKGAVyaFxWTp6ctQzokHhwyo3410116	rogid:0u+oUsmyJGo3qp+Ttj93nnElF9g9606	rigid:sO5vHKMX5r5luN/2FzqawpD4Zaw	false	-	binding-associated region:65-181|mutation decreasing interaction:90-90|mutation decreasing interaction:173-173,129-129,125-125|mutation decreasing interaction:129-129,125-125|mutation decreasing interaction:129-129	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)