#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P37019 uniprotkb:P37019 intact:EBI-15719361|ensemblbacteria:AAC73266|ensemblbacteria:BAB96732|uniprotkb:P77394 intact:EBI-15719361|ensemblbacteria:AAC73266|ensemblbacteria:BAB96732|uniprotkb:P77394 psi-mi:clca_ecoli(display_long)|uniprotkb:clcA(gene name)|psi-mi:clcA(display_short)|uniprotkb:ClC-ec1(gene name synonym)|uniprotkb:eriC(gene name synonym)|uniprotkb:yadQ(gene name synonym)|uniprotkb:JW5012(locus name)|uniprotkb:b0155(locus name) psi-mi:clca_ecoli(display_long)|uniprotkb:clcA(gene name)|psi-mi:clcA(display_short)|uniprotkb:ClC-ec1(gene name synonym)|uniprotkb:eriC(gene name synonym)|uniprotkb:yadQ(gene name synonym)|uniprotkb:JW5012(locus name)|uniprotkb:b0155(locus name) psi-mi:"MI:0071"(molecular sieving) Robertson et al. (2010) pubmed:21048711|doi:10.1038/nature09556|imex:IM-16266 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15890221|imex:IM-16266-1|dip:DIP-88001E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC73266(transcript)|ensemblbacteria:b0155(gene)|ensemblbacteria:BAB96732(gene)|ensemblbacteria:BAB96732(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0062158"("chloride:proton antiporter activity")|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR014743(Chloride channel, core)|interpro:IPR023861|rcsb pdb:1KPK|rcsb pdb:1OTS|rcsb pdb:1OTT|rcsb pdb:1OTU|rcsb pdb:2EXW|rcsb pdb:2EXY|rcsb pdb:2EZ0|rcsb pdb:2FEC|rcsb pdb:2FED|rcsb pdb:2FEE|rcsb pdb:2H2P|rcsb pdb:2H2S|rcsb pdb:2HLF|rcsb pdb:2HT2|rcsb pdb:2HT4|rcsb pdb:2HTK|rcsb pdb:2HTL|rcsb pdb:2R9H|rcsb pdb:3DET|rcsb pdb:3EJY|rcsb pdb:3EJZ|rcsb pdb:3NMO|rcsb pdb:4ENE|rcsb pdb:4FTP|rcsb pdb:4KJP|rcsb pdb:4KJQ|rcsb pdb:4KJW|rcsb pdb:4KK5|rcsb pdb:4KK6|rcsb pdb:4KK8|rcsb pdb:4KK9|rcsb pdb:4KKA|rcsb pdb:4KKB|rcsb pdb:4KKC|rcsb pdb:4KKL|rcsb pdb:4LOU|rcsb pdb:4MQX|rcsb pdb:5HD8|rcsb pdb:6AD7|rcsb pdb:6AD8|rcsb pdb:6ADA|rcsb pdb:6ADB|rcsb pdb:6ADC|rcsb pdb:6K5D|rcsb pdb:6K5F|rcsb pdb:6LSC|rcsb pdb:6V2J|rcsb pdb:2HT3|dip:DIP-9523N|refseq:NP_414697.1|refseq:WP_000845394.1 ensemblbacteria:AAC73266(transcript)|ensemblbacteria:b0155(gene)|ensemblbacteria:BAB96732(gene)|ensemblbacteria:BAB96732(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0062158"("chloride:proton antiporter activity")|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR014743(Chloride channel, core)|interpro:IPR023861|rcsb pdb:1KPK|rcsb pdb:1OTS|rcsb pdb:1OTT|rcsb pdb:1OTU|rcsb pdb:2EXW|rcsb pdb:2EXY|rcsb pdb:2EZ0|rcsb pdb:2FEC|rcsb pdb:2FED|rcsb pdb:2FEE|rcsb pdb:2H2P|rcsb pdb:2H2S|rcsb pdb:2HLF|rcsb pdb:2HT2|rcsb pdb:2HT4|rcsb pdb:2HTK|rcsb pdb:2HTL|rcsb pdb:2R9H|rcsb pdb:3DET|rcsb pdb:3EJY|rcsb pdb:3EJZ|rcsb pdb:3NMO|rcsb pdb:4ENE|rcsb pdb:4FTP|rcsb pdb:4KJP|rcsb pdb:4KJQ|rcsb pdb:4KJW|rcsb pdb:4KK5|rcsb pdb:4KK6|rcsb pdb:4KK8|rcsb pdb:4KK9|rcsb pdb:4KKA|rcsb pdb:4KKB|rcsb pdb:4KKC|rcsb pdb:4KKL|rcsb pdb:4LOU|rcsb pdb:4MQX|rcsb pdb:5HD8|rcsb pdb:6AD7|rcsb pdb:6AD8|rcsb pdb:6ADA|rcsb pdb:6ADB|rcsb pdb:6ADC|rcsb pdb:6K5D|rcsb pdb:6K5F|rcsb pdb:6LSC|rcsb pdb:6V2J|rcsb pdb:2HT3|dip:DIP-9523N|refseq:NP_414697.1|refseq:WP_000845394.1 psi-mi:"MI:0465"(dip) crc64:0B1BC39B417E9690 crc64:0B1BC39B417E9690 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/06 2017/08/10 rogid:cPfURFdid/vdHkPNxx/Plm4lm+k83333 rogid:cPfURFdid/vdHkPNxx/Plm4lm+k83333 rigid:YK+sNRchEk/i1tirnYtoc2au8C8 false mutation decreasing interaction:422-422|mutation disrupting interaction:422-422,201-201|mutation decreasing interaction:201-201|mutation decreasing interaction:434-434|mutation decreasing interaction:406-406 mutation decreasing interaction:422-422|mutation disrupting interaction:422-422,201-201|mutation decreasing interaction:201-201|mutation decreasing interaction:434-434|mutation decreasing interaction:406-406 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P37019 uniprotkb:P37019 intact:EBI-15719361|ensemblbacteria:AAC73266|ensemblbacteria:BAB96732|uniprotkb:P77394 intact:EBI-15719361|ensemblbacteria:AAC73266|ensemblbacteria:BAB96732|uniprotkb:P77394 psi-mi:clca_ecoli(display_long)|uniprotkb:clcA(gene name)|psi-mi:clcA(display_short)|uniprotkb:ClC-ec1(gene name synonym)|uniprotkb:eriC(gene name synonym)|uniprotkb:yadQ(gene name synonym)|uniprotkb:JW5012(locus name)|uniprotkb:b0155(locus name) psi-mi:clca_ecoli(display_long)|uniprotkb:clcA(gene name)|psi-mi:clcA(display_short)|uniprotkb:ClC-ec1(gene name synonym)|uniprotkb:eriC(gene name synonym)|uniprotkb:yadQ(gene name synonym)|uniprotkb:JW5012(locus name)|uniprotkb:b0155(locus name) psi-mi:"MI:0030"(cross-linking study) Robertson et al. (2010) pubmed:21048711|doi:10.1038/nature09556|imex:IM-16266 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15890252|imex:IM-16266-2|dip:DIP-88001E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC73266(transcript)|ensemblbacteria:b0155(gene)|ensemblbacteria:BAB96732(gene)|ensemblbacteria:BAB96732(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0062158"("chloride:proton antiporter activity")|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR014743(Chloride channel, core)|interpro:IPR023861|rcsb pdb:1KPK|rcsb pdb:1OTS|rcsb pdb:1OTT|rcsb pdb:1OTU|rcsb pdb:2EXW|rcsb pdb:2EXY|rcsb pdb:2EZ0|rcsb pdb:2FEC|rcsb pdb:2FED|rcsb pdb:2FEE|rcsb pdb:2H2P|rcsb pdb:2H2S|rcsb pdb:2HLF|rcsb pdb:2HT2|rcsb pdb:2HT4|rcsb pdb:2HTK|rcsb pdb:2HTL|rcsb pdb:2R9H|rcsb pdb:3DET|rcsb pdb:3EJY|rcsb pdb:3EJZ|rcsb pdb:3NMO|rcsb pdb:4ENE|rcsb pdb:4FTP|rcsb pdb:4KJP|rcsb pdb:4KJQ|rcsb pdb:4KJW|rcsb pdb:4KK5|rcsb pdb:4KK6|rcsb pdb:4KK8|rcsb pdb:4KK9|rcsb pdb:4KKA|rcsb pdb:4KKB|rcsb pdb:4KKC|rcsb pdb:4KKL|rcsb pdb:4LOU|rcsb pdb:4MQX|rcsb pdb:5HD8|rcsb pdb:6AD7|rcsb pdb:6AD8|rcsb pdb:6ADA|rcsb pdb:6ADB|rcsb pdb:6ADC|rcsb pdb:6K5D|rcsb pdb:6K5F|rcsb pdb:6LSC|rcsb pdb:6V2J|rcsb pdb:2HT3|dip:DIP-9523N|refseq:NP_414697.1|refseq:WP_000845394.1 ensemblbacteria:AAC73266(transcript)|ensemblbacteria:b0155(gene)|ensemblbacteria:BAB96732(gene)|ensemblbacteria:BAB96732(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0062158"("chloride:proton antiporter activity")|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR014743(Chloride channel, core)|interpro:IPR023861|rcsb pdb:1KPK|rcsb pdb:1OTS|rcsb pdb:1OTT|rcsb pdb:1OTU|rcsb pdb:2EXW|rcsb pdb:2EXY|rcsb pdb:2EZ0|rcsb pdb:2FEC|rcsb pdb:2FED|rcsb pdb:2FEE|rcsb pdb:2H2P|rcsb pdb:2H2S|rcsb pdb:2HLF|rcsb pdb:2HT2|rcsb pdb:2HT4|rcsb pdb:2HTK|rcsb pdb:2HTL|rcsb pdb:2R9H|rcsb pdb:3DET|rcsb pdb:3EJY|rcsb pdb:3EJZ|rcsb pdb:3NMO|rcsb pdb:4ENE|rcsb pdb:4FTP|rcsb pdb:4KJP|rcsb pdb:4KJQ|rcsb pdb:4KJW|rcsb pdb:4KK5|rcsb pdb:4KK6|rcsb pdb:4KK8|rcsb pdb:4KK9|rcsb pdb:4KKA|rcsb pdb:4KKB|rcsb pdb:4KKC|rcsb pdb:4KKL|rcsb pdb:4LOU|rcsb pdb:4MQX|rcsb pdb:5HD8|rcsb pdb:6AD7|rcsb pdb:6AD8|rcsb pdb:6ADA|rcsb pdb:6ADB|rcsb pdb:6ADC|rcsb pdb:6K5D|rcsb pdb:6K5F|rcsb pdb:6LSC|rcsb pdb:6V2J|rcsb pdb:2HT3|dip:DIP-9523N|refseq:NP_414697.1|refseq:WP_000845394.1 psi-mi:"MI:0465"(dip) crc64:0B1BC39B417E9690 crc64:0B1BC39B417E9690 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:cPfURFdid/vdHkPNxx/Plm4lm+k83333 rogid:cPfURFdid/vdHkPNxx/Plm4lm+k83333 rigid:YK+sNRchEk/i1tirnYtoc2au8C8 false mutation disrupting interaction:422-422,201-201 mutation disrupting interaction:422-422,201-201 - 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P37019 uniprotkb:P37019 intact:EBI-15719361|ensemblbacteria:AAC73266|ensemblbacteria:BAB96732|uniprotkb:P77394 intact:EBI-15719361|ensemblbacteria:AAC73266|ensemblbacteria:BAB96732|uniprotkb:P77394 psi-mi:clca_ecoli(display_long)|uniprotkb:clcA(gene name)|psi-mi:clcA(display_short)|uniprotkb:ClC-ec1(gene name synonym)|uniprotkb:eriC(gene name synonym)|uniprotkb:yadQ(gene name synonym)|uniprotkb:JW5012(locus name)|uniprotkb:b0155(locus name) psi-mi:clca_ecoli(display_long)|uniprotkb:clcA(gene name)|psi-mi:clcA(display_short)|uniprotkb:ClC-ec1(gene name synonym)|uniprotkb:eriC(gene name synonym)|uniprotkb:yadQ(gene name synonym)|uniprotkb:JW5012(locus name)|uniprotkb:b0155(locus name) psi-mi:"MI:0030"(cross-linking study) Robertson et al. (2010) pubmed:21048711|doi:10.1038/nature09556|imex:IM-16266 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15890272|imex:IM-16266-3|dip:DIP-88001E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC73266(transcript)|ensemblbacteria:b0155(gene)|ensemblbacteria:BAB96732(gene)|ensemblbacteria:BAB96732(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0062158"("chloride:proton antiporter activity")|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR014743(Chloride channel, core)|interpro:IPR023861|rcsb pdb:1KPK|rcsb pdb:1OTS|rcsb pdb:1OTT|rcsb pdb:1OTU|rcsb pdb:2EXW|rcsb pdb:2EXY|rcsb pdb:2EZ0|rcsb pdb:2FEC|rcsb pdb:2FED|rcsb pdb:2FEE|rcsb pdb:2H2P|rcsb pdb:2H2S|rcsb pdb:2HLF|rcsb pdb:2HT2|rcsb pdb:2HT4|rcsb pdb:2HTK|rcsb pdb:2HTL|rcsb pdb:2R9H|rcsb pdb:3DET|rcsb pdb:3EJY|rcsb pdb:3EJZ|rcsb pdb:3NMO|rcsb pdb:4ENE|rcsb pdb:4FTP|rcsb pdb:4KJP|rcsb pdb:4KJQ|rcsb pdb:4KJW|rcsb pdb:4KK5|rcsb pdb:4KK6|rcsb pdb:4KK8|rcsb pdb:4KK9|rcsb pdb:4KKA|rcsb pdb:4KKB|rcsb pdb:4KKC|rcsb pdb:4KKL|rcsb pdb:4LOU|rcsb pdb:4MQX|rcsb pdb:5HD8|rcsb pdb:6AD7|rcsb pdb:6AD8|rcsb pdb:6ADA|rcsb pdb:6ADB|rcsb pdb:6ADC|rcsb pdb:6K5D|rcsb pdb:6K5F|rcsb pdb:6LSC|rcsb pdb:6V2J|rcsb pdb:2HT3|dip:DIP-9523N|refseq:NP_414697.1|refseq:WP_000845394.1 ensemblbacteria:AAC73266(transcript)|ensemblbacteria:b0155(gene)|ensemblbacteria:BAB96732(gene)|ensemblbacteria:BAB96732(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0062158"("chloride:proton antiporter activity")|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR014743(Chloride channel, core)|interpro:IPR023861|rcsb pdb:1KPK|rcsb pdb:1OTS|rcsb pdb:1OTT|rcsb pdb:1OTU|rcsb pdb:2EXW|rcsb pdb:2EXY|rcsb pdb:2EZ0|rcsb pdb:2FEC|rcsb pdb:2FED|rcsb pdb:2FEE|rcsb pdb:2H2P|rcsb pdb:2H2S|rcsb pdb:2HLF|rcsb pdb:2HT2|rcsb pdb:2HT4|rcsb pdb:2HTK|rcsb pdb:2HTL|rcsb pdb:2R9H|rcsb pdb:3DET|rcsb pdb:3EJY|rcsb pdb:3EJZ|rcsb pdb:3NMO|rcsb pdb:4ENE|rcsb pdb:4FTP|rcsb pdb:4KJP|rcsb pdb:4KJQ|rcsb pdb:4KJW|rcsb pdb:4KK5|rcsb pdb:4KK6|rcsb pdb:4KK8|rcsb pdb:4KK9|rcsb pdb:4KKA|rcsb pdb:4KKB|rcsb pdb:4KKC|rcsb pdb:4KKL|rcsb pdb:4LOU|rcsb pdb:4MQX|rcsb pdb:5HD8|rcsb pdb:6AD7|rcsb pdb:6AD8|rcsb pdb:6ADA|rcsb pdb:6ADB|rcsb pdb:6ADC|rcsb pdb:6K5D|rcsb pdb:6K5F|rcsb pdb:6LSC|rcsb pdb:6V2J|rcsb pdb:2HT3|dip:DIP-9523N|refseq:NP_414697.1|refseq:WP_000845394.1 psi-mi:"MI:0465"(dip) crc64:0B1BC39B417E9690 crc64:0B1BC39B417E9690 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:cPfURFdid/vdHkPNxx/Plm4lm+k83333 rogid:cPfURFdid/vdHkPNxx/Plm4lm+k83333 rigid:YK+sNRchEk/i1tirnYtoc2au8C8 false mutation disrupting interaction:422-422,201-201 mutation disrupting interaction:422-422,201-201 - 0 psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining)