#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O14931 uniprotkb:O14931 intact:EBI-14989262|ensembl:ENSP00000416035|ensembl:ENSP00000416944|ensembl:ENSP00000342156|ensembl:ENSP00000372969|ensembl:ENSP00000389071|ensembl:ENSP00000390131|ensembl:ENSP00000398313|ensembl:ENSP00000405306|uniprotkb:B0S8F2|uniprotkb:B0S8F4|uniprotkb:B0S8F5|uniprotkb:O14930|uniprotkb:O14932|uniprotkb:O95667|uniprotkb:O95668|uniprotkb:O95669|uniprotkb:Q5ST89|uniprotkb:Q5ST90|uniprotkb:Q5ST91|uniprotkb:Q5ST92|uniprotkb:Q5STA3 intact:EBI-14989262|ensembl:ENSP00000416035|ensembl:ENSP00000416944|ensembl:ENSP00000342156|ensembl:ENSP00000372969|ensembl:ENSP00000389071|ensembl:ENSP00000390131|ensembl:ENSP00000398313|ensembl:ENSP00000405306|uniprotkb:B0S8F2|uniprotkb:B0S8F4|uniprotkb:B0S8F5|uniprotkb:O14930|uniprotkb:O14932|uniprotkb:O95667|uniprotkb:O95668|uniprotkb:O95669|uniprotkb:Q5ST89|uniprotkb:Q5ST90|uniprotkb:Q5ST91|uniprotkb:Q5ST92|uniprotkb:Q5STA3 psi-mi:nctr3_human(display_long)|uniprotkb:NCR3(gene name)|psi-mi:NCR3(display_short)|uniprotkb:1C7(gene name synonym)|uniprotkb:LY117(gene name synonym)|uniprotkb:Activating natural killer receptor p30(gene name synonym)|uniprotkb:Natural killer cell p30-related protein(gene name synonym) psi-mi:nctr3_human(display_long)|uniprotkb:NCR3(gene name)|psi-mi:NCR3(display_short)|uniprotkb:1C7(gene name synonym)|uniprotkb:LY117(gene name synonym)|uniprotkb:Activating natural killer receptor p30(gene name synonym)|uniprotkb:Natural killer cell p30-related protein(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Joyce et al. (2011) pubmed:21444796|doi:10.1073/pnas.1100622108|imex:IM-18104 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15917383|imex:IM-18104-1|dip:DIP-189864E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000204475(gene)|ensembl:ENSG00000206430(gene)|ensembl:ENSG00000223833(gene)|ensembl:ENSG00000225211(gene)|ensembl:ENSG00000236315(gene)|ensembl:ENST00000340027(transcript)|ensembl:ENST00000383477(transcript)|ensembl:ENST00000415123(transcript)|ensembl:ENST00000420556(transcript)|ensembl:ENST00000430599(transcript)|ensembl:ENST00000435674(transcript)|ensembl:ENST00000437517(transcript)|ensembl:ENST00000447248(transcript)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008037"(cell recognition)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|ensembl:ENSG00000236979(gene)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|ensembl:ENSG00000237103(gene)|ensembl:ENSG00000237808(gene)|interpro:IPR036179|interpro:IPR043226|rcsb pdb:3PV6|rcsb pdb:3NOI|rcsb pdb:6YJP|reactome:R-HSA-198933|refseq:NP_001138938.1|refseq:NP_001138939.1|refseq:NP_667341.1|refseq:XP_006715112.1|refseq:XP_011512761.1|dip:DIP-59939N ensembl:ENSG00000204475(gene)|ensembl:ENSG00000206430(gene)|ensembl:ENSG00000223833(gene)|ensembl:ENSG00000225211(gene)|ensembl:ENSG00000236315(gene)|ensembl:ENST00000340027(transcript)|ensembl:ENST00000383477(transcript)|ensembl:ENST00000415123(transcript)|ensembl:ENST00000420556(transcript)|ensembl:ENST00000430599(transcript)|ensembl:ENST00000435674(transcript)|ensembl:ENST00000437517(transcript)|ensembl:ENST00000447248(transcript)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008037"(cell recognition)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|ensembl:ENSG00000236979(gene)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|ensembl:ENSG00000237103(gene)|ensembl:ENSG00000237808(gene)|interpro:IPR036179|interpro:IPR043226|rcsb pdb:3PV6|rcsb pdb:3NOI|rcsb pdb:6YJP|reactome:R-HSA-198933|refseq:NP_001138938.1|refseq:NP_001138939.1|refseq:NP_667341.1|refseq:XP_006715112.1|refseq:XP_011512761.1|dip:DIP-59939N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:bS3R8rfddez5+tROQijf3FtslOU9606 rogid:bS3R8rfddez5+tROQijf3FtslOU9606 rigid:HwAl5ms/VoaSCXM5l+0OCkZ9N9Y false sufficient binding region:18-130 sufficient binding region:18-130 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q68D85 uniprotkb:O14931 intact:EBI-14061804|uniprotkb:Q7Z3M6|ensembl:ENSP00000341637|ensembl:ENSP00000434394 intact:EBI-14989262|ensembl:ENSP00000416035|ensembl:ENSP00000416944|ensembl:ENSP00000342156|ensembl:ENSP00000372969|ensembl:ENSP00000389071|ensembl:ENSP00000390131|ensembl:ENSP00000398313|ensembl:ENSP00000405306|uniprotkb:B0S8F2|uniprotkb:B0S8F4|uniprotkb:B0S8F5|uniprotkb:O14930|uniprotkb:O14932|uniprotkb:O95667|uniprotkb:O95668|uniprotkb:O95669|uniprotkb:Q5ST89|uniprotkb:Q5ST90|uniprotkb:Q5ST91|uniprotkb:Q5ST92|uniprotkb:Q5STA3 psi-mi:nr3l1_human(display_long)|uniprotkb:NCR3LG1(gene name)|psi-mi:NCR3LG1(display_short)|uniprotkb:B7 homolog 6(gene name synonym)|uniprotkb:B7H6(gene name synonym) psi-mi:nctr3_human(display_long)|uniprotkb:NCR3(gene name)|psi-mi:NCR3(display_short)|uniprotkb:1C7(gene name synonym)|uniprotkb:LY117(gene name synonym)|uniprotkb:Activating natural killer receptor p30(gene name synonym)|uniprotkb:Natural killer cell p30-related protein(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Joyce et al. (2011) pubmed:21444796|doi:10.1073/pnas.1100622108|imex:IM-18104 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15917401|imex:IM-18104-2|dip:DIP-189865E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001189368.1|ensembl:ENSG00000188211(gene)|ensembl:ENST00000338965(transcript)|ensembl:ENST00000530403(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR036946|rcsb pdb:3PV6|rcsb pdb:3PV7|rcsb pdb:4ZSO|rcsb pdb:6YJP|reactome:R-HSA-198933|dip:DIP-59940N ensembl:ENSG00000204475(gene)|ensembl:ENSG00000206430(gene)|ensembl:ENSG00000223833(gene)|ensembl:ENSG00000225211(gene)|ensembl:ENSG00000236315(gene)|ensembl:ENST00000340027(transcript)|ensembl:ENST00000383477(transcript)|ensembl:ENST00000415123(transcript)|ensembl:ENST00000420556(transcript)|ensembl:ENST00000430599(transcript)|ensembl:ENST00000435674(transcript)|ensembl:ENST00000437517(transcript)|ensembl:ENST00000447248(transcript)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008037"(cell recognition)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|ensembl:ENSG00000236979(gene)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|ensembl:ENSG00000237103(gene)|ensembl:ENSG00000237808(gene)|interpro:IPR036179|interpro:IPR043226|rcsb pdb:3PV6|rcsb pdb:3NOI|rcsb pdb:6YJP|reactome:R-HSA-198933|refseq:NP_001138938.1|refseq:NP_001138939.1|refseq:NP_667341.1|refseq:XP_006715112.1|refseq:XP_011512761.1|dip:DIP-59939N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:zxyF+bJz/qWtsilosYWPqwnDUw89606 rogid:bS3R8rfddez5+tROQijf3FtslOU9606 rigid:RGs60g1CS7VjnF4PJeDm9zXbysI false sufficient binding region:31-144 sufficient binding region:18-130|mutation decreasing interaction strength:52-52,50-50|mutation decreasing interaction strength:67-67,65-65|mutation decreasing interaction strength:113-113,111-111,109-109|mutation decreasing interaction strength:113-113,111-111,109-109 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)