#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P98156 uniprotkb:Q15768 intact:EBI-301063|uniprotkb:Q64022|ensembl:ENSMUSP00000127329 intact:EBI-3908475|uniprotkb:Q92875|uniprotkb:Q8TBH7|uniprotkb:D3DTQ6|uniprotkb:B2RBW2|uniprotkb:O00680|ensembl:ENSP00000226091 psi-mi:vldlr_mouse(display_long)|uniprotkb:Vldlr(gene name)|psi-mi:Vldlr(display_short) psi-mi:efnb3_human(display_long)|uniprotkb:EFNB3(gene name)|psi-mi:EFNB3(display_short)|uniprotkb:EPLG8(gene name synonym)|uniprotkb:LERK8(gene name synonym)|uniprotkb:EPH-related receptor transmembrane ligand ELK-L3(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 8(gene name synonym) psi-mi:"MI:0096"(pull down) Sentürk et al. (2011) pubmed:21460838|doi:10.1038/nature09874|imex:IM-16221 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15919370|imex:IM-16221-1|dip:DIP-187257E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024924(gene)|ensembl:ENSMUST00000167487(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006869"(lipid transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034436"(glycoprotein transport)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0045177"(apical part of cell)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR032931|interpro:IPR036055|mint:P98156|reactome:R-MMU-8866376|reactome:R-MMU-8866427|reactome:R-MMU-8964046|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_001154892.1|refseq:NP_038731.2|refseq:XP_006526980.1|refseq:XP_006526981.1|dip:DIP-33283N refseq:NP_001397.1|ensembl:ENSG00000108947(gene)|ensembl:ENST00000226091(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016198"(axon choice point recognition)|go:"GO:0031295"(T cell costimulation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:Q15768|rcsb pdb:4BKF|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-59196N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:47bXFZMsDTZIk3JFU6zdEh7Zio810090 rogid:SCKHF/6JfjSaED+FsgWMp2o4aDI9606 rigid:drYO9ecEXbXQv8y1EAxlaQqlhjk false - binding-associated region:28-224|fc-igg tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P97318 uniprotkb:Q15768 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 intact:EBI-3908475|uniprotkb:Q92875|uniprotkb:Q8TBH7|uniprotkb:D3DTQ6|uniprotkb:B2RBW2|uniprotkb:O00680|ensembl:ENSP00000226091 psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:efnb3_human(display_long)|uniprotkb:EFNB3(gene name)|psi-mi:EFNB3(display_short)|uniprotkb:EPLG8(gene name synonym)|uniprotkb:LERK8(gene name synonym)|uniprotkb:EPH-related receptor transmembrane ligand ELK-L3(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 8(gene name synonym) psi-mi:"MI:0096"(pull down) Sentürk et al. (2011) pubmed:21460838|doi:10.1038/nature09874|imex:IM-16221 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15919412|imex:IM-16221-3|dip:DIP-187259E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 refseq:NP_001397.1|ensembl:ENSG00000108947(gene)|ensembl:ENST00000226091(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016198"(axon choice point recognition)|go:"GO:0031295"(T cell costimulation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:Q15768|rcsb pdb:4BKF|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-59196N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 rogid:SCKHF/6JfjSaED+FsgWMp2o4aDI9606 rigid:LL5xI4oLB7BFbIid0Rm03JWpLuI false - binding-associated region:28-224|fc-igg tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q924X6 uniprotkb:Q15768 intact:EBI-432319|uniprotkb:Q8CAK9|uniprotkb:Q8CDF5|uniprotkb:Q921B6|ensembl:ENSMUSP00000115854|ensembl:ENSMUSP00000158644 intact:EBI-3908475|uniprotkb:Q92875|uniprotkb:Q8TBH7|uniprotkb:D3DTQ6|uniprotkb:B2RBW2|uniprotkb:O00680|ensembl:ENSP00000226091 psi-mi:lrp8_mouse(display_long)|uniprotkb:Apolipoprotein E receptor 2(gene name synonym)|uniprotkb:Lrp8(gene name)|psi-mi:Lrp8(display_short)|uniprotkb:Apoer2(gene name synonym) psi-mi:efnb3_human(display_long)|uniprotkb:EFNB3(gene name)|psi-mi:EFNB3(display_short)|uniprotkb:EPLG8(gene name synonym)|uniprotkb:LERK8(gene name synonym)|uniprotkb:EPH-related receptor transmembrane ligand ELK-L3(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 8(gene name synonym) psi-mi:"MI:0096"(pull down) Sentürk et al. (2011) pubmed:21460838|doi:10.1038/nature09874|imex:IM-16221 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15919433|imex:IM-16221-4|dip:DIP-187258E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR036055|reactome:R-MMU-432142|interpro:IPR001881(EGF-like calcium-binding)|reactome:R-MMU-975634|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|refseq:XP_011238759.1|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021541"(ammon gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030424"(axon)|ensembl:ENSMUSG00000028613(gene)|ensembl:ENSMUST00000143601(transcript)|ensembl:ENSMUST00000238569(transcript)|go:"GO:0001540"(amyloid-beta binding)|dip:DIP-33284N refseq:NP_001397.1|ensembl:ENSG00000108947(gene)|ensembl:ENST00000226091(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016198"(axon choice point recognition)|go:"GO:0031295"(T cell costimulation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:Q15768|rcsb pdb:4BKF|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-59196N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:FB2l87dbS4aA0V7vavDO3HsBKq810090 rogid:SCKHF/6JfjSaED+FsgWMp2o4aDI9606 rigid:h1YMeROdAu43m8/lSuyEbmxLca0 false - binding-associated region:28-224|fc-igg tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60841 uniprotkb:Q15768 intact:EBI-9248666|uniprotkb:E9PZ78|uniprotkb:Q9CUA6|ensembl:ENSMUSP00000124052 intact:EBI-3908475|uniprotkb:Q92875|uniprotkb:Q8TBH7|uniprotkb:D3DTQ6|uniprotkb:B2RBW2|uniprotkb:O00680|ensembl:ENSP00000226091 psi-mi:reln_mouse(display_long)|uniprotkb:Reln(gene name)|psi-mi:Reln(display_short)|uniprotkb:Rl(gene name synonym)|uniprotkb:Reeler protein(gene name synonym) psi-mi:efnb3_human(display_long)|uniprotkb:EFNB3(gene name)|psi-mi:EFNB3(display_short)|uniprotkb:EPLG8(gene name synonym)|uniprotkb:LERK8(gene name synonym)|uniprotkb:EPH-related receptor transmembrane ligand ELK-L3(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 8(gene name synonym) psi-mi:"MI:0096"(pull down) Sentürk et al. (2011) pubmed:21460838|doi:10.1038/nature09874|imex:IM-16221 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15919454|imex:IM-16221-5|dip:DIP-187256E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035391.2|refseq:NP_001297393.1|dip:DIP-40924N|ensembl:ENSMUSG00000042453(gene)|ensembl:ENSMUST00000161356(transcript)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008306"(associative learning)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021511"(spinal cord patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070325"(lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0097477"(lateral motor column neuron migration)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902078"(positive regulation of lateral motor column neuron migration)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002861(Reeler region)|interpro:IPR034968|interpro:IPR036278|interpro:IPR041161|interpro:IPR042307|rcsb pdb:2DDU|rcsb pdb:2E26|rcsb pdb:3A7Q|rcsb pdb:5B4X|rcsb pdb:6A48|reactome:R-MMU-8866376 refseq:NP_001397.1|ensembl:ENSG00000108947(gene)|ensembl:ENST00000226091(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016198"(axon choice point recognition)|go:"GO:0031295"(T cell costimulation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|mint:Q15768|rcsb pdb:4BKF|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-59196N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:oh9CRa5hVZ2xTcmgcDNSLYX8etU10090 rogid:SCKHF/6JfjSaED+FsgWMp2o4aDI9606 rigid:5Zsq4CRyG/sJfzs77XKKKwZCcVw false - binding-associated region:28-224|fc-igg tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60841 uniprotkb:P52800 intact:EBI-9248666|uniprotkb:E9PZ78|uniprotkb:Q9CUA6|ensembl:ENSMUSP00000124052 intact:EBI-1032676|ensembl:ENSMUSP00000001319 psi-mi:reln_mouse(display_long)|uniprotkb:Reln(gene name)|psi-mi:Reln(display_short)|uniprotkb:Rl(gene name synonym)|uniprotkb:Reeler protein(gene name synonym) psi-mi:efnb2_mouse(display_long)|uniprotkb:Elf2(gene name synonym)|uniprotkb:Epl5(gene name synonym)|uniprotkb:Eplg5(gene name synonym)|uniprotkb:Htkl(gene name synonym)|uniprotkb:Lerk5(gene name synonym)|uniprotkb:Efnb2(gene name)|psi-mi:Efnb2(display_short)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:ELF-2(gene name synonym)|uniprotkb:HTK ligand(gene name synonym) psi-mi:"MI:0096"(pull down) Sentürk et al. (2011) pubmed:21460838|doi:10.1038/nature09874|imex:IM-16221 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15919391|imex:IM-16221-2|dip:DIP-187255E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035391.2|refseq:NP_001297393.1|dip:DIP-40924N|ensembl:ENSMUSG00000042453(gene)|ensembl:ENSMUST00000161356(transcript)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008306"(associative learning)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021511"(spinal cord patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070325"(lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0097477"(lateral motor column neuron migration)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902078"(positive regulation of lateral motor column neuron migration)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002861(Reeler region)|interpro:IPR034968|interpro:IPR036278|interpro:IPR041161|interpro:IPR042307|rcsb pdb:2DDU|rcsb pdb:2E26|rcsb pdb:3A7Q|rcsb pdb:5B4X|rcsb pdb:6A48|reactome:R-MMU-8866376 refseq:NP_034241.2|ensembl:ENSMUSG00000001300(gene)|ensembl:ENSMUST00000001319(transcript)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52800|rcsb pdb:1IKO|rcsb pdb:1KGY|reactome:R-MMU-2682334|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|dip:DIP-29208N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:oh9CRa5hVZ2xTcmgcDNSLYX8etU10090 rogid:P051BaTxVceRTs9h3ugIgtq/EGo10090 rigid:3vRC22aYhvm8sszVtlhuJaAyKWw false - binding-associated region:29-229|fc-igg tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P97318 uniprotkb:P52800 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 intact:EBI-1032676|ensembl:ENSMUSP00000001319 psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:efnb2_mouse(display_long)|uniprotkb:Elf2(gene name synonym)|uniprotkb:Epl5(gene name synonym)|uniprotkb:Eplg5(gene name synonym)|uniprotkb:Htkl(gene name synonym)|uniprotkb:Lerk5(gene name synonym)|uniprotkb:Efnb2(gene name)|psi-mi:Efnb2(display_short)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:ELF-2(gene name synonym)|uniprotkb:HTK ligand(gene name synonym) psi-mi:"MI:0096"(pull down) Sentürk et al. (2011) pubmed:21460838|doi:10.1038/nature09874|imex:IM-16221 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15919475|imex:IM-16221-6|dip:DIP-187260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 refseq:NP_034241.2|ensembl:ENSMUSG00000001300(gene)|ensembl:ENSMUST00000001319(transcript)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52800|rcsb pdb:1IKO|rcsb pdb:1KGY|reactome:R-MMU-2682334|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|dip:DIP-29208N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 rogid:P051BaTxVceRTs9h3ugIgtq/EGo10090 rigid:VRoZ5ko95lFuTEjjqqdXj0C+IHI false - binding-associated region:29-229|fc-igg tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)