#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9QZS8 uniprotkb:O35177 intact:EBI-7964037|uniprotkb:A2AK84|intact:MINT-1503279|uniprotkb:Q9JME1|ensembl:ENSMUSP00000073866 intact:EBI-2642891|uniprotkb:Q8BJL8|uniprotkb:Q8BMI9|uniprotkb:Q8BM94|uniprotkb:Q8BK90|uniprotkb:Q99KE7|uniprotkb:Q8BL52|ensembl:ENSMUSP00000021794 psi-mi:sh2d3_mouse(display_long)|uniprotkb:Sh2d3c(gene name)|psi-mi:Sh2d3c(display_short)|uniprotkb:Chat(gene name synonym)|uniprotkb:Shep1(gene name synonym)|uniprotkb:SH2 domain-containing Eph receptor-binding protein 1(gene name synonym)|uniprotkb:Cas/HEF1-associated signal transducer(gene name synonym) psi-mi:casl_mouse(display_long)|uniprotkb:Casl(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Nedd9(gene name)|psi-mi:Nedd9(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Browne et al. (2010) pubmed:20956287|doi:10.1073/pnas.1007558107|imex:IM-21474 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15885143|imex:IM-21474-1|dip:DIP-191662E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038809.1|refseq:NP_001239476.1|dip:DIP-42657N|ensembl:ENSMUSG00000059013(gene)|ensembl:ENSMUST00000074248(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030424"(axon)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102 refseq:NP_001104794.1|refseq:NP_059492.3|ensembl:ENSMUSG00000021365(gene)|ensembl:ENSMUST00000021794(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|dip:DIP-57058N psi-mi:"MI:0465"(dip) comment:mint|function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:EQM1e5BcyjOWCUs97MgXL5cmtHw10090 rogid:M/DE7RwmYizqy+SKJvp0M1f1odY10090 rigid:oQHyAXENXfCTjAhv/y79kiZsIwk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QZS8 uniprotkb:O35177 intact:EBI-7964037|uniprotkb:A2AK84|intact:MINT-1503279|uniprotkb:Q9JME1|ensembl:ENSMUSP00000073866 intact:EBI-2642891|uniprotkb:Q8BJL8|uniprotkb:Q8BMI9|uniprotkb:Q8BM94|uniprotkb:Q8BK90|uniprotkb:Q99KE7|uniprotkb:Q8BL52|ensembl:ENSMUSP00000021794 psi-mi:sh2d3_mouse(display_long)|uniprotkb:Sh2d3c(gene name)|psi-mi:Sh2d3c(display_short)|uniprotkb:Chat(gene name synonym)|uniprotkb:Shep1(gene name synonym)|uniprotkb:SH2 domain-containing Eph receptor-binding protein 1(gene name synonym)|uniprotkb:Cas/HEF1-associated signal transducer(gene name synonym) psi-mi:casl_mouse(display_long)|uniprotkb:Casl(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Nedd9(gene name)|psi-mi:Nedd9(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Browne et al. (2010) pubmed:20956287|doi:10.1073/pnas.1007558107|imex:IM-21474 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15885160|imex:IM-21474-2|dip:DIP-191662E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038809.1|refseq:NP_001239476.1|dip:DIP-42657N|ensembl:ENSMUSG00000059013(gene)|ensembl:ENSMUST00000074248(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030424"(axon)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102 refseq:NP_001104794.1|refseq:NP_059492.3|ensembl:ENSMUSG00000021365(gene)|ensembl:ENSMUST00000021794(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|dip:DIP-57058N psi-mi:"MI:0465"(dip) comment:mint|function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:EQM1e5BcyjOWCUs97MgXL5cmtHw10090 rogid:M/DE7RwmYizqy+SKJvp0M1f1odY10090 rigid:oQHyAXENXfCTjAhv/y79kiZsIwk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9QZS8-1 uniprotkb:O35177 intact:EBI-15885177|ensembl:ENSMUSP00000073866 intact:EBI-2642891|uniprotkb:Q8BJL8|uniprotkb:Q8BMI9|uniprotkb:Q8BM94|uniprotkb:Q8BK90|uniprotkb:Q99KE7|uniprotkb:Q8BL52|ensembl:ENSMUSP00000021794 psi-mi:q9qzs8-1(display_long)|uniprotkb:Sh2d3c(gene name)|psi-mi:Sh2d3c(display_short)|uniprotkb:Chat(gene name synonym)|uniprotkb:Shep1(gene name synonym)|uniprotkb:Chat-H(isoform synonym)|uniprotkb:Cas/HEF1-associated signal transducer(gene name synonym)|uniprotkb:SH2 domain-containing Eph receptor-binding protein 1(gene name synonym) psi-mi:casl_mouse(display_long)|uniprotkb:Casl(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Nedd9(gene name)|psi-mi:Nedd9(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Browne et al. (2010) pubmed:20956287|doi:10.1073/pnas.1007558107|imex:IM-21474 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15885187|imex:IM-21474-3|dip:DIP-191662E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7964037(isoform-parent)|ensembl:ENSMUSG00000059013(gene)|ensembl:ENSMUST00000074248(transcript) refseq:NP_001104794.1|refseq:NP_059492.3|ensembl:ENSMUSG00000021365(gene)|ensembl:ENSMUST00000021794(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|dip:DIP-57058N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:EQM1e5BcyjOWCUs97MgXL5cmtHw10090 rogid:M/DE7RwmYizqy+SKJvp0M1f1odY10090 rigid:oQHyAXENXfCTjAhv/y79kiZsIwk false mutation disrupting interaction:787-787 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)