#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9QZM5 refseq:NP_001101207 intact:EBI-920097|ensembl:ENSRNOP00000071079 intact:EBI-15899443|dip:DIP-60304N psi-mi:abi1_rat(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym) psi-mi:ralpha4(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ring et al. (2011) pubmed:21173240|doi:10.1073/pnas.1012316108|imex:IM-21216 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15899446|imex:IM-21216-1|dip:DIP-191124E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621008|refseq:XP_006254416.1|dip:DIP-36968N|ensembl:ENSRNOG00000031325(gene)|ensembl:ENSRNOT00000091023(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q9QZM5|reactome:R-RNO-2029482|reactome:R-RNO-4420097|reactome:R-RNO-5663213|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013423 - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/07 2017/08/10 rogid:CjsnJsS1Qxx1udsrO+knqWLXKkc10116 - - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P49023 uniprotkb:P13612 intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307 intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6 psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short) psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym) psi-mi:"MI:0096"(pull down) Ring et al. (2011) pubmed:21173240|doi:10.1073/pnas.1012316108|imex:IM-21216 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15899463|imex:IM-21216-2|dip:DIP-191126E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471 go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606 rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606 rigid:PMn+SWyL6fzUlvxIYmVipB7Gbyg false green fluorescent protein tag:n-n tag:n-n|sufficient binding region:1002-1032 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IZP0-2 uniprotkb:P13612 intact:EBI-7358775|ensembl:ENSP00000365336|intact:MINT-106659 intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6 psi-mi:q8izp0-2(display_long)|uniprotkb:B48(isoform synonym)|uniprotkb:long(isoform synonym)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:e3B1(gene name synonym) psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym) psi-mi:"MI:0096"(pull down) Ring et al. (2011) pubmed:21173240|doi:10.1073/pnas.1012316108|imex:IM-21216 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15899486|imex:IM-21216-3|dip:DIP-191125E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136754(gene)|ensembl:ENST00000376166(transcript)|intact:EBI-375446(isoform-parent) go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:1cfcWG/HNATiicu9GaGCgzqTzmE9606 rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606 rigid:TinpSPow7qsyGf/VDDKqrfubjAc false sufficient binding region:1-111|necessary binding region:1-145|green fluorescent protein tag:?-? sufficient binding region:1002-1032|tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IZP0-2 uniprotkb:P13612 intact:EBI-7358775|ensembl:ENSP00000365336|intact:MINT-106659 intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6 psi-mi:q8izp0-2(display_long)|uniprotkb:B48(isoform synonym)|uniprotkb:long(isoform synonym)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:e3B1(gene name synonym) psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym) psi-mi:"MI:0096"(pull down) Ring et al. (2011) pubmed:21173240|doi:10.1073/pnas.1012316108|imex:IM-21216 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15899515|imex:IM-21216-4|dip:DIP-191125E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136754(gene)|ensembl:ENST00000376166(transcript)|intact:EBI-375446(isoform-parent) go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:1cfcWG/HNATiicu9GaGCgzqTzmE9606 rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606 rigid:TinpSPow7qsyGf/VDDKqrfubjAc false sufficient binding region:1-111|glutathione s tranferase tag:?-? sufficient binding region:1002-1032|tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)