#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P04775 uniprotkb:P07463 intact:EBI-2619448 intact:EBI-15916571|ensemblprotists:CAK80966|uniprotkb:A0DD49 psi-mi:scn2a_rat(display_long)|uniprotkb:Scn2a(gene name)|psi-mi:Scn2a(display_short)|uniprotkb:Scn2a1(gene name synonym)|uniprotkb:Sodium channel protein type II subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.2(gene name synonym)|uniprotkb:Sodium channel protein brain II subunit alpha(gene name synonym) psi-mi:calm_parte(display_long)|uniprotkb:CAM(gene name)|psi-mi:CAM(display_short)|uniprotkb:GSPATT00015825001(orf name) psi-mi:"MI:0077"(nuclear magnetic resonance) Feldkamp et al. (2011) pubmed:21439835|doi:10.1016/j.str.2011.02.009|imex:IM-16154 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:5888(parte)|taxid:5888(Paramecium tetraurelia) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15916593|imex:IM-16154-1|dip:DIP-187144E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3632|refseq:NP_036779.1|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007399"(nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0043194"(axon initial segment)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR010526(Sodium ion transport-associated)|go:"GO:0019228"(neuronal action potential)|interpro:IPR024583|interpro:IPR027359|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034706"(sodium channel complex)|interpro:IPR043203|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042552"(myelination)|interpro:IPR044564|go:"GO:0043005"(neuron projection)|rcsb pdb:1BYY|rcsb pdb:2KXW|rcsb pdb:2M5E|dip:DIP-57088N|reactome:R-RNO-5576892 ensemblprotists:CAK80966(transcript)|ensemblprotists:GSPATT00015825001(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039030|rcsb pdb:1CLM|rcsb pdb:1EXR|rcsb pdb:1N0Y|rcsb pdb:1OSA|rcsb pdb:2KXW|rcsb pdb:2M5E|rcsb pdb:5E1K|rcsb pdb:5E1N|rcsb pdb:5E1P|refseq:XP_001448363.1|dip:DIP-59128N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:LVrZUn6h33H0hSvyff5Fr6mDwxI10116 rogid:VeXnKsnV1mIqwg8fOMpvhP4klgM5888 rigid:MTLY+EbqRa6SkTx/7cEKeB1OkWc false binding-associated region:1901-1927 sufficient binding region:77-149 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04775 uniprotkb:P07463 intact:EBI-2619448 intact:EBI-15916571|ensemblprotists:CAK80966|uniprotkb:A0DD49 psi-mi:scn2a_rat(display_long)|uniprotkb:Scn2a(gene name)|psi-mi:Scn2a(display_short)|uniprotkb:Scn2a1(gene name synonym)|uniprotkb:Sodium channel protein type II subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.2(gene name synonym)|uniprotkb:Sodium channel protein brain II subunit alpha(gene name synonym) psi-mi:calm_parte(display_long)|uniprotkb:CAM(gene name)|psi-mi:CAM(display_short)|uniprotkb:GSPATT00015825001(orf name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Feldkamp et al. (2011) pubmed:21439835|doi:10.1016/j.str.2011.02.009|imex:IM-16154 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:5888(parte)|taxid:5888(Paramecium tetraurelia) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15916614|imex:IM-16154-2|dip:DIP-187144E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3632|refseq:NP_036779.1|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007399"(nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0043194"(axon initial segment)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR010526(Sodium ion transport-associated)|go:"GO:0019228"(neuronal action potential)|interpro:IPR024583|interpro:IPR027359|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034706"(sodium channel complex)|interpro:IPR043203|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042552"(myelination)|interpro:IPR044564|go:"GO:0043005"(neuron projection)|rcsb pdb:1BYY|rcsb pdb:2KXW|rcsb pdb:2M5E|dip:DIP-57088N|reactome:R-RNO-5576892 ensemblprotists:CAK80966(transcript)|ensemblprotists:GSPATT00015825001(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039030|rcsb pdb:1CLM|rcsb pdb:1EXR|rcsb pdb:1N0Y|rcsb pdb:1OSA|rcsb pdb:2KXW|rcsb pdb:2M5E|rcsb pdb:5E1K|rcsb pdb:5E1N|rcsb pdb:5E1P|refseq:XP_001448363.1|dip:DIP-59128N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:LVrZUn6h33H0hSvyff5Fr6mDwxI10116 rogid:VeXnKsnV1mIqwg8fOMpvhP4klgM5888 rigid:MTLY+EbqRa6SkTx/7cEKeB1OkWc false binding-associated region:1901-1927|fluorescein label:n-n sufficient binding region:77-149 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)