#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P68036-1	uniprotkb:Q9Y4X5	intact:EBI-15556257|ensembl:ENSP00000344259	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	psi-mi:p68036-1(display_long)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:"MI:0096"(pull down)	Wenzel et al. (2011)	pubmed:21532592|doi:10.1038/nature09966|imex:IM-16209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15924216|imex:IM-16209-2|dip:DIP-187238E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|intact:EBI-711173(isoform-parent)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rigid:+bLmNdB5LKDddTIODpncrLKrVRA	false	t7 tag:n-n	sufficient binding region:177-316|mutation disrupting interaction:188-188|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05086-2	intact:EBI-4399559	intact:EBI-10175863|ensembl:ENSP00000401265|ensembl:ENSP00000411258|ensembl:ENSP00000457771|ensembl:ENSP00000486349|ensembl:ENSP00000490111|ensembl:ENSP00000490557|ensembl:ENSP00000497549	dip:DIP-24261N	psi-mi:q05086-2(display_long)|uniprotkb:E6AP(gene name synonym)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0808"(comigration in sds page)	Wenzel et al. (2011)	pubmed:21532592|doi:10.1038/nature09966|imex:IM-16209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15924197|imex:IM-16209-1|dip:DIP-187242E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114062(gene)|ensembl:ENST00000428984(transcript)|ensembl:ENST00000438097(transcript)|ensembl:ENST00000566215(transcript)|ensembl:ENST00000630424(transcript)|ensembl:ENST00000638011(transcript)|ensembl:ENST00000649550(transcript)|ensembl:ENST00000638155(transcript)|intact:EBI-954357(isoform-parent)|uniprotkb:Q05086-2(isoform-parent)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	isoform-comment:"Variant in position: 212:D->V (in AS, unknown pathological significance). Variant in position: 237:L->Q (in AS, unknown pathological significance). Variant in position: 263:L->W (in AS, unknown pathological significance). Variant in position: 458:P->L (in AS, unknown pathological significance). Variant in position: 545:G->R (in AS, unknown pathological significance). Variant in position: 584:E->Q (in AS, unknown pathological significance). Variant in position: 656:T->I (in AS, unknown pathological significance). Variant in position: 690:F->C (in AS, unknown pathological significance). Variant in position: 827:P->L (in AS, unknown pathological significance). Variant in position: 106:T->K (in AS, unknown pathological significance). Variant in position: 237:L->H (in AS, unknown pathological significance). Variant in position: 435:L->P (in AS, unknown pathological significance). Variant in position: 477:R->P (in AS, unknown pathological significance). Variant in position: 566:M->K (in AS, unknown pathological significance). Variant in position: 117:C->R (common polymorphism, may be associated with AS). Variant in position: 270:N->T (common polymorphism, may be associated with AS). Variant in position: 762:V->I (common polymorphism, may be associated with AS). Variant in position: 133:V->G (common polymorphism, may be associated with AS). Variant in position: 335:S->T (common polymorphism, may be associated with AS). Variant in position: 478:M->I (common polymorphism, may be associated with AS). Variant in position: 588:Q->E (common polymorphism, may be associated with AS). Variant in position: 588:Q->P (common polymorphism, may be associated with AS). Variant in position: 673:L->R (common polymorphism, may be associated with AS)."	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:HgylveTCwTfrwiB7WXj4Gmcc1EQ9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:dY58K53tMIhDZOX6/52SQQjvmaw	false	binding-associated region:495-852	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:Q9Y4X5	dip:DIP-24261N	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:"MI:0808"(comigration in sds page)	Wenzel et al. (2011)	pubmed:21532592|doi:10.1038/nature09966|imex:IM-16209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15924271|imex:IM-16209-4|dip:DIP-187239E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rigid:zud6i3KsZb4RgLBY/571twB8uJM	false	-	binding-associated region:177-393|mutation disrupting interaction:367-367|mutation disrupting interaction:372-372	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JK66-1	intact:EBI-4399559	intact:EBI-15924242	dip:DIP-24261N	psi-mi:q9jk66-1(display_long)|uniprotkb:Prkn(gene name)|psi-mi:Prkn(display_short)|uniprotkb:Park2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0808"(comigration in sds page)	Wenzel et al. (2011)	pubmed:21532592|doi:10.1038/nature09966|imex:IM-16209	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15924249|imex:IM-16209-3|dip:DIP-187240E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-973793(isoform-parent)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:vFVsO0hjWTYdKnc3eku16TjRFgU10116	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:lfzW01u7LWWaYZbOQnj6LaWeS/s	false	binding-associated region:217-465|mutation disrupting interaction:431-431	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:P68036-1	dip:DIP-24261N	intact:EBI-15556257|ensembl:ENSP00000344259	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:p68036-1(display_long)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Wenzel et al. (2011)	pubmed:21532592|doi:10.1038/nature09966|imex:IM-16209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15924296|imex:IM-16209-5|dip:DIP-187241E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|intact:EBI-711173(isoform-parent)	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	rigid:Bvq0VKx29Se0/1LuAJEeon7PKQU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)