#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9YAV0	uniprotkb:Q9YAF1	intact:EBI-15880729|ensemblbacteria:BAA80848	intact:EBI-15887661|ensemblbacteria:BAA80998	psi-mi:ef1a_aerpe(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:APE_1844(locus name)	psi-mi:rf1_aerpe(display_long)|uniprotkb:Translation termination factor aRF1(gene name synonym)|uniprotkb:APE_1988.1(locus name)|uniprotkb:prf1(gene name)|psi-mi:prf1(display_short)	psi-mi:"MI:0096"(pull down)	Saito et al. (2010)	pubmed:20974926|doi:10.1073/pnas.1009599107|imex:IM-17114	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15887680|imex:IM-17114-1|dip:DIP-188091E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:APE_1844(gene)|ensemblbacteria:BAA80848(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:3VMF|rcsb pdb:3WXM|rcsb pdb:4CXG|rcsb pdb:4CXH|rcsb pdb:6JI2|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-59399N	ensemblbacteria:APE_1988.1(gene)|ensemblbacteria:BAA80998(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016149"(translation release factor activity, codon specific)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR020918|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|rcsb pdb:3AGK|rcsb pdb:3VMF|dip:DIP-59468N	psi-mi:"MI:0465"(dip)	crc64:D6AE87FEB8AD003C	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:PKpZHJ92OzlQhoC1DVmPE4/aIFE272557	rogid:LOf2YPnqT0sAg8MTAAXjZu6EQOg272557	rigid:eCs5W4d+chK36aefPgWVbK7k/jE	false	his tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9YAV0	uniprotkb:Q9YAF1	intact:EBI-15880729|ensemblbacteria:BAA80848	intact:EBI-15887661|ensemblbacteria:BAA80998	psi-mi:ef1a_aerpe(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:APE_1844(locus name)	psi-mi:rf1_aerpe(display_long)|uniprotkb:Translation termination factor aRF1(gene name synonym)|uniprotkb:APE_1988.1(locus name)|uniprotkb:prf1(gene name)|psi-mi:prf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Saito et al. (2010)	pubmed:20974926|doi:10.1073/pnas.1009599107|imex:IM-17114	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15887699|imex:IM-17114-2|dip:DIP-188091E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:APE_1844(gene)|ensemblbacteria:BAA80848(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:3VMF|rcsb pdb:3WXM|rcsb pdb:4CXG|rcsb pdb:4CXH|rcsb pdb:6JI2|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-59399N	ensemblbacteria:APE_1988.1(gene)|ensemblbacteria:BAA80998(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016149"(translation release factor activity, codon specific)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR020918|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|rcsb pdb:3AGK|rcsb pdb:3VMF|dip:DIP-59468N	psi-mi:"MI:0465"(dip)	crc64:D6AE87FEB8AD003C	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:PKpZHJ92OzlQhoC1DVmPE4/aIFE272557	rogid:LOf2YPnqT0sAg8MTAAXjZu6EQOg272557	rigid:eCs5W4d+chK36aefPgWVbK7k/jE	false	-	mutation decreasing interaction:168-168|mutation disrupting interaction:228-228|mutation disrupting interaction:290-290|mutation disrupting interaction:293-293|mutation disrupting interaction:354-354|mutation disrupting interaction:359-359	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9YAZ5	uniprotkb:Q9YAV0	intact:EBI-15880754|ensemblbacteria:BAA80803	intact:EBI-15880729|ensemblbacteria:BAA80848	psi-mi:pelo_aerpe(display_long)|uniprotkb:pelA(gene name)|psi-mi:pelA(display_short)|uniprotkb:APE_1800.1(locus name)	psi-mi:ef1a_aerpe(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:APE_1844(locus name)	psi-mi:"MI:0096"(pull down)	Saito et al. (2010)	pubmed:20974926|doi:10.1073/pnas.1009599107|imex:IM-17114	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15887735|imex:IM-17114-3|dip:DIP-187750E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:APE_1800.1(gene)|ensemblbacteria:BAA80803(transcript)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR023521|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|rcsb pdb:3WXM|rcsb pdb:6JI2|dip:DIP-59400N	ensemblbacteria:APE_1844(gene)|ensemblbacteria:BAA80848(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:3VMF|rcsb pdb:3WXM|rcsb pdb:4CXG|rcsb pdb:4CXH|rcsb pdb:6JI2|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-59399N	psi-mi:"MI:0465"(dip)	crc64:389A5D27B7752986	crc64:D6AE87FEB8AD003C	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:C+3UZIaMXxMkeojAdN7dai8Wt+w272557	rogid:PKpZHJ92OzlQhoC1DVmPE4/aIFE272557	rigid:4uwATGMYzMi6PPJFmIFFbL5VuIc	false	his tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P79063	uniprotkb:O74718	intact:EBI-9024036|ensemblfungi:"SPAC1834.01.1:pep"	intact:EBI-9024038|uniprotkb:P78857|ensemblfungi:"SPCC584.04.1:pep"	psi-mi:erf1_schpo(display_long)|uniprotkb:sup45(gene name)|psi-mi:sup45(display_short)|uniprotkb:SPAC1834.01(orf name)	psi-mi:erf3_schpo(display_long)|uniprotkb:sup35(gene name)|psi-mi:sup35(display_short)|uniprotkb:ERF-3(gene name synonym)|uniprotkb:ERF2(gene name synonym)|uniprotkb:Polypeptide release factor 3(gene name synonym)|uniprotkb:Translation release factor 3(gene name synonym)|uniprotkb:SPCC584.04(orf name)	psi-mi:"MI:0018"(two hybrid)	Saito et al. (2010)	pubmed:20974926|doi:10.1073/pnas.1009599107|imex:IM-17114	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15887755|imex:IM-17114-4|dip:DIP-188092E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_594680.1|reactome:R-SPO-72764|reactome:R-SPO-975956|reactome:R-SPO-975957|dip:DIP-59470N|ensemblfungi:SPAC1834.01(gene)|ensemblfungi:SPAC1834.01.1(transcript)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR042226|rcsb pdb:3E20|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064	refseq:NP_588225.1|reactome:R-SPO-72764|reactome:R-SPO-975956|reactome:R-SPO-975957|dip:DIP-59469N|ensemblfungi:SPCC584.04(gene)|ensemblfungi:SPCC584.04.1(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003747"(translation release factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0018444"(translation release factor complex)|go:"GO:0019003"(GDP binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR003285(Yeast eukaryotic release factor)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1R5B|rcsb pdb:1R5N|rcsb pdb:1R5O|rcsb pdb:3E20	psi-mi:"MI:0465"(dip)	crc64:5648B6EA2FD90997	crc64:54AE41EA6AF6168A	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:lOCPZyRTJH3zSGD0NTe9xLKaYrs284812	rogid:jFZ0qzkVOEgrOl4NPFs41GsKCPw284812	rigid:qCmHTU3icNDdZLsDNkUje4duakA	false	mutation decreasing interaction:173-173|mutation decreasing interaction:176-176|binding-associated region:143-433	binding-associated region:196-662	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9YAZ5	uniprotkb:Q9YAV0	intact:EBI-15880754|ensemblbacteria:BAA80803	intact:EBI-15880729|ensemblbacteria:BAA80848	psi-mi:pelo_aerpe(display_long)|uniprotkb:pelA(gene name)|psi-mi:pelA(display_short)|uniprotkb:APE_1800.1(locus name)	psi-mi:ef1a_aerpe(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:APE_1844(locus name)	psi-mi:"MI:0018"(two hybrid)	Saito et al. (2010)	pubmed:20974926|doi:10.1073/pnas.1009599107|imex:IM-17114	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15887782|imex:IM-17114-5|dip:DIP-187750E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:APE_1800.1(gene)|ensemblbacteria:BAA80803(transcript)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR023521|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|rcsb pdb:3WXM|rcsb pdb:6JI2|dip:DIP-59400N	ensemblbacteria:APE_1844(gene)|ensemblbacteria:BAA80848(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:3VMF|rcsb pdb:3WXM|rcsb pdb:4CXG|rcsb pdb:4CXH|rcsb pdb:6JI2|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-59399N	psi-mi:"MI:0465"(dip)	crc64:389A5D27B7752986	crc64:D6AE87FEB8AD003C	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:C+3UZIaMXxMkeojAdN7dai8Wt+w272557	rogid:PKpZHJ92OzlQhoC1DVmPE4/aIFE272557	rigid:4uwATGMYzMi6PPJFmIFFbL5VuIc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P79063	uniprotkb:O74718	intact:EBI-9024036|ensemblfungi:"SPAC1834.01.1:pep"	intact:EBI-9024038|uniprotkb:P78857|ensemblfungi:"SPCC584.04.1:pep"	psi-mi:erf1_schpo(display_long)|uniprotkb:sup45(gene name)|psi-mi:sup45(display_short)|uniprotkb:SPAC1834.01(orf name)	psi-mi:erf3_schpo(display_long)|uniprotkb:sup35(gene name)|psi-mi:sup35(display_short)|uniprotkb:ERF-3(gene name synonym)|uniprotkb:ERF2(gene name synonym)|uniprotkb:Polypeptide release factor 3(gene name synonym)|uniprotkb:Translation release factor 3(gene name synonym)|uniprotkb:SPCC584.04(orf name)	psi-mi:"MI:0018"(two hybrid)	Saito et al. (2010)	pubmed:20974926|doi:10.1073/pnas.1009599107|imex:IM-17114	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15887799|imex:IM-17114-6|dip:DIP-188092E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_594680.1|reactome:R-SPO-72764|reactome:R-SPO-975956|reactome:R-SPO-975957|dip:DIP-59470N|ensemblfungi:SPAC1834.01(gene)|ensemblfungi:SPAC1834.01.1(transcript)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR042226|rcsb pdb:3E20|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064	refseq:NP_588225.1|reactome:R-SPO-72764|reactome:R-SPO-975956|reactome:R-SPO-975957|dip:DIP-59469N|ensemblfungi:SPCC584.04(gene)|ensemblfungi:SPCC584.04.1(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003747"(translation release factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0018444"(translation release factor complex)|go:"GO:0019003"(GDP binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR003285(Yeast eukaryotic release factor)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1R5B|rcsb pdb:1R5N|rcsb pdb:1R5O|rcsb pdb:3E20	psi-mi:"MI:0465"(dip)	crc64:5648B6EA2FD90997	crc64:54AE41EA6AF6168A	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:lOCPZyRTJH3zSGD0NTe9xLKaYrs284812	rogid:jFZ0qzkVOEgrOl4NPFs41GsKCPw284812	rigid:qCmHTU3icNDdZLsDNkUje4duakA	false	binding-associated region:143-433	mutation decreasing interaction:294-294|mutation decreasing interaction:297-297|mutation decreasing interaction:305-305|mutation disrupting interaction:329-329|mutation disrupting interaction:477-477|binding-associated region:196-662	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9YAV0	uniprotkb:Q9YAF1	intact:EBI-15880729|ensemblbacteria:BAA80848	intact:EBI-15887661|ensemblbacteria:BAA80998	psi-mi:ef1a_aerpe(display_long)|uniprotkb:tuf(gene name)|psi-mi:tuf(display_short)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:APE_1844(locus name)	psi-mi:rf1_aerpe(display_long)|uniprotkb:Translation termination factor aRF1(gene name synonym)|uniprotkb:APE_1988.1(locus name)|uniprotkb:prf1(gene name)|psi-mi:prf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Saito et al. (2010)	pubmed:20974926|doi:10.1073/pnas.1009599107|imex:IM-17114	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	taxid:272557(aerpe)|taxid:272557("Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15887835|imex:IM-17114-7|dip:DIP-188091E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:APE_1844(gene)|ensemblbacteria:BAA80848(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:3VMF|rcsb pdb:3WXM|rcsb pdb:4CXG|rcsb pdb:4CXH|rcsb pdb:6JI2|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-59399N	ensemblbacteria:APE_1988.1(gene)|ensemblbacteria:BAA80998(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016149"(translation release factor activity, codon specific)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR020918|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|rcsb pdb:3AGK|rcsb pdb:3VMF|dip:DIP-59468N	psi-mi:"MI:0465"(dip)	crc64:D6AE87FEB8AD003C	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:PKpZHJ92OzlQhoC1DVmPE4/aIFE272557	rogid:LOf2YPnqT0sAg8MTAAXjZu6EQOg272557	rigid:eCs5W4d+chK36aefPgWVbK7k/jE	false	mutation disrupting interaction:64-64|mutation decreasing interaction:65-65|mutation decreasing interaction:73-73|mutation disrupting interaction:337-337|mutation disrupting interaction:338-338|mutation disrupting interaction:379-379	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)