#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q64729	uniprotkb:P05533	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	intact:EBI-11600492|uniprotkb:Q8BPD0|ensembl:ENSMUSP00000023248|ensembl:ENSMUSP00000140099|ensembl:ENSMUSP00000140287|ensembl:ENSMUSP00000140638|ensembl:ENSMUSP00000140998	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:ly6a_mouse(display_long)|uniprotkb:Ly6a(gene name)|psi-mi:Ly6a(display_short)|uniprotkb:Ly6(gene name synonym)|uniprotkb:Stem cell antigen 1(gene name synonym)|uniprotkb:T-cell-activating protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Upadhyay et al. (2011)	pubmed:21518866|doi:10.1073/pnas.1103441108|imex:IM-17547	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15923058|imex:IM-17547-1|dip:DIP-188868E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N	refseq:NP_001258345.1|refseq:NP_001258346.1|refseq:NP_001258347.1|refseq:NP_001258348.1|refseq:NP_001258375.1|refseq:NP_034868.1|ensembl:ENSMUSG00000075602(gene)|ensembl:ENSMUST00000023248(transcript)|ensembl:ENSMUST00000186526(transcript)|ensembl:ENSMUST00000187171(transcript)|ensembl:ENSMUST00000187994(transcript)|ensembl:ENSMUST00000189068(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR018363|dip:DIP-59628N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	rogid:yHUATpMaRpp791fKl7aAxDRVDBc10090	rigid:hUFE7oZ7WzaPdnZanamd+oqhtrQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62312	uniprotkb:Q64729	intact:EBI-2899332|ensembl:ENSMUSP00000062333|uniprotkb:Q63947	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	psi-mi:tgfr2_mouse(display_long)|uniprotkb:Tgfbr2(gene name)|psi-mi:Tgfbr2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Upadhyay et al. (2011)	pubmed:21518866|doi:10.1073/pnas.1103441108|imex:IM-17547	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15923075|imex:IM-17547-2|dip:DIP-90347E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|ensembl:ENSMUSG00000032440(gene)|ensembl:ENSMUST00000061101(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62312|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:0048185"(activin binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0046872"(metal ion binding)|refseq:NP_033397.3|dip:DIP-44605N	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:zO622M93E590ht8MhEJYcOigw2E10090	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	rigid:Z0DOdB0y7dDFpuNi5aORgZAB18k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q64729	uniprotkb:P05533	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	intact:EBI-11600492|uniprotkb:Q8BPD0|ensembl:ENSMUSP00000023248|ensembl:ENSMUSP00000140099|ensembl:ENSMUSP00000140287|ensembl:ENSMUSP00000140638|ensembl:ENSMUSP00000140998	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:ly6a_mouse(display_long)|uniprotkb:Ly6a(gene name)|psi-mi:Ly6a(display_short)|uniprotkb:Ly6(gene name synonym)|uniprotkb:Stem cell antigen 1(gene name synonym)|uniprotkb:T-cell-activating protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Upadhyay et al. (2011)	pubmed:21518866|doi:10.1073/pnas.1103441108|imex:IM-17547	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15923092|imex:IM-17547-3|dip:DIP-188868E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N	refseq:NP_001258345.1|refseq:NP_001258346.1|refseq:NP_001258347.1|refseq:NP_001258348.1|refseq:NP_001258375.1|refseq:NP_034868.1|ensembl:ENSMUSG00000075602(gene)|ensembl:ENSMUST00000023248(transcript)|ensembl:ENSMUST00000186526(transcript)|ensembl:ENSMUST00000187171(transcript)|ensembl:ENSMUST00000187994(transcript)|ensembl:ENSMUST00000189068(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR018363|dip:DIP-59628N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	rogid:yHUATpMaRpp791fKl7aAxDRVDBc10090	rigid:hUFE7oZ7WzaPdnZanamd+oqhtrQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)