#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6G9L1 uniprotkb:Q6G9L1 intact:EBI-15898345 intact:EBI-15898345 psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:"MI:0071"(molecular sieving) Dorwart et al. (2010) pubmed:21151884|doi:10.1371/journal.pbio.1000555|imex:IM-15891 taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15898358|imex:IM-15891-1|dip:DIP-186260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rigid:+m9SGtge0ydV8kotc4EzhaYbRJ0 false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6G9L1 uniprotkb:Q6G9L1 intact:EBI-15898345 intact:EBI-15898345 psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:"MI:0067"(light scattering) Dorwart et al. (2010) pubmed:21151884|doi:10.1371/journal.pbio.1000555|imex:IM-15891 taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15898392|imex:IM-15891-3|dip:DIP-186260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rigid:+m9SGtge0ydV8kotc4EzhaYbRJ0 false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6G9L1 uniprotkb:Q6G9L1 intact:EBI-15898345 intact:EBI-15898345 psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:"MI:0030"(cross-linking study) Dorwart et al. (2010) pubmed:21151884|doi:10.1371/journal.pbio.1000555|imex:IM-15891 taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15898408|imex:IM-15891-4|dip:DIP-186260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rigid:+m9SGtge0ydV8kotc4EzhaYbRJ0 false his tag:c-c|mutation:91-91,10-10 his tag:c-c|mutation:91-91,10-10 - 0 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6G9L1 uniprotkb:Q6G9L1 intact:EBI-15898345 intact:EBI-15898345 psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:"MI:0028"(cosedimentation in solution) Dorwart et al. (2010) pubmed:21151884|doi:10.1371/journal.pbio.1000555|imex:IM-15891 taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15898430|imex:IM-15891-5|dip:DIP-186260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rigid:+m9SGtge0ydV8kotc4EzhaYbRJ0 false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6G9L1 uniprotkb:Q6G9L1 intact:EBI-15898345 intact:EBI-15898345 psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:"MI:0030"(cross-linking study) Dorwart et al. (2010) pubmed:21151884|doi:10.1371/journal.pbio.1000555|imex:IM-15891 taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15898446|imex:IM-15891-6|dip:DIP-186260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rigid:+m9SGtge0ydV8kotc4EzhaYbRJ0 false his tag:c-c|mutation:90-90,10-10 his tag:c-c|mutation:90-90,10-10 - 0 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6G9L1 uniprotkb:Q6G9L1 intact:EBI-15898345 intact:EBI-15898345 psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:mscl_staas(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:SAS1287(locus name) psi-mi:"MI:0030"(cross-linking study) Dorwart et al. (2010) pubmed:21151884|doi:10.1371/journal.pbio.1000555|imex:IM-15891 taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") taxid:282459(staas)|taxid:282459("Staphylococcus aureus (strain MSSA476)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15898374|imex:IM-15891-2|dip:DIP-186260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|refseq:WP_000910489.1|dip:DIP-58957N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rogid:wyXnyPu9IJBIwVqQS+xOCTlZ5TA282459 rigid:+m9SGtge0ydV8kotc4EzhaYbRJ0 false his tag:c-c his tag:c-c - 0 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P0A742 uniprotkb:P0A742 intact:EBI-909797|ensemblbacteria:AAC76316|ensemblbacteria:BAE78001|uniprotkb:P23867|uniprotkb:Q2M6V5 intact:EBI-909797|ensemblbacteria:AAC76316|ensemblbacteria:BAE78001|uniprotkb:P23867|uniprotkb:Q2M6V5 psi-mi:mscl_ecoli(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:b3291(locus name)|uniprotkb:JW3252(locus name)|uniprotkb:yhdC(gene name synonym) psi-mi:mscl_ecoli(display_long)|uniprotkb:mscL(gene name)|psi-mi:mscL(display_short)|uniprotkb:b3291(locus name)|uniprotkb:JW3252(locus name)|uniprotkb:yhdC(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Dorwart et al. (2010) pubmed:21151884|doi:10.1371/journal.pbio.1000555|imex:IM-15891 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15898468|imex:IM-15891-7|dip:DIP-59313E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006811"(ion transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|ensemblbacteria:AAC76316(transcript)|ensemblbacteria:b3291(gene)|ensemblbacteria:BAE78001(gene)|ensemblbacteria:BAE78001(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|rcsb pdb:1KYK|rcsb pdb:1KYL|rcsb pdb:1KYM|rcsb pdb:4LKU|refseq:NP_417749.1|refseq:WP_000022442.1|dip:DIP-29827N go:"GO:0006811"(ion transport)|go:"GO:0008381"(mechanosensitive ion channel activity)|ensemblbacteria:AAC76316(transcript)|ensemblbacteria:b3291(gene)|ensemblbacteria:BAE78001(gene)|ensemblbacteria:BAE78001(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|interpro:IPR001185(Large-conductance mechanosensitive channel)|interpro:IPR019823|interpro:IPR036019|interpro:IPR037673|rcsb pdb:1KYK|rcsb pdb:1KYL|rcsb pdb:1KYM|rcsb pdb:4LKU|refseq:NP_417749.1|refseq:WP_000022442.1|dip:DIP-29827N psi-mi:"MI:0465"(dip) crc64:18EF7E1BD7DF9491 crc64:18EF7E1BD7DF9491 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:NZFN3l8Q4V5JlMg2ePALtfc/5/c83333 rogid:NZFN3l8Q4V5JlMg2ePALtfc/5/c83333 rigid:PLszzM/ba9zcNqtr7xt9GHHdvGg false his tag:c-c his tag:c-c - 0 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)