#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0071"(molecular sieving) Wang et al. (2011) pubmed:21368759|doi:10.1038/nature09780|imex:IM-16228 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15913843|imex:IM-16228-1|dip:DIP-74072E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI psi-mi:"MI:0465"(dip) crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK crc64:F6E377D8EA241B7D full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false sufficient binding region:1-150|sufficient binding region:150-485 binding-associated region:121-218|mutation disrupting interaction:184-184 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0114"(x-ray crystallography) Wang et al. (2011) pubmed:21368759|doi:10.1038/nature09780|imex:IM-16228 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15913870|imex:IM-16228-2|dip:DIP-74072E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI psi-mi:"MI:0465"(dip) crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK crc64:F6E377D8EA241B7D full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false - binding-associated region:108-218 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0114"(x-ray crystallography) Wang et al. (2011) pubmed:21368759|doi:10.1038/nature09780|imex:IM-16228 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15913891|imex:IM-16228-3|dip:DIP-74072E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI psi-mi:"MI:0465"(dip) crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK crc64:F6E377D8EA241B7D full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false sufficient binding region:1-150 binding-associated region:121-218 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)