#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29678	uniprotkb:Q6VAB6-1	intact:EBI-1631983	intact:EBI-15916808|ensembl:ENSP00000339952	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:q6vab6-1(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916857|imex:IM-16220-3|dip:DIP-187253E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|intact:EBI-6424389(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606	rigid:rGKSvgHc0Elk3gFAz/O5sAeKyRA	false	O-phospho-L-serine:72-72,24-24	binding-associated region:634-950	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29678	uniprotkb:Q6VAB6-1	intact:EBI-1631983	intact:EBI-15916808|ensembl:ENSP00000339952	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:q6vab6-1(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916834|imex:IM-16220-2|dip:DIP-187253E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|intact:EBI-6424389(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/07	2017/08/10	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606	rigid:rGKSvgHc0Elk3gFAz/O5sAeKyRA	false	-	binding-associated region:634-950|mutation disrupting interaction:879-879	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P29678	uniprotkb:Q6VAB6-1	intact:EBI-1631983	intact:EBI-15916808|ensembl:ENSP00000339952	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:q6vab6-1(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short)	psi-mi:"MI:0067"(light scattering)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916815|imex:IM-16220-1|dip:DIP-187253E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|intact:EBI-6424389(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/07	2017/08/10	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606	rigid:rGKSvgHc0Elk3gFAz/O5sAeKyRA	false	-	binding-associated region:634-950	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15056	uniprotkb:P29678	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	intact:EBI-1631983	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916879|imex:IM-16220-4|dip:DIP-187254E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rigid:wvhujCrIINMtf2PNRV8tlDvUELg	false	binding-associated region:432-725	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29678	uniprotkb:Q6VAB6-1	intact:EBI-1631983	intact:EBI-15916808|ensembl:ENSP00000339952	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:q6vab6-1(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916938|imex:IM-16220-7|dip:DIP-187253E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|intact:EBI-6424389(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606	rigid:rGKSvgHc0Elk3gFAz/O5sAeKyRA	false	O-phospho-L-serine:18-18|O-phospho-L-threonine:23-23|mutation:72-72,24-24	binding-associated region:634-950	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29678	uniprotkb:Q6VAB6-1	intact:EBI-1631983	intact:EBI-15916808|ensembl:ENSP00000339952	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:q6vab6-1(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916918|imex:IM-16220-6|dip:DIP-187253E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|intact:EBI-6424389(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606	rigid:rGKSvgHc0Elk3gFAz/O5sAeKyRA	false	-	binding-associated region:634-950	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P29678	uniprotkb:Q6VAB6-1	intact:EBI-1631983	intact:EBI-15916808|ensembl:ENSP00000339952	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:q6vab6-1(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916899|imex:IM-16220-5|dip:DIP-187253E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|intact:EBI-6424389(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/07	2017/08/10	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606	rigid:rGKSvgHc0Elk3gFAz/O5sAeKyRA	false	-	binding-associated region:634-950	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15056	uniprotkb:P29678	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	intact:EBI-1631983	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:mp2k1_rabit(display_long)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Brennan et al. (2011)	pubmed:21441910|doi:10.1038/nature09860|imex:IM-16220	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15916965|imex:IM-16220-8|dip:DIP-187254E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	refseq:NP_001076098.1|dip:DIP-40535N|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|rcsb pdb:7JUW|rcsb pdb:7JUX|rcsb pdb:7JUY|rcsb pdb:7JUZ|rcsb pdb:7JV0|rcsb pdb:7JV1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	rogid:iWhuovLEQN1LC0GdvJhs5VbZ8Dw9986	rigid:wvhujCrIINMtf2PNRV8tlDvUELg	false	binding-associated region:432-725	O-phospho-L-serine:222-222,218-218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)