#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14222	uniprotkb:P14222	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Law et al. (2010)	pubmed:21037563|doi:10.1038/nature09518|imex:IM-16270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15888260|imex:IM-16270-1|dip:DIP-187384E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	rigid:wfhAdNPT6kA2Q21fp6bjWA/YELw	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14222	uniprotkb:P14222	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Law et al. (2010)	pubmed:21037563|doi:10.1038/nature09518|imex:IM-16270	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15888276|imex:IM-16270-2|dip:DIP-187384E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	rigid:wfhAdNPT6kA2Q21fp6bjWA/YELw	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10820	uniprotkb:P10820	intact:EBI-8419458|intact:MINT-4107132|ensembl:ENSMUSP00000041483|ensembl:ENSMUSP00000151354	intact:EBI-8419458|intact:MINT-4107132|ensembl:ENSMUSP00000041483|ensembl:ENSMUSP00000151354	psi-mi:perf_mouse(display_long)|uniprotkb:Prf1(gene name)|psi-mi:Prf1(display_short)|uniprotkb:Pfp(gene name synonym)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)	psi-mi:perf_mouse(display_long)|uniprotkb:Prf1(gene name)|psi-mi:Prf1(display_short)|uniprotkb:Pfp(gene name synonym)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Law et al. (2010)	pubmed:21037563|doi:10.1038/nature09518|imex:IM-16270	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15888292|imex:IM-16270-3|dip:DIP-187385E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035203.3|refseq:XP_006513433.1|dip:DIP-59218N|ensembl:ENSMUSG00000037202(gene)|ensembl:ENSMUST00000035419(transcript)|ensembl:ENSMUST00000219375(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|mint:P10820|rcsb pdb:3NSJ|rcsb pdb:4Y1S|rcsb pdb:4Y1T|rcsb pdb:5UG6|rcsb pdb:5UG7	refseq:NP_035203.3|refseq:XP_006513433.1|dip:DIP-59218N|ensembl:ENSMUSG00000037202(gene)|ensembl:ENSMUST00000035419(transcript)|ensembl:ENSMUST00000219375(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|mint:P10820|rcsb pdb:3NSJ|rcsb pdb:4Y1S|rcsb pdb:4Y1T|rcsb pdb:5UG6|rcsb pdb:5UG7	psi-mi:"MI:0465"(dip)	comment:mint|function:In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing non-specifically a variety of target cells	comment:mint|function:In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing non-specifically a variety of target cells	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:F/Dz+DZ6hUbgjfeFw3njXEf5bYM10090	rogid:F/Dz+DZ6hUbgjfeFw3njXEf5bYM10090	rigid:6axq7r379rSeh2kxShaVpLLundQ	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)