#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9WVK4	uniprotkb:Q80VP1	intact:EBI-8321414|intact:MINT-1863155|ensembl:ENSMUSP00000025684	intact:EBI-7068702|ensembl:ENSMUSP00000043340|ensembl:ENSMUSP00000096445|uniprotkb:Q6NX78|uniprotkb:O70446|intact:MINT-4094555	psi-mi:ehd1_mouse(display_long)|uniprotkb:Ehd1(gene name)|psi-mi:Ehd1(display_short)|uniprotkb:Past1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym)	psi-mi:epn1_mouse(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:Intersectin-EH-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ko et al. (2010)	pubmed:21115825|doi:10.1073/pnas.1016390107|imex:IM-17149	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15895272|imex:IM-17149-1|dip:DIP-188144E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034249.1|dip:DIP-59491N|ensembl:ENSMUSG00000024772(gene)|ensembl:ENSMUST00000025684(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9WVK4|reactome:R-MMU-983231	refseq:XP_006539592.2|refseq:XP_006539594.2|refseq:XP_006539596.1|refseq:XP_006539597.1|refseq:XP_006539598.1|refseq:XP_006539599.1|ensembl:ENSMUSG00000035203(gene)|ensembl:ENSMUST00000045277(transcript)|ensembl:ENSMUST00000098845(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q80VP1|reactome:R-MMU-182971|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_034277.1|refseq:NP_001239383.1|dip:DIP-43943N	psi-mi:"MI:0465"(dip)	comment:mint|function:Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eI3lDw0K5kWK6+oxA8kBTDydHs10090	rogid:M0Wyq39dW71X3O9oW8sRBZLvkuU10090	rigid:j5DC9bphVxPePCPgNBL9MOv2r8o	false	binding-associated region:439-534|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVK4	uniprotkb:Q91W69	intact:EBI-8321414|intact:MINT-1863155|ensembl:ENSMUSP00000025684	intact:EBI-15895244|ensembl:ENSMUSP00000121390|uniprotkb:Q9CV55	psi-mi:ehd1_mouse(display_long)|uniprotkb:Ehd1(gene name)|psi-mi:Ehd1(display_short)|uniprotkb:Past1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym)	psi-mi:epn3_mouse(display_long)|uniprotkb:Epn3(gene name)|psi-mi:Epn3(display_short)|uniprotkb:EPS-15-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ko et al. (2010)	pubmed:21115825|doi:10.1073/pnas.1016390107|imex:IM-17149	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15895272|imex:IM-17149-1|dip:DIP-188144E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034249.1|dip:DIP-59491N|ensembl:ENSMUSG00000024772(gene)|ensembl:ENSMUST00000025684(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9WVK4|reactome:R-MMU-983231	ensembl:ENSMUSG00000010080(gene)|ensembl:ENSMUST00000127305(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1990175"(EH domain binding)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR027318|interpro:IPR013809(Epsin-like, N-terminal)|refseq:NP_082260.1|refseq:XP_006534329.1|dip:DIP-59492N	psi-mi:"MI:0465"(dip)	comment:mint|function:Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eI3lDw0K5kWK6+oxA8kBTDydHs10090	rogid:iApaZuBKb8bJs94yIn1slc2fuwc10090	rigid:j5DC9bphVxPePCPgNBL9MOv2r8o	false	binding-associated region:439-534|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42566-1	uniprotkb:Q80VP1	intact:EBI-15895294|ensembl:ENSP00000360798	intact:EBI-7068702|ensembl:ENSMUSP00000043340|ensembl:ENSMUSP00000096445|uniprotkb:Q6NX78|uniprotkb:O70446|intact:MINT-4094555	psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym)	psi-mi:epn1_mouse(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:Intersectin-EH-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ko et al. (2010)	pubmed:21115825|doi:10.1073/pnas.1016390107|imex:IM-17149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15895302|imex:IM-17149-2|dip:DIP-188146E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent)	refseq:XP_006539592.2|refseq:XP_006539594.2|refseq:XP_006539596.1|refseq:XP_006539597.1|refseq:XP_006539598.1|refseq:XP_006539599.1|ensembl:ENSMUSG00000035203(gene)|ensembl:ENSMUST00000045277(transcript)|ensembl:ENSMUST00000098845(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q80VP1|reactome:R-MMU-182971|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_034277.1|refseq:NP_001239383.1|dip:DIP-43943N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606	rogid:M0Wyq39dW71X3O9oW8sRBZLvkuU10090	rigid:CmD77MygLu5j5wPrW+tgwF+v+pE	false	binding-associated region:15-314|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42566-1	uniprotkb:Q91W69	intact:EBI-15895294|ensembl:ENSP00000360798	intact:EBI-15895244|ensembl:ENSMUSP00000121390|uniprotkb:Q9CV55	psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym)	psi-mi:epn3_mouse(display_long)|uniprotkb:Epn3(gene name)|psi-mi:Epn3(display_short)|uniprotkb:EPS-15-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ko et al. (2010)	pubmed:21115825|doi:10.1073/pnas.1016390107|imex:IM-17149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15895302|imex:IM-17149-2|dip:DIP-188146E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent)	ensembl:ENSMUSG00000010080(gene)|ensembl:ENSMUST00000127305(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1990175"(EH domain binding)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR027318|interpro:IPR013809(Epsin-like, N-terminal)|refseq:NP_082260.1|refseq:XP_006534329.1|dip:DIP-59492N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606	rogid:iApaZuBKb8bJs94yIn1slc2fuwc10090	rigid:CmD77MygLu5j5wPrW+tgwF+v+pE	false	binding-associated region:15-314|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BH64	uniprotkb:Q80VP1	intact:EBI-1994334|uniprotkb:Q8BL28|ensembl:ENSMUSP00000096397	intact:EBI-7068702|ensembl:ENSMUSP00000043340|ensembl:ENSMUSP00000096445|uniprotkb:Q6NX78|uniprotkb:O70446|intact:MINT-4094555	psi-mi:ehd2_mouse(display_long)|uniprotkb:Ehd2(gene name)|psi-mi:Ehd2(display_short)	psi-mi:epn1_mouse(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:Intersectin-EH-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ko et al. (2010)	pubmed:21115825|doi:10.1073/pnas.1016390107|imex:IM-17149	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15895326|imex:IM-17149-3|dip:DIP-188145E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011248884.1|refseq:NP_694708.2|dip:DIP-46806N|ensembl:ENSMUSG00000074364(gene)|ensembl:ENSMUST00000098799(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029945|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|rcsb pdb:2QPT|rcsb pdb:4CID|reactome:R-MMU-983231	refseq:XP_006539592.2|refseq:XP_006539594.2|refseq:XP_006539596.1|refseq:XP_006539597.1|refseq:XP_006539598.1|refseq:XP_006539599.1|ensembl:ENSMUSG00000035203(gene)|ensembl:ENSMUST00000045277(transcript)|ensembl:ENSMUST00000098845(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q80VP1|reactome:R-MMU-182971|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_034277.1|refseq:NP_001239383.1|dip:DIP-43943N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:Y6gH2n3nnVFeqaZE0T6T2gGqtyw10090	rogid:M0Wyq39dW71X3O9oW8sRBZLvkuU10090	rigid:CZpNFfo+i06L8QKFW0B9eNqi/Ro	false	glutathione s tranferase tag:n-n|binding-associated region:444-543	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BH64	uniprotkb:Q91W69	intact:EBI-1994334|uniprotkb:Q8BL28|ensembl:ENSMUSP00000096397	intact:EBI-15895244|ensembl:ENSMUSP00000121390|uniprotkb:Q9CV55	psi-mi:ehd2_mouse(display_long)|uniprotkb:Ehd2(gene name)|psi-mi:Ehd2(display_short)	psi-mi:epn3_mouse(display_long)|uniprotkb:Epn3(gene name)|psi-mi:Epn3(display_short)|uniprotkb:EPS-15-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ko et al. (2010)	pubmed:21115825|doi:10.1073/pnas.1016390107|imex:IM-17149	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15895326|imex:IM-17149-3|dip:DIP-188145E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011248884.1|refseq:NP_694708.2|dip:DIP-46806N|ensembl:ENSMUSG00000074364(gene)|ensembl:ENSMUST00000098799(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029945|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|rcsb pdb:2QPT|rcsb pdb:4CID|reactome:R-MMU-983231	ensembl:ENSMUSG00000010080(gene)|ensembl:ENSMUST00000127305(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1990175"(EH domain binding)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR027318|interpro:IPR013809(Epsin-like, N-terminal)|refseq:NP_082260.1|refseq:XP_006534329.1|dip:DIP-59492N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:Y6gH2n3nnVFeqaZE0T6T2gGqtyw10090	rogid:iApaZuBKb8bJs94yIn1slc2fuwc10090	rigid:CZpNFfo+i06L8QKFW0B9eNqi/Ro	false	glutathione s tranferase tag:n-n|binding-associated region:444-543	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)