#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35305	uniprotkb:O35235-1	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ta et al. (2010)	pubmed:21059944|doi:10.1073/pnas.1011686107|imex:IM-17137	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15890899|imex:IM-17137-1|dip:DIP-188121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:i4ywqFZctL9NJvryst9My52nv4810090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:gysElnU5AHMMqiW+O+Ju4WqfNVs	false	binding-associated region:32-201|mutation disrupting interaction:126-126|mutation disrupting interaction:97-97|mutation decreasing interaction:85-85|mutation disrupting interaction:127-127|mutation disrupting interaction:54-54|mutation disrupting interaction:171-171	binding-associated region:157-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35305	uniprotkb:O35235-1	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Ta et al. (2010)	pubmed:21059944|doi:10.1073/pnas.1011686107|imex:IM-17137	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15890938|imex:IM-17137-2|dip:DIP-188121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:i4ywqFZctL9NJvryst9My52nv4810090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:gysElnU5AHMMqiW+O+Ju4WqfNVs	false	binding-associated region:32-201	binding-associated region:157-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15890959	uniprotkb:O35235-1	dip:DIP-59482N	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:op34(display_short)|psi-mi:EBI-15890959(display_long)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ta et al. (2010)	pubmed:21059944|doi:10.1073/pnas.1011686107|imex:IM-17137	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15890962|imex:IM-17137-3|dip:DIP-188123E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:9w113KaDKzWn8N5oa6jbocVZPm0-2	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:ob9lgFdEyv3rWQHVVphISLVfaTs	false	-	binding-associated region:157-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35305	uniprotkb:O35235-1	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ta et al. (2010)	pubmed:21059944|doi:10.1073/pnas.1011686107|imex:IM-17137	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15890982|imex:IM-17137-4|dip:DIP-188121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:i4ywqFZctL9NJvryst9My52nv4810090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:gysElnU5AHMMqiW+O+Ju4WqfNVs	false	binding-associated region:32-201	binding-associated region:157-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15891003	uniprotkb:O35235-1	dip:DIP-59481N	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:l33(display_short)|psi-mi:EBI-15891003(display_long)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ta et al. (2010)	pubmed:21059944|doi:10.1073/pnas.1011686107|imex:IM-17137	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15891006|imex:IM-17137-5|dip:DIP-188122E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:59oeGwTCfRvUnsRT3tJe83Jz7BU-2	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:zGm9lqtLpGfWgsNfYmPS+V2gg/Q	false	-	binding-associated region:157-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)