#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P47863	uniprotkb:Q9ERZ8	intact:EBI-15907593|ensembl:ENSRNOP00000063720|intact:EBI-15907702|uniprotkb:A0A0G2K4I1|uniprotkb:Q8CIY8	intact:EBI-10095418|ensembl:ENSRNOP00000001586	psi-mi:aqp4_rat(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:trpv4_rat(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907642|imex:IM-21623-1|dip:DIP-192047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|rcsb pdb:2D57|rcsb pdb:2ZZ9|rcsb pdb:3IYZ|reactome:R-RNO-432040|reactome:R-RNO-432047|refseq:NP_001135838.1|refseq:XP_017456346.1|refseq:NP_001257487.1|refseq:NP_036957.1|rgd:2143|dip:DIP-59601N	rgd:69337|refseq:NP_076460.1|refseq:XP_006249528.1|ensembl:ENSRNOG00000001195(gene)|ensembl:ENSRNOT00000001586(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|reactome:R-RNO-3295583|dip:DIP-59600N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rogid:K9C+gk06aTVdE0P7gtn/xrhej0I10116	rigid:LfsZ860Fpa4hHjuhCrygclR7ehU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBA0	uniprotkb:P47863-1	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	intact:EBI-15907676|ensembl:ENSRNOP00000063720	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:p47863-1(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)|uniprotkb:AQP4-M1(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907683|imex:IM-21623-3|dip:DIP-192049E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|intact:EBI-15907593(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/07	2017/08/10	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rigid:LXTlF8Uv6O+4Zraw9i7ewJVwUrE	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9EPK8	uniprotkb:P55088	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-6273066|uniprotkb:P97818|uniprotkb:Q4FJP1|uniprotkb:Q61131|uniprotkb:Q61132|uniprotkb:Q8VHE4|uniprotkb:Q8VHE5|uniprotkb:Q9EQI3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:aqp4_mouse(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907659|imex:IM-21623-2|dip:DIP-192048E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|reactome:R-MMU-432040|reactome:R-MMU-432047|refseq:NP_001304658.1|mint:P55088|refseq:NP_033830.2|refseq:NP_001295571.1|refseq:NP_001295572.1|refseq:NP_001295573.1|refseq:NP_001295574.1|refseq:NP_001295575.1|refseq:NP_001295576.1|refseq:NP_001295570.1|dip:DIP-59602N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:R1pHxg/qJU3jENYB2XxWYroS2lc10090	rigid:by+OGjbSUTxPDc4h2l5L7oj2QJU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HBA0	uniprotkb:P47863	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	intact:EBI-15907593|ensembl:ENSRNOP00000063720|intact:EBI-15907702|uniprotkb:A0A0G2K4I1|uniprotkb:Q8CIY8	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:aqp4_rat(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907720|imex:IM-21623-4|dip:DIP-192049E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|rcsb pdb:2D57|rcsb pdb:2ZZ9|rcsb pdb:3IYZ|reactome:R-RNO-432040|reactome:R-RNO-432047|refseq:NP_001135838.1|refseq:XP_017456346.1|refseq:NP_001257487.1|refseq:NP_036957.1|rgd:2143|dip:DIP-59601N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/07	2019/05/28	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rigid:LXTlF8Uv6O+4Zraw9i7ewJVwUrE	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HBA0	uniprotkb:P47863	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	intact:EBI-15907593|ensembl:ENSRNOP00000063720|intact:EBI-15907702|uniprotkb:A0A0G2K4I1|uniprotkb:Q8CIY8	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:aqp4_rat(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907807|imex:IM-21623-9|dip:DIP-192049E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|rcsb pdb:2D57|rcsb pdb:2ZZ9|rcsb pdb:3IYZ|reactome:R-RNO-432040|reactome:R-RNO-432047|refseq:NP_001135838.1|refseq:XP_017456346.1|refseq:NP_001257487.1|refseq:NP_036957.1|rgd:2143|dip:DIP-59601N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/07	2019/05/28	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rigid:LXTlF8Uv6O+4Zraw9i7ewJVwUrE	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HBA0	uniprotkb:P47863-1	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	intact:EBI-15907676|ensembl:ENSRNOP00000063720	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:p47863-1(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)|uniprotkb:AQP4-M1(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907826|imex:IM-21623-10|dip:DIP-192049E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|intact:EBI-15907593(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/07	2017/08/10	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rigid:LXTlF8Uv6O+4Zraw9i7ewJVwUrE	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9EPK8	uniprotkb:P55088	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-6273066|uniprotkb:P97818|uniprotkb:Q4FJP1|uniprotkb:Q61131|uniprotkb:Q61132|uniprotkb:Q8VHE4|uniprotkb:Q8VHE5|uniprotkb:Q9EQI3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:aqp4_mouse(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907845|imex:IM-21623-11|dip:DIP-192048E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|reactome:R-MMU-432040|reactome:R-MMU-432047|refseq:NP_001304658.1|mint:P55088|refseq:NP_033830.2|refseq:NP_001295571.1|refseq:NP_001295572.1|refseq:NP_001295573.1|refseq:NP_001295574.1|refseq:NP_001295575.1|refseq:NP_001295576.1|refseq:NP_001295570.1|dip:DIP-59602N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:R1pHxg/qJU3jENYB2XxWYroS2lc10090	rigid:by+OGjbSUTxPDc4h2l5L7oj2QJU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47863	uniprotkb:Q9ERZ8	intact:EBI-15907593|ensembl:ENSRNOP00000063720|intact:EBI-15907702|uniprotkb:A0A0G2K4I1|uniprotkb:Q8CIY8	intact:EBI-10095418|ensembl:ENSRNOP00000001586	psi-mi:aqp4_rat(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:trpv4_rat(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907790|imex:IM-21623-8|dip:DIP-192047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|rcsb pdb:2D57|rcsb pdb:2ZZ9|rcsb pdb:3IYZ|reactome:R-RNO-432040|reactome:R-RNO-432047|refseq:NP_001135838.1|refseq:XP_017456346.1|refseq:NP_001257487.1|refseq:NP_036957.1|rgd:2143|dip:DIP-59601N	rgd:69337|refseq:NP_076460.1|refseq:XP_006249528.1|ensembl:ENSRNOG00000001195(gene)|ensembl:ENSRNOT00000001586(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|reactome:R-RNO-3295583|dip:DIP-59600N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2019/05/28	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rogid:K9C+gk06aTVdE0P7gtn/xrhej0I10116	rigid:LfsZ860Fpa4hHjuhCrygclR7ehU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47863-1	uniprotkb:Q9ERZ8	intact:EBI-15907676|ensembl:ENSRNOP00000063720	intact:EBI-10095418|ensembl:ENSRNOP00000001586	psi-mi:p47863-1(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)|uniprotkb:AQP4-M1(isoform synonym)	psi-mi:trpv4_rat(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907773|imex:IM-21623-7|dip:DIP-192047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|intact:EBI-15907593(isoform-parent)	rgd:69337|refseq:NP_076460.1|refseq:XP_006249528.1|ensembl:ENSRNOG00000001195(gene)|ensembl:ENSRNOT00000001586(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|reactome:R-RNO-3295583|dip:DIP-59600N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rogid:K9C+gk06aTVdE0P7gtn/xrhej0I10116	rigid:LfsZ860Fpa4hHjuhCrygclR7ehU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47863-1	uniprotkb:Q9ERZ8	intact:EBI-15907676|ensembl:ENSRNOP00000063720	intact:EBI-10095418|ensembl:ENSRNOP00000001586	psi-mi:p47863-1(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)|uniprotkb:AQP4-M1(isoform synonym)	psi-mi:trpv4_rat(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907756|imex:IM-21623-6|dip:DIP-192047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|intact:EBI-15907593(isoform-parent)	rgd:69337|refseq:NP_076460.1|refseq:XP_006249528.1|ensembl:ENSRNOG00000001195(gene)|ensembl:ENSRNOT00000001586(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|reactome:R-RNO-3295583|dip:DIP-59600N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rogid:K9C+gk06aTVdE0P7gtn/xrhej0I10116	rigid:LfsZ860Fpa4hHjuhCrygclR7ehU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47863	uniprotkb:Q9ERZ8	intact:EBI-15907593|ensembl:ENSRNOP00000063720|intact:EBI-15907702|uniprotkb:A0A0G2K4I1|uniprotkb:Q8CIY8	intact:EBI-10095418|ensembl:ENSRNOP00000001586	psi-mi:aqp4_rat(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:trpv4_rat(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907739|imex:IM-21623-5|dip:DIP-192047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|rcsb pdb:2D57|rcsb pdb:2ZZ9|rcsb pdb:3IYZ|reactome:R-RNO-432040|reactome:R-RNO-432047|refseq:NP_001135838.1|refseq:XP_017456346.1|refseq:NP_001257487.1|refseq:NP_036957.1|rgd:2143|dip:DIP-59601N	rgd:69337|refseq:NP_076460.1|refseq:XP_006249528.1|ensembl:ENSRNOG00000001195(gene)|ensembl:ENSRNOT00000001586(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|reactome:R-RNO-3295583|dip:DIP-59600N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rogid:K9C+gk06aTVdE0P7gtn/xrhej0I10116	rigid:LfsZ860Fpa4hHjuhCrygclR7ehU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47863	uniprotkb:Q9ERZ8	intact:EBI-15907593|ensembl:ENSRNOP00000063720|intact:EBI-15907702|uniprotkb:A0A0G2K4I1|uniprotkb:Q8CIY8	intact:EBI-10095418|ensembl:ENSRNOP00000001586	psi-mi:aqp4_rat(display_long)|uniprotkb:Aqp4(gene name)|psi-mi:Aqp4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:trpv4_rat(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Benfenati et al. (2011)	pubmed:21262839|doi:10.1073/pnas.1012867108|imex:IM-21623	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15907862|imex:IM-21623-12|dip:DIP-192047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016043(gene)|ensembl:ENSRNOT00000068150(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006833"(water transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0042383"(sarcolemma)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070295"(renal water absorption)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|rcsb pdb:2D57|rcsb pdb:2ZZ9|rcsb pdb:3IYZ|reactome:R-RNO-432040|reactome:R-RNO-432047|refseq:NP_001135838.1|refseq:XP_017456346.1|refseq:NP_001257487.1|refseq:NP_036957.1|rgd:2143|dip:DIP-59601N	rgd:69337|refseq:NP_076460.1|refseq:XP_006249528.1|ensembl:ENSRNOG00000001195(gene)|ensembl:ENSRNOT00000001586(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|reactome:R-RNO-3295583|dip:DIP-59600N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2019/05/28	rogid:/LpV+Quxz5vZ60SEYiVCCGsMP9A10116	rogid:K9C+gk06aTVdE0P7gtn/xrhej0I10116	rigid:LfsZ860Fpa4hHjuhCrygclR7ehU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)