#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O95150-1 uniprotkb:O95407 intact:EBI-15910629|ensembl:ENSP00000363157 intact:EBI-524171|ensembl:ENSP00000359013 psi-mi:o95150-1(display_long)|uniprotkb:TNFSF15(gene name)|psi-mi:TNFSF15(display_short)|uniprotkb:TL1(gene name synonym)|uniprotkb:VEGI(gene name synonym)|uniprotkb:TNF ligand-related molecule 1(gene name synonym)|uniprotkb:Vascular endothelial cell growth inhibitor(gene name synonym)|uniprotkb:TL1A(isoform synonym)|uniprotkb:VEGI-251(isoform synonym) psi-mi:tnf6b_human(display_long)|uniprotkb:Decoy receptor for Fas ligand(gene name synonym)|uniprotkb:Decoy receptor 3(gene name synonym)|uniprotkb:M68(gene name synonym)|uniprotkb:UNQ186/PRO212(orf name)|uniprotkb:TNFRSF6B(gene name)|psi-mi:TNFRSF6B(display_short)|uniprotkb:DCR3(gene name synonym)|uniprotkb:TR6(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Zhan et al. (2011) pubmed:21300286|doi:10.1016/j.str.2010.12.004|imex:IM-17471 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15910640|imex:IM-17471-1|dip:DIP-188685E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000181634(gene)|ensembl:ENST00000374045(transcript)|intact:EBI-16355546(isoform-parent) refseq:NP_003814.1|ensembl:ENSG00000243509(gene)|ensembl:ENST00000369996(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR034023|rcsb pdb:3K51|rcsb pdb:3MHD|rcsb pdb:3MI8|rcsb pdb:4J6G|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4MSV|rcsb pdb:5L36|reactome:R-HSA-5669034 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:SMdgVbHGHp1NMl1vkuNIXY/IYto9606 rogid:6TcPTYX4msQy2jsSWmzZFE0+7MY9606 rigid:d60uZ0h5U6pSs7iUrqFs/3bVQRU false binding-associated region:72-251 binding-associated region:30-195 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43557-1 uniprotkb:O95407 intact:EBI-15910661|ensembl:ENSP00000469049|ensembl:ENSP00000502837 intact:EBI-524171|ensembl:ENSP00000359013 psi-mi:o43557-1(display_long)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym) psi-mi:tnf6b_human(display_long)|uniprotkb:Decoy receptor for Fas ligand(gene name synonym)|uniprotkb:Decoy receptor 3(gene name synonym)|uniprotkb:M68(gene name synonym)|uniprotkb:UNQ186/PRO212(orf name)|uniprotkb:TNFRSF6B(gene name)|psi-mi:TNFRSF6B(display_short)|uniprotkb:DCR3(gene name synonym)|uniprotkb:TR6(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Zhan et al. (2011) pubmed:21300286|doi:10.1016/j.str.2010.12.004|imex:IM-17471 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15910671|imex:IM-17471-2|dip:DIP-4223E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|intact:EBI-524131(isoform-parent) refseq:NP_003814.1|ensembl:ENSG00000243509(gene)|ensembl:ENST00000369996(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR034023|rcsb pdb:3K51|rcsb pdb:3MHD|rcsb pdb:3MI8|rcsb pdb:4J6G|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4MSV|rcsb pdb:5L36|reactome:R-HSA-5669034 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606 rogid:6TcPTYX4msQy2jsSWmzZFE0+7MY9606 rigid:k+fmhsBi7T8R173Dr9AVzhWMcqE false binding-associated region:74-240 binding-associated region:30-195|mutation decreasing interaction:89-89,85-85 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95150-1 uniprotkb:O95407 intact:EBI-15910629|ensembl:ENSP00000363157 intact:EBI-524171|ensembl:ENSP00000359013 psi-mi:o95150-1(display_long)|uniprotkb:TNFSF15(gene name)|psi-mi:TNFSF15(display_short)|uniprotkb:TL1(gene name synonym)|uniprotkb:VEGI(gene name synonym)|uniprotkb:TNF ligand-related molecule 1(gene name synonym)|uniprotkb:Vascular endothelial cell growth inhibitor(gene name synonym)|uniprotkb:TL1A(isoform synonym)|uniprotkb:VEGI-251(isoform synonym) psi-mi:tnf6b_human(display_long)|uniprotkb:Decoy receptor for Fas ligand(gene name synonym)|uniprotkb:Decoy receptor 3(gene name synonym)|uniprotkb:M68(gene name synonym)|uniprotkb:UNQ186/PRO212(orf name)|uniprotkb:TNFRSF6B(gene name)|psi-mi:TNFRSF6B(display_short)|uniprotkb:DCR3(gene name synonym)|uniprotkb:TR6(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Zhan et al. (2011) pubmed:21300286|doi:10.1016/j.str.2010.12.004|imex:IM-17471 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15910696|imex:IM-17471-3|dip:DIP-188685E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000181634(gene)|ensembl:ENST00000374045(transcript)|intact:EBI-16355546(isoform-parent) refseq:NP_003814.1|ensembl:ENSG00000243509(gene)|ensembl:ENST00000369996(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR034023|rcsb pdb:3K51|rcsb pdb:3MHD|rcsb pdb:3MI8|rcsb pdb:4J6G|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4MSV|rcsb pdb:5L36|reactome:R-HSA-5669034 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:SMdgVbHGHp1NMl1vkuNIXY/IYto9606 rogid:6TcPTYX4msQy2jsSWmzZFE0+7MY9606 rigid:d60uZ0h5U6pSs7iUrqFs/3bVQRU false binding-associated region:72-251 binding-associated region:24-300 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95150-1 uniprotkb:O95407 intact:EBI-15910629|ensembl:ENSP00000363157 intact:EBI-524171|ensembl:ENSP00000359013 psi-mi:o95150-1(display_long)|uniprotkb:TNFSF15(gene name)|psi-mi:TNFSF15(display_short)|uniprotkb:TL1(gene name synonym)|uniprotkb:VEGI(gene name synonym)|uniprotkb:TNF ligand-related molecule 1(gene name synonym)|uniprotkb:Vascular endothelial cell growth inhibitor(gene name synonym)|uniprotkb:TL1A(isoform synonym)|uniprotkb:VEGI-251(isoform synonym) psi-mi:tnf6b_human(display_long)|uniprotkb:Decoy receptor for Fas ligand(gene name synonym)|uniprotkb:Decoy receptor 3(gene name synonym)|uniprotkb:M68(gene name synonym)|uniprotkb:UNQ186/PRO212(orf name)|uniprotkb:TNFRSF6B(gene name)|psi-mi:TNFRSF6B(display_short)|uniprotkb:DCR3(gene name synonym)|uniprotkb:TR6(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Zhan et al. (2011) pubmed:21300286|doi:10.1016/j.str.2010.12.004|imex:IM-17471 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15910717|imex:IM-17471-4|dip:DIP-188685E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000181634(gene)|ensembl:ENST00000374045(transcript)|intact:EBI-16355546(isoform-parent) refseq:NP_003814.1|ensembl:ENSG00000243509(gene)|ensembl:ENST00000369996(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR034023|rcsb pdb:3K51|rcsb pdb:3MHD|rcsb pdb:3MI8|rcsb pdb:4J6G|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4MSV|rcsb pdb:5L36|reactome:R-HSA-5669034 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:SMdgVbHGHp1NMl1vkuNIXY/IYto9606 rogid:6TcPTYX4msQy2jsSWmzZFE0+7MY9606 rigid:d60uZ0h5U6pSs7iUrqFs/3bVQRU false binding-associated region:72-251 binding-associated region:30-195|mutation decreasing interaction:89-89,85-85 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P48023 uniprotkb:O95407 intact:EBI-495538|uniprotkb:Q9BZP9|ensembl:ENSP00000356694 intact:EBI-524171|ensembl:ENSP00000359013 psi-mi:tnfl6_human(display_long)|uniprotkb:Fas antigen ligand(gene name synonym)|uniprotkb:CD95L(gene name synonym)|uniprotkb:Apoptosis antigen ligand(gene name synonym)|uniprotkb:FASLG(gene name)|psi-mi:FASLG(display_short)|uniprotkb:APT1LG1(gene name synonym)|uniprotkb:FASL(gene name synonym)|uniprotkb:TNFSF6(gene name synonym)|uniprotkb:CD95 ligand(gene name synonym) psi-mi:tnf6b_human(display_long)|uniprotkb:Decoy receptor for Fas ligand(gene name synonym)|uniprotkb:Decoy receptor 3(gene name synonym)|uniprotkb:M68(gene name synonym)|uniprotkb:UNQ186/PRO212(orf name)|uniprotkb:TNFRSF6B(gene name)|psi-mi:TNFRSF6B(display_short)|uniprotkb:DCR3(gene name synonym)|uniprotkb:TR6(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Zhan et al. (2011) pubmed:21300286|doi:10.1016/j.str.2010.12.004|imex:IM-17471 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15910742|imex:IM-17471-5|dip:DIP-4222E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000630.1|refseq:NP_001289675.1|dip:DIP-2997N|ensembl:ENSG00000117560(gene)|ensembl:ENST00000367721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1903514"(release of sequestered calcium ion into cytosol by endoplasmic reticulum)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR028326|mint:P48023|rcsb pdb:1BZI|rcsb pdb:4MSV|rcsb pdb:5L19|rcsb pdb:5L36|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6785807|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-8862803|reactome:R-HSA-9614657|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048388"(endosomal lumen acidification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070848"(response to growth factor) refseq:NP_003814.1|ensembl:ENSG00000243509(gene)|ensembl:ENST00000369996(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR034023|rcsb pdb:3K51|rcsb pdb:3MHD|rcsb pdb:3MI8|rcsb pdb:4J6G|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4MSV|rcsb pdb:5L36|reactome:R-HSA-5669034 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:3/Op+1mSXMoGr/8mhnh1oCpQ4sQ9606 rogid:6TcPTYX4msQy2jsSWmzZFE0+7MY9606 rigid:AGtPOkOR020aYK1l7vAubfmHLOc false binding-associated region:134-281 binding-associated region:30-195|mutation disrupting interaction:89-89,85-85 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93038-1 uniprotkb:O95150-1 intact:EBI-15910767|ensembl:ENSP00000349341 intact:EBI-15910629|ensembl:ENSP00000363157 psi-mi:q93038-1(display_long)|uniprotkb:TNFRSF25(gene name)|psi-mi:TNFRSF25(display_short)|uniprotkb:APO3(gene name synonym)|uniprotkb:DDR3(gene name synonym)|uniprotkb:DR3(gene name synonym)|uniprotkb:TNFRSF12(gene name synonym)|uniprotkb:WSL(gene name synonym)|uniprotkb:WSL1(gene name synonym)|uniprotkb:UNQ455/PRO779(orf name)|uniprotkb:WSL-1(isoform synonym)|uniprotkb:LARD-1A(isoform synonym)|uniprotkb:Apo-3(gene name synonym)|uniprotkb:Apoptosis-inducing receptor AIR(gene name synonym)|uniprotkb:Apoptosis-mediating receptor DR3(gene name synonym)|uniprotkb:Apoptosis-mediating receptor TRAMP(gene name synonym)|uniprotkb:Death receptor 3(gene name synonym)|uniprotkb:Lymphocyte-associated receptor of death(gene name synonym)|uniprotkb:Protein WSL(gene name synonym)|uniprotkb:Protein WSL-1(gene name synonym) psi-mi:o95150-1(display_long)|uniprotkb:TNFSF15(gene name)|psi-mi:TNFSF15(display_short)|uniprotkb:TL1(gene name synonym)|uniprotkb:VEGI(gene name synonym)|uniprotkb:TNF ligand-related molecule 1(gene name synonym)|uniprotkb:Vascular endothelial cell growth inhibitor(gene name synonym)|uniprotkb:TL1A(isoform synonym)|uniprotkb:VEGI-251(isoform synonym) psi-mi:"MI:0107"(surface plasmon resonance) Zhan et al. (2011) pubmed:21300286|doi:10.1016/j.str.2010.12.004|imex:IM-17471 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15910789|imex:IM-17471-6|dip:DIP-188686E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000215788(gene)|ensembl:ENST00000356876(transcript)|intact:EBI-16355592(isoform-parent) ensembl:ENSG00000181634(gene)|ensembl:ENST00000374045(transcript)|intact:EBI-16355546(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:AFki/fab5B0aiC0BSU15bGXW2Bk9606 rogid:SMdgVbHGHp1NMl1vkuNIXY/IYto9606 rigid:vckBUqXh+5X6y5ROpbilm8FpiQo false binding-associated region:25-201 binding-associated region:72-251|mutation disrupting interaction:202-202,190-190,187-187,162-162 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)