#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909666|imex:IM-21229-1|dip:DIP-191153E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:Rtd0v+iMgDDRwnJ9iQJ5OclVVb8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60855	intact:EBI-520001	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909666|imex:IM-21229-1|dip:DIP-191153E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rigid:Rtd0v+iMgDDRwnJ9iQJ5OclVVb8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88522	intact:EBI-520001	intact:EBI-998011|uniprotkb:Q924H4|ensembl:ENSMUSP00000109762|ensembl:ENSMUSP00000109763|ensembl:ENSMUSP00000109768|ensembl:ENSMUSP00000126770	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:nemo_mouse(display_long)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Ikbkg(gene name)|psi-mi:Ikbkg(display_short)|uniprotkb:Nemo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909666|imex:IM-21229-1|dip:DIP-191153E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:O88522|rcsb pdb:2V4H|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3F89|rcsb pdb:3JSV|rcsb pdb:4OWF|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-4755510|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0010628"(positive regulation of gene expression)|reactome:R-MMU-975144|ensembl:ENSMUSG00000004221(gene)|ensembl:ENSMUST00000114127(transcript)|ensembl:ENSMUST00000114128(transcript)|ensembl:ENSMUST00000114133(transcript)|ensembl:ENSMUST00000164101(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|refseq:XP_011245829.1|refseq:NP_001154895.1|refseq:NP_034677.2|refseq:XP_006527913.1|refseq:XP_006527914.1|refseq:XP_006527915.1|dip:DIP-29811N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:xdq9J5m7CDC1X/4TfHZVGSYKq8U10090	rigid:Rtd0v+iMgDDRwnJ9iQJ5OclVVb8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909666|imex:IM-21229-1|dip:DIP-191153E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:Rtd0v+iMgDDRwnJ9iQJ5OclVVb8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60680	intact:EBI-520001	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909666|imex:IM-21229-1|dip:DIP-191153E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rigid:Rtd0v+iMgDDRwnJ9iQJ5OclVVb8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909666|imex:IM-21229-1|dip:DIP-191153E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:Rtd0v+iMgDDRwnJ9iQJ5OclVVb8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909713|imex:IM-21229-3|dip:DIP-191157E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:0ebSRZ5uhLm/8SWoHZA1Wx7ixH0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909713|imex:IM-21229-3|dip:DIP-191157E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:0ebSRZ5uhLm/8SWoHZA1Wx7ixH0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60680	intact:EBI-520001	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909713|imex:IM-21229-3|dip:DIP-191157E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rigid:0ebSRZ5uhLm/8SWoHZA1Wx7ixH0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909713|imex:IM-21229-3|dip:DIP-191157E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:0ebSRZ5uhLm/8SWoHZA1Wx7ixH0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P62991	intact:EBI-520001	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909735|imex:IM-21229-4|dip:DIP-191159E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rigid:GCRWxKAL/DaPnpbbdiH/gvE+siE	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88522	intact:EBI-520001	intact:EBI-998011|uniprotkb:Q924H4|ensembl:ENSMUSP00000109762|ensembl:ENSMUSP00000109763|ensembl:ENSMUSP00000109768|ensembl:ENSMUSP00000126770	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:nemo_mouse(display_long)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Ikbkg(gene name)|psi-mi:Ikbkg(display_short)|uniprotkb:Nemo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909735|imex:IM-21229-4|dip:DIP-191159E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:O88522|rcsb pdb:2V4H|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3F89|rcsb pdb:3JSV|rcsb pdb:4OWF|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-4755510|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0010628"(positive regulation of gene expression)|reactome:R-MMU-975144|ensembl:ENSMUSG00000004221(gene)|ensembl:ENSMUST00000114127(transcript)|ensembl:ENSMUST00000114128(transcript)|ensembl:ENSMUST00000114133(transcript)|ensembl:ENSMUST00000164101(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|refseq:XP_011245829.1|refseq:NP_001154895.1|refseq:NP_034677.2|refseq:XP_006527913.1|refseq:XP_006527914.1|refseq:XP_006527915.1|dip:DIP-29811N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:xdq9J5m7CDC1X/4TfHZVGSYKq8U10090	rigid:GCRWxKAL/DaPnpbbdiH/gvE+siE	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909735|imex:IM-21229-4|dip:DIP-191159E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:GCRWxKAL/DaPnpbbdiH/gvE+siE	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60680	intact:EBI-520001	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909735|imex:IM-21229-4|dip:DIP-191159E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rigid:GCRWxKAL/DaPnpbbdiH/gvE+siE	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909735|imex:IM-21229-4|dip:DIP-191159E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:GCRWxKAL/DaPnpbbdiH/gvE+siE	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q02111	intact:EBI-520001	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909758|imex:IM-21229-5|dip:DIP-191162E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	rigid:bKx6da/IeZyJOPAnU6loByoeV/s	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909758|imex:IM-21229-5|dip:DIP-191162E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:bKx6da/IeZyJOPAnU6loByoeV/s	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909690|imex:IM-21229-2|dip:DIP-191155E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:q/9uFLB+JDZ3R0G/4OF0NRI2+9E	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60855	intact:EBI-520001	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909690|imex:IM-21229-2|dip:DIP-191155E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rigid:q/9uFLB+JDZ3R0G/4OF0NRI2+9E	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909690|imex:IM-21229-2|dip:DIP-191155E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:q/9uFLB+JDZ3R0G/4OF0NRI2+9E	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60680	intact:EBI-520001	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909690|imex:IM-21229-2|dip:DIP-191155E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rigid:q/9uFLB+JDZ3R0G/4OF0NRI2+9E	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909690|imex:IM-21229-2|dip:DIP-191155E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:q/9uFLB+JDZ3R0G/4OF0NRI2+9E	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P62991	intact:EBI-520001	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909778|imex:IM-21229-6|dip:DIP-191158E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rigid:F7IZ9IPfInXV0ueSIZg4bu2hZ/g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909778|imex:IM-21229-6|dip:DIP-191158E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:F7IZ9IPfInXV0ueSIZg4bu2hZ/g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60855	intact:EBI-520001	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909778|imex:IM-21229-6|dip:DIP-191158E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rigid:F7IZ9IPfInXV0ueSIZg4bu2hZ/g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88522	intact:EBI-520001	intact:EBI-998011|uniprotkb:Q924H4|ensembl:ENSMUSP00000109762|ensembl:ENSMUSP00000109763|ensembl:ENSMUSP00000109768|ensembl:ENSMUSP00000126770	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:nemo_mouse(display_long)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Ikbkg(gene name)|psi-mi:Ikbkg(display_short)|uniprotkb:Nemo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909778|imex:IM-21229-6|dip:DIP-191158E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:O88522|rcsb pdb:2V4H|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3F89|rcsb pdb:3JSV|rcsb pdb:4OWF|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-4755510|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0010628"(positive regulation of gene expression)|reactome:R-MMU-975144|ensembl:ENSMUSG00000004221(gene)|ensembl:ENSMUST00000114127(transcript)|ensembl:ENSMUST00000114128(transcript)|ensembl:ENSMUST00000114133(transcript)|ensembl:ENSMUST00000164101(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|refseq:XP_011245829.1|refseq:NP_001154895.1|refseq:NP_034677.2|refseq:XP_006527913.1|refseq:XP_006527914.1|refseq:XP_006527915.1|dip:DIP-29811N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:xdq9J5m7CDC1X/4TfHZVGSYKq8U10090	rigid:F7IZ9IPfInXV0ueSIZg4bu2hZ/g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909778|imex:IM-21229-6|dip:DIP-191158E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:F7IZ9IPfInXV0ueSIZg4bu2hZ/g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60680	intact:EBI-520001	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909778|imex:IM-21229-6|dip:DIP-191158E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rigid:F7IZ9IPfInXV0ueSIZg4bu2hZ/g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909778|imex:IM-21229-6|dip:DIP-191158E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:F7IZ9IPfInXV0ueSIZg4bu2hZ/g	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q9Z0H7	intact:EBI-520001	intact:EBI-8545413|intact:UNK-5560748|uniprotkb:Q3UBN4|ensembl:ENSMUSP00000029842	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:bcl10_mouse(display_long)|uniprotkb:Bcl10(gene name)|psi-mi:Bcl10(display_short)|uniprotkb:Ciper(gene name synonym)|uniprotkb:Clap(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909866|imex:IM-21229-7|dip:DIP-191160E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033870.1|dip:DIP-60309N|ensembl:ENSMUSG00000028191(gene)|ensembl:ENSMUST00000029842(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009620"(response to fungus)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0043621"(protein self-association)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-8866654	psi-mi:"MI:0465"(dip)	-	comment:mint|comment:homomint|function:Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:20gxkBjtsGLmnabow2Dv/z8Vew410090	rigid:8cqYrpxPPysghbMDaf6CNr72QKQ	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q02111	intact:EBI-520001	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909866|imex:IM-21229-7|dip:DIP-191160E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	rigid:8cqYrpxPPysghbMDaf6CNr72QKQ	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q2TBA3	intact:EBI-520001	intact:EBI-15909803|ensembl:ENSMUSP00000153585|uniprotkb:Q2TBA2|uniprotkb:Q811E3|uniprotkb:Q8BFT0|uniprotkb:Q8C7N9	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:malt1_mouse(display_long)|uniprotkb:Malt1(gene name)|psi-mi:Malt1(display_short)|uniprotkb:Paracaspase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909866|imex:IM-21229-7|dip:DIP-191160E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	ensembl:ENSMUSG00000032688(gene)|ensembl:ENSMUST00000224056(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001923"(B-1 B cell differentiation)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0009620"(response to fungus)|go:"GO:0019209"(kinase activator activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032449"(CBM complex)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051168"(nuclear export)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000321"(positive regulation of T-helper 17 cell differentiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011029(DEATH-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029030|interpro:IPR033540|interpro:IPR036179|interpro:IPR037940|interpro:IPR041077|rcsb pdb:3V4L|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-5660668|refseq:NP_766421.1|refseq:XP_006526000.1|dip:DIP-60308N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:jtvSV5MAbfzEtAq41TND7GOpdCw10090	rigid:8cqYrpxPPysghbMDaf6CNr72QKQ	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909866|imex:IM-21229-7|dip:DIP-191160E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:8cqYrpxPPysghbMDaf6CNr72QKQ	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60855	intact:EBI-520001	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909866|imex:IM-21229-7|dip:DIP-191160E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rigid:8cqYrpxPPysghbMDaf6CNr72QKQ	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909866|imex:IM-21229-7|dip:DIP-191160E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:8cqYrpxPPysghbMDaf6CNr72QKQ	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909866|imex:IM-21229-7|dip:DIP-191160E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:8cqYrpxPPysghbMDaf6CNr72QKQ	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q02111	intact:EBI-520001	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909891|imex:IM-21229-8|dip:DIP-191161E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	rigid:x9AjSBPo060X90eLeLNyjYfcOC0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909891|imex:IM-21229-8|dip:DIP-191161E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:x9AjSBPo060X90eLeLNyjYfcOC0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909891|imex:IM-21229-8|dip:DIP-191161E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:x9AjSBPo060X90eLeLNyjYfcOC0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909891|imex:IM-21229-8|dip:DIP-191161E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:x9AjSBPo060X90eLeLNyjYfcOC0	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62991	uniprotkb:P47741	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	intact:EBI-520001	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909913|imex:IM-21229-9|dip:DIP-191164E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rigid:RtNC8fRH0loqQ9XIoVkv6jN+byM	false	-	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60855	uniprotkb:Q9Z0H7	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	intact:EBI-8545413|intact:UNK-5560748|uniprotkb:Q3UBN4|ensembl:ENSMUSP00000029842	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:bcl10_mouse(display_long)|uniprotkb:Bcl10(gene name)|psi-mi:Bcl10(display_short)|uniprotkb:Ciper(gene name synonym)|uniprotkb:Clap(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909932|imex:IM-21229-10|dip:DIP-191163E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	refseq:NP_033870.1|dip:DIP-60309N|ensembl:ENSMUSG00000028191(gene)|ensembl:ENSMUST00000029842(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009620"(response to fungus)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0043621"(protein self-association)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-8866654	psi-mi:"MI:0465"(dip)	-	comment:mint|comment:homomint|function:Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rogid:20gxkBjtsGLmnabow2Dv/z8Vew410090	rigid:EZPl2l/n0aqoNCQXYkQJ1fkYoGU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60855	uniprotkb:Q02111	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909932|imex:IM-21229-10|dip:DIP-191163E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	rigid:EZPl2l/n0aqoNCQXYkQJ1fkYoGU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60855	uniprotkb:Q2TBA3	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	intact:EBI-15909803|ensembl:ENSMUSP00000153585|uniprotkb:Q2TBA2|uniprotkb:Q811E3|uniprotkb:Q8BFT0|uniprotkb:Q8C7N9	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:malt1_mouse(display_long)|uniprotkb:Malt1(gene name)|psi-mi:Malt1(display_short)|uniprotkb:Paracaspase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909932|imex:IM-21229-10|dip:DIP-191163E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	ensembl:ENSMUSG00000032688(gene)|ensembl:ENSMUST00000224056(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001923"(B-1 B cell differentiation)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0009620"(response to fungus)|go:"GO:0019209"(kinase activator activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032449"(CBM complex)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051168"(nuclear export)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000321"(positive regulation of T-helper 17 cell differentiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011029(DEATH-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029030|interpro:IPR033540|interpro:IPR036179|interpro:IPR037940|interpro:IPR041077|rcsb pdb:3V4L|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-5660668|refseq:NP_766421.1|refseq:XP_006526000.1|dip:DIP-60308N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rogid:jtvSV5MAbfzEtAq41TND7GOpdCw10090	rigid:EZPl2l/n0aqoNCQXYkQJ1fkYoGU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60855	uniprotkb:Q8CIS0	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909932|imex:IM-21229-10|dip:DIP-191163E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:EZPl2l/n0aqoNCQXYkQJ1fkYoGU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60855	uniprotkb:P47741	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	intact:EBI-520001	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909932|imex:IM-21229-10|dip:DIP-191163E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rigid:EZPl2l/n0aqoNCQXYkQJ1fkYoGU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909953|imex:IM-21229-11|dip:DIP-191154E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:YRJWL6tuwPZszGhBIQonme8+MUY	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60855	intact:EBI-520001	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909953|imex:IM-21229-11|dip:DIP-191154E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rigid:YRJWL6tuwPZszGhBIQonme8+MUY	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:O88351	intact:EBI-520001	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909953|imex:IM-21229-11|dip:DIP-191154E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rigid:YRJWL6tuwPZszGhBIQonme8+MUY	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909953|imex:IM-21229-11|dip:DIP-191154E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:YRJWL6tuwPZszGhBIQonme8+MUY	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q8CIS0	intact:EBI-520001	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909975|imex:IM-21229-12|dip:DIP-191156E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:1D9vsJ1y29gj7nupZmsKTr0dyn8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:Q60855	intact:EBI-520001	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909975|imex:IM-21229-12|dip:DIP-191156E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rigid:1D9vsJ1y29gj7nupZmsKTr0dyn8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47741	uniprotkb:P39429	intact:EBI-520001	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909975|imex:IM-21229-12|dip:DIP-191156E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rigid:1D9vsJ1y29gj7nupZmsKTr0dyn8	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:P47741	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-520001	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	So et al. (2011)	pubmed:21282629|doi:10.1073/pnas.1008765108|imex:IM-21229	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15909998|imex:IM-21229-13|dip:DIP-62820E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rigid:Xy9RYQZY1CY/6J9hfyfZY9nu6Io	false	-	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)