#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42003	uniprotkb:Q7KNS3	intact:EBI-162238|uniprotkb:Q9VQM3|ensemblmetazoa:FBpp0077302	intact:EBI-156005|uniprotkb:O96698|uniprotkb:Q5BI20|uniprotkb:A4UZJ3|uniprotkb:Q8SXJ6|ensemblmetazoa:FBpp0086375|ensemblmetazoa:FBpp0086379|ensemblmetazoa:FBpp0089100|ensemblmetazoa:FBpp0293289	psi-mi:mad_drome(display_long)|uniprotkb:Mad(gene name)|psi-mi:Mad(display_short)|uniprotkb:CG12399(orf name)	psi-mi:lis1_drome(display_long)|uniprotkb:Lis-1(gene name)|psi-mi:Lis-1(display_short)|uniprotkb:Lis1(gene name synonym)|uniprotkb:CG8440(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2010)	pubmed:21041636|doi:10.1073/pnas.1008606107|imex:IM-17119	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15889017|imex:IM-17119-1|dip:DIP-188107E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477017.1|flybase:FBgn0011648|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007419"(ventral cord development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007560"(imaginal disc morphogenesis)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009653"(anatomical structure morphogenesis)|ensemblmetazoa:FBgn0011648(gene)|ensemblmetazoa:FBtr0077616(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035290"(trunk segmentation)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:3DIT|reactome:R-DME-201451|reactome:R-DME-8941326|rcsb pdb:3GMJ|dip:DIP-18256N	refseq:NP_001246361.1|refseq:NP_477160.1|refseq:NP_788370.1|refseq:NP_995852.1|flybase:FBgn0015754|dip:DIP-59474N|ensemblmetazoa:FBgn0015754(gene)|ensemblmetazoa:FBtr0087236(transcript)|ensemblmetazoa:FBtr0087240(transcript)|ensemblmetazoa:FBtr0087241(transcript)|ensemblmetazoa:FBtr0304747(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007303"(cytoplasmic transport, nurse cell to oocyte)|go:"GO:0007312"(oocyte nucleus migration involved in oocyte dorsal/ventral axis specification)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010970"(transport along microtubule)|go:"GO:0016319"(mushroom body development)|go:"GO:0016358"(dendrite development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030286"(dynein complex)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030706"(germarium-derived oocyte differentiation)|go:"GO:0030716"(oocyte fate determination)|go:"GO:0030723"(ovarian fusome organization)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042052"(rhabdomere development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043143"(regulation of translation by machinery localization)|go:"GO:0045478"(fusome organization)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048135"(female germ-line cyst formation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048477"(oogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051299"(centrosome separation)|go:"GO:0051383"(kinetochore organization)|go:"GO:0051642"(centrosome localization)|go:"GO:0051647"(nucleus localization)|go:"GO:0061883"(clathrin-dependent endocytosis involved in vitellogenesis)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:0098930"(axonal transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017252(Dynein regulator)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037190|reactome:R-DME-6811436	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/06	2017/08/10	rogid:WIV5vzeVJTr8sKiZNxHA9qmPahE7227	rogid:rHPRtKv4RO4FNzniB0NCsOvuw9o7227	rigid:T/WmdpxsOZB129LZ+uWnPeeirvU	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42003	uniprotkb:Q7KNS3	intact:EBI-162238|uniprotkb:Q9VQM3|ensemblmetazoa:FBpp0077302	intact:EBI-156005|uniprotkb:O96698|uniprotkb:Q5BI20|uniprotkb:A4UZJ3|uniprotkb:Q8SXJ6|ensemblmetazoa:FBpp0086375|ensemblmetazoa:FBpp0086379|ensemblmetazoa:FBpp0089100|ensemblmetazoa:FBpp0293289	psi-mi:mad_drome(display_long)|uniprotkb:Mad(gene name)|psi-mi:Mad(display_short)|uniprotkb:CG12399(orf name)	psi-mi:lis1_drome(display_long)|uniprotkb:Lis-1(gene name)|psi-mi:Lis-1(display_short)|uniprotkb:Lis1(gene name synonym)|uniprotkb:CG8440(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2010)	pubmed:21041636|doi:10.1073/pnas.1008606107|imex:IM-17119	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15889038|imex:IM-17119-2|dip:DIP-188107E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477017.1|flybase:FBgn0011648|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007419"(ventral cord development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007560"(imaginal disc morphogenesis)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009653"(anatomical structure morphogenesis)|ensemblmetazoa:FBgn0011648(gene)|ensemblmetazoa:FBtr0077616(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035290"(trunk segmentation)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:3DIT|reactome:R-DME-201451|reactome:R-DME-8941326|rcsb pdb:3GMJ|dip:DIP-18256N	refseq:NP_001246361.1|refseq:NP_477160.1|refseq:NP_788370.1|refseq:NP_995852.1|flybase:FBgn0015754|dip:DIP-59474N|ensemblmetazoa:FBgn0015754(gene)|ensemblmetazoa:FBtr0087236(transcript)|ensemblmetazoa:FBtr0087240(transcript)|ensemblmetazoa:FBtr0087241(transcript)|ensemblmetazoa:FBtr0304747(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007303"(cytoplasmic transport, nurse cell to oocyte)|go:"GO:0007312"(oocyte nucleus migration involved in oocyte dorsal/ventral axis specification)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010970"(transport along microtubule)|go:"GO:0016319"(mushroom body development)|go:"GO:0016358"(dendrite development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030286"(dynein complex)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030706"(germarium-derived oocyte differentiation)|go:"GO:0030716"(oocyte fate determination)|go:"GO:0030723"(ovarian fusome organization)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042052"(rhabdomere development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043143"(regulation of translation by machinery localization)|go:"GO:0045478"(fusome organization)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048135"(female germ-line cyst formation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048477"(oogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051299"(centrosome separation)|go:"GO:0051383"(kinetochore organization)|go:"GO:0051642"(centrosome localization)|go:"GO:0051647"(nucleus localization)|go:"GO:0061883"(clathrin-dependent endocytosis involved in vitellogenesis)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:0098930"(axonal transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017252(Dynein regulator)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037190|reactome:R-DME-6811436	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/06	2017/08/10	rogid:WIV5vzeVJTr8sKiZNxHA9qmPahE7227	rogid:rHPRtKv4RO4FNzniB0NCsOvuw9o7227	rigid:T/WmdpxsOZB129LZ+uWnPeeirvU	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)