#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7KLI1	uniprotkb:Q7KLI1	intact:EBI-3404349|ensemblmetazoa:FBpp0086122	intact:EBI-3404349|ensemblmetazoa:FBpp0086122	psi-mi:q7kli1_drome(display_long)|uniprotkb:Dark(gene name)|psi-mi:Dark(display_short)|uniprotkb:Ark(gene name synonym)|uniprotkb:Ark-RB(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:dapaf-1L(gene name synonym)|uniprotkb:APAF-1(gene name synonym)|uniprotkb:APAF1(gene name synonym)|uniprotkb:ARK(gene name synonym)|uniprotkb:Apaf-1(gene name synonym)|uniprotkb:Apaf-I(gene name synonym)|uniprotkb:Apaf1(gene name synonym)|uniprotkb:D-Apaf-1(gene name synonym)|uniprotkb:DARK(gene name synonym)|uniprotkb:Dapaf-1(gene name synonym)|uniprotkb:Dmel\CG6829(gene name synonym)|uniprotkb:HAC-1(gene name synonym)|uniprotkb:HAC1(gene name synonym)|uniprotkb:Hac-1(gene name synonym)|uniprotkb:T1(gene name synonym)|uniprotkb:anon-53Fa(gene name synonym)|uniprotkb:apaf-1(gene name synonym)|uniprotkb:apaf1(gene name synonym)|uniprotkb:arc(gene name synonym)|uniprotkb:ark(gene name synonym)|uniprotkb:dAPAF-1(gene name synonym)|uniprotkb:dApaf-1(gene name synonym)|uniprotkb:dApaf1(gene name synonym)|uniprotkb:dArk(gene name synonym)|uniprotkb:dapaf(gene name synonym)|uniprotkb:dapaf-1(gene name synonym)|uniprotkb:dapaf-1S(gene name synonym)|uniprotkb:dark(gene name synonym)|uniprotkb:hac-1(gene name synonym)|uniprotkb:hac1(gene name synonym)|uniprotkb:"l(2)SH0173"(gene name synonym)|uniprotkb:CG6829(orf name)|uniprotkb:Dmel_CG6829(orf name)|uniprotkb:Apaf(gene name synonym)	psi-mi:q7kli1_drome(display_long)|uniprotkb:Dark(gene name)|psi-mi:Dark(display_short)|uniprotkb:Ark(gene name synonym)|uniprotkb:Ark-RB(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:dapaf-1L(gene name synonym)|uniprotkb:APAF-1(gene name synonym)|uniprotkb:APAF1(gene name synonym)|uniprotkb:ARK(gene name synonym)|uniprotkb:Apaf-1(gene name synonym)|uniprotkb:Apaf-I(gene name synonym)|uniprotkb:Apaf1(gene name synonym)|uniprotkb:D-Apaf-1(gene name synonym)|uniprotkb:DARK(gene name synonym)|uniprotkb:Dapaf-1(gene name synonym)|uniprotkb:Dmel\CG6829(gene name synonym)|uniprotkb:HAC-1(gene name synonym)|uniprotkb:HAC1(gene name synonym)|uniprotkb:Hac-1(gene name synonym)|uniprotkb:T1(gene name synonym)|uniprotkb:anon-53Fa(gene name synonym)|uniprotkb:apaf-1(gene name synonym)|uniprotkb:apaf1(gene name synonym)|uniprotkb:arc(gene name synonym)|uniprotkb:ark(gene name synonym)|uniprotkb:dAPAF-1(gene name synonym)|uniprotkb:dApaf-1(gene name synonym)|uniprotkb:dApaf1(gene name synonym)|uniprotkb:dArk(gene name synonym)|uniprotkb:dapaf(gene name synonym)|uniprotkb:dapaf-1(gene name synonym)|uniprotkb:dapaf-1S(gene name synonym)|uniprotkb:dark(gene name synonym)|uniprotkb:hac-1(gene name synonym)|uniprotkb:hac1(gene name synonym)|uniprotkb:"l(2)SH0173"(gene name synonym)|uniprotkb:CG6829(orf name)|uniprotkb:Dmel_CG6829(orf name)|uniprotkb:Apaf(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Yuan et al. (2011)	pubmed:21220123|doi:10.1016/j.str.2010.10.009|imex:IM-16137	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15904236|imex:IM-16137-1|dip:DIP-187069E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0263864(gene)|ensemblmetazoa:FBtr0086968(transcript)|go:"GO:0002921"(negative regulation of humoral immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0012501"(programmed cell death)|go:"GO:0021556"(central nervous system formation)|go:"GO:0022416"(chaeta development)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043531"(ADP binding)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901053"(sarcosine catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|interpro:IPR036388|rcsb pdb:3J9K|rcsb pdb:3J9L|rcsb pdb:4V4L|rcsb pdb:5JUL|flybase:FBgn0263864|refseq:NP_725637.1	ensemblmetazoa:FBgn0263864(gene)|ensemblmetazoa:FBtr0086968(transcript)|go:"GO:0002921"(negative regulation of humoral immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0012501"(programmed cell death)|go:"GO:0021556"(central nervous system formation)|go:"GO:0022416"(chaeta development)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043531"(ADP binding)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901053"(sarcosine catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|interpro:IPR036388|rcsb pdb:3J9K|rcsb pdb:3J9L|rcsb pdb:4V4L|rcsb pdb:5JUL|flybase:FBgn0263864|refseq:NP_725637.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:oX7ecezYeP4wxL1mtHP4lvmzEtY7227	rogid:oX7ecezYeP4wxL1mtHP4lvmzEtY7227	rigid:asTCkI0/3Ti9jv0JpSQrpP401vg	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7KLI1	uniprotkb:Q7KLI1	intact:EBI-3404349|ensemblmetazoa:FBpp0086122	intact:EBI-3404349|ensemblmetazoa:FBpp0086122	psi-mi:q7kli1_drome(display_long)|uniprotkb:Dark(gene name)|psi-mi:Dark(display_short)|uniprotkb:Ark(gene name synonym)|uniprotkb:Ark-RB(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:dapaf-1L(gene name synonym)|uniprotkb:APAF-1(gene name synonym)|uniprotkb:APAF1(gene name synonym)|uniprotkb:ARK(gene name synonym)|uniprotkb:Apaf-1(gene name synonym)|uniprotkb:Apaf-I(gene name synonym)|uniprotkb:Apaf1(gene name synonym)|uniprotkb:D-Apaf-1(gene name synonym)|uniprotkb:DARK(gene name synonym)|uniprotkb:Dapaf-1(gene name synonym)|uniprotkb:Dmel\CG6829(gene name synonym)|uniprotkb:HAC-1(gene name synonym)|uniprotkb:HAC1(gene name synonym)|uniprotkb:Hac-1(gene name synonym)|uniprotkb:T1(gene name synonym)|uniprotkb:anon-53Fa(gene name synonym)|uniprotkb:apaf-1(gene name synonym)|uniprotkb:apaf1(gene name synonym)|uniprotkb:arc(gene name synonym)|uniprotkb:ark(gene name synonym)|uniprotkb:dAPAF-1(gene name synonym)|uniprotkb:dApaf-1(gene name synonym)|uniprotkb:dApaf1(gene name synonym)|uniprotkb:dArk(gene name synonym)|uniprotkb:dapaf(gene name synonym)|uniprotkb:dapaf-1(gene name synonym)|uniprotkb:dapaf-1S(gene name synonym)|uniprotkb:dark(gene name synonym)|uniprotkb:hac-1(gene name synonym)|uniprotkb:hac1(gene name synonym)|uniprotkb:"l(2)SH0173"(gene name synonym)|uniprotkb:CG6829(orf name)|uniprotkb:Dmel_CG6829(orf name)|uniprotkb:Apaf(gene name synonym)	psi-mi:q7kli1_drome(display_long)|uniprotkb:Dark(gene name)|psi-mi:Dark(display_short)|uniprotkb:Ark(gene name synonym)|uniprotkb:Ark-RB(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:dapaf-1L(gene name synonym)|uniprotkb:APAF-1(gene name synonym)|uniprotkb:APAF1(gene name synonym)|uniprotkb:ARK(gene name synonym)|uniprotkb:Apaf-1(gene name synonym)|uniprotkb:Apaf-I(gene name synonym)|uniprotkb:Apaf1(gene name synonym)|uniprotkb:D-Apaf-1(gene name synonym)|uniprotkb:DARK(gene name synonym)|uniprotkb:Dapaf-1(gene name synonym)|uniprotkb:Dmel\CG6829(gene name synonym)|uniprotkb:HAC-1(gene name synonym)|uniprotkb:HAC1(gene name synonym)|uniprotkb:Hac-1(gene name synonym)|uniprotkb:T1(gene name synonym)|uniprotkb:anon-53Fa(gene name synonym)|uniprotkb:apaf-1(gene name synonym)|uniprotkb:apaf1(gene name synonym)|uniprotkb:arc(gene name synonym)|uniprotkb:ark(gene name synonym)|uniprotkb:dAPAF-1(gene name synonym)|uniprotkb:dApaf-1(gene name synonym)|uniprotkb:dApaf1(gene name synonym)|uniprotkb:dArk(gene name synonym)|uniprotkb:dapaf(gene name synonym)|uniprotkb:dapaf-1(gene name synonym)|uniprotkb:dapaf-1S(gene name synonym)|uniprotkb:dark(gene name synonym)|uniprotkb:hac-1(gene name synonym)|uniprotkb:hac1(gene name synonym)|uniprotkb:"l(2)SH0173"(gene name synonym)|uniprotkb:CG6829(orf name)|uniprotkb:Dmel_CG6829(orf name)|uniprotkb:Apaf(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Yuan et al. (2011)	pubmed:21220123|doi:10.1016/j.str.2010.10.009|imex:IM-16137	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15904253|imex:IM-16137-2|dip:DIP-187069E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0263864(gene)|ensemblmetazoa:FBtr0086968(transcript)|go:"GO:0002921"(negative regulation of humoral immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0012501"(programmed cell death)|go:"GO:0021556"(central nervous system formation)|go:"GO:0022416"(chaeta development)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043531"(ADP binding)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901053"(sarcosine catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|interpro:IPR036388|rcsb pdb:3J9K|rcsb pdb:3J9L|rcsb pdb:4V4L|rcsb pdb:5JUL|flybase:FBgn0263864|refseq:NP_725637.1	ensemblmetazoa:FBgn0263864(gene)|ensemblmetazoa:FBtr0086968(transcript)|go:"GO:0002921"(negative regulation of humoral immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0012501"(programmed cell death)|go:"GO:0021556"(central nervous system formation)|go:"GO:0022416"(chaeta development)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043531"(ADP binding)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901053"(sarcosine catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|interpro:IPR036388|rcsb pdb:3J9K|rcsb pdb:3J9L|rcsb pdb:4V4L|rcsb pdb:5JUL|flybase:FBgn0263864|refseq:NP_725637.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:oX7ecezYeP4wxL1mtHP4lvmzEtY7227	rogid:oX7ecezYeP4wxL1mtHP4lvmzEtY7227	rigid:asTCkI0/3Ti9jv0JpSQrpP401vg	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XYF4	uniprotkb:Q7KLI1	intact:EBI-108311|ensemblmetazoa:FBpp0076076	intact:EBI-3404349|ensemblmetazoa:FBpp0086122	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:q7kli1_drome(display_long)|uniprotkb:Dark(gene name)|psi-mi:Dark(display_short)|uniprotkb:Ark(gene name synonym)|uniprotkb:Ark-RB(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:dapaf-1L(gene name synonym)|uniprotkb:APAF-1(gene name synonym)|uniprotkb:APAF1(gene name synonym)|uniprotkb:ARK(gene name synonym)|uniprotkb:Apaf-1(gene name synonym)|uniprotkb:Apaf-I(gene name synonym)|uniprotkb:Apaf1(gene name synonym)|uniprotkb:D-Apaf-1(gene name synonym)|uniprotkb:DARK(gene name synonym)|uniprotkb:Dapaf-1(gene name synonym)|uniprotkb:Dmel\CG6829(gene name synonym)|uniprotkb:HAC-1(gene name synonym)|uniprotkb:HAC1(gene name synonym)|uniprotkb:Hac-1(gene name synonym)|uniprotkb:T1(gene name synonym)|uniprotkb:anon-53Fa(gene name synonym)|uniprotkb:apaf-1(gene name synonym)|uniprotkb:apaf1(gene name synonym)|uniprotkb:arc(gene name synonym)|uniprotkb:ark(gene name synonym)|uniprotkb:dAPAF-1(gene name synonym)|uniprotkb:dApaf-1(gene name synonym)|uniprotkb:dApaf1(gene name synonym)|uniprotkb:dArk(gene name synonym)|uniprotkb:dapaf(gene name synonym)|uniprotkb:dapaf-1(gene name synonym)|uniprotkb:dapaf-1S(gene name synonym)|uniprotkb:dark(gene name synonym)|uniprotkb:hac-1(gene name synonym)|uniprotkb:hac1(gene name synonym)|uniprotkb:"l(2)SH0173"(gene name synonym)|uniprotkb:CG6829(orf name)|uniprotkb:Dmel_CG6829(orf name)|uniprotkb:Apaf(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Yuan et al. (2011)	pubmed:21220123|doi:10.1016/j.str.2010.10.009|imex:IM-16137	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15904269|imex:IM-16137-3|dip:DIP-187070E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836	ensemblmetazoa:FBgn0263864(gene)|ensemblmetazoa:FBtr0086968(transcript)|go:"GO:0002921"(negative regulation of humoral immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0012501"(programmed cell death)|go:"GO:0021556"(central nervous system formation)|go:"GO:0022416"(chaeta development)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043531"(ADP binding)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901053"(sarcosine catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|interpro:IPR036388|rcsb pdb:3J9K|rcsb pdb:3J9L|rcsb pdb:4V4L|rcsb pdb:5JUL|flybase:FBgn0263864|refseq:NP_725637.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	rogid:oX7ecezYeP4wxL1mtHP4lvmzEtY7227	rigid:39MR9SgQ+PsRHwkukDAvbsTTI0U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XYF4	uniprotkb:Q7KLI1	intact:EBI-108311|ensemblmetazoa:FBpp0076076	intact:EBI-3404349|ensemblmetazoa:FBpp0086122	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:q7kli1_drome(display_long)|uniprotkb:Dark(gene name)|psi-mi:Dark(display_short)|uniprotkb:Ark(gene name synonym)|uniprotkb:Ark-RB(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:dapaf-1L(gene name synonym)|uniprotkb:APAF-1(gene name synonym)|uniprotkb:APAF1(gene name synonym)|uniprotkb:ARK(gene name synonym)|uniprotkb:Apaf-1(gene name synonym)|uniprotkb:Apaf-I(gene name synonym)|uniprotkb:Apaf1(gene name synonym)|uniprotkb:D-Apaf-1(gene name synonym)|uniprotkb:DARK(gene name synonym)|uniprotkb:Dapaf-1(gene name synonym)|uniprotkb:Dmel\CG6829(gene name synonym)|uniprotkb:HAC-1(gene name synonym)|uniprotkb:HAC1(gene name synonym)|uniprotkb:Hac-1(gene name synonym)|uniprotkb:T1(gene name synonym)|uniprotkb:anon-53Fa(gene name synonym)|uniprotkb:apaf-1(gene name synonym)|uniprotkb:apaf1(gene name synonym)|uniprotkb:arc(gene name synonym)|uniprotkb:ark(gene name synonym)|uniprotkb:dAPAF-1(gene name synonym)|uniprotkb:dApaf-1(gene name synonym)|uniprotkb:dApaf1(gene name synonym)|uniprotkb:dArk(gene name synonym)|uniprotkb:dapaf(gene name synonym)|uniprotkb:dapaf-1(gene name synonym)|uniprotkb:dapaf-1S(gene name synonym)|uniprotkb:dark(gene name synonym)|uniprotkb:hac-1(gene name synonym)|uniprotkb:hac1(gene name synonym)|uniprotkb:"l(2)SH0173"(gene name synonym)|uniprotkb:CG6829(orf name)|uniprotkb:Dmel_CG6829(orf name)|uniprotkb:Apaf(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Yuan et al. (2011)	pubmed:21220123|doi:10.1016/j.str.2010.10.009|imex:IM-16137	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15904286|imex:IM-16137-4|dip:DIP-187070E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836	ensemblmetazoa:FBgn0263864(gene)|ensemblmetazoa:FBtr0086968(transcript)|go:"GO:0002921"(negative regulation of humoral immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0012501"(programmed cell death)|go:"GO:0021556"(central nervous system formation)|go:"GO:0022416"(chaeta development)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043531"(ADP binding)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901053"(sarcosine catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|interpro:IPR036388|rcsb pdb:3J9K|rcsb pdb:3J9L|rcsb pdb:4V4L|rcsb pdb:5JUL|flybase:FBgn0263864|refseq:NP_725637.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	rogid:oX7ecezYeP4wxL1mtHP4lvmzEtY7227	rigid:39MR9SgQ+PsRHwkukDAvbsTTI0U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)