#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18654	uniprotkb:P30309	intact:EBI-397744|ensembl:ENSMUSP00000033671|uniprotkb:Q03140|uniprotkb:Q8K3J8|uniprotkb:B1AXN4	intact:EBI-15888737	psi-mi:ks6a3_mouse(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:Rps6ka-rs1(gene name synonym)|uniprotkb:Rsk2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:Mapkapk1b(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)	psi-mi:mpi1b_xenla(display_long)|uniprotkb:cdc25-1-b(gene name)|psi-mi:cdc25-1-b(display_short)|uniprotkb:cdc25b(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2010)	pubmed:21041626|doi:10.1073/pnas.1003528107|imex:IM-17118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15888755|imex:IM-17118-1|dip:DIP-188106E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031309(gene)|ensembl:ENSMUST00000033671(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:P18654|rcsb pdb:2QR7|rcsb pdb:2QR8|rcsb pdb:3G51|rcsb pdb:3UBD|rcsb pdb:4EL9|rcsb pdb:4GUE|rcsb pdb:4M8T|rcsb pdb:4MAO|rcsb pdb:5O1S|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_683747.1|dip:DIP-31554N	go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|refseq:NP_001081918.1|refseq:XP_018106285.1|dip:DIP-176N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:5h7ZnIO/ZD+MvfouRrhQzWM3Q0010090	rogid:ntj+598IEaSwrAktBJDjMsjZ5ks8355	rigid:hWIebQEKNdOw+5wMW6T4pKu7xqw	false	-	sufficient binding region:300-349|O-phospho-L-serine:317-317|O-phospho-L-threonine:318-318|mutation decreasing interaction rate:319-319|mutation disrupting interaction rate:319-319,318-318,317-317|necessary binding region:317-321	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18654	uniprotkb:P30309	intact:EBI-397744|ensembl:ENSMUSP00000033671|uniprotkb:Q03140|uniprotkb:Q8K3J8|uniprotkb:B1AXN4	intact:EBI-15888737	psi-mi:ks6a3_mouse(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:Rps6ka-rs1(gene name synonym)|uniprotkb:Rsk2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:Mapkapk1b(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)	psi-mi:mpi1b_xenla(display_long)|uniprotkb:cdc25-1-b(gene name)|psi-mi:cdc25-1-b(display_short)|uniprotkb:cdc25b(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2010)	pubmed:21041626|doi:10.1073/pnas.1003528107|imex:IM-17118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15888791|imex:IM-17118-2|dip:DIP-188106E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031309(gene)|ensembl:ENSMUST00000033671(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:P18654|rcsb pdb:2QR7|rcsb pdb:2QR8|rcsb pdb:3G51|rcsb pdb:3UBD|rcsb pdb:4EL9|rcsb pdb:4GUE|rcsb pdb:4M8T|rcsb pdb:4MAO|rcsb pdb:5O1S|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_683747.1|dip:DIP-31554N	go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|refseq:NP_001081918.1|refseq:XP_018106285.1|dip:DIP-176N	psi-mi:"MI:0465"(dip)	-	-	comment:Deletion of region 317-321 decreased the interaction rate/strength.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:5h7ZnIO/ZD+MvfouRrhQzWM3Q0010090	rogid:ntj+598IEaSwrAktBJDjMsjZ5ks8355	rigid:hWIebQEKNdOw+5wMW6T4pKu7xqw	false	-	sufficient binding region:251-353|mutation disrupting interaction rate:319-319,318-318,317-317|phosphorus containing modified residue:?-?|O-phospho-L-serine:319-319|O-phospho-L-threonine:318-318	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18654	uniprotkb:P30309	intact:EBI-397744|ensembl:ENSMUSP00000033671|uniprotkb:Q03140|uniprotkb:Q8K3J8|uniprotkb:B1AXN4	intact:EBI-15888737	psi-mi:ks6a3_mouse(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:Rps6ka-rs1(gene name synonym)|uniprotkb:Rsk2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:Mapkapk1b(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)	psi-mi:mpi1b_xenla(display_long)|uniprotkb:cdc25-1-b(gene name)|psi-mi:cdc25-1-b(display_short)|uniprotkb:cdc25b(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2010)	pubmed:21041626|doi:10.1073/pnas.1003528107|imex:IM-17118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15888822|imex:IM-17118-3|dip:DIP-188106E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031309(gene)|ensembl:ENSMUST00000033671(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:P18654|rcsb pdb:2QR7|rcsb pdb:2QR8|rcsb pdb:3G51|rcsb pdb:3UBD|rcsb pdb:4EL9|rcsb pdb:4GUE|rcsb pdb:4M8T|rcsb pdb:4MAO|rcsb pdb:5O1S|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_683747.1|dip:DIP-31554N	go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|refseq:NP_001081918.1|refseq:XP_018106285.1|dip:DIP-176N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:5h7ZnIO/ZD+MvfouRrhQzWM3Q0010090	rogid:ntj+598IEaSwrAktBJDjMsjZ5ks8355	rigid:hWIebQEKNdOw+5wMW6T4pKu7xqw	false	-	sufficient binding region:278-308|mutation disrupting interaction rate:287-287	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)