#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63015 uniprotkb:P63166 intact:EBI-1395428|uniprotkb:P32117|uniprotkb:P70601|uniprotkb:Q62222|uniprotkb:Q64037|uniprotkb:Q8CEI5|uniprotkb:Q8VDB5|uniprotkb:Q921Q8|uniprotkb:Q3UTV5|ensembl:ENSMUSP00000087878|ensembl:ENSMUSP00000106711|ensembl:ENSMUSP00000106712|ensembl:ENSMUSP00000106716 intact:EBI-80152|uniprotkb:P55856|uniprotkb:Q3TX92|uniprotkb:Q93068|ensembl:ENSMUSP00000088935 psi-mi:pax6_mouse(display_long)|uniprotkb:Pax-6(gene name synonym)|uniprotkb:Sey(gene name synonym)|uniprotkb:Pax6(gene name)|psi-mi:Pax6(display_short)|uniprotkb:Oculorhombin(gene name synonym) psi-mi:sumo1_mouse(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)|uniprotkb:Smt3c(gene name synonym)|uniprotkb:Smt3h3(gene name synonym)|uniprotkb:Ubl1(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yan et al. (2010) pubmed:21084637|doi:10.1073/pnas.1007866107|imex:IM-21473 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15892975|imex:IM-21473-2|dip:DIP-191659E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038655.1|refseq:NP_001297073.1|refseq:NP_001297074.1|refseq:NP_001297075.1|refseq:NP_001231127.1|refseq:NP_001231129.1|refseq:NP_001231130.1|refseq:NP_001231131.1|dip:DIP-38879N|ensembl:ENSMUSG00000027168(gene)|ensembl:ENSMUST00000090397(transcript)|ensembl:ENSMUST00000111082(transcript)|ensembl:ENSMUST00000111083(transcript)|ensembl:ENSMUST00000111087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003002"(regionalization)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003310"(pancreatic A cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021543"(pallium development)|go:"GO:0021593"(rhombomere morphogenesis)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0098598"(learned vocalization behavior or vocal learning)|go:"GO:0120008"(positive regulation of glutamatergic neuron differentiation)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904937"(sensory neuron migration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|go:"GO:0003690"(double-stranded DNA binding)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|mint:P63015|interpro:IPR009057(Homeodomain-like) refseq:NP_033486.1|reactome:R-MMU-4755510|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-877312|reactome:R-MMU-8866904|reactome:R-MMU-9615933|ensembl:ENSMUSG00000026021(gene)|ensembl:ENSMUST00000091374(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0001741"(XY body)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|reactome:R-MMU-3065676|reactome:R-MMU-3065678|reactome:R-MMU-3065679|reactome:R-MMU-3108214|reactome:R-MMU-3108232|reactome:R-MMU-3232118|reactome:R-MMU-3232142|reactome:R-MMU-3899300|reactome:R-MMU-4085377|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-4570464|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|reactome:R-MMU-4615885|reactome:R-MMU-4655427|dip:DIP-29278N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM10090 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10090 rigid:U6xWc7PO1MZ52ZQQopASRcRrsdg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26367-1 uniprotkb:P63166 intact:EBI-15892945|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109 intact:EBI-80152|uniprotkb:P55856|uniprotkb:Q3TX92|uniprotkb:Q93068|ensembl:ENSMUSP00000088935 psi-mi:p26367-1(display_long)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:Oculorhombin(gene name synonym) psi-mi:sumo1_mouse(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)|uniprotkb:Smt3c(gene name synonym)|uniprotkb:Smt3h3(gene name synonym)|uniprotkb:Ubl1(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yan et al. (2010) pubmed:21084637|doi:10.1073/pnas.1007866107|imex:IM-21473 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15892953|imex:IM-21473-1|dip:DIP-191661E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000007372(gene)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|intact:EBI-747278(isoform-parent)|uniprotkb:P26367-1(isoform-parent) refseq:NP_033486.1|reactome:R-MMU-4755510|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-877312|reactome:R-MMU-8866904|reactome:R-MMU-9615933|ensembl:ENSMUSG00000026021(gene)|ensembl:ENSMUST00000091374(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0001741"(XY body)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|reactome:R-MMU-3065676|reactome:R-MMU-3065678|reactome:R-MMU-3065679|reactome:R-MMU-3108214|reactome:R-MMU-3108232|reactome:R-MMU-3232118|reactome:R-MMU-3232142|reactome:R-MMU-3899300|reactome:R-MMU-4085377|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-4570464|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|reactome:R-MMU-4615885|reactome:R-MMU-4655427|dip:DIP-29278N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10090 rigid:inMVQtu7NeFjytlZi/gJn9GVK84 false binding-associated region:137-422|mutation disrupting interaction:227-227 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26367 uniprotkb:P63165 intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109 intact:EBI-80140|uniprotkb:P55856|uniprotkb:Q6FGG0|uniprotkb:Q6NZ62|uniprotkb:Q93068|intact:EBI-28970052|ensembl:ENSP00000376076|ensembl:ENSP00000376077|uniprotkb:B2R4I5|uniprotkb:A8MUS8 psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym) psi-mi:sumo1_human(display_long)|uniprotkb:SUMO1(gene name)|psi-mi:SUMO1(display_short)|uniprotkb:Sentrin(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)|uniprotkb:Ubiquitin-like protein UBL1(gene name synonym)|uniprotkb:GAP-modifying protein 1(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:SMT3C(gene name synonym)|uniprotkb:SMT3H3(gene name synonym)|uniprotkb:UBL1(gene name synonym)|uniprotkb:OK/SW-cl.43(orf name) psi-mi:"MI:0808"(comigration in sds page) Yan et al. (2010) pubmed:21084637|doi:10.1073/pnas.1007866107|imex:IM-21473 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15892992|imex:IM-21473-3|dip:DIP-191660E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N refseq:NP_001005781.1|refseq:NP_003343.1|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:P63165|rcsb pdb:1A5R|rcsb pdb:1TGZ|rcsb pdb:1WYW|rcsb pdb:1Y8R|rcsb pdb:1Z5S|rcsb pdb:2ASQ|rcsb pdb:2BF8|rcsb pdb:2G4D|rcsb pdb:2IO2|rcsb pdb:2IY0|rcsb pdb:2IY1|rcsb pdb:2KQS|rcsb pdb:2LAS|rcsb pdb:2MW5|rcsb pdb:2N1A|rcsb pdb:2N1V|rcsb pdb:2PE6|rcsb pdb:2UYZ|rcsb pdb:2VRR|rcsb pdb:3KYC|rcsb pdb:3KYD|rcsb pdb:3RZW|rcsb pdb:3UIP|rcsb pdb:4WJN|rcsb pdb:4WJO|rcsb pdb:4WJP|rcsb pdb:4WJQ|rcsb pdb:5AEK|rcsb pdb:5B7A|rcsb pdb:5ELJ|rcsb pdb:5GHD|rcsb pdb:6EOP|rcsb pdb:6EOT|rcsb pdb:6J4I|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6K5T|rcsb pdb:6TRW|rcsb pdb:6UYO|rcsb pdb:6UYP|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|ensembl:ENSG00000116030(gene)|ensembl:ENST00000392245(transcript)|ensembl:ENST00000392246(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|rcsb pdb:6UYU|rcsb pdb:6UYV|rcsb pdb:6UYX|rcsb pdb:6UYY|rcsb pdb:6UYZ|rcsb pdb:6V7P|rcsb pdb:6V7Q|rcsb pdb:6V7R|rcsb pdb:6UYT|rcsb pdb:6V7S|rcsb pdb:6WW3|rcsb pdb:6XOG|rcsb pdb:6XOH|rcsb pdb:6XOI|reactome:R-HSA-3065676|reactome:R-HSA-3065678|reactome:R-HSA-3065679|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-4551638|reactome:R-HSA-877312|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000392244|ensembl:ENSP00000376075|ensembl:ENSP00000376076|ensembl:ENSP00000376077|refseq:NP_001005782.1|dip:DIP-29080N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ9606 rigid:AZKIUm5coAK9hFZRCEq8MShVWyM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26367-1 uniprotkb:P63166 intact:EBI-15892945|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109 intact:EBI-80152|uniprotkb:P55856|uniprotkb:Q3TX92|uniprotkb:Q93068|ensembl:ENSMUSP00000088935 psi-mi:p26367-1(display_long)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:Oculorhombin(gene name synonym) psi-mi:sumo1_mouse(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)|uniprotkb:Smt3c(gene name synonym)|uniprotkb:Smt3h3(gene name synonym)|uniprotkb:Ubl1(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yan et al. (2010) pubmed:21084637|doi:10.1073/pnas.1007866107|imex:IM-21473 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15893026|imex:IM-21473-5|dip:DIP-191661E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000007372(gene)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|intact:EBI-747278(isoform-parent)|uniprotkb:P26367-1(isoform-parent) refseq:NP_033486.1|reactome:R-MMU-4755510|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-877312|reactome:R-MMU-8866904|reactome:R-MMU-9615933|ensembl:ENSMUSG00000026021(gene)|ensembl:ENSMUST00000091374(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0001741"(XY body)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|reactome:R-MMU-3065676|reactome:R-MMU-3065678|reactome:R-MMU-3065679|reactome:R-MMU-3108214|reactome:R-MMU-3108232|reactome:R-MMU-3232118|reactome:R-MMU-3232142|reactome:R-MMU-3899300|reactome:R-MMU-4085377|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-4570464|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|reactome:R-MMU-4615885|reactome:R-MMU-4655427|dip:DIP-29278N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10090 rigid:inMVQtu7NeFjytlZi/gJn9GVK84 false binding-associated region:137-422|mutation disrupting interaction:227-227 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63015 uniprotkb:P63166 intact:EBI-1395428|uniprotkb:P32117|uniprotkb:P70601|uniprotkb:Q62222|uniprotkb:Q64037|uniprotkb:Q8CEI5|uniprotkb:Q8VDB5|uniprotkb:Q921Q8|uniprotkb:Q3UTV5|ensembl:ENSMUSP00000087878|ensembl:ENSMUSP00000106711|ensembl:ENSMUSP00000106712|ensembl:ENSMUSP00000106716 intact:EBI-80152|uniprotkb:P55856|uniprotkb:Q3TX92|uniprotkb:Q93068|ensembl:ENSMUSP00000088935 psi-mi:pax6_mouse(display_long)|uniprotkb:Pax-6(gene name synonym)|uniprotkb:Sey(gene name synonym)|uniprotkb:Pax6(gene name)|psi-mi:Pax6(display_short)|uniprotkb:Oculorhombin(gene name synonym) psi-mi:sumo1_mouse(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)|uniprotkb:Smt3c(gene name synonym)|uniprotkb:Smt3h3(gene name synonym)|uniprotkb:Ubl1(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yan et al. (2010) pubmed:21084637|doi:10.1073/pnas.1007866107|imex:IM-21473 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15893009|imex:IM-21473-4|dip:DIP-191659E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038655.1|refseq:NP_001297073.1|refseq:NP_001297074.1|refseq:NP_001297075.1|refseq:NP_001231127.1|refseq:NP_001231129.1|refseq:NP_001231130.1|refseq:NP_001231131.1|dip:DIP-38879N|ensembl:ENSMUSG00000027168(gene)|ensembl:ENSMUST00000090397(transcript)|ensembl:ENSMUST00000111082(transcript)|ensembl:ENSMUST00000111083(transcript)|ensembl:ENSMUST00000111087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003002"(regionalization)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003310"(pancreatic A cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021543"(pallium development)|go:"GO:0021593"(rhombomere morphogenesis)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0098598"(learned vocalization behavior or vocal learning)|go:"GO:0120008"(positive regulation of glutamatergic neuron differentiation)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904937"(sensory neuron migration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|go:"GO:0003690"(double-stranded DNA binding)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|mint:P63015|interpro:IPR009057(Homeodomain-like) refseq:NP_033486.1|reactome:R-MMU-4755510|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-877312|reactome:R-MMU-8866904|reactome:R-MMU-9615933|ensembl:ENSMUSG00000026021(gene)|ensembl:ENSMUST00000091374(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0001741"(XY body)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|reactome:R-MMU-3065676|reactome:R-MMU-3065678|reactome:R-MMU-3065679|reactome:R-MMU-3108214|reactome:R-MMU-3108232|reactome:R-MMU-3232118|reactome:R-MMU-3232142|reactome:R-MMU-3899300|reactome:R-MMU-4085377|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-4570464|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|reactome:R-MMU-4615885|reactome:R-MMU-4655427|dip:DIP-29278N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM10090 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10090 rigid:U6xWc7PO1MZ52ZQQopASRcRrsdg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63165 uniprotkb:P26367-1 intact:EBI-80140|uniprotkb:P55856|uniprotkb:Q6FGG0|uniprotkb:Q6NZ62|uniprotkb:Q93068|intact:EBI-28970052|ensembl:ENSP00000376076|ensembl:ENSP00000376077|uniprotkb:B2R4I5|uniprotkb:A8MUS8 intact:EBI-15892945|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109 psi-mi:sumo1_human(display_long)|uniprotkb:SUMO1(gene name)|psi-mi:SUMO1(display_short)|uniprotkb:Sentrin(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)|uniprotkb:Ubiquitin-like protein UBL1(gene name synonym)|uniprotkb:GAP-modifying protein 1(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:SMT3C(gene name synonym)|uniprotkb:SMT3H3(gene name synonym)|uniprotkb:UBL1(gene name synonym)|uniprotkb:OK/SW-cl.43(orf name) psi-mi:p26367-1(display_long)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:Oculorhombin(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Yan et al. (2010) pubmed:21084637|doi:10.1073/pnas.1007866107|imex:IM-21473 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15893048|imex:IM-21473-6|dip:DIP-191660E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001005781.1|refseq:NP_003343.1|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:P63165|rcsb pdb:1A5R|rcsb pdb:1TGZ|rcsb pdb:1WYW|rcsb pdb:1Y8R|rcsb pdb:1Z5S|rcsb pdb:2ASQ|rcsb pdb:2BF8|rcsb pdb:2G4D|rcsb pdb:2IO2|rcsb pdb:2IY0|rcsb pdb:2IY1|rcsb pdb:2KQS|rcsb pdb:2LAS|rcsb pdb:2MW5|rcsb pdb:2N1A|rcsb pdb:2N1V|rcsb pdb:2PE6|rcsb pdb:2UYZ|rcsb pdb:2VRR|rcsb pdb:3KYC|rcsb pdb:3KYD|rcsb pdb:3RZW|rcsb pdb:3UIP|rcsb pdb:4WJN|rcsb pdb:4WJO|rcsb pdb:4WJP|rcsb pdb:4WJQ|rcsb pdb:5AEK|rcsb pdb:5B7A|rcsb pdb:5ELJ|rcsb pdb:5GHD|rcsb pdb:6EOP|rcsb pdb:6EOT|rcsb pdb:6J4I|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6K5T|rcsb pdb:6TRW|rcsb pdb:6UYO|rcsb pdb:6UYP|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|ensembl:ENSG00000116030(gene)|ensembl:ENST00000392245(transcript)|ensembl:ENST00000392246(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|rcsb pdb:6UYU|rcsb pdb:6UYV|rcsb pdb:6UYX|rcsb pdb:6UYY|rcsb pdb:6UYZ|rcsb pdb:6V7P|rcsb pdb:6V7Q|rcsb pdb:6V7R|rcsb pdb:6UYT|rcsb pdb:6V7S|rcsb pdb:6WW3|rcsb pdb:6XOG|rcsb pdb:6XOH|rcsb pdb:6XOI|reactome:R-HSA-3065676|reactome:R-HSA-3065678|reactome:R-HSA-3065679|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-4551638|reactome:R-HSA-877312|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000392244|ensembl:ENSP00000376075|ensembl:ENSP00000376076|ensembl:ENSP00000376077|refseq:NP_001005782.1|dip:DIP-29080N ensembl:ENSG00000007372(gene)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|intact:EBI-747278(isoform-parent)|uniprotkb:P26367-1(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ9606 rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606 rigid:AZKIUm5coAK9hFZRCEq8MShVWyM false - binding-associated region:137-422 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)