#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63000-1 uniprotkb:Q9Y2A7 intact:EBI-7212896|uniprotkb:P15154-1|intact:MINT-124079|ensembl:ENSP00000258737 intact:EBI-389845|uniprotkb:O60329|uniprotkb:Q53QN5|uniprotkb:Q53S94|uniprotkb:Q53Y35|ensembl:ENSP00000355348 psi-mi:p63000-1(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:TC25(gene name synonym)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:MIG5(orf name)|uniprotkb:Rac1A(isoform synonym) psi-mi:nckp1_human(display_long)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym) psi-mi:"MI:0096"(pull down) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15894549|imex:IM-21510-1|dip:DIP-103067E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-413628(isoform-parent)|ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript) refseq:NP_038464.1|refseq:NP_995314.1|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:Q9Y2A7|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|dip:DIP-31119N psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606 rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606 rigid:7uj6VTjQP+pDWfEZ5DHMqB/4cJ0 false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P63000-1 uniprotkb:Q7L576 intact:EBI-7212896|uniprotkb:P15154-1|intact:MINT-124079|ensembl:ENSP00000258737 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:p63000-1(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:TC25(gene name synonym)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:MIG5(orf name)|uniprotkb:Rac1A(isoform synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0096"(pull down) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15894549|imex:IM-21510-1|dip:DIP-103067E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-413628(isoform-parent)|ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript) refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rigid:7uj6VTjQP+pDWfEZ5DHMqB/4cJ0 false glutathione s tranferase tag:n-n mutation disrupting interaction:179-179|mutation disrupting interaction:190-190|mutation decreasing interaction:626-626,434-434|mutation decreasing interaction:632-632 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9NYB9 uniprotkb:Q8WUW1 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-2837444|uniprotkb:Q9P082|uniprotkb:B2R5E2|ensembl:ENSP00000432472 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:brk1_human(display_long)|uniprotkb:C3orf10(gene name synonym)|uniprotkb:BRK1(gene name)|psi-mi:BRK1(display_short)|uniprotkb:HSPC300(orf name)|uniprotkb:MDS027(orf name) psi-mi:"MI:0114"(x-ray crystallography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894605|imex:IM-21510-3|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_060932.2|dip:DIP-41554N|ensembl:ENSG00000254999(gene)|ensembl:ENST00000530758(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:IZ0oK9Z3VxULlM+igusbB5mwyyo9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q7L576 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894605|imex:IM-21510-3|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q9Y2A7 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-389845|uniprotkb:O60329|uniprotkb:Q53QN5|uniprotkb:Q53S94|uniprotkb:Q53Y35|ensembl:ENSP00000355348 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:nckp1_human(display_long)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894605|imex:IM-21510-3|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_038464.1|refseq:NP_995314.1|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:Q9Y2A7|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|dip:DIP-31119N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q92558 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1548747|uniprotkb:E1P5F2|uniprotkb:Q5SZK7|ensembl:ENSP00000352425|ensembl:ENSP00000376365|ensembl:ENSP00000376366|ensembl:ENSP00000376367|ensembl:ENSP00000376368 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:wasf1_human(display_long)|uniprotkb:WASF1(gene name)|psi-mi:WASF1(display_short)|uniprotkb:KIAA0269(gene name synonym)|uniprotkb:SCAR1(gene name synonym)|uniprotkb:WAVE1(gene name synonym)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894605|imex:IM-21510-3|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001020105.1|refseq:NP_001020106.1|refseq:NP_001020107.1|refseq:NP_003922.1|refseq:XP_011534535.1|refseq:XP_011534536.1|refseq:XP_016866926.1|refseq:XP_016866927.1|refseq:XP_005267260.1|refseq:XP_005267262.1|refseq:XP_005267263.1|refseq:XP_005267264.1|dip:DIP-39391N|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000112290(gene)|ensembl:ENST00000359451(transcript)|ensembl:ENST00000392586(transcript)|ensembl:ENST00000392587(transcript)|ensembl:ENST00000392588(transcript)|ensembl:ENST00000392589(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q92558|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:kDHL44b54o8tE3+OR+M2CC6zi/k9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 binding-associated region:485-559,1-186 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q8WUW1 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-2837444|uniprotkb:Q9P082|uniprotkb:B2R5E2|ensembl:ENSP00000432472 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:brk1_human(display_long)|uniprotkb:C3orf10(gene name synonym)|uniprotkb:BRK1(gene name)|psi-mi:BRK1(display_short)|uniprotkb:HSPC300(orf name)|uniprotkb:MDS027(orf name) psi-mi:"MI:0226"(ion exchange chromatography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894582|imex:IM-21510-2|dip:DIP-103065E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_060932.2|dip:DIP-41554N|ensembl:ENSG00000254999(gene)|ensembl:ENST00000530758(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:IZ0oK9Z3VxULlM+igusbB5mwyyo9606 rigid:I9UVsd+hfe7smfJIkAOoKcH6HNM false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q92558 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1548747|uniprotkb:E1P5F2|uniprotkb:Q5SZK7|ensembl:ENSP00000352425|ensembl:ENSP00000376365|ensembl:ENSP00000376366|ensembl:ENSP00000376367|ensembl:ENSP00000376368 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:wasf1_human(display_long)|uniprotkb:WASF1(gene name)|psi-mi:WASF1(display_short)|uniprotkb:KIAA0269(gene name synonym)|uniprotkb:SCAR1(gene name synonym)|uniprotkb:WAVE1(gene name synonym)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 1(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894582|imex:IM-21510-2|dip:DIP-103065E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001020105.1|refseq:NP_001020106.1|refseq:NP_001020107.1|refseq:NP_003922.1|refseq:XP_011534535.1|refseq:XP_011534536.1|refseq:XP_016866926.1|refseq:XP_016866927.1|refseq:XP_005267260.1|refseq:XP_005267262.1|refseq:XP_005267263.1|refseq:XP_005267264.1|dip:DIP-39391N|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000112290(gene)|ensembl:ENST00000359451(transcript)|ensembl:ENST00000392586(transcript)|ensembl:ENST00000392587(transcript)|ensembl:ENST00000392588(transcript)|ensembl:ENST00000392589(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q92558|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:kDHL44b54o8tE3+OR+M2CC6zi/k9606 rigid:I9UVsd+hfe7smfJIkAOoKcH6HNM false binding-associated region:1-158 binding-associated region:1-154 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q8WUW1 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-2837444|uniprotkb:Q9P082|uniprotkb:B2R5E2|ensembl:ENSP00000432472 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:brk1_human(display_long)|uniprotkb:C3orf10(gene name synonym)|uniprotkb:BRK1(gene name)|psi-mi:BRK1(display_short)|uniprotkb:HSPC300(orf name)|uniprotkb:MDS027(orf name) psi-mi:"MI:0226"(ion exchange chromatography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894630|imex:IM-21510-4|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_060932.2|dip:DIP-41554N|ensembl:ENSG00000254999(gene)|ensembl:ENST00000530758(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:IZ0oK9Z3VxULlM+igusbB5mwyyo9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q7L576 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894630|imex:IM-21510-4|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q9Y2A7 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-389845|uniprotkb:O60329|uniprotkb:Q53QN5|uniprotkb:Q53S94|uniprotkb:Q53Y35|ensembl:ENSP00000355348 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:nckp1_human(display_long)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894630|imex:IM-21510-4|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_038464.1|refseq:NP_995314.1|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:Q9Y2A7|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|dip:DIP-31119N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q92558 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1548747|uniprotkb:E1P5F2|uniprotkb:Q5SZK7|ensembl:ENSP00000352425|ensembl:ENSP00000376365|ensembl:ENSP00000376366|ensembl:ENSP00000376367|ensembl:ENSP00000376368 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:wasf1_human(display_long)|uniprotkb:WASF1(gene name)|psi-mi:WASF1(display_short)|uniprotkb:KIAA0269(gene name synonym)|uniprotkb:SCAR1(gene name synonym)|uniprotkb:WAVE1(gene name synonym)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 1(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894630|imex:IM-21510-4|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001020105.1|refseq:NP_001020106.1|refseq:NP_001020107.1|refseq:NP_003922.1|refseq:XP_011534535.1|refseq:XP_011534536.1|refseq:XP_016866926.1|refseq:XP_016866927.1|refseq:XP_005267260.1|refseq:XP_005267262.1|refseq:XP_005267263.1|refseq:XP_005267264.1|dip:DIP-39391N|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000112290(gene)|ensembl:ENST00000359451(transcript)|ensembl:ENST00000392586(transcript)|ensembl:ENST00000392587(transcript)|ensembl:ENST00000392588(transcript)|ensembl:ENST00000392589(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q92558|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:kDHL44b54o8tE3+OR+M2CC6zi/k9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 binding-associated region:1-154 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q8WUW1 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-2837444|uniprotkb:Q9P082|uniprotkb:B2R5E2|ensembl:ENSP00000432472 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:brk1_human(display_long)|uniprotkb:C3orf10(gene name synonym)|uniprotkb:BRK1(gene name)|psi-mi:BRK1(display_short)|uniprotkb:HSPC300(orf name)|uniprotkb:MDS027(orf name) psi-mi:"MI:0020"(transmission electron microscopy) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894706|imex:IM-21510-7|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_060932.2|dip:DIP-41554N|ensembl:ENSG00000254999(gene)|ensembl:ENST00000530758(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:IZ0oK9Z3VxULlM+igusbB5mwyyo9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q7L576 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894706|imex:IM-21510-7|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q9Y2A7 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-389845|uniprotkb:O60329|uniprotkb:Q53QN5|uniprotkb:Q53S94|uniprotkb:Q53Y35|ensembl:ENSP00000355348 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:nckp1_human(display_long)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894706|imex:IM-21510-7|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_038464.1|refseq:NP_995314.1|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:Q9Y2A7|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|dip:DIP-31119N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q92558 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1548747|uniprotkb:E1P5F2|uniprotkb:Q5SZK7|ensembl:ENSP00000352425|ensembl:ENSP00000376365|ensembl:ENSP00000376366|ensembl:ENSP00000376367|ensembl:ENSP00000376368 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:wasf1_human(display_long)|uniprotkb:WASF1(gene name)|psi-mi:WASF1(display_short)|uniprotkb:KIAA0269(gene name synonym)|uniprotkb:SCAR1(gene name synonym)|uniprotkb:WAVE1(gene name synonym)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 1(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894706|imex:IM-21510-7|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001020105.1|refseq:NP_001020106.1|refseq:NP_001020107.1|refseq:NP_003922.1|refseq:XP_011534535.1|refseq:XP_011534536.1|refseq:XP_016866926.1|refseq:XP_016866927.1|refseq:XP_005267260.1|refseq:XP_005267262.1|refseq:XP_005267263.1|refseq:XP_005267264.1|dip:DIP-39391N|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000112290(gene)|ensembl:ENST00000359451(transcript)|ensembl:ENST00000392586(transcript)|ensembl:ENST00000392587(transcript)|ensembl:ENST00000392588(transcript)|ensembl:ENST00000392589(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q92558|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:kDHL44b54o8tE3+OR+M2CC6zi/k9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 binding-associated region:485-559,1-186 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y6W5 uniprotkb:Q9Y2A7 intact:EBI-4290615|uniprotkb:O60794|uniprotkb:Q9UDY7|intact:EBI-28973998|ensembl:ENSP00000483313|uniprotkb:B4DZN0 intact:EBI-389845|uniprotkb:O60329|uniprotkb:Q53QN5|uniprotkb:Q53S94|uniprotkb:Q53Y35|ensembl:ENSP00000355348 psi-mi:wasf2_human(display_long)|uniprotkb:WASF2(gene name)|psi-mi:WASF2(display_short)|uniprotkb:WAVE2(gene name synonym)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 2(gene name synonym) psi-mi:nckp1_human(display_long)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15894678|imex:IM-21510-6|dip:DIP-191814E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008921.1|ensembl:ENST00000536657|ensembl:ENSP00000439883|ensembl:ENSP00000483313|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q9Y6W5|rcsb pdb:2A40|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|ensembl:ENSG00000158195(gene)|ensembl:ENST00000618852(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|refseq:NP_001188333.1|dip:DIP-41817N refseq:NP_038464.1|refseq:NP_995314.1|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:Q9Y2A7|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|dip:DIP-31119N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:lRPT4syjPdKz2JoqWQQm3xw4hWc9606 rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606 rigid:Qo0FiU40hcrG9uFBCLrYT80DDXs false mutation disrupting interaction:51-51,40-40|mutation disrupting interaction:54-54,50-50|ha tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Y6W5 uniprotkb:Q7L576 intact:EBI-4290615|uniprotkb:O60794|uniprotkb:Q9UDY7|intact:EBI-28973998|ensembl:ENSP00000483313|uniprotkb:B4DZN0 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:wasf2_human(display_long)|uniprotkb:WASF2(gene name)|psi-mi:WASF2(display_short)|uniprotkb:WAVE2(gene name synonym)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 2(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15894678|imex:IM-21510-6|dip:DIP-191814E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008921.1|ensembl:ENST00000536657|ensembl:ENSP00000439883|ensembl:ENSP00000483313|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q9Y6W5|rcsb pdb:2A40|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|ensembl:ENSG00000158195(gene)|ensembl:ENST00000618852(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|refseq:NP_001188333.1|dip:DIP-41817N refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:lRPT4syjPdKz2JoqWQQm3xw4hWc9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rigid:Qo0FiU40hcrG9uFBCLrYT80DDXs false mutation disrupting interaction:51-51,40-40|mutation disrupting interaction:54-54,50-50|ha tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NYB9 uniprotkb:Q8WUW1 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-2837444|uniprotkb:Q9P082|uniprotkb:B2R5E2|ensembl:ENSP00000432472 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:brk1_human(display_long)|uniprotkb:C3orf10(gene name synonym)|uniprotkb:BRK1(gene name)|psi-mi:BRK1(display_short)|uniprotkb:HSPC300(orf name)|uniprotkb:MDS027(orf name) psi-mi:"MI:0071"(molecular sieving) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894654|imex:IM-21510-5|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_060932.2|dip:DIP-41554N|ensembl:ENSG00000254999(gene)|ensembl:ENST00000530758(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:IZ0oK9Z3VxULlM+igusbB5mwyyo9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q7L576 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894654|imex:IM-21510-5|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q9Y2A7 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-389845|uniprotkb:O60329|uniprotkb:Q53QN5|uniprotkb:Q53S94|uniprotkb:Q53Y35|ensembl:ENSP00000355348 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:nckp1_human(display_long)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894654|imex:IM-21510-5|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_038464.1|refseq:NP_995314.1|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:Q9Y2A7|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|dip:DIP-31119N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYB9 uniprotkb:Q92558 intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1 intact:EBI-1548747|uniprotkb:E1P5F2|uniprotkb:Q5SZK7|ensembl:ENSP00000352425|ensembl:ENSP00000376365|ensembl:ENSP00000376366|ensembl:ENSP00000376367|ensembl:ENSP00000376368 psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym) psi-mi:wasf1_human(display_long)|uniprotkb:WASF1(gene name)|psi-mi:WASF1(display_short)|uniprotkb:KIAA0269(gene name synonym)|uniprotkb:SCAR1(gene name synonym)|uniprotkb:WAVE1(gene name synonym)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894654|imex:IM-21510-5|dip:DIP-103064E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N refseq:NP_001020105.1|refseq:NP_001020106.1|refseq:NP_001020107.1|refseq:NP_003922.1|refseq:XP_011534535.1|refseq:XP_011534536.1|refseq:XP_016866926.1|refseq:XP_016866927.1|refseq:XP_005267260.1|refseq:XP_005267262.1|refseq:XP_005267263.1|refseq:XP_005267264.1|dip:DIP-39391N|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000112290(gene)|ensembl:ENST00000359451(transcript)|ensembl:ENST00000392586(transcript)|ensembl:ENST00000392587(transcript)|ensembl:ENST00000392588(transcript)|ensembl:ENST00000392589(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q92558|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606 rogid:kDHL44b54o8tE3+OR+M2CC6zi/k9606 rigid:Csl+Pmj544UNvin01Pw1NvB5x3M false binding-associated region:1-158 binding-associated region:1-154 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y2A7 uniprotkb:Q7L576 intact:EBI-389845|uniprotkb:O60329|uniprotkb:Q53QN5|uniprotkb:Q53S94|uniprotkb:Q53Y35|ensembl:ENSP00000355348 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:nckp1_human(display_long)|uniprotkb:NCKAP1(gene name)|psi-mi:NCKAP1(display_short)|uniprotkb:HEM2(gene name synonym)|uniprotkb:KIAA0587(gene name synonym)|uniprotkb:NAP1(gene name synonym)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0096"(pull down) Chen et al. (2010) pubmed:21107423|doi:10.1038/nature09623|imex:IM-21510 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15894731|imex:IM-21510-8|dip:DIP-66914E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038464.1|refseq:NP_995314.1|ensembl:ENSG00000061676(gene)|ensembl:ENST00000361354(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR019137|mint:Q9Y2A7|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|dip:DIP-31119N refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:xj4ySr6cf374UbE/gfuxMx1X0tw9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rigid:c5z+7UvD8Bu4hDJ7fniCHH32AmY false - his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)