#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05161	uniprotkb:Q6TQR6	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	intact:EBI-4403908	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:l_cchfi(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Akutsu et al. (2011)	pubmed:21266548|doi:10.1073/pnas.1015287108|imex:IM-21228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:652961(cchfi)|taxid:652961("Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15908432|imex:IM-21228-1|dip:DIP-191149E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	dip:DIP-60307N|go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR007322(RNA-dependent RNA polymerase, bunyaviral)|interpro:IPR015843(RNA-directed RNA polymerase, Nairovirus type)|interpro:IPR038765|rcsb pdb:3PHU|rcsb pdb:3PHW|rcsb pdb:3PHX|rcsb pdb:3ZNH|rcsb pdb:5V5G|rcsb pdb:5V5H|rcsb pdb:5V5I	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rogid:paHNeXwUbcZb6uvxGNFxHPEX3jo652961	rigid:/gH3Ii033/atRxU9gTYVODeXIUQ	false	aminomethylcoumarin label:c-c	sufficient binding region:1-183|necessary binding region:1-20|mutation disrupting interaction rate:40-40|mutation decreasing interaction rate:77-77	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:Q6TQR6	dip:DIP-24261N	intact:EBI-4403908	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:l_cchfi(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym)	psi-mi:"MI:0998"(deubiquitinase assay)	Akutsu et al. (2011)	pubmed:21266548|doi:10.1073/pnas.1015287108|imex:IM-21228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:652961(cchfi)|taxid:652961("Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970)")	psi-mi:"MI:0204"(deubiquitination reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15908496|imex:IM-21228-3|dip:DIP-191150E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	dip:DIP-60307N|go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR007322(RNA-dependent RNA polymerase, bunyaviral)|interpro:IPR015843(RNA-directed RNA polymerase, Nairovirus type)|interpro:IPR038765|rcsb pdb:3PHU|rcsb pdb:3PHW|rcsb pdb:3PHX|rcsb pdb:3ZNH|rcsb pdb:5V5G|rcsb pdb:5V5H|rcsb pdb:5V5I	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:paHNeXwUbcZb6uvxGNFxHPEX3jo652961	rigid:3ursNPG9OTN8Updy7b3fvScHLCs	false	fiash label:0-0|ubiquitinylated lysine:63-63	sufficient binding region:1-183	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:Q6TQR6	dip:DIP-24261N	intact:EBI-4403908	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:l_cchfi(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym)	psi-mi:"MI:0998"(deubiquitinase assay)	Akutsu et al. (2011)	pubmed:21266548|doi:10.1073/pnas.1015287108|imex:IM-21228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:652961(cchfi)|taxid:652961("Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970)")	psi-mi:"MI:0204"(deubiquitination reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15908462|imex:IM-21228-2|dip:DIP-191150E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	dip:DIP-60307N|go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR007322(RNA-dependent RNA polymerase, bunyaviral)|interpro:IPR015843(RNA-directed RNA polymerase, Nairovirus type)|interpro:IPR038765|rcsb pdb:3PHU|rcsb pdb:3PHW|rcsb pdb:3PHX|rcsb pdb:3ZNH|rcsb pdb:5V5G|rcsb pdb:5V5H|rcsb pdb:5V5I	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:paHNeXwUbcZb6uvxGNFxHPEX3jo652961	rigid:3ursNPG9OTN8Updy7b3fvScHLCs	false	ubiquitinylated lysine:63-63|ubiquitinylated lysine:48-48|ubiquitinylated lysine:11-11|ubiquitinylated lysine:6-6	sufficient binding region:1-183|mutation disrupting interaction rate:16-16	-	-	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
intact:EBI-4399559	uniprotkb:Q6TQR6	dip:DIP-24261N	intact:EBI-4403908	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:l_cchfi(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Akutsu et al. (2011)	pubmed:21266548|doi:10.1073/pnas.1015287108|imex:IM-21228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:652961(cchfi)|taxid:652961("Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15908519|imex:IM-21228-4|dip:DIP-191150E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	dip:DIP-60307N|go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR007322(RNA-dependent RNA polymerase, bunyaviral)|interpro:IPR015843(RNA-directed RNA polymerase, Nairovirus type)|interpro:IPR038765|rcsb pdb:3PHU|rcsb pdb:3PHW|rcsb pdb:3PHX|rcsb pdb:3ZNH|rcsb pdb:5V5G|rcsb pdb:5V5H|rcsb pdb:5V5I	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:paHNeXwUbcZb6uvxGNFxHPEX3jo652961	rigid:3ursNPG9OTN8Updy7b3fvScHLCs	false	aminomethylcoumarin label:0-0	sufficient binding region:1-183|necessary binding region:1-20|mutation disrupting interaction rate:40-40|mutation disrupting interaction rate:16-16	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)