#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BT43 uniprotkb:Q9BUI4 intact:EBI-2855862|uniprotkb:B1MVG5|ensembl:ENSP00000358320 intact:EBI-5452779|uniprotkb:O15317|uniprotkb:Q9Y3R6|ensembl:ENSP00000334564 psi-mi:rpc7l_human(display_long)|uniprotkb:POLR3GL(gene name)|psi-mi:POLR3GL(display_short)|uniprotkb:RNA polymerase III 32 kDa beta subunit(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III subunit G-like(gene name synonym) psi-mi:rpc3_human(display_long)|uniprotkb:POLR3C(gene name)|psi-mi:POLR3C(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit C(gene name synonym)|uniprotkb:RNA polymerase III 62 kDa subunit(gene name synonym) psi-mi:"MI:0018"(two hybrid) Lefèvre et al. (2011) pubmed:21358628|doi:10.1038/nsmb.1996|imex:IM-16087 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15913552|imex:IM-16087-1|dip:DIP-186977E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115681.1|refseq:NP_001317614.1|refseq:XP_005277488.1|dip:DIP-59080N|ensembl:ENSG00000121851(gene)|ensembl:ENST00000369314(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006383"(transcription by RNA polymerase III)|interpro:IPR024661|rcsb pdb:5AFQ|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071 refseq:NP_001290385.1|dip:DIP-59078N|refseq:NP_006459.3|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR008806(RNA polymerase III Rpc82, C -terminal)|interpro:IPR013197(RNA polymerase III subunit RPC82-related, helix-turn-helix)|interpro:IPR036388|interpro:IPR039748|rcsb pdb:2XUB|rcsb pdb:2XV4|rcsb pdb:5AFQ|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|ensembl:ENSG00000186141(gene)|ensembl:ENST00000334163(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:x1mjzD1yrnS90eNa57yBIOX62SU9606 rogid:2yQkAYuLbQEg5mNlIcFGbArFMOg9606 rigid:S6eOUPXjvJX+Ugl6XU13T/p+1dU false - mutation disrupting interaction:312-312|necessary binding region:450-508|necessary binding region:1-238|necessary binding region:1-78 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H1D9 uniprotkb:Q9BUI4 intact:EBI-710067|uniprotkb:O15319|uniprotkb:A8K4C7|ensembl:ENSP00000366828 intact:EBI-5452779|uniprotkb:O15317|uniprotkb:Q9Y3R6|ensembl:ENSP00000334564 psi-mi:rpc6_human(display_long)|uniprotkb:DNA-directed RNA polymerase III subunit F(gene name synonym)|uniprotkb:RNA polymerase III 39 kDa subunit(gene name synonym)|uniprotkb:POLR3F(gene name)|psi-mi:POLR3F(display_short) psi-mi:rpc3_human(display_long)|uniprotkb:POLR3C(gene name)|psi-mi:POLR3C(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit C(gene name synonym)|uniprotkb:RNA polymerase III 62 kDa subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Lefèvre et al. (2011) pubmed:21358628|doi:10.1038/nsmb.1996|imex:IM-16087 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15913581|imex:IM-16087-2|dip:DIP-186979E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269455.1|refseq:NP_006457.2|dip:DIP-34646N|ensembl:ENSG00000132664(gene)|ensembl:ENST00000377603(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR007832(RNA polymerase Rpc34)|interpro:IPR016049(RNA polymerase Rpc34-like)|interpro:IPR036388|interpro:IPR036390|mint:Q9H1D9|rcsb pdb:2DK5|rcsb pdb:2YU3|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071 refseq:NP_001290385.1|dip:DIP-59078N|refseq:NP_006459.3|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR008806(RNA polymerase III Rpc82, C -terminal)|interpro:IPR013197(RNA polymerase III subunit RPC82-related, helix-turn-helix)|interpro:IPR036388|interpro:IPR039748|rcsb pdb:2XUB|rcsb pdb:2XV4|rcsb pdb:5AFQ|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|ensembl:ENSG00000186141(gene)|ensembl:ENST00000334163(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:uqwUHkGa31Zl21767NrQK6nKbF09606 rogid:2yQkAYuLbQEg5mNlIcFGbArFMOg9606 rigid:i5oDrV8mnlnaHV6wm2NgFfUbL3c false - necessary binding region:1-238|necessary binding region:1-78|his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15318 uniprotkb:Q9BUI4 intact:EBI-12362221|ensembl:ENSP00000421637|ensembl:ENSP00000498469|uniprotkb:A8MTH0 intact:EBI-5452779|uniprotkb:O15317|uniprotkb:Q9Y3R6|ensembl:ENSP00000334564 psi-mi:rpc7_human(display_long)|uniprotkb:POLR3G(gene name)|psi-mi:POLR3G(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit G(gene name synonym)|uniprotkb:RNA polymerase III 32 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III 32 kDa apha subunit(gene name synonym) psi-mi:rpc3_human(display_long)|uniprotkb:POLR3C(gene name)|psi-mi:POLR3C(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit C(gene name synonym)|uniprotkb:RNA polymerase III 62 kDa subunit(gene name synonym) psi-mi:"MI:0018"(two hybrid) Lefèvre et al. (2011) pubmed:21358628|doi:10.1038/nsmb.1996|imex:IM-16087 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15913606|imex:IM-16087-3|dip:DIP-186978E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113356(gene)|ensembl:ENST00000504930(transcript)|ensembl:ENST00000651687(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR024661|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_006458.2|refseq:XP_005248461.1|refseq:XP_011541402.1|refseq:XP_011541403.1|refseq:XP_011541404.1|refseq:XP_016864446.1|dip:DIP-59079N refseq:NP_001290385.1|dip:DIP-59078N|refseq:NP_006459.3|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR008806(RNA polymerase III Rpc82, C -terminal)|interpro:IPR013197(RNA polymerase III subunit RPC82-related, helix-turn-helix)|interpro:IPR036388|interpro:IPR039748|rcsb pdb:2XUB|rcsb pdb:2XV4|rcsb pdb:5AFQ|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|ensembl:ENSG00000186141(gene)|ensembl:ENST00000334163(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:lhoY+KmpqdrQUaB/04JHWT93H6Q9606 rogid:2yQkAYuLbQEg5mNlIcFGbArFMOg9606 rigid:q5PeOKTZP6sVJh5SnMHsTnV6M4s false - mutation disrupting interaction:312-312|necessary binding region:1-238|necessary binding region:1-78 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H1D9 uniprotkb:Q9BUI4 intact:EBI-710067|uniprotkb:O15319|uniprotkb:A8K4C7|ensembl:ENSP00000366828 intact:EBI-5452779|uniprotkb:O15317|uniprotkb:Q9Y3R6|ensembl:ENSP00000334564 psi-mi:rpc6_human(display_long)|uniprotkb:DNA-directed RNA polymerase III subunit F(gene name synonym)|uniprotkb:RNA polymerase III 39 kDa subunit(gene name synonym)|uniprotkb:POLR3F(gene name)|psi-mi:POLR3F(display_short) psi-mi:rpc3_human(display_long)|uniprotkb:POLR3C(gene name)|psi-mi:POLR3C(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit C(gene name synonym)|uniprotkb:RNA polymerase III 62 kDa subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Lefèvre et al. (2011) pubmed:21358628|doi:10.1038/nsmb.1996|imex:IM-16087 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15913632|imex:IM-16087-4|dip:DIP-186979E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269455.1|refseq:NP_006457.2|dip:DIP-34646N|ensembl:ENSG00000132664(gene)|ensembl:ENST00000377603(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR007832(RNA polymerase Rpc34)|interpro:IPR016049(RNA polymerase Rpc34-like)|interpro:IPR036388|interpro:IPR036390|mint:Q9H1D9|rcsb pdb:2DK5|rcsb pdb:2YU3|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071 refseq:NP_001290385.1|dip:DIP-59078N|refseq:NP_006459.3|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR008806(RNA polymerase III Rpc82, C -terminal)|interpro:IPR013197(RNA polymerase III subunit RPC82-related, helix-turn-helix)|interpro:IPR036388|interpro:IPR039748|rcsb pdb:2XUB|rcsb pdb:2XV4|rcsb pdb:5AFQ|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|ensembl:ENSG00000186141(gene)|ensembl:ENST00000334163(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:uqwUHkGa31Zl21767NrQK6nKbF09606 rogid:2yQkAYuLbQEg5mNlIcFGbArFMOg9606 rigid:i5oDrV8mnlnaHV6wm2NgFfUbL3c false sufficient binding region:158-316|his tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)